Achievement Highlights

HKU Department of Medicine, School of Clinical Medicine is at the frontier of the discovery of cutting-edge medical research findings. Our academics are recognised globally for their research innovations and have issued several high impact publications with high impact factor. A number of them have also earned the honour of being named as the most influential in the world by Clarivate Analytics in its list of "Highly Cited Researchers 2020”. Their works have been highly cited by fellow academics and have significantly impacted their respective fields.

"Highly Cited Researchers 2020", released by the Clarivate Analytics, identifies the most influential researchers as determined by their peers around the world. The honour is given to researchers who published multiple papers that rank in the top 1% by citations for their fields and year of publication.

High Impact Publications

Authors & Articles Impact Factor
Cost-effectiveness of universal screening for chronic hepatitis B virus infection in China: an economic evaluation. 
Su, S., Wong, W.C., Zou, Z., Cheng, D.D., Ong, J.J., Chan, P., Ji, F., Yuen, M.F., Zhuang, G., Seto, W.K., Zhang, L. (2022). Lancet Global Health, 10(2): e278-287.
Statin associated lower cancer risk and related mortality in patients with heart failure.
Ren, Q. W., Yu, S. Y., Teng, T. K., Li, X., Cheung, K. S., Wu, M. Z., Li, H. L., Wong, P. F., Tse, H. F., Lam, C., & Yiu, K. H. (2021). European heart journal, 42(32), 3049–3059.
Role of serum HBV RNA and hepatitis B surface antigen levels in identifying Asian patients with chronic hepatitis B suitable for entecavir cessation.
Seto, W. K., Liu, K. S., Mak, L. Y., Cloherty, G., Wong, D. K., Gersch, J., Lam, Y. F., Cheung, K. S., Chow, N., Ko, K. L., To, W. P., Fung, J., & Yuen, M. F. (2021). Gut, 70(4), 775–783.
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.
Yuen, M. F., Heo, J., Jang, J. W., Yoon, J. H., Kweon, Y. O., Park, S. J., Tami, Y., You, S., Yates, P., Tao, Y., Cremer, J., Campbell, F., Elston, R., Theodore, D., Paff, M., Bennett, C. F., & Kwoh, T. J. (2021). Nature medicine, 27(10), 1725–1734.
Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment.
Yuen, M. F., Wong, D. K., Schluep, T., Lai, C. L., Ferrari, C., Locarnini, S., Lo, R. C., Gish, R. G., Hamilton, J., Wooddell, C. I., Mak, L. Y., & Given, B. D. (2021).  Gut, gutjnl-2020-323445. Advance online publication.
Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis.
Cheung, K. S., Hung, I., Chan, P., Lung, K. C., Tso, E., Liu, R., Ng, Y. Y., Chu, M. Y., Chung, T., Tam, A. R., Yip, C., Leung, K. H., Fung, A. Y., Zhang, R. R., Lin, Y., Cheng, H. M., Zhang, A., To, K., Chan, K. H., Yuen, K. Y., … Leung, W. K. (2020). Gastroenterology, 159(1), 81–95.
Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori: a territory-wide cohort study.
Guo, C. G., Cheung, K. S., Zhang, F., Chan, E. W., Chen, L., Wong, I. C., & Leung, W. K. (2020). Gut, 69(3), 445–452.
SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking a cruise ship: a case series.
Hung, I. F., Cheng, V. C., Li, X., Tam, A. R., Hung, D. L., Chiu, K. H., Yip, C. C., Cai, J. P., Ho, D. T., Wong, S. C., Leung, S. S., Chu, M. Y., Tang, M. O., Chen, J. H., Poon, R. W., Fung, A. Y., Zhang, R. R., Yan, E. Y., Chen, L. L., Choi, C. Y., … Yuen, K. Y. (2020). The Lancet. Infectious diseases, 20(9), 1051–1060.
Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial.
Hung, I. F., Lung, K. C., Tso, E. Y., Liu, R., Chung, T. W., Chu, M. Y., Ng, Y. Y., Lo, J., Chan, J., Tam, A. R., Shum, H. P., Chan, V., Wu, A. K., Sin, K. M., Leung, W. S., Law, W. L., Lung, D. C., Sin, S., Yeung, P., Yip, C. C., … Yuen, K. Y. (2020). The Lancet (London, England), 395(10238), 1695–1704.
Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention.
Liu, Y., Wang, Y., Ni, Y., Cheung, C., Lam, K., Wang, Y., Xia, Z., Ye, D., Guo, J., Tse, M. A., Panagiotou, G., & Xu, A. (2020). Cell metabolism, 31(1), 77–91.e5.
Impacts of the Coronavirus 2019 Pandemic on Gastrointestinal Endoscopy Volume and Diagnosis of Gastric and Colorectal Cancers: A Population-Based Study.
Lui, T., Leung, K., Guo, C. G., Tsui, V., Wu, J. T., & Leung, W. K. (2020). Gastroenterology, 159(3), 1164–1166.e3.
Diverse effects of hepatic steatosis on fibrosis progression and functional cure in virologically quiescent chronic hepatitis B.
Mak, L. Y., Hui, R. W., Fung, J., Liu, F., Wong, D. K., Cheung, K. S., Yuen, M. F., & Seto, W. K. (2020). Journal of hepatology, 73(4), 800–806.
Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients.
Cheung, K. S., Chen, L., Chan, E. W., Seto, W. K., Wong, I., & Leung, W. K. (2019). Gut, 68(11), 1979–1985.
Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.
Yuen, M. F., Gane, E. J., Kim, D. J., Weilert, F., Yuen Chan, H. L., Lalezari, J., Hwang, S. G., Nguyen, T., Flores, O., Hartman, G., Liaw, S., Lenz, O., Kakuda, T. N., Talloen, W., Schwabe, C., Klumpp, K., & Brown, N. (2019). Gastroenterology, 156(5), 1392–1403.e7.

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study.
Cheung, K. S., Chan, E. W., Wong, A., Chen, L., Wong, I., & Leung, W. K. (2018). Gut, 67(1), 28–35.

Effects of Helicobacter pylori Treatment on Incidence of Gastric Cancer in Older Individuals.
Leung, W. K., Wong, I., Cheung, K. S., Yeung, K. F., Chan, E. W., Wong, A., Chen, L., Wong, I., & Graham, D. Y. (2018). Gastroenterology, 155(1), 67–75.

Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users.
Seto, W. K., Mak, S. K., Chiu, K., Vardhanabhuti, V., Wong, H. F., Leong, H. T., Lee, P., Ho, Y. C., Lee, C. K., Cheung, K. S., Yuen, M. F., & Leung, W. K. (2018). Journal of Hepatology, 69(1), 121–128.

Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial.
Hung, I. F., Zhang, A. J., To, K. K., Chan, J. F., Li, P., Wong, T. L., Zhang, R., Chan, T. C., Chan, B. C., Wai, H. H., Chan, L. W., Fong, H. P., Hui, R. K., Kong, K. L., Leung, A. C., Ngan, A. H., Tsang, L. W., Yeung, A. P., Yiu, G. C., Yung, W., … Yuen, K. Y. (2016). The Lancet. Infectious diseases, 16(2), 209–218.

Researchers in the Top 1% Worldwide Ranked by Clarivate Analytics

This list recognizes the Department’s researchers ranked by Clarivate Analytics in the top 1% worldwide by citations in at least one of the 22 research fields. Data is drawn from Essential Science Indicators (ESI).

Highly Cited Researchers 2020

Selected Publications

2021 2020 2019
  • Gu P, Hui X, Zheng Q, Gao Y, Jin L, Jiang W, Zhou C, Liu T, Huang Y, Liu Q, Nie T, Wang Y, Wang Y, Zhao J, Xu A.; Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1β production; Sci Adv 2021 Dec 10;7(50):eabl4024. doi: 10.1126/sciadv.abl4024.
  • Ranyao Yang, Yue Hu, Chi Ho Lee, Yan Liu, Candela Diaz-Canestro, Carol Ho Yi Fong, Huige Lin, Kenneth K Y Cheng, Aparna Padmanabhan Pravelil, Erfei Song, Karen S L Lam, Aimin Xu; PM20D1 is a circulating biomarker closely associated with obesity, insulin resistance and metabolic syndrome; Eur J Endocrinol 2021 Dec 10;186(2):151-161.
  • Chan YH, Schooling CM, Zhao J, Au Yeung SL, Hai JJ, Thomas GN, Cheng KK, Jiang CQ, Wong YK, Au KW, Tang CS, Cheung CYY, Xu A, Sham PC, Lam TH, Lam KS, Tse HF.; Mendelian Randomization Focused Analysis of Vitamin D on the Secondary Prevention of Ischemic Stroke; Stroke 2021 Dec;52(12):3926-3937. doi: 10.1161/STROKEAHA.120.032634. 
  • Yap DYH, Li PH, Tang C, So BYF, Kwan LPY, Chan GCW, Lau CS, Chan; Long-term results of triple immunosuppression with tacrolimus added to mycophenolate and corticosteroids in the treatment of lupus nephritis; Kidney International Reports (2022), doi:
  • Zhang Z, Guo L, Huang L, Zhang C, Luo R, Zeng L, Liang H, Li Q, Lu X, Wang X, Ma CY, Shao J, Luo W, Li L, Liu L, Li Z, Zhou X, Zhang X, Liu J, Yang J, Kwan KY, Liu W, Xu Y, Jiang H, Liu H, Du H, Wu Y, Yu G, Chen J, Wu J, Zhang J, Liao C, Chen HJ, Chen Z, Tse HF, Xia H, Lian Q.; Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells; Clin Infect Dis 2021 Dec 6;73(11):e4154-e4165. doi: 10.1093/cid/ciaa1911.
  • Wong CKH, Lui DTW, Lui AYC, Kwok ACY, Low MCH, Lau KTK, Au ICH, Xiong X, Chung MSH, Lau EHY, Cowling BJ.; Use of DPP4i reduced odds of clinical deterioration and hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: propensity score analysis of a territory-wide cohort in Hong Kong; Diabetes Metab 2021 Dec 1;101307. doi: 10.1016/j.diabet.2021.101307
  • Lee CO, Li HL, Tsoi MF, Cheung CL, Cheung BMY.; Association between the liver fat score (LFS) and cardiovascular diseases in the national health and nutrition examination survey 1999-2016; Ann Med 2021 Dec;53(1):1065-1073. doi: 10.1080/07853890.2021.1943514.
  • Li B, Leung JCK, Chan LYY, Li HY, Yiu WH, Lok SWY, Xue R, Zou YX, Chen W, Lai KN, Tang SCW.; Tubule-specific deletion of LincRNA-p21 ameliorates lipotoxic kidney injury; Mol Ther Nucleic Acids 2021 Nov 4;26:1280-1290. doi: 10.1016/j.omtn.2021.10.029.
  • Mak LY, Hoang J, Jun DW, Chen CH, Peng CY, Yeh ML, Kim SE, Huang DQ, Jeong JY, Yoon E, Oh H, Tsai PC, Huang CF, Ahn SB, Trinh H, Xie Q, Wong GLH, Enomoto M, Shim JJ, Lee DH, Liu L, Kozuka R, Cho YK, Jeong SW, Kim HS, Trinh L, Dao A, Huang R, Hui RW, Tsui V, Quek S, Khine HHTW, Ogawa E, Dai CY, Huang JF, Cheung R, Wu C, Chuang WL, Lim SG, Yu ML, Yuen MF, Nguyen MH; Longitudinal renal changes in chronic hepatitis B patients treated with entecavir versus TDF: a REAL-B study; Hepatol Int 2021 Nov 25. doi: 10.1007/s12072-021-10271-x.
  • Jiang F, Guo CG, Cheung KS, Leung WK.; Long-term risk of upper gastrointestinal bleeding after Helicobacter pylori eradication: a population-based cohort study; Aliment Pharmacol Ther 2021 Nov;54(9):1162-1169. doi: 10.1111/apt.16604. Epub 2021 Sep 16.
  • Guo CG, Jiang F, Cheung KS, Li B, Ooi PH, Leung WK.; Timing of prior exposure to antibiotics and failure of Helicobacter pylori eradication: a population-based study; J Antimicrob Chemother 2021 Nov 13;dkab415. doi: 10.1093/jac/dkab415. 
  • Liang Y, Du R, Chen R, Chu PH, Ip MSM, Zhang KYB, Mak JCW.; Therapeutic potential and mechanism of Dendrobium officinale polysaccharides on cigarette smoke-induced airway inflammation in rat; Biomed Pharmacother 2021 Nov;143:112101. doi: 10.1016/j.biopha.2021.112101. Epub 2021 Aug 30.
  • Lui MM, Tse HF, Lam DC, Lau KK, Chan CW, Ip MS.; Continuous positive airway pressure improves blood pressure and serum cardiovascular biomarkers in obstructive sleep apnoea and hypertension; Eur Respir J 2021 Nov 4;58(5):2003687. doi: 10.1183/13993003.03687-2020. Print 2021 Oct.
  • Huang J, Xu J, Lai JHC, Chen Z, Lee CY, Mak HKF, Chan KH, Chan KWY.; Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis; Neuroimage Clin 2021;32:102867. doi: 10.1016/j.nicl.2021.102867. Epub 2021 Oct 28.
  • Huang J, Xu J, Lai JHC, Chen Z, Lee CY, Mak HKF, Chan KH, Chan KWY.; Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis; Neuroimage Clin 2021 Oct 28;32:102867. doi: 10.1016/j.nicl.2021.102867
  • Rui Chen, Charalambos Michaeloudes, Yingmin Liang, Pankaj K Bhavsar, Kian Fan Chung, Mary S M Ip, Judith C W Mak; ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells; J Allergy Clin Immunol 2021 Oct 5;S0091-6749(21)01514-1. doi: 10.1016/j.jaci.2021.09.028.
  • Gane E, Yuen MF, Kim DJ, Chan HL, Surujbally B, Pavlovic V, Das S, Triyatni M, Kazma R, Grippo JF, Buatois S, Lemenuel-Diot A, Krippendorff BF, Mueller H, Zhang Y, Kim HJ, Leerapun A, Lim TH, Lim YS, Tanwandee T, Kim W, Cheng W, Hu TH, Wat C.; Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B; Hepatology. 2021 Oct;74(4):1795-1808. doi: 10.1002/hep.31920. Epub 2021 Aug 25.PMID: 34037271
  • Feng Q, Tsoi MF, Fei Y, Cheung CL, Cheung BMY.; Use of ticagrelor and the risks of pneumonia and pneumonia-specific death in patients with non-acute coronary syndrome conditions: a population-based cohort study; Sci Rep 2021 Oct 14;11(1):20468. doi: 10.1038/s41598-021-00105-z.
  • Li X, Tong X, Yeung WWY, Kuan P, Yum SHH, Chui CSL, Lai FTT, Wan EYF, Wong CKH, Chan EWY, Lau CS, Wong ICK.; Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong; Ann Rheum Dis 2021 Oct 22;annrheumdis-2021-221571. doi: 10.1136/annrheumdis-2021-221571.
  • Yuen MF, Heo J, Jang JW, Yoon JH, Kweon YO, Park SJ, Tami Y, You S, Yates P, Tao Y, Cremer J, Campbell F, Elston R, Theodore D, Paff M, Bennett CF, Kwoh TJ.; Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial; Nat Med. 2021 Oct;27(10):1725-1734. doi: 10.1038/s41591-021-01513-4. Epub 2021 Oct 12.PMID: 34642494 
  • Liu H, Ho PW, Leung CT, Pang SY, Chang EES, Choi ZY, Kung MH, Ramsden DB, Ho SL.; Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 R1441G mice; Autophagy 2021 Oct;17(10):3196-3220. doi: 10.1080/15548627.2020.1850008. Epub 2020 Dec 10.
  • Man-Fung Yuen, Xue Zhou, Edward Gane, Christian Schwabe, Tawesak Tanwandee, Sheng Feng, Yuyan Jin, Miriam Triyatni, Annabelle Lemenuel-Diot, Valerie Cosson, Zenghui Xue, Remi Kazma, Qingyan Bo; Safety, pharmacokinetics, and antiviral activity of RO7049389, a core protein allosteric modulator, in patients with chronic hepatitis B virus infection: a multicentre, randomised, placebo-controlled, phase 1 trial; Lancet Gastroenterol Hepatol 2021 Sep;6(9):723-732. doi: 10.1016/S2468-1253(21)00176-X.
  • Ju-Hua Liu, Mei-Zhen Wu, Si-Min Li, Yan Chen, Qing-Wen Ren, Qing-Shan Lin, Ming-Yen Ng, Hung-Fat Tse, Kai-Hang Yiu; Association of serum uric acid with biventricular myocardial dysfunction in patients with type 2 diabetes mellitus; Nutr Metab Cardiovasc Dis. 2021 Sep 22;31(10):2912-2920. doi: 10.1016/j.numecd.2021.06.012. Epub 2021 Jun 29.
  • Lui DTW, Hung IFN, Lee CH, Lee ACH, Tam AR, Pang P, Ho TY, Cheung CYY, Fong CHY, Law CY, To KKW, Lam CW, Chow WS, Woo YC, Lam KSL, Tan KCB.; The Impact of Interferon Beta-1b Therapy on Thyroid Function and Autoimmunity Among COVID-19 Survivors; Front Endocrinol (Lausanne) 2021 Sep 30;12:746602. doi: 10.3389/fendo.2021.746602.
  • Chan KW, Lee PW, Leung CP, Law YK, Gao L, Chan GC, Yiu WH, Lam TP, Tang SC.; PRAgmatic Clinical Trial Design of Integrative MediCinE (PRACTICE): A Focus Group Series and Systematic Review on Trials of Diabetes and Kidney Disease; Front Med (Lausanne) 2021 Aug 27;8:668913. doi: 10.3389/fmed.2021.668913. eCollection 2021.
  • Ren QW, Yu SY, Teng TK, Li X, Cheung KS, Wu MZ, Li HL, Wong PF, Tse HF, Lam CSP, Yiu KH.; Statin associated lower cancer risk and related mortality in patients with heart failure; Eur Heart J 2021 Aug 21;42(32):3049-3059. doi: 10.1093/eurheartj/ehab325.
  • Mak LY, Hui RW, Fung J, Liu F, Wong DK, Li B, Cheung KS, Yuen MF, Seto WK.; Reduced hepatic steatosis is associated with higher risk of hepatocellular carcinoma in chronic hepatitis B infection; Hepatol Int 2021 Aug;15(4):901-911. doi: 10.1007/s12072-021-10218-2. Epub 2021 Jun 21.
  • Lui DTW, Lee CH, Woo YC, Fong CHY, Tso AWK, Cheung BMY, Lam TH, Janus E, Lam KSL.; Cohort Profile: The Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) and the follow-up studies; Int J Epidemiol. 2021 Aug 30;50(4):1069-1069h. doi: 10.1093/ije/dyaa240.
  • Guo CG, Tian L, Zhang F, Cheung KS, Leung WK.; Associations of seasonal variations and meteorological parameters with incidences of upper and lower gastrointestinal bleeding; J Gastroenterol Hepatol 2021 Jul 21. doi: 10.1111/jgh.15632. 
  • Chan SCW, Teo CK, Li PH, Lau KK, Lau CS, Chung HY.; Cardiovascular risk in patients with spondyloarthritis and association with anti-TNF drugs; Ther Adv Musculoskelet Dis 2021 Jul 27;13:1759720X211032444. doi: 10.1177/1759720X211032444. eCollection 2021.
  • Chung HY, Chan SCW, Chui ETF, Yau T, Lau CS.; Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs; Clin Exp Rheumatol 2021 Jul 24.
  • Gill H, Yung Y, Chu HT, Au WY, Yip PK, Lee E, Yim R, Lee P, Cheuk D, Ha SY, Leung RYY, Ma ESK, Kumana CR, Kwong YL.; Characteristics and predictors of early hospital deaths in newly diagnosed APL: a 13-year population-wide study; Blood Adv 2021 Jul 27;5(14):2829-2838. doi: 10.1182/bloodadvances.2021004789.
  • Si-Jia Sun, Rui Wei, Fei Li, Song-Yan Liao, Hung-Fat Tse; Mesenchymal stromal cell-derived exosomes in cardiac regeneration and repair; Stem Cell Reports 2021 Jul 13;16(7):1662-1673. doi: 10.1016/j.stemcr.2021.05.003.
  • Guo CG, Zhang F, Wu JT, Cheung KS, Li B, Law SYK, Leung WK.; Divergent trends of hospitalizations for upper and lower gastrointestinal bleeding based on population prescriptions of aspirin, proton pump inhibitors and Helicobacter pylori eradication therapy: Trends of upper and lower gastrointestinal bleeding; United European Gastroenterol J 2021 Jun;9(5):543-551. doi: 10.1002/ueg2.12067. Epub 2021 May 6.
  • Lung-Yi Mak,Gavin Cloherty,Danny Ka-Ho Wong,Jeffrey Gersch,Wai-Kay Seto,James Fung,Man-Fung Yuen; HBV RNA Profiles in Patients With Chronic Hepatitis B Under Different Disease Phases and Antiviral Therapy; Hepatology. 2021 Jun;73(6):2167-2179. doi: 10.1002/hep.31616.
  • Li B, Cheung KS, Wong IY, Leung WK, Law S.; Nonaspirin nonsteroidal anti-inflammatory drugs and gastric cancer risk after Helicobacter pylori eradication: A territory-wide study; Cancer 2021 Jun 1;127(11):1805-1815. doi: 10.1002/cncr.33412. Epub 2021 Jan 20.
  • Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL.; Insights from a Prospective Follow-up of Thyroid Function and Autoimmunity among COVID-19 Survivors; Endocrinol Metab (Seoul) 2021 Jun;36(3):582-589. doi: 10.3803/EnM.2021.983. Epub 2021 Jun 8.
  • Li B, Cheung KS, Wong IY, Leung WK, Law S.; Calcium channel blockers are associated with lower gastric cancer risk: A territory-wide study with propensity score analysis; Int J Cancer 2021 May 1;148(9):2148-2157. doi: 10.1002/ijc.33379. Epub 2020 Nov 30.
  • Kam Wa Chan, Tak Yee Chow, Kam Yan Yu, Yulong Xu, Nevin Lianwen Zhang, Vivian Taam Wong, Saimei Li, Sydney Chi Wai Tang; SYmptom-Based STratification of DiabEtes Mellitus by Renal Function Decline (SYSTEM): A Retrospective Cohort Study and Modeling Assessment; Front Med (Lausanne) 2021 Jun 14;8:682090. doi: 10.3389/fmed.2021.682090. eCollection 2021.
  • Kam Wa Chan, Kam Yan Yu, Pak Wing Lee, Kar Neng Lai, Sydney Chi-Wai Tang; Global REnal Involvement of CORonavirus Disease 2019 (RECORD): A Systematic Review and Meta-Analysis of Incidence, Risk Factors, and Clinical Outcomes; Front Med (Lausanne) 2021 May 25;8:678200. doi: 10.3389/fmed.2021.678200. eCollection 2021.
  • Li HL, Lip GYH, Feng Q, Fei Y, Tse YK, Wu MZ, Ren QW, Tse HF, Cheung BY, Yiu KH.; Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis; Cardiovasc Diabetol. 2021 May 7;20(1):100. doi: 10.1186/s12933-021-01293-8
  • Lung-Yi Mak, Qi Huang, Danny Ka-Ho Wong, Luisa Stamm, Ka-Shing Cheung, Kwan-Lung Ko, Ran Yan, Lea Ouyang, James Fung, Wai-Kay Seto, Man-Fung Yuen; Residual HBV DNA and pgRNA viraemia is associated with hepatocellular carcinoma in chronic hepatitis B patients on antiviral therapy; J Gastroenterol. 2021 May;56(5):479-488. doi: 10.1007/s00535-021-01780-5. Epub 2021 Mar 27.
  • Leung WK, Cheung KS, Li B, Law SYK, Lui TKL.; Applications of machine learning models in the prediction of gastric cancer risk in patients after Helicobacter pylori eradication; Aliment Pharmacol Ther 2021 Apr;53(8):864-872. doi: 10.1111/apt.16272. 
  • Fung-Yu Huang, Danny Ka-Ho Wong, Wai-Kay Seto, Lung-Yi Mak, Tan-To Cheung, Man-Fung Yuen; Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma; Cell Death Discov 2021 Apr 30;7(1):88. doi: 10.1038/s41420-021-00470-8.
  • Wong YK, Chan YH, Hai JSH, Lau KK, Tse HF.; Predictive value of visit-to-visit blood pressure variability for cardiovascular events in patients with coronary artery disease with and without diabetes mellitus; Cardiovasc Diabetol 2021 Apr 24;20(1):88. doi: 10.1186/s12933-021-01280-z.
  • Yan Chen, Yap-Hang Chan, Mei-Zhen Wu, Yu-Juan Yu, Qing-Wen Ren, Yui-Ming Lam, Wai-Kay Seto, Man-Fung Yuen, Albert Chi-Yan Chan, Chu-Pak Lau, Hung-Fat Tse, Kai-Hang Yiu; Prognostic value and reversibility of liver stiffness in patients undergoing tricuspid annuloplasty; Eur Heart J Cardiovasc Imaging 2021 Apr 7;jeab059. doi: 10.1093/ehjci/jeab059.
  • Jie Ma, Ian Kar Yin Lam, Chak-Sing Lau, Vera Sau Fong Chan; Elevated Interleukin-18 Receptor Accessory Protein Mediates Enhancement in Reactive Oxygen Species Production in Neutrophils of Systemic Lupus Erythematosus Patients; Cells 2021 Apr 21;10(5):964. doi: 10.3390/cells10050964.
  • Wong JS, Dong Y, Tang V, Leung T, Yeung CSY, Tai A, Law A, Shum T, Kwok GG, Li BC, Leung R, Chiu J, Ma KW, She WH, Tsang J, Cheung TT, Yau T.; The Use of Cabozantinib in Advanced Hepatocellular Carcinoma in Hong Kong-A Territory-Wide Cohort Study; Cancers (Basel). 2021 Apr 21;13(9):2002. doi: 10.3390/cancers13092002.
  • Yang Xiao, Lingling Shu, Xiaoping Wu, Yang Liu, Lai Yee Cheong, Boya Liao, Xiaoyu Xiao, Ruby Lc Hoo, Zhiguang Zhou, Aimin Xu; Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages; JCI Insight 2021 Apr 8;6(7):e141814. doi: 10.1172/jci.insight.141814.
  • Yin Cai, Hao Liu, Erfei Song, Lin Wang, Jindong Xu, Yi He, Dengwen Zhang, Liyan Zhang, Kenneth King-yip Cheng, Leigang Jin, Min Wu, Shiming Liu, Dake Qi, Liangqing Zhang, Gary D. Lopaschuk, Sheng Wang,Aimin Xu, and Zhengyuan Xia; Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling; Theranostics. 2021 Mar 4; 11(10): 4710–4727.
  • Wong JC, Au EY, Yeung HH, Lau CS, Li PH.; Piperacillin-Tazobactam Allergies: An Exception to Usual Penicillin Allergy; Allergy Asthma Immunol Res 2021 Mar;13(2):284-294. doi: 10.4168/aair.2021.13.2.284.
  • Yiu WH, Chan KW, Chan LYY, Leung JCK, Lai KN, Tang SCW.; Spleen Tyrosine Kinase Inhibition Ameliorates Tubular Inflammation in IgA Nephropathy; Front Physiol 2021 Mar 15;12:650888. doi: 10.3389/fphys.2021.650888. eCollection 2021.
  • David T.W. Lui, Ching-Lung Cheung, Alan C.H. Lee, Ying Wong, Sammy W.M. Shiu and Kathryn C.B. Tan; Carbamylated HDL and Mortality Outcomes in Type 2 Diabetes; Diabetes Care 2021 Mar; 44(3): 804-809.
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