Publications

2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005
  • Zhang C, Chan CCY, Cheung KF, Chau MKM, Yap DYH, Ma MKM, Chan KW, Yung S*, Chan TM. Effect of mycophenolate and rapamycin on Rehabilitation Medicine fibrosis in lupus nephritis. Clin Sci 2019; 133: 1721-1744.
  • Chu JYS, Chau MKM, Chan CCY, Tai ACP, Cheung KF, Chan TM, Yung S*. miR-200c Prevents TGF-beta1-Induced Epithelial-to-Mesenchymal Transition and Fibrogenesis in Mesothelial Cells by Targeting ZEB2 and Notch1. Mol Ther Nucleic Acids 2019; 17: 78-91.
  • Li C, Yap DYH, Chan G, Wen YB, Li H, Tang C, Li XM, Li XW, Chan TM*. Clinical outcomes and clinico-pathological correlations in lupus nephritis with kidney biopsy showing thrombotic microangiopathy. J Rheumatology and Clinical Immunologytol,2019.
  • Yap DYH, Kwan LPY, Ma MKM, Mok MMY, Chan GCW, Chan TM*. Preemptive immunosuppressive treatment for asymptomatic serological reactivation may reduce Rehabilitation Medicine flares in patients with lupus nephritis: a cohort study. Nephrol Dial Transplant 2019; 34: 467-473.
  • Yap DYH, Tam CH, Yung S, Wong S, Tang CSO, Mok TMY, Yuen CKY, Ma MKM, Lau CS, Chan TM*. Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis. Nephrol Dial Transplant,2019.
  • Zhang C, Chan CCY, Cheung KF, Chau MKM, Yap DYH, Ma MKM, Chan KW, Yung S, Chan TM*. Effect of mycophenolate and rapamycin on Rehabilitation Medicine fibrosis in lupus nephritis. Clin Sci 2019; 133: 1721-1744.
  • Kwok HH, Ning Z, Chong PW, Wan TS, Ng MH, Ho GY, Ip MS,Lam DC. Transfer of extracellular vesicle-associated-RNAs induces drug resistance in ALK-translocated lung adenocarcinoma.Cancers2019; Jan 17;11(1). pii: E104.
  • Kwok WC, Liang BM, Lui MM, Tam TC, Sim JP, Tse EW, Leung AY, Kwong YL, Lie AK, Ip MS,Lam DC. Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome.Respirology2019 Jan 20.(In press)
  • Lam SK, Yan S, Xu S, U KP, Cheng PN, Ho JC*. Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma. Oncogenesis 2019 Feb 26;8(3):18. doi: 10.1038/s41389-019-0128-0.
  • Gill H, Ip HW, Yim R, Tang WF, Pang HH, Lee P, Leung GMK, Li J, Tang K, So JCC, Leung RYY, Li J, Panagioutou G, Lam CCK, Kwong YL. Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis. Ann. Hematol. 2019; 98(4): 869-879
  • Gill H, Kumana CR, Yim R, Hwang YY, Chan TS, Yip SF, Lee HK, Mak V, Lau JS, Chan CC, Kho B. Oral arsenic trioxide incorporation into frontline treatment with all?trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5?year prospective study. Cancer. 2019 May 15. [Epub]
  • Ho PWL, Leung MCT, Liu HF, Pang SYY, Lam CSC, Xian JW, Li LF, Kung MHW, Ramsden DB, Ho SL. (2019) Age-dependent accumulation of oligomeric ?-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson's disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).. Autophagy. 2019 Apr 14:1-24. doi: 10.1080/15548627.2019.1603545.
  • Pang SYY, Ho PWL, Liu HF, Leung CT, Li LF, Chang EES, Ramsden DB, Ho SL. The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease. Translational Neurodegeneration. 2019
  • Cheung KS, Chan EW, Wong AYS, Chen L, Seto WK, Wong ICK, Leung WK. Metformin use and gastric cancer risk in diabetic patients after Helicobacter pylori eradication. J Natl Cancer Inst 2019;111: 484-489 (2018 impact factor 10.211)
  • Cheung KS, Chen L, Chan EW, Seto WK, Wong ICK, Leung WK. Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187897 patients. Gut 2019 [epub ahead of print] (2018 impact factor 17.943)
  • Yuen MF, Gane EJ, Kim DJ, Weilert F, Chan HLY, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N. Antiviral activity, safety, and pharmacokinetics of capsid assembly modulator NVR 3-778 in patients with chronic HBV infection. Gastroenterology 2019;156(5):1392-1403.
  • Yuen MF, Gane EJ, Kim DJ, Weilert F, Yuen Chan HL, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N. Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection. Gastroenterology. 2019 Apr;156(5):1392-1403.e7.
  • Mak LY, Wong DK, Seto WK, Ning Q, Cheung KS, Fung J, Lai CL, Yuen MF. Correlation of serum Mac-2-binding protein glycosylation isomer (M2BPGi) and liver stiffness in chronic hepatitis B infection. Hepatol Int. 2019 Mar;13(2):148-156
  • Liu KSH, Seto WK, Lau EHY, Wong DK, Lam YF, Cheung KS, Mak LY, Ko KL, To WP, Law MWK, Wu JT, Lai CL, Yuen MF. A Territorywide Prevalence Study on Blood-Borne and Enteric Viral Hepatitis in Hong Kong. J Infect Dis. 2019 May 24;219(12):1924-1933.
  • Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2019 Apr 14:1-24.
  • Mak LY, Seto WK, Hui RW, Fung J, Wong DK, Lai CL, Yuen MF. Fibrosis evolution in chronic hepatitis B e antigen-negative patients across a 10-year interval. J Viral Hepat. 2019 Jul;26(7):818-827.
  • Mak LY, Lee CH, Cheung KS, Wong DK, Liu F, Hui RW, Fung J, Xu A, Lam KS, Yuen MF, Seto WK. Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long-term nucleoside analogue. Liver Int. 2019 Jul;39(7):1217-1225.
  • Li Z, Wong KY, Calin GA, Chng WJ, Chan GC, Chim CS. Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact. Clin Epigenetics. 2019 May 7;11(1):71.
  • Liu F, Seto WK, Wong DK, Huang FY, Cheung KS, Mak LY, Sharma R, Zhang S, Fung J, Lai CL, Yuen MF. Plasma Fibronectin Levels Identified via Quantitative Proteomics Profiling Predicts Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B. J Infect Dis. 2019 Aug 9;220(6):940-950
  • Wang Y, Lee MYK, Mak JCW, Ip MSM. Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice. Diabetes Metab J. 2019 Apr 23.
  • Geng L, Liao B, Jin L, Huang Z, Triggle CR, Ding H, Zhang J, Huang Y, Lin Z, Xu A. Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. Cell Rep. 2019 Mar 5;26(10):2738-2752.e4
  • Chan YH, Ngai MC, Chen Y, Wu MZ, Yu YJ, Zhen Z, Lai K, Cheung T, Ho LM, Chung HY, Lau CS, Tse HF, Yiu KH. Cumulative Rheumatic Inflammation Modulates the Bone-Vascular Axis and Risk of Coronary Calcification. J Am Heart Assoc. 2019 Jun 4;8(11):e011540.
  • Pan Y, Hui X, Hoo RLC, Ye D, Chan CYC, Feng T, Wang Y, Lam KSL, Xu A. Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation. J Clin Invest. 2019 Feb 1;129(2):834-849.
  • Jian M, Kwan JS, Bunting M, Ng RC, Chan KH. Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway. J Neuroinflammation. 2019 May 25;16(1):110.
  • Li B, Leung JCK, Chan LYY, Yiu WH, Li Y, Lok SWY, Liu WH, Chan KW, Tse HF, Lai KN, Tang SCW. Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury. Stem Cells Transl Med. 2019 Sep;8(9):898-910
  • Zhang C, Chan CCY, Cheung KF, Chau MKM, Yap DYH, Ma MKM, Chan KW, Yung S, Chan TM. Effect of mycophenolate and rapamycin on renal fibrosis in lupus nephritis. Clin Sci (Lond). 2019 Aug 5;133(15):1721-1744.
  • Cheung CYY, Lee CH, Tang CS, Xu A, Au KW, Fong CHY, Ng KKK, Kwok KHM, Chow WS, Woo YC, Yuen MMA, Hai J, Tan KCB, Lam TH, Tse HF, Sham PC, Lam KSL.Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes. Diabetes. 2019 Jan;68(1):198-206.
  • Lee CH, Cheung CYY, Woo YC, Lui DTW, Yuen MMA, Fong CHY, Chow WS, Xu A, Lam KSL. Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes. Diabetologia. 2019 Jan;62(1):169-177
  • Cheung KS, Chan EW, Wong AYS, Chen L, Seto WK, Wong ICK, Leung WK. Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication. J Natl Cancer Inst. 2019 May 1;111(5):484-489
  • Guo CG, Chen L, Chan EW, Cheung KS, Isshiki T, Wong ICK, Leung WK. Systematic review with meta-analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel. Aliment Pharmacol Ther. 2019 Jan;49(1):7-19
  • Wu MZ, Chen Y, Zou Y, Zhen Z, Yu YJ, Liu YX, Yuen M, Ho LM, Siu-Ling Lam K, Tse HF, Yiu KH. Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus. Eur Heart J Cardiovasc Imaging. 2019 Jul 1;20(7):816-827
  • Kwok HH, Ning Z, Chong PW, Wan TS, Ng MH, Ho GYF, Ip MS, Lam DC. Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma. Cancers (Basel). 2019 Jan 17;11(1)
  • Wu MZ, Chen Y, Zou Y, Zhen Z, Yu YJ, Liu YX, Yuen M, Ho LM, Siu-Ling Lam K, Tse HF, Yiu KH. Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus. Eur Heart J Cardiovasc Imaging. 2019 Jul 1;
  • Wong DW, Yiu WH, Chan KW, Li Y, Li B, Lok SW, Taketo MM, Igarashi P, Chan LYY, Leung JCK, Lai KN, Tang SCW. Activated Rehabilitation Medicine tubular Wnt/?-catenin signaling triggers Rehabilitation Medicine inflammation during overload proteinuria. Kidney Int 2018; 93: 1367-1383
  • Yap DY, Kwan LPY, Ma MKM, Mok MMY, Chan GCW, Chan TM. Pre-emptive immunosuppressive treatment for asymptomatic serological reactivation may reduce Rehabilitation Medicine flares in patients with lupus nephritis. Nephrol Dial Transplant 2018 (Epub ahead of print).
  • Yap DY, Tam CH, Yung S, Wong S, Tang CSO, Mok TMY, Yuen CKY, Ma MKM, Lau CS, Chan TM. Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis. Nephrol Dial Transplant. 2018 Sep 11.
  • Yap DYH, Tang C, Chan GCW, Kwan LPY, Ma MKM, Mok MMY, Chan TM*. Longterm data on sirolimus treatment in patients with lupus nephritis. J Rheumatology and Clinical Immunologytol 2018; 45: 1663-1670.
  • Yung S*, Ng CY, Au KY, Cheung KF, Zhang Q, Zhang C, Yap DY, Chau MK, Chan TM. Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to Rehabilitation Medicine tubulointerstitial inflammation. Clin Sci 2017; 131: 49-67.
  • Chan HS, Ko FK, Chan JW, So LK,Lam DC, Chan VL, Tam CY, Yu WC. Co-morbidities, mortality and management of chronic obstructive pulmonary disease patients who required admissions to public hospitals in Hong Kong – computerized data collection and analysis.International Journal of COPD 2018; Jun 13; 13: 1913-1925.
  • Lam DCL, Kwok HH, Yu WC, Ko FW, Tam CY, Lau AC, Fong DY, Ip MS. Serum CC16 levels correlates with smoking-related lung function decline. Submitted toBMC Pulmonary Medicine2018 Mar 16;18(1):47.
  • Man KM, Tian Z,Lam DC, Wan JM, Tan-Un KC. Satisfaction, preference and error occurrence of three dry powder inhalers as assessed by a cohort naïve to inhaler operation.International Journal of COPD2018; Jun 15; 13: 1949-1963.
  • Muruganandani S, Azzopardi M, Fitzgerald DB, Shrestha R, Kwan BCH,Lam DCL, de Chaneet CC, Rashid Ali MRS, Yap E, Tobin CL, Garske LA, Nguyen PT, Stanley C, Popowicz ND, Kosky C, Thomas R, Read CA, Budgeon CA, Feller-Kopman D, Maskell NA, Murray K, Lee YCG. Aggressive versus Symptom-guided Drainage of Malignant Pleural Effusion via Indwelling Pleural Catheters: The Australasian Malignant Pleural Effusion (AMPLE) Trial-2 randomized clinical trial.Lancet Respiratory Medicine2018 Sep;6(9):671-680.
  • Wu YL, Lu S, Lu Y, Zhou JY, Shi YK, Sriuranpong V, Ho JCM, Ong CK, Tsai CM, Chung CH, Wilner KD, Tang Y, Masters ET, Selaru, P, Mok TS. First-line crizotinib versus chemotherapy in East Asian patients with ALK-positive advanced non-small cell lung cancer: phase III study results. J Thorac Oncol 2018;pii: S1556-0864(18)30721-4. doi: 10.1016/j.jtho.2018.06.012.
  • Xu S, Lam SK, Cheng PN, Ho JC*. Recombinant human arginase induces apoptosis via oxidative stress and cell cycle arrest in small cell lung cancer. Cancer Sci 2018 Aug 28. doi: 10.1111/cas.13782.
  • Gill H, Yim R, Lee HKK, Mak V, Lin SY, Kho B, Yip SF, Lau JSM, Li W, Ip HW, Hwang YY, Chan TSY, Tse E, Au WY, Kumana CR, Kwong YL. Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: A 15-year prospective study. Cancer. 2018; 124 (11): 2316-2326
  • Kwong YL, Kim SJ, Tse E, Oh SY, Kwak JY, Eom HS, Do YR, Mun YC, Lee SR, Shin HJ, Suh C, Chuang SS, Lee YS, Lim ST, Izutsu K, Suzuki R, Relander T, d'Amore F, Schmitz N, Jaccard A, Kim WS. Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma. Ann Oncol. 29(1):256-263, 2018
  • Zhou Y, Wang H, Tse E, Li H, Sun H. Cell cycle–dependent uptake and cytotoxicity of arsenic-based drugs in single leukemia cells. Anal Chem. 90(17):10465-10471, 2018.
  • CYY Cheung, PCH Lee, C Tang, A Xu, KW Au, CHY Fong, K Ng, K Kwok, WS Chow, CY Woo, MMY Yuen, JJ Hai, KCB Tan, TH Lam, HF Tse, PC Sham, KSL Lam. Genetic regulation of pigment epithelium-derived factor (PEDF): an Exome-chip association analysis in Chinese subjects with type 2 diabetes. Diabetes [IF:7.273]2018 Oct 10 Epub ahead of print
  • PCH Lee, CYY Cheung, YC Woo, DTW Lui, MMA Yuen, CHY Fong, WS Chow, A Xu, KSL Lam. Circulating adipocyte fatty acid-binding protein concentrations predict multiple mortality outcomes among men and women with diabetes. Clin Chem 2018 Jul 18 Epub ahead of print [IF:8.636] #citations on 19/11/18: 1
  • PCH Lee, CYY Cheung, YC Woo, DTW Lui, MMA Yuen, CHY Fong, WS Chow, A Xu, KSL Lam. Prospective association of circulating adipocyte fatty acid-binding protein levels with risk of Rehabilitation Medicine outcomes and mortality in type 2 diabetes. Diabetologia 2018 Sep 28 Epub ahead of print [IF:6.023]
  • YK Wong, CYY Cheung, CS Tang, KW Au, JSH Hai, PCH Lee, KK Lau, BMY Cheung, PC Sham, A Xu, KSL Lam (Co-corresponding author), HF Tse. Age-Biomarkers-Clinical (ABC) risk factor for prediction of cardiovascular events in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2018 (Accepted) [IF:6.086]
  • Lau KK, Li L, Simoni M, Mehta Z, Kuker W, Rothwell PM. Long-term premorbid blood pressure and cerebral small vessel disease burden on imaging in TIA and ischaemic stroke: population-based study. Stroke 2018; 49(9): 2053-2060 (Impact factor 6.046)
  • Lau KK, Lovelock CE, Li L, Simoni M, Gutnikov S, Kuker W, Mak HKF, Rothwell PM. Antiplatelet treatment after TIA and ischaemic stroke in patients with cerebral microbleeds in two large cohorts and an updated systematic review. Stroke 2018; 40(6):1434-1442. (Impact factor 6.046)
  • Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR. (2018) Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase. Biochem J. 2018 Jan 2;475(1):1-22. doi: 10.1042/BCJ20170802.
  • Cheung KS, Chan EW, Chen L, Seto WK, Wong ICK, Leung WK. Diabetes mellitus increases risk of gastric cancer after Helicobacter pylori eradication: a territory-wide study with propensity score analysis. Diabetes Care 2019 [epub ahead of print] (2018 impact factor 15.270)
  • Cheung KS, Chan EW, Wong AYS, Chen L, Seto WK, Wong ICK, Leung WK. Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study. J Natl Cancer Inst 2018;110:743-749 (2018 impact factor 10.211)
  • Cheung KS, Chan EW, Wong AYS, Chen L, Wong ICK, Leung WK. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study. Gut 2018;67:28-35 (2018 impact factor 17.943)
  • Cheung KS, Chen L, Seto WK, Leung WK. Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Asia: a population-based study. J Gastroenterol Hepatol 2019 [epub ahead of print] (2018 impact factor 3.632)
  • Fung J, Cheung KS, Wong DK, Mak LY, To WP, Seto WK, Lai CL, Yuen MF. Long Term Outcomes and Predictive Scores for Hepatocellular Carcinoma and HBsAg Seroclearance after HBeAg Seroclearance. J Hepatol 2018;68:462-472 (2018 impact factor 18.946)
  • Leung WK, Wong IOL, Cheung KS, Yeung KF, Chan EW, Wong AYS, Chen L, Wong ICK, Graham DY. Effects of Helicobacter pylori Treatment on Incidence of Gastric Cancer in Older Individuals. Gastroenterology 2018;155:67-75 (2018 impact factor 19.233)
  • Seto WK, Lo YR, Pawlotsky JM, Yuen MF. Chronic hepatitis B virus infection. Lancet 2018;392(10161):2313-2324.
  • Seto WK, Mak SK, Chiu K, Vardhanabhuti V, Wong HF, Leong HT, Lee PSF, Ho YC, Lee CK, Cheung KS, Yuen MF, Leung WK. Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users. J Hepatol. 2018 Mar 16. pii: S0168-8278(18)30164-8.
  • Liu Z, Jin L, Yang JK, Wang B, Wu KKL, Hallenborg P, Xu A, Cheng KKY. The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy. Diabetes. 2018 Nov;67(11):2397-2409
  • Ng KM, Lau YM, Dhandhania V, Cai ZJ, Lee YK, Lai WH, Tse HF, Siu CW. Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes. Sci Rep. 2018 Oct 5;8(1):14872
  • Mak LY, Wong DK, Cheung KS, Seto WK, Lai CL, Yuen MF. Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection. Clin Transl Gastroenterol. 2018 Jun 19;9(6):163
  • Cheung KS, Leung WK. Modification of gastric cancer risk associated with proton pump inhibitors by aspirin after Helicobacter pylori eradication. Oncotarget. 2018 Dec 11;9(97):36891-36893.
  • Han Q, Li G, Ip MS, Zhang Y, Zhen Z, Mak JC, Zhang N. Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission. J Cell Mol Med. 2018 May;22(5):2717-2726.
  • Mak TSH, Lee YK, Tang CS, Hai JSH, Ran X, Sham PC, Tse HF. Coverage and diagnostic yield of Whole Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic Cardiomyopathy. Sci Rep. 2018 Jul 18;8(1):10846.
  • Hai JJ, Un KC, Wong CK, Wong KL, Zhang ZY, Chan PH, Lau CP, Siu CW, Tse HF. Prognostic implications of early monomorphic and non-monomorphic tachyarrhythmias in patients discharged with acute coronary syndrome. Heart Rhythm. 2018 Jun;15(6):822-829.
  • Chung HY*, X. Xu, V Lau, G Ho, KL Lee, P Li, H Tsang, SK Kwok, CS Lau, CS Wong. Comparing diffusion weighted imaging (DWI) with clinical and blood parameters, and with short tau inversion recovery (STIR) sequence in detecting spinal and sacroiliac (SI) joint inflammation in axial Spondyloarthritis (axSpA). Clin Exp Rheumatology and Clinical Immunologytol, 2017 Mar-Apr; 35(2):262-269.
  • CWS Chan, HY Chung, CS Lau, HHL Tsang. Spontaneous pneumomediastium in a dermatomyositis patient with anti-melanoma differentiation-associated gene-5 antibody and interstitial lung disease despite an initial response to immunosuppressant. Int J Rheum Dis. 2017 Jun 4. Doi:10.1111/1756-185X. 13112.
  • Cheung KF, Yung S, Chau MK, Yap DY, Chan KW, Lee CK, Tang CS, Chan TM*. Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations. Clin Sci 2017; 131: 653-671.
  • Yap DY, Tang C, Ma MKM, Mok MMY, Chan GCW, Kwan LPY, Chan TM. Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years. J Rheumatology and Clinical Immunologytol 2017; 44: 1375-1383.
  • Yung S, Ng CY, Au KY, Cheung KF, Zhang Q, Zhang C, Yap DY, Chau MK, Chan TM*. Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to Rehabilitation Medicine tubulointerstitial inflammation. Clin Sci 2017; 131: 49-67.
  • Han L, Lee CK, Pang H, Chan HT, Lo IL, Lam SK, Cheong TH, Ho JC*. Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status. Lung Cancer 2017;114:79-89.
  • Ho JC*, Lam SK. Combining arginine depletion and chemotherapy in thoracic malignancies. J Clin Oncol 2017;35(16):1758-1759.
  • Lam SK, Li YY, Xu S, Leung LL, U KP, Zheng YF, Cheng PN, Ho JC*. Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts. Respir Res 2017;18(1):80. Doi: 10.1186/s12931-017-0564-3.
  • Lam SK, U KP, Li YY, Xu S, Cheng PN, Ho JC*. Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. Oncology Reports 2018;40(4):1994-2004.
  • Thomas R, Fysh ETH, Smith NA, Lee P, Kwan BCH, Yap E, Horwood FC, Piccolo F, Lam DCL, Garske LA, Shrestha R, Kosky C, Read CA, Murray K, Lee YCG. Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients with Malignant Pleural Effusion: The AMPLE Randomized Clinical Trial.JAMA2017 Nov 21;318(19):1903-1912.
  • Cynthia YY Chan, Tsang HHL, Lau CS, Chung HY^. Prevalence of depressive and anxiety disorders and validation of the Hospital Anxiety and Depression Scale as a screening tool in Axial Spondyloarthritis patients. Int J Rheum Dis. 2017 Mar; 20(3): 317-325.
  • Cheng CW, Leong KW, Ng YM, Kwong YL, Tse E. The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27. J Biol Chem. 292(52):21431-21441, 2017
  • Chim CS, Kumar S, Orlowski R, Cook G, Richardson PG, Gertz M, Giralt S, Marivi Mateos, Leleu X, Anderson KC. Management of relapsed & refractory multiple myeloma – novel agents, antibodies, immunotherapies and beyond. Leukemia, 2017, in press. (Invited review)(IF: 11.702)
  • Chim CS. LDH as a prognostic marker in AL amyloidosis: expected or unexpected? (Invited editorial) Br J Haematol, 2017 Sep; 178(6):833-835. (IF: 5.67)
  • Kwong YL, Chan TS, Tan D, Kim SJ, Poon LM, Mow B, Khong PL, Loong F, Au-Yeung, R, Iqbal J, Phipps C, Tse E. PD1 blockade with pembrolizumab is highly effective in relapsed and refractory NK/T-cell lymphoma failing L-asparaginase. Blood. 129(17):2437-2442, 2017.
  • Leong KW, Cheng CW, Wong CM, Ng IO, Kwong YL, Tse E. miR-874-3p is downregulated in hepatocellular carcinoma and negatively regulates PIN1 expression. Oncotarget. 8(7):11343-11355, 2017.
  • Piao WY, Chau D, Yue LM, Kwong YL, Tse E. Arsenic trioxide degrades NPM-ALK fusion protein and inhibits growth of ALK-positive anaplastic large cell lymphoma. Leukemia. 31(2):522-6, 2017.
  • Reddy A, ……, Tse E, ……, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 171(2):481-94, 2017.
  • Tse E and Kwong YL. How I Treat NK/T-cell Lymphoma. Blood. 121(25):4997-5005, 2013.
  • Yinlei Bai, Alberto Orfao, Chor Sang Chim. Molecular Detection of Minimal Residual Disease in Multiple Myeloma. British Journal of Haematology, 2017, in press. (Invited review) (IF: 5.67)
  • Liu JH, Ng MY, Cheung T, Chung HY, Chen Y, Zhen Z, Zou Y, Mak KF, Khong PL, Lau CS, Tse HF, Yiu KH. Ten-year progression of coronary artery, carotid artery, and aortic calcification in patients with Rheumatology and Clinical Immunologytoid arthritis. Clin Rheumatology and Clinical Immunologytol. 2017 Apr; 36(4): 807-816.
  • Chan PH, Wong CK, Pun L, Wong YF, Wong MM, Chu DW, Siu CW. Head-to-Head Comparison of the AliveCor Heart Monitor and Microlife WatchBP Office AFIB for Atrial Fibrillation Screening in a Primary Care Setting. Circulation 2017;135:110-112
  • PH Li, TJ Watts, MS Lui, CS Lau, HY Chung^. Recall Urticaria in Adalimumab Hypersensitivity. J Allergy Clin Immunol Pract. 2017 Nov 22. pii: S2213-2198(17)30877-2. Doi: 10.1016/j.jaip.2017.10.03
  • Lau KK, Li L, Lovelock CE, Zamboni G, Chan TT, Chiang MF, Lo KT, Kuker W, Mak HKF, Rothwell PM. Clinical correlates, ethnic differences and prognostic implications of perivascular spaces in TIA and ischaemic stroke. Stroke 2017; 48:1470-1477 (Impact factor 6.046)
  • Lau KK, Li L, Schulz U, Simoni M, Chan KH, Ho SL, Cheung RTF, Kuker W, Mak HKF, Rothwell PM. Total Small Vessel Disease Score and risk of recurrent stroke – validation in two large cohorts. Neurology 2017; 88: 2260-2267 (Impact factor 8.689)
  • Lau KK, Wong YK, Teo KC, Chang RSK, Tse MY, Hoi CP, Chan CY, Chan OL, Cheung RHK, Wong EKM, Kwan JSK, Hui ES, Mak HKF. Long-term prognostic implications of cerebral microbleeds in Chinese with ischaemic stroke. Journal of American Heart Association 2017; 7;6(12). pii: e007360 (Impact factor 4.45)
  • Liu HF, Ho PW, Leung GC, Lam CS, Pang SY, Li L, Kung MH, Ramsden DB, Ho SL. (2017) Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease. Scientific Reports. 7:40887. doi: 10.1038/srep40887. 2017
  • Pang SY, Hsu JS, Teo KC, Li Y, Kung MHW, Cheah KSE, Chan D, Cheung KMC, Li MX, Sham PC, Ho SL. (2017) Burden of rare variants in ALS genes influences survival in familial and sporadic ALS. Neurobiol Aging. 2017 Oct;58:238.e9-238.e15. doi: 10.1016/j.neurobiolaging. 2017.06.007.
  • Pang SY, Teo KC, Hsu JS, Chang RSK, Li MX, Sham PC, Ho SL. (2017) The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review. Translational Neurodegeneration.2017 6:27. doi: 10.1186/s40035-017-0098-0.
  • Tsang HHL, HY Chung^ The discriminative values of BASDAI, ASDAS, C-reactive protein and erythrocyte sedimentation rate in spondyloarthritis related axial arthritis. J Clin Rheumatology and Clinical Immunologytol. 2017 Aug; 23(5):267-272.
  • Cheung KS, Seto WK, Fung J, Lai CL, Yuen MF. Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015. Clin Transl Gastroenterol 2017;8:e116 (2018 impact factor 4.803)
  • Cheung KS, Seto WK, Fung J, Lai CL, Yuen MF. Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid. Clin Transl Gastroenterol 2017;8:e100 (2018 impact factor 4.803)
  • Cheung KS, Seto WK, Fung J, Mak LY, Lai CL, Yuen MF. Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016. World J Gastroenterol 2017;23:7716-7726 (2018 impact factor 3.411)
  • Cheung KS, Seto WK, Fung J, Mak LY, Lai CL, Yuen MF. Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis. World J Gastroenterol 2017;23:7863-7874 (2018 impact factor 3.411)
  • Cheung KS, Seto WK, Wong DK, Lai CL, Yuen MF. Relationship between HBsAg, HBcrAg and hepatocellular carcinoma in patients with undetectable HBV DNA under nucleos(t)ide therapy. J Viral Hepat 2017;24:654-661 (2018 impact factor 4.016)
  • Fung J, Wong T, Chok K, Chan A, Cheung TT, Dai JW, Sin SL, Ma KW, Ng K, Ng KT, Seto WK, Lai CL, Yuen MF, Lo CM. Long-term outcomes of entecavir monotherapy for chronic hepatitis B after liver transplantation: Results up to 8 years. Hepatology 2017;66(4):1036-1044.
  • Seto WK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Lau HY, Cheung KS, Lie AK, Lai CL, Kwong YL, Yuen MF. Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: a prospective study. Hepatology 2017 65:1451-61 (2017 impact factor 14.079)
  • Seto WK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Lie AK, Lai CL, Kwong YL, Yuen MF. Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study. J Clin Oncol 2014; 32: 3736-43. (2017 impact factor 26.303)
  • Seto WK, Lo YR, Pawlotsky JP, Yuen MF. Chronic hepatitis B virus infection. Lancet 2018; 392:2313-2324 (2017 impact factor 53.254).
  • Seto WK, Sau-Yan Chan T, Hwang YY, Wong DK, Fung J, Liu KS, Gill H, Lam YF, Lau EH, Cheung KS, Lie AK, Lai CL, Kwong YL, Yuen MF. Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study. Hepatology 2017;65(5);1451-1461.
  • Wooddell CI*, Yuen MF*, Chan HLY, Gish RG, Locarnini SA, Chavez D, Ferrari C, Given BD, Hamilton J, Kanner SB, Lai CL, Lau JYN, Schuluep T, Xu Z, Lanford RE, Lewis DL. RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg. Sci Transl Med 2017;9(409). * co-first author
  • Yap DY, Yung S, Zhang Q, Tang C, Chan TM. Serum level of proximal Rehabilitation Medicine tubular epithelial cell-binding immunoglobulin G in patients with lupus nephritis. Lupus. 2016 ;25:46-53.
  • Yiu WH, Wong DW, Wu HJ, Yam I, Li RX, Chan LY, Leung JC, Lan HY, Lai KN, Tang SC: Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress. Kidney Int 2016; 89: 386-398
  • Bai CX, Choi CM, Chu CM, Anantham D, Ho JC, Khan AZ, Lee JM, Li SY, Saenghirunvattana S, Yim A. Evaluation of pulmonary nodules: clinical practice consensus guidelines for Asia. Chest 2016; 150(4):877-893.
  • Lam SK, Leung LL, Li YY, Zheng CY, Ho JC*. Combination effects of arsenic trioxide and fibroblast growth factor receptor inhibitor in squamous cell lung carcinoma. Lung Cancer 2016;100:111-119.
  • Gill H, Leung AY, Chan CC, Lau JS, Chan C, Yip SF, Liu H, Koh B, Mak V, Lin SY, Lau CK, Kwong YL. Clinicopathologic features and prognostic indicators in Chinese patients with myelofibrosis. Hematology. 2016; 21(1): 10-18
  • Gill H, Leung AY, Kwong YL. Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy. Int J Mol Sci. 2016; 17(4): 440.
  • Lam SS, Ho ES, He BL, Wong WW, Cher CY, Ng NK, Man CH, Gill H, Cheung AM, Ip HW, So CC, Tamburini J, So CW, Ho DN, Au CH, Chan TL, Ma ES, Liang R, Kwong YL, Leung AY. Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia. Sci Transl Med 2016; 8(359): 359ra129.
  • LQ Wang, KY Wong, ZH Li, CS Chim. Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia. Oncotarget, 2016; 7(50):82400-82410. (IF: 5.168)
  • Yinlei Bai, KY Wong, TK Fung, CS Chim. High applicability of ASO-RQPCR for detection of minimal residual disease in multiple myeloma by entirely patient-specific primers/probes. Journal of Hematology & Oncology, 2016; 9: 107. (IF: 6.350)
  • Chan PH, Hai J, Yeung CY, Lip GY, Lam KS, Tse HF, Siu CW. Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis. Europace 2016;18:665-71
  • Chan PH, Huang D, Hai J, Li WH, Yin LX, Chan EW, Wong IC, Lau CP, Chiang CE, Zhu J, Tse HF, Siu CW. Stroke Prevention Using Dabigatran in the Very Elderly with Atrial Fibrillation. Heart Rhythm 2016;13:366-73
  • Chan PH, Huang D, Lau CP, Chan EW, Wong IC, Lip GY, Tse HF, Siu CW. Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range. Can J Cardiol 2016;32:1247.e15-1247.e21
  • Chan PH, Wong CK, Poh YC, Pun L, Leung WW, Wong YF, Wong MM, Poh MZ, Chu DW, Siu CW. Diagnostic Performance of a Smartphone-Based Photoplethysmographic Application for Atrial Fibrillation Screening in a Primary Care Setting. J Am Heart Assoc 2016;5(7). pii: e003428
  • Ito G, Katsemonova K, Tonelli F, Lis P, Baptista M, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi D. (2016) Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochemical Journal. 473(17):2671-85. 2016
  • CWS Chan, HHL Tsang, CS Lau, HY Chung^. Male smokers with HLA-B27 positivity, SI joints inflammation have more radiological damages and higher prevalence of AS while females have higher BASDAI scores: observations from cluster analyses of a group of SpA patients. Hong Kong Bull Rheum Dis. 2016; 16(2): 42-47.
  • Seto WK, Hui AJ, Wong VW, Wong GL, Liu K, Lai CL, Yuen MF, Chan HL. Treatment cessation of entecavir in Asian patients with hepatitis B e antigen negative chronic hepatitis B: a multicenter prospective study. Gut 2015; 64: 667-72. (2017 impact factor 17.016)
  • Seto WK, Wong DH, Chan TY, Hwang YY, Fung J, Liu KS, Gill H, Lam YF, Cheung KS, Lie AK, Lai CL, Kwong YL, Yuen MF. Association of Hepatitis B Core-Related Antigen With Hepatitis B Virus Reactivation in Occult Viral Carriers Undergoing High-Risk Immunosuppressive Therapy. Am J Gastroenterol 2016;111(12):1788-1795.
  • KMK Ng, TT Cheung, CS Lau, HY Chung* The role of magnetic resonance imaging in a patient with Rheumatology and Clinical Immunologytoid arthritis presented with lymphedema-like swelling: a case report. Hong Kong Bull Rheum Dis. Nov 2016.
  • Seto WK, Wong DK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Cheung KS, Lie AK, Lai CL, Kwong YL, Yuen MF. Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy. Am J Gastroenterol 2016; 111:1788-1795. (2017 impact factor 10.231)
  • Seto WK, Yuen MF. “Immune tolerance” in HBV infection: danger lurks. Nat Rev Gastroenterol Hepatol 2016 44: 1071-1079. (2017 impact factor 16.990)
  • Yung S*, Zhang Q, Chau MK, Chan TM. Distinct effects of mycophenolate mofetil and cyclophosphamide on Rehabilitation Medicine fibrosis in NZBWF1/J mice. Autoimmunity 2015; 48: 471-487.
  • Yung S*, Ng CY, Ho SK, Cheung KF, Chan KW, Zhang Q, Chau MK, Chan TM. Anti-dsDNA antibody induces soluble fibronectin secretion by proximal Rehabilitation Medicine tubular epithelial cells and downstream increase of TGF-beta1 and collagen synthesis. J Autoimmun 2015; 58: 111-122.
  • Yung S*, Lui SL, Ng CK, Yim A, Ma MK, Lo KY, Chow CC, Chu KH, Chak WL, Lam MF, Yung CY, Yip TP, Wong S, Tang CS, Ng FS, Chan TM. Impact of a low-glucose peritoneal dialysis regimen on fibrosis and inflammation biomarkers. Perit Dial Int 2015; 35: 147-158.
  • Chan TM*. Treatment of severe lupus nephritis: the new horizon. Nat Rev Nephrol 2015; 11: 46-61.
  • Yap DY, Chan TM. Lupus Nephritis in Asia: Clinical Features and Management. Kidney Dis (Basel). 2015; 1: 100-9.
  • Yung S, Ng CY, Ho SK, Cheung KF, Chan KW, Zhang Q, Chau MK, Chan TM*. Anti-dsDNA antibody induces soluble fibronectin secretion by proximal Rehabilitation Medicine tubular epithelial cells and downstream increase of TGF-beta1 and collagen synthesis. J Autoimmun 2015; 58: 111-122.
  • Lam DC, Luo SY, Deng W, Cheung AL, Cheng GH, Lin CH, Sham PC, Wan TS, Tsao SW. Oncogenic mutation profiling in new lung cancer and mesothelioma cell lines.Journal of OncoTargets and Therapy2015; 8: 195 – 209.
  • Lam DC, Tam TC, Lau KM, Wong WM, Hui CK, Lam JC, Wang JK, Lui MM, Ho JC, Ip MS. EGFR Array for diagnostic detection of plasmaEGFRmutation and association with survival outcomes in advanced stage lung cancer patients.Clinical Lung Cancer2015 Nov;16(6):507-13.
  • Lam DC,Chan SC, Mak JC, Freeman C, Ip MSM, Shum DK. S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation.Scientific Reports2015 Aug; 10; 5: 12945.
  • Lam DC,Fu KH, Luo SY, Lui MS, Chan KH, Wistuba II, Gao B, Tsao SW, Ip MS, Minna JD. Expression of nicotinic acetylcholine receptor subunit genes in bronchial epithelium correlates with lung function.American Journal of Physiology – Lung Cell and Molecular Physiology2015; Nov 25:ajplung.00101.2015.
  • Chau D, Ng K, Chan TS, Cheng YY, Fong B, Tam S, Kwong YL, Tse E. Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by upregulating the arsenic transporter aquaglyceroporin 9. J Hematol Oncol. 8(1):46, 2015.
  • Chng WJ, Dispenzieri A, Chim CS, Fonseca R, Goldschmidt H, Lentzsch S, Munshi N, Palumbo A, Miguel JS, Sonneveld P, Cavo M, Usmani S, Durie BG, Avet-Loiseau H. IMWG consensus on risk stratification in multiple myeloma. Leukemia. 2014;28: 269-77.(IF: 11.702)
  • Gill H, Leung AY, Kwong YL. Molecularly targeted therapy in acute myeloid leukemia. Future Oncol. 2015; 12(6): 826-38
  • Gill H, Man CH, Ip AH, Choi WW, Chow HC, Kwong YL, Leung AY. Azacitidine as post-remission consolidation for sorafenib-induced remission of Fms-like tyrosine kinase-3 internal tandem duplication positive acute myeloid leukemia. Haematologica 2015; 100(7): e250-3.
  • Lu Qian Wang, Kwan Yeung Wong, Anders Rosèn and Chor Sang Chim. Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways. Oncotarget. 2015; 6(42):44422-36. (IF: 5.168)
  • Man CH, Fung TK, Wan H, Cher CY, Fan A, Ng N, Ho C, Wan TS, Tanaka T, So EC, Kwong YL, Leung AY. Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia. Blood. 2015;125(25):3928-36
  • Meletios Athanasios Dimopoulos, Jens Hillengass, Saad Usmani, Elena Zamagni, Suzanne Lentzsch, Faith Davies, Noopur Raje, Orhan Sezer, Sonja Zweegman, Jatin Shah, Ashraf Badros, Kazuyuki Shimizu, Philippe Moreau, Chor-Sang Chim, Juan Jose Lahuerta, Jian Hou, Artur Jurczyszyn, Hartmut Goldschmidt, Pieter Sonneveld, Antonio Palumbo, Heinz Ludwig, Michele Cavo, Bart Barlogie, Kenneth C Anderson, G David Roodman, S. Vincent Rajkumar, Brian Durie, and Evangelos Terpos. The Role of Magnetic Resonance Imaging in the Management of Patients with Multiple Myeloma: a Consensus Statement on behalf of the International Myeloma Working Group. J Clin Oncol, 2015 Feb 20;33(6):657-64. (IF: 24.008)
  • Shi X, He BL, Ma AC, Guo Y, Chi Y, Man CH, Zhang W, Zhang Y, Wen Z, Cheng T, Leung AY. Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Blood. 2015;125(19):2974-84.
  • Tse E, Kwong YL. T-cell lymphoma: microenvironment-related biomarkers. Semin Cancer Biol. 34:46-51, 2015.
  • CH Lee, EYL Hui, YC Woo, CY Yeung, WS Chow, MAM Yuen, CHY Fong, A Xu, KSL Lam. Circulating fibroblast growth factor 21 levels predict progressive kidney disease in subjects with type 2 diabetes and normoalbuminuria. J Clin Endocrinol Metab 2015;100:1368-75 [IF:5.789] #citations on 19/11/18: 32
  • CS Tang, H Zhang, CYY Cheung, M Xu, JCY Ho, Wi Zhou, SS Cherny, Y Zhang, O Holmen, KW Au, H Yu, L Xu, J Jia, RM Porsch, L Sun, W Xu, H Zheng, LY Wong, Y Mu, J Dou, CHY Fong, Su Wang, X Hung, L Dong, Y Liao, J Wang, LSM Lam, ML Yang, J Chen, CW Siu, G Xie, YC Woo, Y Wu, KCB Tan, K Hveem, BMY Cheung, S Zöllner, A Xu, YE Chen, CQ Jiang, Y Zhang, TH Lam, S Ganesh, Y Huo, *PC Sham, *KSL Lam, *CJ Willer, *HF Tse, *W Gao. (co-supervising authors) Exome-wide Association Analysis Reveals Novel Coding Sequence Variants Associated with Lipid Traits in Chinese. Nat Commun2015;6:10206 [IF:12.353] #citations on 19/11/18: 21
  • Lee CH, Cheung CYY, Chow WS, Woo YC, Yeung CY, Lang BHH, Fong CHY, Kwok KHM, Chen SPL, Mak CM, Tan KCB, Lam KSL. Genetics of apparently sporadic phaeochromocytoma in a Chinese population. Horm Metab Res 2015 (Provisionally accepted)
  • Lee CH, Hui EYL, Woo YC, Yeung CY, Chow WS, Yuen MMA, Fong CHY, Xu A, Lam KSL. Circulating fibroblast growth factor 21 levels predict progressive kidney disease in subjects with type 2 diabetes and normoalbuminuria. J Clin Endocrinol Metab 2015 (Epub ahead of print)
  • Lee CH, Lam KS. Biomarkers of progression in diabetic nephropathy – the past, present and future. J Diabetes Investig 2015 (Epub ahead of print)
  • Lee CH, Woo YC, Fong CHY, Lam JKY, Cheung BMY, Lam KSL, Tan KCB. Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese. J Clin Lipidol 2015 (In Press)
  • Woo YC, Cheung BMY, Yeung CY, Lee CH, Hui EYL, Fong CHY, Tso AWK, Tam S, Lam KSL. Cardiometabolic risk profile of subjects with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age. Diabet Med 2015 (Epub ahead of print)
  • Chan PH, Alegria-Barrero E, Foin N, et al. Extended use of the GuideLiner in complex coronary interventions. EuroIntervention 2015;11:325-35
  • Chan PH, Li WH, Hai JJ, Tse HF, Siu CW. Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease. PLoS One 2015;10:e0131479
  • Chan PH, Siu CW. Clinical Benefit of Warfarin in Dialysis Patients With Atrial Fibrillation. J Am Coll Cardiol 2015;66:1310-1
  • Lau KK, Wong YK, Chan YH, Li Oi, Chan KH, Lee P, Yuen P, Wong YK, Tong S, Wong D, Cheung RTF, Siu CW, Ho SL, Tse HF. Mediterranean-style diet is associated with reduced blood pressure variability and subsequent stroke risk in patients with coronary artery disease. American Journal of Hypertension 2015; 28(4): 501-507 (Impact factor 2.530)
  • Chan EW, Lau WC, Leung WK, Mok MT, He Y, Tong TS, Wong IC. Prevention of dabigatran-related gastrointestinal bleeding with gastroprotective agents: A population-based study. Gastroenterology 2015;149:586-95.e3
  • Yuen MF, Ahn SH, Lee KS, Um SH, Cho M, Yoon SK, Lee JW, Park NH, Kweon YO, Sohn JH, Lee J, Kim AE, Lai CL, Han KH. Two-year treatment outcome of chronic hepatitis B infection treated with besifovir vs. entecavir: results from a multicentre study. J Hepatol 2015;62(3):526-32.
  • Chen Y*, Chung HY*, Zhao CT, Wong A, Zhen Z, Tsang HHL, Lau CS, Tse HF, Yiu KH Left ventricular myocardial dysfunction and premature atherosclerosis in patients with axial Spondyloarthritis Rheumatology and Clinical Immunologytology(Oxford). 2015 Feb; 54(2): 292-301.
  • Wong PYS, Chung HY^, A patient suffering from rapidly progressive peripheral Spondyloarthritis. Hong Kong Bull Rheum Dis. 2015; 15:57-61.
  • Au YL, Wong WS, Mok MY, Chung HY, Chan E, Lau CS. Disease activity assessment in ankylosing spondylitis in a Chinese cohort: BASDAI or ASDAS? Clin Rheumatology and Clinical Immunologytol. 2014 Jul 1.
  • Ngan W, Chiu PK, Chung HY. Primary Sjogren Syndrome masquerading as a false-positive Venereal Disease Research Laboratory and Fluorescent Treponemal Antibody Absorption Test in an elderly woman. J Am Geriatr Soc. 2014 Sep; 62(9):1817-1818.
  • Mok CC, Yap DY*, Navarra SV, Liu ZH, Zhao MH, Lu L, Takeuchi T, Avihingsanon Y, Yu XQ, Lapid EA, Lugue-Lizardo LR, Sumethkul V, Shen N, Chen SL, Chan TM; Asian Lupus Nephritis Network (ALNN). Overview of Lupus Nephritis Management Guidelines and Perspective from Asia. Co-published in Int J Rheum Dis 2013; 16; 625-36 & Nephrology (Carlton) 2014; 19: 11-20 [*co-first author].
  • Yap DY, Chan TM. Evolution of hepatitis B management in kidney transplantation. World J Gastroenterol 2014; 20: 468-74.
  • Yap DY, Ma MK, Mok MM, Kwan LP, Chan GC, Chan TM*. Long-term data on tacrolimus treatment in lupus nephritis. Rheumatology and Clinical Immunologytology (Oxford) 2014; 53: 2232-2237.
  • Yap DY, Yung S, Tang CS, Seto WK, Ma MK, Mok MM, Kwan LP, Chan GC, Choy BY, Yuen MF, Chan TM. Entecavir treatment in kidney transplant recipients infected with hepatitis B. Clin Transplant 2014; 28: 1010-5.
  • Yap DY, Yung S, Zhang Q, Tang C, Chan TM. Mesangial cell-binding activity of serum immunoglobulin g in patients with lupus nephritis. PLoS One 2014 Jul 9; 9: e101987.
  • Luo SY, Sit AK, Sihoe AD, Suen WS, Au WK, Tang X, Ma ES, Chan WK, Wistuba II, Minna JD, Tsao SW,Lam DC. Aberrant Large Tumor Suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas.Lung Cancer2014; 85(2): 282 - 292
  • Chi-lai Ho, S Chen, YL Leung, T Cheng, Ka-nin Wong, SK Cheung, R Liang, C S Chim. 11C-Acetate for Metabolic Characterization of Multiple Myeloma – A Comparative PET/CT Study with 18F-Fluorodeoxyglucose PET/CT. Journal of Nuclear Medicine, 2014 May;55(5):749-52 (IF: 6.646)
  • Gill H, Au WY, Cheung WW, Kwong YL. Oral arsenic trioxide based regimen as salvage treatment for relapsed or refractory mantle cell lymphoma. Ann. Oncol. 2014; 25 (7): 1391-7
  • He BL, Shi X, Man CH, Ma AC, Ekker SC, Chow HC, So CW, Choi WW, Zhang W, Zhang Y, Leung AY*. Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia. Blood. 2014;123(16):2518-29.
  • Man CH, Lam SS, Sun MK, Chow HC, Gill H, Kwong YL, Leung AY*. A novel tescalcin-sodium/hydrogen exchange axis underlying sorafenib resistance in FLT3-ITD+ AML. Blood. 2014;123(16):2530-9.
  • RLH YIM, KY WONG, YL KWONG, Florence LOONG, CY LEUNG, Raymond CHU, WW LAM, PK HUI, Raymond LAI, CS CHIM. Methylation of miR-155-3p in mantle cell and other non-Hodgkin's lymphoma. Oncotarget, 2014; 5: 9770-82 (IF: 5.168)
  • Hui E, Xu A, Chow WS, Lee CH, Fong HY, Cheung CW, Tse HF, Chau MT, Cheung BMY, Lam KSL. Hypoadiponectinaemia as an independent predictor for the progression of carotid atherosclerosis: a 5-year prospective study. Metab Syndr Relat Disord 2014, 12: 517-522
  • Hui E, Yeung CY, Lee CH, Woo YC, Fong CH, Chow WS, Xu A, Lam KS. Elevated circulating pigment epithelium-derived factor predicts the progression of diabetic nephropathy in patients with type 2 diabetes. J Clin Endocrinol Metab 2014, 99:E2169-E2177
  • Lee CH, Woo YC, Wang Y, Yeung CY, Xu A, Lam KS. Obesity, adipokines and cancer: an update. Clin Endocrinol (Oxf). 2014 (Epub ahead of print)
  • Shiu SWM, Xiao SM, Wong Y, Chow WS, Lam KS, Tan KC. Carbamylation of LDL and its relationship with myeloperoxidase in type 2 diabetes mellitus. Clin Sci 2014;126:175-181
  • Alegria-Barrero E, Chan PH*, Foin N, et al. Concept of the central clip: when to use one or two MitraClips. EuroIntervention 2014;9:1217-24 (*co-first author)
  • Lau CP, Siu CW, Tse HF. The future of implantable devices for cardiac rhythm management. Circulation 2014;129:811-22.
  • Yiu KH, Wong A, Pu L, Chiang MF, Sit KY, Chan D, Lee HY, Lam YM, Chen Y, Siu CW, Lau CP, Au WK, Tse HF. Prognostic Value of Preoperative Right Ventricular Geometry and Tricuspid Valve Tethering Area in Patients Undergoing Tricuspid Annuloplasty. Circulation 2014;129:87-92.
  • Yiu KH, Wong A, Pu L, Chiang R, Sit KY, Chan D, Lee HY, Lam YM, Chen Y, Siu CW, Lau CP, Au WK, Tse HF. Prognostic value of preoperative right ventricular geometry and tricuspid valve tethering area in patients undergoing tricuspid annuloplasty. Circulation 2014;129:87-92.
  • Lau KK, Wong YK, Chan YH, Teo KC, Chan KH, Li LSW, Cheung RTF, Siu CW, Ho SL and Tse HF. Visit-to-visit blood pressure variability as a prognostic marker in patients with cardiovascular and cerebrovascular diseases – relationships and comparisons with vascular markers of atherosclerosis. Atherosclerosis 2014; 235(1): 230-5 (Impact factor: 4.255)
  • Lau KK, Wong YK, Chang RSK, Teo KC, Hon SFK, Chan KH, Wat KL, Cheung RTF, Li LSW, Siu CW, Ho SL and Tse HF. Visit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct. European Journal of Neurology 2014; 21(2): 319-25 (Impact factor 4.387)
  • Lau KK, Wong YK, Teo KC, Chang RSK, Chan KH, Hon SFK, Wat KL, Cheung RTF, Li LSW, Siu CW and Tse HF. Long-term prognostic implications of visit-to-visit blood pressure variability in patients with ischemic stroke. American Journal of Hypertension 2014; 27(12): 1486-94 (Impact factor 2.530)
  • Liu HF, Lu S, Ho PWL, Tse HM, Pang SYY, Kung MHW, Ho JWM, Ramsden DB, Zhou ZJ, Ho SL. (2014) LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity. Annals of Clinical and Translational Neurology. 1(3):199-208..2014
  • Fung J, Wong DKH, Seto WK, Kopaniszen M, Lai CL, Yuen MF. Hepatitis B surface antigen seroclearance: relationship to hepatitis B e antigen seroclearance and hepatitis B e antigen-negative hepatitis. Am J Gastroenterol 2014;109(11):1764-70.
  • Liu KS, Hung IF, Seto WK, Tong T, Hsu AS, Lam FY, But DY, Wong SY, Leung WK. Ten day sequential versus 10 day modified bismuth quadruple therapy as firstline and secondline treatment for Helicobacter pylori in Chinese patients: an open label randomized crossover trial. Gut 2014;63:1410-5
  • Wong DK, Seto WK, Fung J, Ip P, Huang FY, Lai CL, Yuen MF. Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency. Clin Gastroenterol Hepatol. 2013; 11:1004-1010 [impact factor: 6.64]
  • Wong DK, Watanabe T, Tanaka Y, Seto WK, Lee CK, Fung J, Lin CK, Huang FY, Lai CL, Yuen MF. Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese. PlosOne. 2013; 8:e66920 [impact factor: 3.73]
  • Seto WK, Wong DK, Fung J, Huang FY, Lai CL, Yuen MF. Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy. Hepatology. 2013; 58:923-31 [impact factor: 12]
  • Seto WK, Wong DK, Kopaniszen M, Proitsi P, Sham PC, Hung IF, Fung J, Lai CL, Yuen MF. HLA-DP and IL28B Polymorphisms: Influence of Host Genome on Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B. Clin Infect Dis. 2013; 56:1695-1703. [impact factor: 9.37]
  • Chan VS, Tsang HH, Tam RC, Lu L, Lau CS. B-cell-targeted therapies in systemic lupus erythematosus. Cell Mol Immuno, 2013; 10:133-42
  • Chen Y, Hwang SL, Chan VS, Chung NP, Wang SR, Li Z, Ma J, Lin CW, Hsieh YJ, Chang KP, Kung SS, Wu YC, Chu CW, Tai HT, Gao GF, Zheng B, Yokoyama KK, Austyn JM, Lin CL. Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells. PLoS Pathog, 2013, 9(1):e1003100.
  • Chung HY*, Cynthia YY Chan, Tsang HHL, Au YL, Lau CS. The socio-economic impacts on household income, employment status, need for public assistance, and marriage opportunities in patients with Spondyloarthritis: A comparison with the Hong Kong population. Hong Kong Bull Rheum Dis 2013; 13: 39-46.
  • Yung S*, Chau MKM, Zhang Q, Zhang CZ, Chan TM. Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy. PLoS ONE 2013; 8: e54501.
  • Lin M, Yiu WH, Li RX, Wu HJ, Wong DL, Chan LY, Leung JC, Lai KN, Tang SC: The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy. Kidney Int 2013; 83: 887-900
  • Yap DY, Ma MK, Mok MM, Tang CS, Chan TM*. Long-term data on corticosteroids and mycophenolate mofetil treatment in lupus nephritis. Rheumatology and Clinical Immunologytology (Oxford) 2013; 52: 480-486.
  • Mak A, Isenberg DA, Lau CS. Global trends, potential mechanisms and early detection of organ damage in SLE. Nature Reviews Rheumatology and Clinical Immunologytology, 2013; 9(5): 301-310
  • Cooper W,Lam DC, O’Toole S, Minna JD. Oncogenes and Tumor suppressor hallmarks in lung cancer.J Thoracic Disease2013; 5(Suppl 5): S479-490.
  • Guan S, Tee W, Ng D, Chan T, Peh H, Ho W, Cheng C, Mak J, Wong W. Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br. J. Pharmacol. 2013;168:1707-1718. (2012 Impact F. 5.067; 5-year Impact F. 4.898)
  • Han KQ, Yeung SC, Ip MSM, Mak JCW. Intermittent hypoxia-induced NFkB and HO-1 regulation in human endothelial EA.hy926 cells. Cell Biochemistry & Biophysics. 2013; 66(3): 431-441.
  • Ho JC *, Au WY, Han L, Kwong YL, Ip MS. Effect of therapeutic arsenic exposure on pulmonary function. Respiratory Medicine 2013; 107(9):1423-30.
  • Lai AYK, Fong DYT, Lam JCM, Weaver T, Ip MSM. Linguistic and psychometric validation of the Chinese version of the Self-Efficacy Measures for Sleep Apnea. Sleep Medicine 2013; 14(11): 1192-1198.
  • Li YY, Lam SK, Mak JC, Zheng CY, Ho JC*. Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer. Lung Cancer 2013; 81(3):354-61.
  • Tam TC, Ho JC, Wong MK, Wong WM, Wang JK, Lam JC, Lui MM, Lam WK, Ip MS,Lam DC. Treatment Outcomes in Elderly with Advanced-stage Non-small Cell Lung Cancer.LUNG2013; 191(6):645-654.
  • Thompson P, Salvi S, Lin J, Cho YJ, Eng P, Manap RA, Boonsawat W, Hsu JY, Faruqi RA, Moreno-Cantu JJ, Fish JE, Ho JC. Insights, attitudes, and perceptions about asthma and its treatment: Findings from a multinational survey of patients from 8 Asia-Pacific countries and Hong Kong. Respirology 2013; 18(6):957-67.
  • Wu YL, Lee JS, Thongprasert S, Yu CJ, Zhang L, Ladrera G, Srimuninnimit V, Sriuranpong V, Sandoval-Tan J, Zhu Y, Liao M, Zhou C, Pan H, Lee V, Chen YM, Sun Y, Margono B, Fuerte F, Chang GC, Seetalarom K, Wang J, Cheng A, Syahruddin E, Qian X, Ho JC, Kurnianda J, Liu HE, Jin K, Truman M, Bara I, Mok TS. Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small cell lung cancer. Lancet Oncology 2013;14(8):777-86.
  • Zheng CY, Lam SK, Li YY, Fong BM, Mak JC, Ho JC*. Combination of arsenic trioxide and chemotherapy in small cell lung cancer. Lung Cancer 2013 ;82(2):222-30.
  • Cheng CW, Chow AK, Pang R, Fok EW, Kwong YL and Tse E. PIN1 inhibits apoptosis in hepatocellular carcinoma through modulation of the anti-apoptotic function of survivin. Am J Pathol. 182(3):765-75, 2013.
  • Kwong YL, Pang AW, Leung AY, Chim CS, Tse E. Quantification of circulating Epstein-Barr virus DNA in NK/T-cell lymphoma treated with the SMILE protocol: diagnostic and prognostic significance. Leukemia 2013 Jul 11. [Epub ahead of print] (Impact factor: 10.164)
  • Wang LQ, Kwong YL, Kho CS, Wong KF, Wong KY, Ferracin M, Calin GA, Chim CS. Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NF?B pathway. Mol Cancer. 2013;12:173. (IF: 6.204)
  • Wong KY, Yim RL, Kwong YL, Leung CY, Hui PK, Cheung F, Liang R, Jin DY, Chim CS. Epigenetic inactivation of the MIR129-2 in hematological malignancies. J Hematol Oncol. 2013; 6:16. (IF: 6.350)
  • Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, Itoh N, Wang Y, Bornstein SR, Xu A*, Li X. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metabolism. 2013, 17:779-89 (cited ~30 times within 8 months after publication)
  • RL Hoo, PC Lee, Mi Zhou, YL Wong, X Hui, A Xu, KSL Lam. Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice. J Hepatol 2013;58:358-64 [IF:15.04] #citations on 19/11/18: 27
  • WS Chow, A Xu, YC Woo, AWK Tso, SC Cheung, CHY Fong, HF Tse, MT Chau, BMY Cheung, KSL Lam. Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors. Arterioscler Thromb Vasc Biol 2013;33:2454-9 [IF:6.086] #citations on 19/11/18: 78
  • Lau CP, Tachapong N, Wang CC, Wang JF, Abe H, Kong CW, Liew R, Shin DG, Padeletti L, Kim YH, Omar R, Jirarojanakorn K, Kim YM, Chen MC, Sriratanasathavorn C, Munawar M, Kam R, Chen JY, Cho YK, Li YG, Wu SL, Bailleul C, Tse HF, for SAFE Study Prospective Randomized Study to Assess the Efficacy of Site and Rate of Atrial Pacing on Long-term Progression of Atrial Fibrillation in Sick Sinus Syndrome- Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study. Circulation 2013;128:687-93.
  • Tse HF, Ho JC, Buter AW, Lee YK, Choi SW, Ng KM, Siu CW, Simpson MA, Lai WH, Chan YC, Zhang J, Lay KW, Esteban MA, Colman A, Sham PC. Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing. Hum Mol Genet 2013;22:1395-1403.
  • Viceconte N, Chan PH, Alegria-Barrero E, et al. Frequency domain optical coherence tomography for guidance of coronary stenting. Int J Cardiol 2013;166:722-8
  • Yiu KH, Yeung CK, Zhao CT, Chan JC, Siu CW, Tam S, Wong CS, Yan GH, Yue WS, Khong PL, Chan HH, Tse HF. Prevalence and extent of subclinical atherosclerosis in patients with psoriasis. J Intern Med. 2013 ;273:273-82.
  • Chan KH, R Lee, JCY Lee, ACT Tse, SYY Pang, GKK Lau, KC Teo, PWL Ho. Central nervous system inflammatory demyelinating disorders among Hong Kong Chinese. Journal of Neuroimmunology 2013;262:100-105 (JIF 3.10)
  • Gao J, Cheung RTF, Chan YS, Chu LW, Lee TM. Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed. Neuropsychology, Development and Cognition. Section B: Aging, Neuropsychology and Cognition 2013; 20(1): 80-100.
  • Guo Y, Chan KH, Lai WH, Siu CW, Kwan SC, Tse HF, Ho WL, Ho WM. Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis. Neuroimmunomodulation 2013;20:294-303 (JIF 2.38)
  • Ho PWL, Tse HM, So DHF, Ho JWM, Liu HF, Kung MHW, Ramsden DB, Ho SL. (2013) Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O-methyltransferase (COMT) expression in an ELISA-based system. PloS One. 8(9):e74065. doi: 10.1371/journal.pone.0074065. eCollection 2013.
  • Sang YH, Liang YX, Liu LG, Ellis-Behnke RG, Wu WT, So KF, Cheung RTF. A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection. Experimental Animals 2013; 62(1): 63-69.
  • Teo KC, Ho SL. (2013) Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson’s disease. Translational Neurodegeneration. 2(1):19. doi: 10.1186/2047-9158-2-19. 2013
  • Lai CL, Ahn SH, Lee KS, Um SH, Cho M, Yoon SK, Lee JW, Park NH, Kweon YO, Sohn JH, Lee J, Kim JA, Han KH, Yuen MF. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Gut. 2013 Aug 31.
  • Seto WK, Liu K, Wong DK, Fung J, Huang FY, Hung IF, Lai CL, Yuen MF. Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment. J Hepatol 2013; 4:709-16. (2017 impact factor 15.040).
  • Seto WK, Wong DK, Fung J, Huang FY, Lai CL, Yuen MF. Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy. Hepatology 2013; 58: 923-31. 61 (2017 impact factor 14.079)
  • Tan VP, Chung A, Yan BP, Gibson PR. Venous and arterial disease in inflammatory bowel disease. J Gastroenterol Hepatol. 2013 Jul;28(7):1095-113
  • Tan VP, Wong BC. Gastric Cancer Chemoprevention: The current evidence Gastroenterology Clinics of North America. 2013 Jun 42(2):299-316
  • Lin M, Au WS, Chan AW, Yiu WH, Chan LY, Leung JC, Chan KW, Lai KN, Tang SC: Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. J Am Soc Nephrol 2012; 23: 86-102
  • Yap DY, Ma MK, Tang CS, Chan TM. Proliferation signal inhibitors in the treatment of lupus nephritis: preliminary experience. Nephrology (Carlton) 2012; 17: 676-80.
  • Yap DY, Tang CS, Ma MK, Lam MF, Chan TM. Survival analysis and causes of mortality in patients with lupus nephritis. Nephrol Dial Transplant 2012; 27: 3248-54.
  • Yap DY, Yu X, Chen XM, Lu F, Chen N, Li XW, Tang CS, Chan TM. Pilot 24 month study to compare mycophenolate mofetil and tacrolimus in the treatment of membranous lupus nephritis with nephrotic syndrome. Nephrology (Carlton) 2012; 17: 352-7.
  • Chan VS, Nie YJ, Shen N, Yan S, Mok MY, and Lau CS. Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus. Autoimmun Rev, 2012, 11: 890-7.
  • Chung HY*, Machado P, van der Heijde D, D’Agostino MA, Dougados M. Smokers in early axial spondyloarthritis have earlier disease onset, more disease activity, inflammation and damage, and poorer function and health related quality of life: results from the DESIR cohort. Ann Rheum Dis 2012 Jun; 71(6): 809-16. (Editor’s choice)
  • HL Tsang, HY Chung, MY Mok, CS Lau. Kinase Inhibitors for the Treatment of Rheumatology and Clinical Immunologytoid Arthritis. Hong Kong Bulletin on Rheumatology and Clinical Immunologytic Diseases 2012; 12: 43-49.
  • Chan KH, Chan SCH, Yeung SC, Man RYK, Ip MSM, Mak JCW*. Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity. Free Radic. Res. 2012; 46:1123-1129. (2012 Impact F. 3.279; 5-year Impact F. 2.836)
  • Ho Y-S, Yang X, Yeung S-C, Chiu K, Lau CF, Tsang AW-T, Mak JC-W, Chang RC-C. Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats. PLoS One. 7:e36752, 2012. (2012 Impact F. 3.730; 5-year Impact F. 4.244)
  • Lam DC, Fong DYT, Yu WC, Ko FW, Lau AC, Chan JW, Choo KL, Mok TY, Tam CY, Ip MSM, Chan-yeung M. FEV3, FEV6 and their derivatives for detecting airflow obstruction in adult Chinese.Int J Tuberc Lung Dis. 2012 May;16(5):681-6.
  • Lau WKW, Chan SC, Law AC, Ip MS, Mak JCW*. The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells. Toxicol. Sci. 2012; 125:569-577. (2012 Impact F. 4.328; 5-year Impact F. 4.836)
  • Lau WKW, Chan-Yeung MMW, Yip BHK, Cheung AHK, Ip MSM, Mak JCW*. The Role of Circulating Serotonin in Development of Chronic Obstructive Pulmonary Disease. PLoS One 2012; 7:e31617. (2012 Impact F. 3.730; 5-year Impact F. 4.244)
  • Lau WKW, Li X, Yeung DSC, Chan KH, Ip MSM, Mak JCW*. The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo. Free Radic. Res. 2012;46:1413-1419. (2012 Impact F. 3.279; 5-year Impact F. 2.836)
  • Yam I,Lam DC, Chan K, Chung-Man Ho J, Ip M, Lam WK, Chan TK, Chan V. EGFR array: uses in the detection of plasma EGFR mutations in non-small cell lung cancer patients.J Thorac Oncol. 2012 Jul; 7(7):1131-40.
  • Chim CS, Lie AK, Chan EY, Liu HS, Lau CW, Yip SF, Sim J, Wan TS, Ma ES, Liang R, Tse E, Kwong YL; Hong Kong Society of Myeloma. Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD. J Hematol Oncol. 2012;5:28. (IF: 6.350)
  • Kwong YL, Kim WS, Lim ST, Kim SJ, Tang T, Tse E, Leung AY, Chim CS. SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group. Blood 2012;120(15):2973-80. (Impact factor: 9.060)
  • Man CH, Fung TK, Ho C, Han HH, Chow HC, Ma AC, Choi WW, Cheung AM, Eaves CJ, Kwong YL, Leung AY*. Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness with the emergence of a D835 mutation. Blood 2012; 119(22): 5133-43.
  • Man CH, Fung TK, Ho C, Han HH, Chow HC, Ma AC, Choi WW, Lok S, Cheung AM, Eaves C, Kwong YL, Leung AY. Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. Blood 2012;119(22):5133-43. (Impact factor: 9.060)
  • Wong KY, Huang X, Chim CS. DNA methylation of microRNA genes in multiple myeloma. Carcinogenesis. 2012 Sep;33(9):1629-38. (IF: 5.105)
  • Yim RL, Kwong YL, Wong KY, Chim CS. DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin's Lymphomas. Front Genet. 2012 Nov 8;3:233.
  • Cheng KK, Lam KS, Wu D, Wang Y.. and Xu A*. APPL1 potentiates insulin secretion in pancreatic beta-cells by increasing Akt-dependent expression of SNARE proteins in mice.Proc. Natl. Acad. Sci. USA. 2012, 109:8919-24, selected for commentary.
  • Lee CH, Yuen MM, Chow WS, Tso AW, Yeung CK, Chan JC, Chau CH, Lam KS. A man with blistering eruption and tuberculosis. BMJ 2012; 344:d8351
  • Li FY, Lam KS, Tse HF, Chen C, Wang Y, Vanhoutte PM, Xu A*. Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice. Circulation. 2012, 126:1267-77.
  • Shea YF, Lee CH, Gill H, Chow WS, Lam YM, Luk HM, Lam ST, Chu LW. Delayed diagnosis of 22q11.2 deletion syndrome in an adult Chinese lady. Chin Med J 2012, 125:2945-2947
  • Y Xiao, A Xu, LSC Law, C Chen, H Li, X Li, L Yang, S Liu, Z Zhou, KSL Lam. Distinct changes in serum fibroblast growth factor 21 level in different subtypes of diabetes. J Clin Endocrinol Metab2012;97(1):E54-8 [IF:5.789] #citations on 19/11/18: 60
  • Ye D, Li Y, Lam KS, Li H, Jia W, Wang Y, Man K, Li X and Xu A*. TLR4 mediates obesity-induced nonalcoholic steatohepatitis through activation of X-box binding protein in mice. Gut. 2012, 61: 1058-67
  • Alegri?a-Barrero E, Chan PH, Di Mario C, et al. Tools and techniques: edge-to-edge percutaneous MitraClip implantation. EuroIntervention 2012;7:1476-8
  • Alegria-Barrero E, Chan PH, Paulo M, et al. Edge-to-Edge Percutaneous Repair of Severe Mitral Regurgitation - state-of-the-art for Mitraclip implantation. Circ J 2012;76:801-8
  • Alegri?a-Barrero E, Foin N, Chan PH, et al. Optical coherence tomography for guidance of distal cell recrossing in bifurcation stenting: choosing the right cell matters. EuroIntervention 2012;8:205-13
  • Chan PH, Alegria-Barrero E, Di Mario C. Tools and Techniques: Intravascular Ultrasound and Optical Coherence Tomography. EuroIntervention 2012;7:1343-1349
  • Chan PH, Di Mario C, Franzen O. Dissociation between anatomical and functional results after MitraClip implantation. Int J Cardiol 2012;155:175-6
  • Chan PH, She HL, Alegria-Barrero E, et al. Real-World Experience of MitraClip for Treatment of Severe Mitral Regurgitation. Circ J 2012;76:2488-9
  • Lip GY, Tse HF, Lane DA. Management of atrial fibrillation. Lancet 2012 18;379:648-61.
  • Siu CW, Lee YK, Ho JC, Lai WH, Chan YC, Ng KM, Wong LY, Au KW, Lau YM, Zhang J, Lay KW,Colman A, Tse HF. Modeling of lamin A/C mutation premature cardiac aging using patient?specific induced pluripotent stem cells. Aging (Albany NY). 2012 Nov;4(11):803-822.
  • Siu CW, Wong MP, Ho CM, Lam CL, Tse HF. Fatal lung toxic effects related to dronedarone. Arch Intern Med. 2012;172:516-7.
  • Yeung CY, Lam KS, Li SW, Lam KF, Tse HF, Siu CW. Sudden cardiac death after myocardial infarction in type 2 diabetic patients with no residual myocardial ischemia. Diabetes Care. 2012 Dec;35(12):2564-9
  • Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, Marsan NA, Veltman CE, de Roos A, Pazhenkottil A, Kroft LJ, Boersma E, Herzog B, Leung M, Maffei E, Leung DY, Kaufmann PA, Cademartiri F, Bax JJ, Jukema JW. Age- and gender-specific differences in the prognostic value of CT coronary angiography. Heart. 2012;98:232-7.
  • Chan KH, Lam KSL, Cheng OY, Kwan JSC, Ho PWL, Cheng KKY, Chung SK, Ho JWM, Guo VY, Xu A. Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity. PLOS ONE 2012;7(12):e52354 (JIF 4.35)
  • Chan KH, Zhang R, Kwan JSC, Guo VY, Ho PWL, Ho JWM, Chu ACY. Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse. Journal of Neuroimmunology 2012;245:32-38 (JIF 3.10)
  • Lau KK, Wong YK, Chan YH, Yiu KH, Teo KC, Li LS, Ho SL, Chan KH, Siu CW and Tse HF. Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes. Cardiovascular Diabetology 2012; 11: 101 (Impact factor 5.948)
  • Seto WK, Wong DK, Fung J, Hung IF, Fong DY, Yuen JC, Tong T, Lai CL, Yuen MF. A large case-control study on the predictability of hepatitis B surface antigen three years before HBsAg seroclearance. Hepatology 2012 56: 812-9. 61 (2017 impact factor 14.079)
  • Tan VP, Cheung TK, Wong WM, Chan OO, Hung IFN, Chan P, Chan CK, Fung J, Yuen MF, Wong BCY. Double-Blind, Randomized, Placebo-Controlled Study of four weeks of Sertraline for the Treatment of Functional Dyspepsia. World J Gastroenterol. 2012 Nov 14;18(42):6127-33
  • Zou B, Chim CS, Pang R, Zeng H, Dai Y, Zhang R, Lam CS, Tan VP, Hung IF, Lan HY, Wong BC. XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification. Mol Carcinog. 2012 May;51(5):422-32
  • Wong DK, Huang FY, Lai CL, Poon RT, Seto WK, Fung J, Hung IF, Yuen MF. Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma. Hepatology. 2011; 54:829-36 [impact factor: 12]
  • K.N. Lai and S.C.W. Tang, eds. Karger AG. Diabetes and the Kidney. , 2011 (Book)
  • Chung HY*, Lau CS, Wu KP, Wong WS, Mok MY. Comparison of performance of the Assessment of SpondyloArthritis International Society, the European Spondyloarthropathy Study Group and the modified New York criteria in a cohort of Chinese patients with spondyloarthritis. Clin Rheumatology and Clinical Immunologytol. 2011 Jul; 30(7): 947-53.
  • Chung HY*, Machado P, van der Heijde D, D’Agostino MA, Dougados M. HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIR cohort of patients with recent onset axial spondyloarthritis. Ann Rheum Dis. 2011 Nov; 70(11): 1930-6.
  • Lam DC, Lam B, Wong MKY, Lu C, Au WY, Tse EWC, Leung AYH, Kwong YL, Liang RHS, Lam WK, Ip MSM, Lie AKW. Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study.Bone Marrow Transplantation2011; 46 (12): 1551 – 56.
  • Chung HY*, Mok MY, Wong WS, Lau CS. Improvement in diagnostic delay in spondyloarthritis patients over time but disease control is still inadequate. Hong Kong Bulletin on Rheumatology and Clinical Immunologytic Disease 2011 Dec; 11(2): 48-52
  • Dejnirattisai W, Webb AI, Chan VS, Jumnainsong A, Davidson A, Mongkolsapaya J, and Screaton G. Lectin Switching During Dengue Virus Infection. J Infect Dis, 2011, 203: 1775-1783.
  • Yiu KH, Tse HF, Mok MY, Lau CS. Ethnic differences in cardiovascular risk in Rheumatology and Clinical Immunologytic disease: focus on Asians. Nat Rev Rheumatology and Clinical Immunologytol, 2011; 7(10):609-18
  • Au WY, Kumana CR, Lee HK, Lin SY, Liu H, Yeung DY, Lau JS, Kwong YL. Oral arsenic trioxide-based maintenance regimens for first complete remission of acute promyelocytic leukemia: a 10-year follow-up study. Blood 2011;118(25):6535-43. (Impact factor: 9.060)
  • Kwan-Yeung Wong, Raymond Liang, Chi-Chiu So, Yanting Qi, Dong-Yan Jin, Joseph F. Costello, Chim CS. Epigenetic silencing of miR-203 in multiple myeloma. Br J Haematol, 2011 Sep; 154(5): 569-78. (IF: 5.67)
  • KY Wong, Rita LH Yim, CC So, DY Jin, Raymond Liang, Chim CS. Epigenetic inactivation of the MIR34B/C in multiple myeloma. Blood 2011; 118: 5901-5904 (IF: 13.164).
  • Ma AC, Fung TK, Lin RH, Chung MI, Yang D, Ekker SC, Leung AY*. Methionine aminopeptidase 2 is required for hematopoietic stem cell initiation and proliferation. Blood 2011; 118(20):5448-57.
  • Wong KY, Yu L, Chim CS. DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family. Epigenomics. 2011 Feb;3(1):83-92. (IF: 4.541)
  • Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R. Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study. J Clin Oncol 2011;29(33):4410-6. (Impact factor: 18.038)
  • AWK Tso, TKY Lam, A Xu, KH Yiu, HF Tse, LSW Li, LSC Law, BMY Cheung, RTF Cheung, KSL Lam. Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death. Neurology 2011;76:1968-75 [IF:8.055] #citations on 19/11/18: 31
  • C Chen, BMY Cheung, AWK Tso, Y Wang, LS Law, KL Ong, NMS Wat, A Xu, KSL Lam. High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects. Diabetes Care 2011;34:2113-5 [IF:13.397] #citations on 19/11/18: 86
  • Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao W, DeMicco DA, Preston GM, Tan K, Fuller JH. Total soluble and endogenous secretory receptor for advanced glyation endproducts as predictive biomarkers of Coronary Heart Disease risk in patients with type 2 diabetes; an analysis from the CARDS trial. Diabetes, 2011;60:2379-85.
  • Tam HL, Shiu SWM, Leng L, Bucala R, Betteridge DJ, Tan KC. Enhanced expression of receptor for advanced glycation end products is associated with low circulating soluble isoforms of the receptor in type 2 diabetes. Clin Sci 2011;120:81-89.
  • Wang Y, Cheng KK, Lam KS, Wu D, Wang Y, Huang Y, Vanhoutte PM, Sweeney G, Li Y, Xu A*. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes, 2011, 60: 3044-54.
  • Wong WT, Tian XY, Xu A*, Yu J, Lau CW, Hoo R, Wang Y, Lee VW, Lam KS, Vanhoutte PM, and Huang Y. The obligatory role of adiponectin in restoring endothelial function in PPAR? agonist-treated diabetic mice. Cell Metabolism, 2011, 16:101-15.
  • X Zhang, A Xu, SK Chung, JH Cresser, G Sweeney, RLC Wong, A Lin, KSL Lam. Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes 2011;60:486-95 [IF:7.273] #citations on 19/11/18: 69
  • Chan PH, Di Mario C, Davies SW, et al. Transcatheter Aortic Valve Implantation in Degenerate Aortic Homograft Root Replacements. J Am Coll Cardiol 2011;58:1729-30
  • Lee YK, Ng KM, Lai WH, Chan YC, Lau YM, Lian Q, Tse HF, Siu CW. Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Rev. 2011 Nov;7(4):976-86.
  • Lee YK, Ng KM, Lai WH, Man C, Lieu DK, Lau CP, Tse HF, Siu CW. Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway. Acta Pharmacol Sin. 2011 Jan;32(1):52-61.
  • Ng AC, Yiu KH*, Ewe SH, van der Kley F, Bertini M, de Weger A, de Roos A, Leung DY, Schuijf JD, Schalij MJ, Bax JJ, Delgado V. Influence of left ventricular geometry and function on aortic annular dimensions as assessed with multi-detector row computed tomography: implications for transcatheter aortic valve implantation. Eur Heart J. 2011;32:2806-13. * Co-first author
  • Ng KM, Lee YK, Lai WH, Chan YC, Fung ML, Tse HF, Siu CW. Exogenous expression of human apoA-I enhances cardiac differentiation of pluripotent stem cells. PLoS One. 2011 May 11;6(5):e19787.
  • Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ. Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Arthritis Rheum. 2011;63:3969-78.
  • Yiu KH, Tse HF, Mok MY, Lau CS. Ethnic differences in cardiovascular risk in Rheumatology and Clinical Immunologytic disease: focus on Asians. Nat Rev Rheumatology and Clinical Immunologytol. 2011;7:609-18.
  • Yiu KH, Wang S, Mok MY, Ooi GC, Khong PL, Lau CS, Tse HF. Relationship between cardiac valvular and arterial calcification in patients with Rheumatology and Clinical Immunologytoid arthritis and systemic lupus erythematosus. J Rheumatology and Clinical Immunologytol. 2011;38:621-7.
  • Yiu KH, Yeung CK, Chan HT, Wong RM, Tam S, Lam KF, Yan GH, Yue WS, Chan HH, Tse HF. Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation. Br J Dermatol. 2011;164:514-20.
  • Ong KL, Tso AW, Xu A, Law LS, Li M, Wat NM, Rye KA, Lam TH, Cheung BM*, Lam KS*. Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years. Diabetologia. 2011 Oct;54(10):2552-60.[Impact factor: 6.81. No. of citations: 11]
  • Chan KH, Tse CT, Chung CP, Lee R, Kwan JSC, Ho PWL, Ho. JWM Brain involvement of neuromyelitis optica spectrum disorders. Archives of Neurology 2011;68(11):1432-1439 (JIF 7.58)
  • Gao J, Cheung RTF, Lee TM, Chu LW, Chan YS, Mak HK, Zhang JX, Qiu D, Fung G, Cheung C. Possible retrogenesis observed with fiber tracking: An anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer's disease. Journal of Alzheimers Disease 2011; 26(1): 47-58.
  • Sang YH, Su HX, Wu WT, So KF, Cheung RTF. Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury. Journal of Neurotrauma 2011; 28(12): 2523-2534.
  • Tso AW, Lam TK, Xu A, Yiu KH, Tse HF, Li LS, Law LS, Cheung BM, Cheung RTF, Lam KS. Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death. Neurology 2011; 76(23): 1968-1975.
  • Ma TK, Lam YY, Tan VP, Yan BP. Variability in response to clopidogrel: how important are pharmacogenetics and drug interactions? Br J Clin Pharmacol. 2011 Oct;72(4):697-706
  • Seto WK, Lai CL, Fung J, Wong DK, Yuen JC, Hung IF, Yuen MF Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome. J Hepatol 2011; 55(3): 522-8. (2017 impact factor 15.040)
  • Tan VP, Wong BC. Helicobacter pylori and gastritis: Untangling a complex relationship 27 years on. J Gast Hep 26 (2011) Suppl. 1; 42–45
  • Tan VP, Wong WM, Cheung TK, Lai KC, Hung IF, Chan P, Pang R, Wong BCY. Treatment of non-erosive reflux disease with proton pump inhibitor in Chinese patients: a randomized controlled trial. J Gastroenterol. 2011 Jul;46(7):906-12
  • Zhang W, Yang Y, Jiang B, Peng J, Tu S, Sardet C, Zhang Y, Pang R, Hung IF, Tan VP, Lam CS, Wang J, Wong BC. XIAP-associated factor 1 interacts with and attenuates the trans-activity of four and a Half LIM protein. Mol Carcinog. 2011 Mar;50(3):199-207
  • Yung S, Cheung KF, Zhang Q, Chan TM. Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. J Am Soc Nephrol 2010; 21: 1912-1927.
  • Tang SC, Lam B, Leung WS, Chu CM, Ho YW, Ip MS, Lai KN: Sleep apnea as a novel risk predictor for cardiovascular morbidity and death in peritoneal dialysis patients. Kidney Int 2010; 77: 1031-1038
  • Tang SC, Tang AW, Wong SS, Leung JC, Ho YW, Lai KN: Long-term study of mycophenolate mofetil treatment in IgA nephropathy. Kidney Int 2010; 77: 543-549
  • Yap DY, Tang CS, Yung S, Choy BY, Yuen MF, Chan TM. Long-term outcome of Rehabilitation Medicine transplant recipients with chronic hepatitis B infection-impact of antiviral treatments. Transplantation 2010; 90: 325-30.
  • Yung S, Cheung KF, Zhang Q, Chan TM*. Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. J Am Soc Nephrol 2010; 21: 1912-1927.
  • Chan KH, Yeung SC, Yao TJ, Ip MSM, Cheung AHK, Chan-Yeung MMW, Mak JCW*. Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease. Int. J. Tuberc. Lung Dis. 14:1193-200, 2010. (2012 Impact F. 2.610; 5-year Impact F. 2.502)
  • Lam DC, Lui MM, Lam JC, Ong LH, Lam KS, Ip MSM. Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus. Chest 2010; 138: 1101-1107.
  • Lam JCM, Lam B, Yao TJ, Lai AYK, Ooi CG, Tam S, Lam KSL, Ip MSM. A randomized controlled trial of nCPAP on insulin sensitivity in obstructive sleep apnea. European Respiratory Journal 2010; 35(1): 138-145.
  • Jin O, Kavikondala S, Mok MY, Sun L, Gu JR, Fu R, Chan A, Yeung J, Nie YJ, Lau CS. Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus. Arthritis Res Ther 2010; 12(4): R137
  • Mok MY, Wu HJ, Lo Y, Lau CS. The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus. The Journal of Rheumatology and Clinical Immunologytology 2010; 37(10): 2046-2052
  • Mok MY, Lau CS. The burden and measurement of cardiovascular disease in systemic sclerosis. Nature Reviews Rheumatology and Clinical Immunologytology 2010; 6(7): 430-434
  • Nie YJ, Mok MY, Chan GCF, Chan A, Lie AWK, Lau CS. Phenotypic and functional abnormalities of bone marrow-derived dendritic cells in systemic lupus erythematosus. Arthritis Res Ther 2010; 12(3): R91
  • Chim CS, KY Wong, Y Qi, Loong F, WL Lam, LG Wong, Jin DY, Costello JF, Liang R. Epigenetic inactivation of the miR-34a in hematological malignancies. Carcinogenesis, 2010, 31(4):745-50 (Impact Factor: 5.105).
  • Ma AC, Chung MI, Liang R, Leung AY*. A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Leukemia. 2010; 24(12):2090-9.
  • Nie YJ, Lau CS, Lie AK, Chan GC, Mok MY. Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2010; 19(7): 850-9
  • Chang J , Li Y , Huang Y , Lam KS, Hoo LC, Wong WT, Cheng KK, Wang Y, Vanhoutte PM , and Xu A*. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP kinase/p16INK4A Signaling Pathway. Diabetes, 2010, 59: 2949-59
  • CYY Cheung, AWK Tso, BMY Cheung, A Xu, KL Ong, CHY Fong, NMS Wat, ED Janus, PC Sham, KSL Lam. Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population. J Clin Endocrinol Metab 2010; 95:1395-403 [IF:5.789] #citations on 19/11/18: 58
  • Tam HL, Shiu SWM, Wong Y, Chow WS, Betteridge DJ, Tan KC. Effects of atorvastatin on serum soluble receptors for advanced glycation end-products in type 2 diabetes. Atherosclerosis 2010;209:173-177.
  • Lai WH, Ho JC, Lee YK, Ng KM, Au KW, Chan YC, Lau CP, Tse HF, Siu CW. ROCK inhibition facilitates the generation of human-induced pluripotent stem cells in a defined, feeder-, and serum-free system. Cell Reprogram. 2010 Dec;12(6):641-53.
  • Lee YK, Ng KM, Chan YC, Lai WH, Au KW, Ho CY, Wong LY, Lau CP, Tse HF, Siu CW. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol Endocrinol. 2010 Sep;24(9):1728-36.
  • Lian Q, Zhang Y, Zhang J, Zhang HK, Wu X, Zhang Y, Lam FY, Kang S, Xia JC, Lai WH, Au KW, Chow YY, Siu CW, Lee CN, Tse HF. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation 2010;121:1113-23.
  • Siu CW, Pong V, Ho HH, Liu S, Lau CP, Li SW, Tse HF. Are MADIT II criteria for implantable cardioverter defibrillator implantation appropriate for Chinese patients? J Cardiovasc Electrophysiol. 2010 Mar;21(3):231-5.
  • Yiu KH, Wang S, Mok MY, Ooi GC, Khong PL, Lau CP, Lai WH, Wong LY, Lam KF, Lau CS, Tse HF. Role of circulating endothelial progenitor cells in patients with Rheumatology and Clinical Immunologytoid arthritis with coronary calcification. J Rheumatology and Clinical Immunologytol. 2010;37:529-35.
  • Zhang J, Lian Q, Zhu G, Zhou F, Sui L, Tan C, Abdul Mutalif R, Navasankari R, Zhang Y, Tse HF, Stewart CL, Colman A. A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell. 2010;8:31-45.
  • Cheung BMY, Lam KSL. Is intensive LDL-cholesterol lowering beneficial and safe? Lancet 2010 Nov; 376(9753):1622-4. [IF 33.633; ]
  • Ong KL, Tso AWK, Lam KSL, Cherny SS, Sham PC, Cheung BMY. Using glycosylated hemoglobin to define the metabolic syndrome in United States adults. Diabetes Care 2010; 33(8):1856-8. [IF 7.141;]
  • Chan KH, Kwan JSC, Ho PWL, Ho SL, Chui WH, Chu ACY, Ho JWM, Zhang WY, Kung MHW. Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis. Journal of Neuroimmunology 2010, 227, 178-184. (JIF 3.10)
  • Chan KH, Kwan SC, Ho WL, Ho WM, Chu ACY, Ramsden DB. Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays. Journal of Neuroinflammation, 2010, 7(1), 50 (JIF =4.53)
  • Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. An fMRI study showing effect of acupuncture in chronic stage stroke patients with aphasia. Journal of Acupuncture & Meridian Studies 2010; 3(1): 53-57.
  • Cheung RTF, Lyden PD, Tsoi TH, Huang Y, Liu M, Hon SFK, Raman R, Liu L. Production and validation of Putonghua- and Cantonese-Chinese language National Institutes of Health Stroke Scale training and certification videos. International Journal of Stroke 2010; 5(2): 74-79.
  • Chang TT, Lai CL, Kew Yoon S, Lee SS, Coelho HS, Carrilho FJ, Poordad F, Halota W, Horsmans Y, Tsai N, Zhang H, Tenney DJ, Tamez R, Iloeje U. Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B. Hepatology. 2010; 51:422-30.
  • Lam PK, Ng ML, Cheung TK, Wong BY, Tan VP, Fong DY, Wei WI, Wong BCY. Rabeprazole is effective in treating laryngopharyngeal reflux. Clin Gastroenterol Hepatol. 2010 Sep;8(9):770-6
  • Tan VP, Yan BPY, Hunt RH, Wong BCY. Proton Pump and Clopidogrel: The Case for Watchful Waiting. Journal of Gastroenterology & Hepatology, 2010 Aug;25(8):1342-7
  • Yuen MF, Lee CK, Wong DK, Fung J, Hung I, Hsu A, But DY, Cheung TK, Chan P, Yuen JC, Fung FK, Seto WK, Lin CK, Lai CL. Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population. Gut. 2010; 59:1389-93.
  • Yuen MF, Fung J, Wong DK, Lai CL. Prevention and management of drug resistance for antihepatitis B treatment. Lancet Infect Dis. 2009; 9:256-264. [impact factor: 19.96]
  • Yung S, Zhang Q, Zhang CZ, Chan KW, Lui SL, Chan TM. Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid. Arthritis Rheum 2009; 60: 2071-2082.
  • Tang SC, Lai KN: The ubiquitin-proteasome pathway and IgA nephropathy: a novel link? Kidney Int 2009; 75, 457-459 [invited review article]
  • Yung S, Zhang Q, Zhang CZ, Chan KW, Lui SL, Chan TM*. Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid. Arthritis Rheum 2009; 60: 2071-2082.
  • Chan KH, Ho SP, Yeung SC, So WHL, Cho CH, Koo MWL, Lam WK, Ip MSM, Man RYK, Mak JCW*. Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats. Respir. Med. 103:1746-1754, 2009. (2012 Impact F. 2.585; 5-year Impact F. 2.659)
  • Ho JC*, Lam DC, Wong MK, Lam B, Ip MS, Lam WK. Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung. J Thorac Oncol 2009;4(9):1174-1177.
  • Lam DCL, Girard L, Ramirez R, Chau WS, Suen WS, Sheridan S, Tin VPC, Chung LP, Wong MP, Shay JW, Gazdar AF, Lam WK, Minna JD. Expression of Nicotinic Acetylcholine Receptor Subunit Genes showed difference in expression pattern in smokers and non-smokers.Cancer Research2007; 67(10): 4638 – 47.
  • Lam DCL, Xu A, Lam KSL, Lam B, Lam JCM, Lui MMS, Ip MSM. Serum adipocyte-fatty acid binding protein (A-FABP) level is elevated in severe obstructive sleep apnea (OSA) and correlates with insulin resistance. European Respiratory Journal 2009; 33(2): 346-351.
  • Lui MMS, Lam JCM, Mak H, Xu A, Ooi C, Lam DCL, Mak J, Khong PL, Ip MSM. C-reactive protein is associated with obstructive sleep apnea independent of visceral obesity. Chest 2009; 135: 950-956.
  • Ma AC, Chung MI, Liang R, Leung AY*. The role of survivin2 in primitive hematopoiesis during zebrafish development. Leukemia. 2009;23(4):712-20.
  • Chung HY*, Nigel TJ Smith, Yeung CK, Mok MY. Degos’ disease: a rare condition simulating Rheumatology and Clinical Immunologytic diseases. Clin Rheumatology and Clinical Immunologytol 2009; 28: 861-863
  • Lau CS, Mak A. The socioeconomic burden of SLE. Nature Reviews Rheumatology and Clinical Immunologytology 2009; 5(7): 400-404
  • Mak A, Cheak AAC, Tan JYS, Su HC, Ho RCM, Lau CS. Mycophenolate mofetil is as efficacious as but safer than cyclophosphamide in the treatment of proliferative lupus nephritis: a meta-analysis and meta-regression. Rheumatology and Clinical Immunologytology (Oxford) 2009; 48(8): 944-952
  • Reid DM, Devogelaer JP, Saag K, Roux C, Lau CS, Reginster JY, Papanstasiou P, Ferreira A, Hartl F, Fashola T, Mesenbrink P, Sambrook P. Zoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomized controlled trial. Lancet 2009; 373(9671): 1253- 1263
  • To CH, Mok CC, Tan SS, Ying KY, Wong RW, Lau CS. Prognostically distinct clinical patterns of systemic lupus erythematosus identified by cluster analysis. Lupus 2009; 18(14): 1267-1275
  • Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney, Zhu W, Vanhoutte PM, Kraegen EW and Xu A*. APPL1 Potentiates Insulin-mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice. Cell Metabolism, 2009, 9:417-27.
  • DCY Yeung, A Xu, AWK Tso, WS Chow, NMS Wat, CHY Fong, S Tam, PC Sham, KSL Lam. Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients. Diabetes Care 2009;32:132-4 [IF: 13.397] #citations on 19/11/18: 40
  • Shiu SWM, Tan KC, Wong Y, Leng L, Bucala R. Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus. Atherosclerosis, 2009;203:522-52.
  • Tan KC. Reverse cholesterol transport in type 2 diabetes mellitus. Diabetes, Obes Metab 2009;11:534-43.
  • Yiu KH, Jim MH, Siu CW, Lee CH, Yuen M, Mok M, Shea YF, Fan K, Tse HF, Chow WH. Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome. J Clin Endocrinol Metab 2009, 94: 109-114
  • Siu CW, Jim MH, Zhang X, Chan YH, Pong V, Kwok J, Kung AW, Lau CP, Tse HF. Comparison of atrial fibrillation recurrence rates after successful electrical cardioversion in patients with hyperthyroidism-induced versus non-hyperthyroidism-induced persistent atrial fibrillation. Am J Cardiol. 2009 Feb 15;103(4):540-3. .
  • Siu CW, Lau CP, Lee WL, Lam KF, Tse HF. Intravenous diltiazem is superior to intravenous amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation. Crit Care Med. 2009 Jul;37(7):2174-9
  • Siu CW, Pong V, Zhang X, Chan YH, Jim MH, Liu S, Yiu KH, Kung AW, Lau CP, Tse HF. Risk of ischemic stroke after new-onset atrial fibrillation in patients with hyperthyroidism. Heart Rhythm. 2009 Feb;6(2):169-73.
  • Wang S, Yiu KH*, Mok MY, Ooi GC, Khong PL, Mak KF, Lau CP, Lam KF, Lau CS, Tse HF. Prevalence and extent of calcification over aorta, coronary and carotid arteries in patients with Rheumatology and Clinical Immunologytoid arthritis. J Intern Med. 2009 ;266:445-52. * Co-first author
  • Yiu KH, Jim MH, Siu CW, Lee CH, Yuen M, Mok M, Shea YF, Fan K, Tse HF, Chow WH. Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome. J Clin Endocrinol Metab. 2009 Jan;94:109-14.
  • Cheung BM*, Ong KL, Cherny SS, Sham PC, Tso AW, Lam KS. Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006. Am J Med. 2009 May;122(5):443-53.[Impact factor: 4.91. No. of citations: 167.]
  • Cheung BMY, Ong KL, Wong LYF. Elevated Serum Alkaline Phosphatase and Peripheral Arterial Disease in the United States National Health and Nutrition Examination Survey 1999-2004. Int J Cardiol 2009; 135(2):156-61. [IF 3.469; ].
  • Chan KH, Ramsden DB, Yu YL, Kwok KHH, Chu ACY, Ho PWL, Kwan JSC, Lee R, Lim E, Kung MHW, Ho SL. NMO-IgG in idiopathic inflammatory demyelinating disorders among Hong Kong Chinese. European Journal of Neurology 2009;16:310-316 (JIF 4.17)
  • Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. Acupuncture of motor-implicated acupoints on subacute stroke: a fMRI study. Medical Acupuncture 2009; 21(4): 233-241.
  • Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. Increased brain activation in motor cortex after acupuncture treatment for motor recovery in chronic stroke patients. The Open Rehabilitation Journal 2009; 2(1): 89-94.
  • Yu J, Zeng J, Cheung RTF, Xiong L, He M, Liang Z, Hong H, Huang R. Intracerebroventricular injection of epidermal growth factor reduces neurological deficit and infarct volume and enhances nestin expression following focal cerebral infarction in adult hypertensive rats. Clinical and Experimental Pharmacology and Physiology 2009; 36(5-6): 539-546.
  • Yuen MF, Wong DK, Fung J, Ip P, But D, Hung I, Lau K, Yuen JC, Lai CL. HBsAg Seroclearance in chronic hepatitis B in Asian patients: replicative level and risk of hepatocellular carcinoma. Gastroenterology. 2008; 135:1192-1199. [impact factor: 12.82]
  • Tang SC, Leung JC, Chan LY, Eddy AA, Lai KN: Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy. Kidney Int 2008; 73: 288-299
  • Lam JCM, Xu A, Tam S, Khong PL, Yao TJ, Lam DCL, Lai AYK, Lam B, Lam KSL, Ip MSM. Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea. Sleep 2008; 31: 1721-1727.
  • Au WY, Tam S, Fong BM, Kwong YL. Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy. Blood 2008;112(9):3587-90. (Impact factor: 9.060)
  • Cheung WH, Chan VS, Pang HW, Wong MK, Guo ZH, Tam PK, Che CM, Lin CL, and Yu WY. Conjugation of Latent Membrane Protein (LMP)-2 Epitope to Gold Nanoparticles as Highly Immunogenic Multiple Antigenic Peptides for Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses in Vitro. Bioconjugate Chem 2008, 20:24–31
  • Tan KC, Shiu SWM, Wong Y, Leng L, Bucala R. Soluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitus. J Lipid Res 2008;49:1438-1444.
  • XM Zhang, DCY Yeung, M Karpisek, D Stejskal, F Liu, RLC Wong, *KSL Lam, *A Xu. (*co-corresponding authors). Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008;57:1246-53 [IF:7.273] #citations on 19/11/18: 443
  • Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, Wong RL, Chow WS, Tso AW, Lam KS, Xu A*. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes, 2008, 57:1246-53.
  • Jin O, Kavikondala S, Sun L, Fu R, Mok MY, Chan A, Yeung J, Lau CS. Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression. Lupus 2008; 17(7): 654-62
  • To YF, Sun RW, Chen Y, Chan VS*, Yu WY, Tam PK, Che CM, and Lin CL. Gold(III) porphyrin complex is more potent than cisplatin in inhibiting growth of nasopharyngeal carcinoma in vitro and in vivo. Int J Cancer 2008, 124:1971-1979 (*corresponding author)
  • Chan YH, Lau KK, Yiu KH, Li SW, Chan HT, Fong YT, Tam S, Lau CP, Tse HF. Reduction of C-Reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke. Eur Heart J 2008;29:2800-2807.
  • Cheung BM, Wat NM, Tso AW, Tam S, Thomas GN, Leung GM, Tse HF, Woo J, Janus ED, Lau CP, Lam TH, Lam KS. Association between raised blood pressure and dysglycemia in Hong Kong Chinese. Diabetes Care 2008; 31(9):1889-91. [IF 7.349;]
  • Cheung BM. Statins for people with diabetes. Lancet. 2008 Jan 12; 371(9607):94-5. [IF 28.409; ]
  • Ong KL, Tso AW, Lam KS, Cheung BM*. Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension. Hypertension. 2008 Apr;51(4):1142-8 [Impact factor: 7.37. No. of citations: 61]
  • Lai CL, Yuen MF. Chronic hepatitis B - new goals, new treatment. N Engl J Med. 2008; 359:2488-91.
  • Leung WK, Wu MS, Kakugawa Y, Kim JJ, Yeoh KG, Goh KL, Wu KC, Wu DC, Sollano J, Kachitorm U, Gotoda T, Lin JT, You WC, Ng EK, Sung JJ, and the Asia Pacific Working Group on Gastric Cancer. Screening for gastric cancer in Asia: Current evidence and practice. Lancet Oncol 2008;9:279-287
  • Lai KN, Leung JCK, Chan LY, Guo H, Tang SC: Interaction between proximal tubular epithelial cells and infiltrating monocytes/T cells in the proteinuric state. Kidney Int 2007; 71: 526-538
  • Ho JC*, Chan-Yeung M, Ho SP, Mak JC, Ip MS, Ooi GC, Wong MP, Tsang KW, Lam WK. Disturbance of systemic antioxidant profile in non-small cell lung carcinoma. Eur Respir J 2007;29:273-278.
  • Lam B, Sam K, Mok WYW, Cheung MT, Fong DY, Lam J, Lam DC, Yam L, Ip MSM. Randomised study of three non-surgical treatments in mild to moderate obstructive sleep apnoea. Thorax 2007; 62; 354-359.
  • Chim CS, Pang R, Fung TK, Choi CL, Liang R. Epigenetic Dysregulation of Wnt Signaling Pathway in Multiple Myeloma. Leukemia; 21(12): 2527-36, 2007. (IF: 11.702)
  • Leung J, Pang A, Yuen WH, Kwong YL, Tse EW. Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells. Blood 2007;109(2):740-6. (Impact factor: 9.060)
  • Ma AC, Ward AC, Liang R, Leung AY*. The role of Jak2a in zebrafish hematopoiesis. Blood 2007;110(6):1824-30.
  • Pang R, Lee TKW, Poon RT, Fan ST, Wong KB, Kwong YL and Tse E. Pin1 interacts with a specific serine-proline motif of hepatitis B virus x-protein to enhance hepatocarcinogenesis. Gastroenterology. 132(3):1088-103, 2007.
  • Wong AS, Chan KH, Cheng VC, Yuen KY, Kwong YL, Leung AY. Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation. Clin Infect Dis 2007;44(6):830-7. (Impact factor: 9.374)
  • A Xu, AWK Tso, BMY Cheung, Y Wang, NMS Wat, CHY Fong, ED Janus, KSL Lam. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation 2007;115:1537-43 [IF:18.881] #citations on 19/11/18: 239
  • AWK Tso, A Xu, PC Sham, NMS Wat, Y Wang, CHY Fong, BMY Cheung, ED Janus, KSL Lam. Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes - a 10-year prospective study in Chinese. Diabetes Care 2007:30:2667-72 [IF:13.397] #citations on 19/11/18: 172
  • Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A*. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes. 2007, 56:1387-94 (cited over 170 times).
  • DCY Yeung, A Xu, SCW Cheung, NMS Wat, MH Yau, CHY Fong, MT Chau, KSL Lam. Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis. Arterioscler Thromb Vasc Biol 2007;27:1796-802 [IF:6.086] #citations on 19/11/18: 129
  • Tan KC, Chow WS, Tso AWK, Xu A, Tse HF, Hoo RLC, Betteridge DJ, Lam KS. Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes. Diabetologia 2007;50:1819-1825.
  • Chen, Y*, Chan VS*, Zheng B, Chan KY, Xu X, To YF, Huang FP, Khoo US and Lin CL. A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung. J Exp Med 2007, 204:2529-2536. (*equal contribution)
  • Lip GY, Tse HF. Management of atrial fibrillation. Lancet 2007;370:604-18.
  • Siu CW, Jim MH, Ho HH, Miu R, Lee SW, Lau CP, Tse HF. Transient atrial fibrillation complicating acute inferior myocardial infarction: implications for future risk of ischemic stroke. Chest. 2007 Jul;132(1):44-9.
  • Siu CW, Yeung CY, Lau CP, Kung AW, Tse HF. Incidence, clinical characteristics and outcome of congestive heart failure as the initial presentation in patients with primary hyperthyroidism. Heart. 2007 Apr;93(4):483-7.
  • Siu CW, Zhang XH, Yung C, Kung AW, Lau CP, Tse HF. Hemodynamic changes in hyperthyroidism-related pulmonary hypertension: a prospective echocardiographic study. J Clin Endocrinol Metab. 2007 May;92(5):1736-42.
  • Tse HF, Thambar S, Kwong YL, Rowlings P, Bellamy G, McCrohon J, Thomas P. Bastian B, Chan JKF, Lo G, Ho CL, Chan WS, Kwong RY, Parker A, Hauser T, Chan J, Fong YT, Lau CP. Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial).Eur Heart J. 2007; 28: 2998-3005.
  • Yiu KH, Siu CW, Lee KL, Fong YT, Chan HW, Lee SW, Lau CP, Tse HF. Emerging trends of community acquired infective endocarditis. Int J Cardiol. 2007;121:119-22
  • Cheung BMY, Wat NMW, Man YB, Tam S, Thomas GN, Leung GM, Cheng CH, Woo J, Janus ED, Lau CP, Lam TH, Lam KSL. Development of diabetes in Chinese with the metabolic syndrome - a six year prospective study. Diabetes Care 2007; 30(6):1430-6. [IF 7.851;]
  • Chow WS, Cheung BM, Tso AW, Xu A, Wat NM, Fong CH, Ong LH, Tam S, Tan KC, Janus ED, Lam TH, Lam KS. Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension. 2007; 49(6): 1455-61. [IF 7.194; ]
  • Ong, K.L., Cheung, B.M.Y*., Man, Y.B., Lau, C.P., Lam, K.S.L. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 2007; 49 (1): 69-75[Impact factor: 7.19. No. of citations: 715]
  • Cheung RTF. Sexual dysfunctions after stroke: a need for more study. European Journal of Neurology 2008; 15(7): 641.
  • Lai CL, Gane E, Liaw YF, Hsu CW, Thongawat S, Wang YM, Chen YG, Heathcote EJ, Rasenack J, Bzowej N, Naoumov NV, DiBisceglie AM, Zeuzem S, Moon YM, Goodman Z, Chao G, Constance BF, Brown NA, for the GLOBE Study Group. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med 2007; 357:2576-88.
  • Lai CL, Yuen MF. The natural history and treatment of CHB: Critical evaluation of treatment criteria and endpoints. Ann Intern Med 2007; 147:58-61.
  • Lau JYW, Leung WK, Wu JCY, Chan FKL. Wong VWS, Chiu PWY, Lee VWY, Lee KKC, Cheung FKY, Siu P, Ng EKW, Sung JJY. Omeprazole before endoscopy in patients with gastrointestinal bleeding. N Engl J Med 2007;356:1631-40.
  • Wong DK, Yuen MF, Ngai VWS, Fung J, Lai CL. One-year entecavir or lamivudine therapy results in reduction of HBV intrahepatic covalently closed circular DNA levels. Antivir Ther. 2006; 11:909-916. [impact factor: 3.07]
  • Wong DK, Yuen MF, Poon RT, Yuen JC, Fung J, Lai CL. Quantitation of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma. J Hepatol. 2006; 45:553-559. [impact factor: 9.85]
  • Yung S*, Tsang RC, Leung JK, Chan TM. Increased mesangial cell hyaluronan expression in lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta. Kidney Int 2006; 69: 272-280.
  • Tang SC, Lam B, Ku PP, Leung WS, Chu CM, Ho YW, Ip MS, Lai KN: Alleviation of sleep apnea in patients with chronic Rehabilitation Medicine failure by nocturnal cycler-assisted peritoneal dialysis. J Am Soc Nephrol 2006; 17: 2607-2616
  • Tang SC, Leung JC, Chan LY, Tsang AW, Lai KN: Activation of tubular epithelial cells in diabetic nephropathy and the role of the PPAR-gamma agonist. J Am Soc Nephrol 2006; 17: 1633-1643
  • Ho JC*, Mak JC, Ho SP, Ip MS, Tsang KW, Lam WK, Chan-Yeung M. Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. J Thorac Oncol 2006;1:648-653.
  • Ip MSM, Ko KW, Lau CW, Yu WC, Choo K, Tang KS, Chan-Yeung M. Update reference values of spirometry for adult Chinese in Hong Kong and implications on clinical utilization. Chest 2006; 129: 384-392.
  • Lam DC, Girard L, Suen WS, Chung LP, Tin VP, Lam WK, Minna JD, Wong MP. Establishment and Expression Profiling of New Primary Lung Cancer Cell Lines from Chinese Smokers and Life-time Never-Smokers.Journal of Thoracic Oncology2006; 1(9): 932 – 942.
  • Au WY, Tam S, Fong BM, Kwong YL. Elemental arsenic entered the cerebrospinal fluid during oral arsenic trioxide treatment of meningeal relapse of acute promyelocytic leukemia. Blood 2006;107(7):3012-3. (Impact factor: 9.060)
  • Siu CW, Au WY, Yung C, Kumana CR, Lau CP, Kwong YL, Tse HF. Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promyelocytic leukemia: implications for long-term cardiac safety. Blood 2006;108(1):103-6. (Impact factor: 9.060)
  • Tan KC, Chow WS, Lam JCM, Lam B, Bucala R, Betteridge DJ, Ip MSM. Advanced glycation end products in non-diabetic patients with obstructive sleep apnea. Sleep 2006;29:329-33
  • Tan KC, Shiu SWM, Chow WS, Leng L, Bucala R, Betteridge DJ. Association between serum level of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes. Diabetologia 2006;49:2756-2762.
  • Chan VS*, Chan KY*, Chen Y*, Poon LL, Cheung A, Zheng B, Chan KH., Mak W, Ngan HY, Xu X, Screaton G., Tam PK, Austyn J, Chan LC, Yip SP, Peiris M, Khoo US and Lin CL. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat Genet 2006, 38:38-46 (*equal contribution)
  • Chan VS, Chau S, Tian L, Chen Y, Kwong SKY, Quackenbush J, Dallman M, Lamb J and Tam PKH. Sonic hedgehog promotes CD4+ lymphocyte proliferation and modulates the expression of a subset of CD28 targeted genes. Int Immunol 2006, 18:1627-1636.
  • Siu CW, Au WY, Yung C, Kumana CR, Lau CP, Kwong YL, Tse HF. Effects of oral arsenic trioxide therapy on QT intervals: implications on long-term cardiac safety. Blood. 2006; 108: 103-6.
  • Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA. Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model. Circulation. 2006; 114: 1000-11.
  • Chan KH, Tsang KL, Fong CY, Ho SL, Cheung RTF, Mak W. Idiopathic inflammatory demyelinating disorders after acute transverse myelitis. European Journal of Neurology 2006;13:862-868 (JIF 4.17)
  • Cheung RTF, Tipoe GL, Tam S, Ma ESK, Zou LY, Chan PS. Preclinical evaluation of pharmacokinetics and safety of melatonin in propylene glycol for intravenous administration. Journal of Pineal Research 2006; 41(4): 337-343.
  • Cheung RTF. Update on medical and surgical management of intracerebral hemorrhage. Reviews on Recent Clinical Trials 2007; 2(3): 174-181.
  • Zou LY, Cheung RTF, Liu SR, Li G, Huang L. Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice. Journal of Pineal Research 2006; 41(2): 150-156.
  • Lai CL, Shouval D, Lok AS, Chang TT, Cheinquer H, Goodman Z, DeHertogh D, Wilber R, Zink RC, Cross A, Colonno R, Fernandes L; BEHoLD AI463027 Study Group. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2006; 354:1011-20.
  • Poon TCW, Sung JJY, Chow SM, Ng EKW, Yu ACW, Chu ESH, Hui AMY, Leung WK. Diagnosis of gastric cancer by serum proteomic fingerprinting. Gastroenterology 2006;130:1858-64
  • Lai CL, Leung N, Teo EK, Tong M, Wong F, Hann H-W, Han S, Poynard T, Myers M, Chao G, Lloyd D, Brown NA, and the Telbivudine Phase II Investigator Group. A One-Year Trial of Telbivudine, Lamivudine, and the Combination in Patients with HBeAg-Positive Chronic Hepatitis B. Gastroenterology 2005; 129:528-536.
  • Yung S*, Tsang RC, Sun Y, Leung JK, Chan TM. Effect of human anti-DNA antibodies on proximal Rehabilitation Medicine tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis. J Am Soc Nephrol 2005; 16: 3281-3294.
  • Chan TM*, Tse KC, Tang CS, Mok MY, Li FK, Hong Kong Nephrology Study Group. Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis. J Am Soc Nephrol 2005; 16: 1076-1084.
  • Au WY, Ma SY, Chim CS, Choy C, Loong F, Lie AK, Lam CC, Leung AY, Tse E, Yau CC, Liang R, Kwong YL. Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years. Ann Oncol 2005;16(2):206-14. (Impact factor: 7.384)
  • Au WY, Pang A, Chan EC, Chu KM, Shek TW, Kwong YL. Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation. Gastroenterology 2005;129(6):2058-63. (Impact factor: 12.821)
  • Chim CS, Kwong YL, Lie AK, Ma SK, Chan CC, Wong LG, Kho BC, Lee HK, Sim JP, Chan CH, Chan JC, Yeung YM, Law M, Liang R. Long-term outcome of 231 patients with Essential Thrombocythemia: Prognostic factors for bleeding, thrombosis, myelofibrosis and leukaemia. JAMA Internal Medicine (previously Archives Int Med), 2005, 165: 2651-2658. (IF:16.538)
  • Chim CS, Wong SY, Pang A, Chu P, Lau JS, Wong KF, Kwong YL. Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia. Leukemia. 2005; 19(12): 2241-6 (IF: 11.702).
  • Leung AY, Chan MT, Yuen KY, Cheng VC, Chan KH, Wong CL, Liang R, Lie AK, Kwong YL. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2005;40(4):528-37. (Impact factor: 9.374)
  • Xu A*, Lam MCL, Chan KW, Wang Y, Hoo RCL, Zhang JL, Tso A and Lam KSL, ANGPTL4 decreases blood glucose, improve glucose tolerance, but induces hyperlipidemia and hepatic steatosis in mice, Proc. Natl. Acad. Sci. USA, 2005, 102, 6089-6091
  • Ng MW, Lau CS, Chan TM, Wong WHS, Lau YL. Polymorphisms of the toll-like receptor 9 (TLR9) gene with systemic lupus erythematosus in Chinese. Rheumatology and Clinical Immunologytology 2005; 44(11): 1456-7
  • Chen SH, Cheung RTF. Neuropeptide Y and its receptor analogs differentially modulate the immunoreactivity for neuronal or endothelial nitric oxide synthase in the rat brain following focal ischemia with reperfusion. Journal of Biomedical Science 2005; 12(2): 267-278.