Dr CHEUNG Ka Shing, Michael

Dr Michael Cheung

Clinical Assistant Professor

  • MBBS(HK) MD(HK) MPH(HK) MRCP(UK) FRCP(Edin) FHKCP FHKAM (Medicine)
Biography 傳記

Dr. Michael Ka Shing Cheung graduated from The University of Hong Kong in 2008, and received his Fellowship in Gastroenterology and Hepatology from the Hong Kong College of Physicians in 2015 and Fellowship from the Royal College of Physicians of Edinburgh in 2021. He obtained his Master of Public Health degree with distinction in 2016 and Doctor of Medicine degree (with Sir Patrick Manson Gold Medal) in 2020. He is currently the Clinical Assistant Professor in the Department of Medicine, the University of Hong Kong, Hong Kong. He is also the associate consultant in the University of Hong Kong-Shenzhen Hospital, Shenzhen, China, and honorary associate consultant in Queen Mary Hospital. Dr. Cheung’s research interests are gastrointestinal and hepatobiliary oncology (including gastric cancer, colorectal cancer, liver cancer), gut microbiota, gastrointestinal bleeding, inflammatory bowel disease, liver diseases (including hepatitis B virus, fatty liver, cirrhosis, liver cancer) and COVID-19 disease. He is experienced in various kinds of study design including randomized controlled trial, prospective cohort study, and retrospective cohort study (with particular focus on Big Data analysis). He has published over 100 international peer-reviewed journal articles since 2016, including first- or corresponding-authored articles in Gut (impact factor 23.059), Gastroenterology (impact factor 22.682), Diabetes Care (impact factor 19.112), Journal of the National Cancer Institute (impact factor 13.506), Liver Cancer (impact factor 11.740), Hypertension (impact factor 10.190), Canadian Medical Association Journal (impact factor 8.262), Alimentary Pharmacology & Therapeutics (impact factor 8.171), International Journal of Cancer (impact factor 7.396), Cancer (impact factor 6.860), Hepatology International (impact factor 6.047), Clinical and Molecular Hepatology (impact factor 6.074), Journal of Antimicrobial Chemotherapy (impact factor 5.790), Word Journal of Gastroenterology (impact factor 5.742), Clinical and Translational Gastroenterology (impact factor 4.488) and Cancer Epidemiology Biomarkers & Prevention (impact factor 4.254). He was invited to deliver 52 presentations (including oral plenary session) and lectures at international and local conferences and institutions. He currently serves as an Editorial Board member in Artificial Intelligence in Gastroenterology. He has been invited to be the reviewer of 17 international journals including Gut, Clinical Gastroenterology & Hepatology, Alimentary Pharmacology & Therapeutics, British Journal of Cancer, Journal of Gastroenterology & Hepatology, Hepatology International, Gut Pathogens, Digestive Diseases & Sciences, Cancer Medicine and PLOS ONE.

Dr. Cheung was awarded the Professor Anthony Hedley Prize in Public Health for the highest place (with distinction in both written exam and thesis) in 2016 and the Sir Patrick Manson Gold Medal for his Doctor of Medicine in 2020. He received the National Scholar Award at United European Gastroenterology Week in 2021, Travel Grant Award for abstract presentation at United European Gastroenterology Week in 2019, APDWF/JGHG Young Investigator’s Award at Asian Pacific Digestive Week in 2017, Distinguished Research Paper Award for Young Investigator (2018 with Gold Medal Award, 2019, 2020 and 2021) from the Hong Kong College of Physicians, Faculty Outstanding Research Output Award (2018, 2019, 2020 and 2021) from the University of Hong Kong, Faculty Knowledge Exchange Award from the University of Hong Kong (2018), Best Abstract Award in Clinical Medicine in Medical Research Conference from the University of Hong Kong (2018, 2019, 2020 and 2021) as well as multiple other awards for abstract presentation in local and overseas conferences.

Dr. Cheung received the Health and Medical Research Fund (HMRF) from the Research Grant Council, the Government of HKSAR to conduct a research investigating the epidemiology, risk factors and chemopreventive agents of post-colonoscopy colorectal cancer in Hong Kong. He also received another HMRF to conduct a research investigating the epidemiology and risk factors of major osteoporotic fracture after Helicobacter pylori eradication and its interaction with proton pump inhibitors on fracture risk. In addition, he received an HMRF to conduct a commissioned research to investigate the role of gut microbiota in COVID-19 vaccine immunogenicity and adverse events.

Dr. Cheung was also the awardee of the Clinical Research Fellowship Programme and received the General Research Fund (GRF) from the Research Grant Council, the Government of HKSAR to conduct a 2-year project (2021-2022) which is a randomized controlled trial on treating fatty liver disease. In addition, he received another GRF to conduct a 3-year project (2022-2024) for a randomized controlled trial on preventing fibrosis and cirrhosis progression in chronic hepatitis B patients.

 

張嘉盛醫生 2008年畢業於香港大學,並於 2015 年獲得香港內科醫學院腸胃臟科院士,並且在 2021 年獲得英國愛丁堡皇家內科醫學院院士資格。他於 2016 年以第一名的成績獲得公共衛生碩士學位Professor Anthony Hedley Prize in Public Health,並於 2020 年以第一名的成績獲得醫學博士學位Sir Patrick Manson Gold Medal。張嘉盛醫生現任香港大學醫學系臨床助理教授。同時,他也是中國香港大學深圳醫院的副顧問醫生,以及瑪麗醫院的名譽副顧問醫生。張醫生的研究興趣為胃腸及肝膽腫瘤(包括胃癌、結直腸癌、肝癌)、幽門螺桿菌感染、胃腸道出血、炎症性腸病、肝病(包括乙型肝炎病毒、脂肪肝、肝硬化、肝癌、腸道菌群和COVID-19與腸肝臟疾病的關係。他在各種研究設計方面有豐富的經驗,包括隨機對照試驗、前瞻性隊列研究和回顧性隊列研究(特別注大數據分析)。自 2016 年以來,張醫生已發表了超過 100 篇國際同行評審期刊文章,其中包括Gut(影響因子 23.059)、Gastroenterology(影響因子 22.682)、Diabetes Care(影響因子 19.112)、Journal of the National Cancer Institute(影響因子 13.506),Liver Cancer(影響因子 11.740),Hypertension(影響因子 10.190),Canadian Medical Association Journal(影響因子 8.262),Alimentary Pharmacology & Therapeutics(影響因子 8.171),International Journal of Cancer(影響因子 7.396)、Cancer(影響因子 6.860)、Hepatology International(影響因子 6.047)、Clinical and Molecular Hepatology(影響因子 6.074)、Journal of Antimicrobial Chemotherapy(影響因子 5.790)、Word Journal of Gastroenterology(影響因子 5.742)、Clinical and Translational Gastroenterology(影響因子 4.488)和Cancer Epidemiology Biomarkers & Prevention(影響因子 4.254)。除此之外, 張醫生也被受邀到國際和本地會議和機構發表演講(包括口頭全體會議)和講座共52次。他目前擔任胃腸病學人工智能的編委, 也受邀擔任 GutClinical Gastroenterology & HepatologyAlimentary Pharmacology & TherapeuticsBritish Journal of CancerJournal of Gastroenterology & HepatologyHepatology InternationalGut PathogensDigestive Diseases & SciencesCancer Medicine PLOS ONE 17 種國際期刊的審稿人。

張醫生於 2016 年獲頒 Professor Anthony Hedley 公共衛生第一獎,並於 2020 年獲頒 Sir Patrick Manson 醫學博士金獎。他還獲得了 2021 歐洲消化疾病週(United European Gastroenterology Week)國家學者獎、2019 歐洲消化疾病週(United European Gastroenterology Week口頭摘要演講旅遊經費2017 年亞太消化週Asia Pacific Digestive WeekAPDWF/JGHG 青年研究員獎第一名香港內科醫學院青年研究員傑出研究論文獎(2018 年金獎,2019 年、2020 年和 2021 年)香港大學學院傑出研究成果獎(2018201920202021年),香港大學學院知識交流獎(2018年),香港大學醫學研究會議最佳摘要獎(2018 年、2019 年、2020 年和 2021 年)以及多個其他在本地和海外會議上發表摘要的獎項。

張醫生獲得香港特別行政區政府研究資助局的健康及醫學研究基金(Health and Medical Research Fund, 簡稱HMRF),以進行一項研究調查香港結腸鏡檢查後大腸癌的流行病學、危險因素和預防藥物。他還獲得了另一個 HMRF研究基金,以開展一項研究 調查幽門螺桿菌根除後主要骨質疏鬆性骨折的流行病學和危險因素及其與質子泵抑製劑對骨折風險的相互作用。此外,他還接受了 HMRF 委託進行一項關於腸道微生物群在新冠肺炎疫苗免疫原性和不良事件中的作用研究

張醫生也是臨床研究獎學金計劃的獲得者,並獲得香港特別行政區政府研究資助局的研究基金(General Research Fund, 簡稱GRF)。這是一項為期兩年的項目(2021-2022),以隨機對照試驗探索關於脂肪肝治療。此外,他還接受了另一項 GRF研究基金,以開展一項為期 3 年的項目(2022-2024 年),預防慢性乙型肝炎患者纖維化和肝硬化進展的隨機對照試驗。


Research Profile 研究範疇
  1. Big Data analysis大數據分析
  2. Epidemiology and chemoprevention of gastrointestinal and hepatobiliary cancers胃腸道和肝膽道癌症的流行病學和藥物預防
  3. Helicobacter pylori infection幽門螺桿菌感染
  4. Gastrointestinal bleeding 胃腸道出血
  5. Inflammatory bowel disease 炎症性腸病
  6. Liver diseases including hepatitis B virus infection, fatty liver and liver cancer 乙肝病毒感染、脂肪肝、肝癌等肝病
  7. Gut microbiota 腸道菌群
  8. COVID-19 disease    2019冠狀病毒病

Selected Publications 以第一作者身份著述的國際期刊文章
  1. Cheung KS, Chan EW, Wong AYS, et al. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study. Gut 2018;67:28-35 (impact factor 23.059)
  2. Cheung KS, Chen L, Chan EW, et al. Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187897 patients. Gut 2019;68:1979-1985 (impact factor 23.059)
  3. Cheung KS, Hung IF, Chan PP, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis. Gastroenterology 2020;159:81-95 (impact factor 22.682)
  4. Cheung KS, Hung IF, Leung WK. Association between famotidine use and COVID-19 severity in Hong Kong. Gastroenterology 2021;160:1898-1899 (impact factor 22.682)
  5. Leung WK, Wong IOL, Cheung KS, et al. Effects of Helicobacter pylori Treatment on Incidence of Gastric Cancer in Older Individuals. Gastroenterology 2018;155:67-75 (impact factor 22.682)
  6. Cheung KS, Chan EW, Chen L, et al. Diabetes mellitus increases risk of gastric cancer after Helicobacter pylori eradication: a territory-wide study with propensity score analysis. Diabetes Care 2019;42:1769-1775 (impact factor 19.112)
  7. Cheung KS, Chan EW, Wong AYS, et al. Metformin use and gastric cancer risk in diabetic patients after Helicobacter pylori eradication. J Natl Cancer Inst 2019;111: 484-489 (impact factor 13.506)
  8. Cheung KS, Chan EW, Wong AYS, et al. Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study. J Natl Cancer Inst 2018;110:743-749 (impact factor 13.506)
  9. Cheung KS, Lam LK, Seto WK, et al. Use of antibiotics during immune checkpoint inhibitors associates with lower survival in hepatocellcular carcinoma. Liver Cancer 2021;10:606-614. (impact factor 11.740)
  10. Cheung KS, Chan EW, Wong AYS, et al. ACE (Angiotensin converting enzyme) inhibitors/angiotensin receptor blockers are associated with lower colorectal cancer risk: a territory-wide study with propensity score analysis. Hypertension 2020;76:968-975 (impact factor 10.190)
  11. Cheung KS, Hung IF, Leung WK. Association between angiotensin blockade and COVID-19 severity in Hong Kong. CMAJ 2020;192:E635 (impact factor 8.262)
  12. Cheung KS, Chen L, Chan EW, et al. Non-steroidal anti-inflammatory drugs but not aspirin are associated with a lower risk of post-colonoscopy colorectal cancer. Aliment Pharmacol Ther 2020;51:899-908 (impact factor 8.171)
  13. Li B*, Cheung KS*, Wong IYH, et al. Calcium channel blockers are associated with lower gastric cancer risk: a territory-wide study with propensity score analysis. Int J Cancer 2021;148:2148-2157 (impact factor 7.396) * co-first authorship
  14. Li B*, Cheung KS*, Wong IYH, et al. Non-aspirin non-steroidal anti-inflammatory drugs and gastric cancer risk after Helicobacter pylori eradication: a territory-wide study. Cancer 2021;127:1805-1815 (impact factor 6.860) * co-first authorship
  15. Cheung KS,* Lam LK,* Hui RWH, et al. Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients. Clin Mol Hepatol 2022 [in press] (impact factor 6.074) * co-first authorship
  16. Cheung KS, Lam LK, Hui RWH, et al. Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients. Clin Mol Hepatol 2022 [in press] (impact factor 6.074)
  17. Cheung KS, Mak LY, Lam LK, et al. Statins associate with better clinical outcomes in chronic hepatitis B patients with HBsAg seroclearance. Hepatol Int 2021;15:881-891 (impact factor 6.047)
  18. Cheung KS, Seto WK, Lai CL, et al. Prevention and management of hepatitis B virus reactivation in cancer patients. Hepatol Int 2016;10:407-14 (impact factor 6.047)
  19. Lyu Tao,* Cheung KS,* Ni L, et al. High prevalence and risk factors of multiple antibiotic resistance in patients who fail first-line Helicobacter pylori therapy in southern China: a municipality-wide multi-center, prospective cohort study. J Antimicrob Chemother 2020;75:3391-3394 (impact factor 5.790) * co-first authorship
  20. Cheung KS, Seto WK, Leung WK. Application of Big Data analysis in gastrointestinal research. World J Gastroenterol 2019;25:2990-3008 (impact factor 5.742)
  21. Cheung KS, Seto WK, Fung J, et al. Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis. World J Gastroenterol 2017;23:7863-7874 (impact factor 5.742)
  22. Cheung KS, Seto WK, Fung J, et al. Epidemiology and natural history of Wilson's disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016. World J Gastroenterol 2017;23:7716-7726 (impact factor 5.742)
  23. Cheung KS, Leung WK. Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management. World J Gastroenterol 2017;23:1954-1963 (impact factor 5.742)
  24. Cheung KS, Chung KL, Leung WK. Chemopreventive effect of metformin on gastric cancer development. Gut Liver 2022;16:147-156 (impact factor 4.519)
  25. Cheung KS*, Mak LY, Liu SH, Cheng HM, Seto WK, Yuen MF, Lai CL*. Entecavir vs tenofovir in hepatocellular carcinoma presentation in chronic hepatitis B infection: a systematic review and meta-analysis. Clin Transl Gastroenterol 2020;11:e00236 (impact factor 4.488) * co-corresponding authorship
  26. Cheung KS, Seto WK, Fung J, et al. Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015. Clin Transl Gastroenterol 2017;8:e116 (impact factor 4.488)
  27. Cheung KS, Seto WK, Fung J, et al. Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid. Clin Transl Gastroenterol 2017;8:e100 (impact factor 4.488)
  28. Cheung KS,* Yeung YWM,* Wong WS,* et al. Statins associate with lower risk of biliary tract cancers: a systematic review and meta-analysis. Cancer Med 2022 [in press] (impact factor 4.452) * co-corresponding authorship
  29. Cheung KS, Chan EW, Tam A et al. Association between antibiotic consumption and colon and rectal cancer development in older individuals: a territory-wide study. Cancer Med 2022 [in press] (impact factor 4.452)
  30. Cheung KS, Leung WK. Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence. Therap Adv Gastroenterol 2019;12:1756284819834511 (impact factor 4.409)
  31. Cheung KS, Chan EW, Wong AYS, et al. Statins were associated with a reduced gastric cancer risk in patients with eradicated Helicobacter pylori infection: a territory-wide propensity score matched study. Cancer Epidemiol Biomarkers Prev 2020;29:493-499 (impact factor 4.254)
  32. Cheung KS, Chen L, Seto WK, et al. Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Asia: a population-based study. J Gastroenterol Hepatol 2019;34:1545-1553 (impact factor 4.029)
  33. Cheung KS, Seto WK, Wong DK, et al. Relationship between HBsAg, HBcrAg and hepatocellular carcinoma in patients with undetectable HBV DNA under nucleos(t)ide therapy. J Viral Hepat 2017;24:654-661 (impact factor 3.728)

Awards and Prizes 獎項及殊榮
  1. National Scholar Award for United European Gastroenterology Week (2021)
  2. Faculty Outstanding Research Output Award, The University of Hong Kong (2021)
  3. Distinguished Research Paper Award for Young Investigator, Hong Kong College of Physicians (2021)
  4. Best Abstract Award in Clinical Medicine in 26th Medical Research Conference (eposter presentation), The University of Hong Kong (2021)
  5. Clinical Research Fellowship programme, Research Grant Council, The Government of HKSAR (2020/2021)
  6. Distinguished Research Paper Award for Young Investigator, Hong Kong College of Physicians (2020)
  7. Faculty Outstanding Research Output Award, The University of Hong Kong (2020)
  8. Best Abstract Award in Clinical Medicine in 25th Medical Research Conference (oral presentation), The University of Hong Kong (2020)
  9. Faculty Outstanding Research Output Award, The University of Hong Kong (2019)
  10. Travel Grant Award for oral abstract presentation, United European Gastroenterology Week (2019)
  11. Distinguished Research Paper Award for Young Investigator, Hong Kong College of Physicians (2019)
  12. Best Abstract Award in Clinical Medicine in 24th Medical Research Conference (oral presentation), The University of Hong Kong (2019)
  13. Faculty Outstanding Research Output Award, The University of Hong Kong (2018)
  14. Faculty Knowledge Exchange Award, The University of Hong Kong (2018)
  15. Sir Robert Black Trust Fund Postgraduate Scholarship (2018-2019)
  16. Distinguished Research Paper Award for Young Investigator (with Gold Medal Award), Hong Kong College of Physicians (2018)
  17. Best Poster Award, Silver Prize in 9th Asian-Pacific Topic Conference (2018)
  18. Best Abstract Award in Clinical Medicine in 23rd Medical Research Conference (oral presentation), The University of Hong Kong (2018)
  19. APDWF / JGHF Young Investigator’s Award, Asian Pacific Digestive Week (2017)
  20. Professor Anthony Hedley Prize in Public Health for highest place in Master of Public Health, The University of Hong Kong (2016)
  21. Distinction for both written exam and thesis in Master of Public Health, The University of Hong Kong (2016)
  22. Best Thesis Award for Exit Assessment Dissertations, Hong Kong College of Physicians (2015)

 


Grant Record

Research grants as principal investigator 作為首席研究員的研究資金

  1. Health and Medical Research Fund, Commissioned Research on the Novel Coronavirus Disease (COVID-19), Food and Health Bureau, The Government of HKSAR, 2021 (Commissioned Research on the Novel Coronavirus Disease (COVID-19) (Ref no: COVID1903010; HKD $1,990,000)
  2. General Research Fund, Research Grant Council, The Government of HKSAR, 2021/2022 (Ref no: 17109321; HKD $1,125,732)
  3. Health and Medical Research Fund, Food and Health Bureau, The Government of HKSAR, 2019 (Ref no: 18191921; HKD $958,936)
  4. General Research Fund & Clinical Research Fellowship Programme, Research Grant Council, The Government of HKSAR, 2020/2021 (Ref no: 17110420; HKD $2,093,053)
  5. Start-up Fund, The University of Hong Kong, 2019 (HKD $1,850,000)
  6. Health and Medical Research Fund, Food and Health Bureau, The Government of HKSAR, 2017 (Ref no: 16173001; HKD $619,520)
  7. URC Seed Funding for Basic Research for New Staff (Ref no: 201904185020; HKD $150,000)
  8. Young Investigator Research Grant, Hong Kong College of Physicians, 2021 (HKD $50,000)
  9. Young Investigator Research Grant, Hong Kong College of Physicians, 2020 (HKD $50,000)
  10. Young Investigator Research Grant, Hong Kong College of Physicians, 2018 (HKD $50,000)
  11. Young Investigator Research Grant, Hong Kong College of Physicians, 2016 (HKD $50,000)