Dr LUI Tak Wai, David

Dr David Lui

Clinical Assistant Professor

  • MBBS (Hons) (HK); MRCP (UK); FHKCP; FHKAM (Medicine)
Biography
Dr David Lui obtained his MBBS degree with Honours from the University of Hong Kong in 2012 and obtained his MRCP (UK) in 2015. He completed his specialty training in Endocrinology, Diabetes and Metabolism in 2019 and Advanced Internal Medicine in 2020 at the Queen Mary Hospital. He joined the Department of Medicine, the University of Hong Kong, as a Clinical Assistant Professor since March 2021.

Dr Lui’s research interests include diabetic bone disease, pharmacoepidemiology in type 2 diabetes and the interrelationship between COVID-19 and endocrinology. Supported by the Hong Kong Society of Endocrinology, Metabolism and Reproduction and the Training and Research Assistance Scheme of the Queen Mary Hospital Charitable Trust, he studied the role of biomarkers in the bone health in type 2 diabetes. Later he went on to study the epidemiological aspect of fractures in diabetes using a territory-wide electronic health database. Amidst the COVID-19 pandemic, he has established a cohort of COVID-19 patients for the ongoing evaluation of endocrine dysfunction associated with COVID-19. Two of his publications have been listed among the Highly Cited Articles (2019–2021) in the Journal of Clinical Endocrinology & Metabolism, and the Top Cited Articles (2020–2021) in Clinical Endocrinology, respectively. He has published over 40 peer-reviewed articles in international journals including Diabetes Care, EClinicalMedicine, and Cardiovascular Diabetology. In recognition of his research work, he has been awarded both locally and internationally, including the Distinguished Research Paper Award for Young Investigators from the Hong Kong College of Physicians (2021) and the Rising Star Award in the International Congress of Diabetes and Metabolism (2021).

Research Profile
  • COVID-19 and Endocrinology
  • Osteoporosis and Fragility Fractures
  • Diabetic Bone Disease
  • Pharmacoepidemiology in Type 2 Diabetes
  • Lipidology
  • Endocrine Complications of Cancer Treatments

Selected publications

    COVID-19 and Thyroid

    • Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL. Thyroid dysfunction in relation to immune profile, disease status and outcome in 191 patients with COVID-19. J Clin Endocrinol Metab. 2021 Jan 23;106(2):e926-e935. (JCEM Highly Cited Articles in 2019–2021)
    • Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL. Role of non-thyroidal illness syndrome in predicting adverse outcomes in COVID-19 patients predominantly of mild to moderate severity. Clin Endocrinol (Oxf). 2021 Sep;95(3):469-477. (Top Cited Article 2020–2021 in Clinical Endocrinology)
    • Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Cheung CYY, Fong CHY, Kwok STM, Law CY, To KKW, Lam CW, Tan KCB, Woo YC, Hung IFN, Lam KSL. Development of a prediction score (ThyroCOVID) for identifying abnormal thyroid function in COVID-19 patients. J Endocrinol Invest. 2022. (in press)
    • Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Pang P, Ho TY, Cheung CYY, Fong CHY, Law CY, To KKW, Lam CW, Tan KCB, Woo YC, Hung IFN, Lam KSL. The independent association of TSH and free triiodothyronine levels with lymphocyte counts among COVID-19 patients. Front Endocrinol (Lausanne). 2022 Jan 13;12:774346.
    • Lui DTW, Hung IFN, Lee CH, Lee ACH, Tam AR, Pang P, Ho TY, Cheung CYY, Fong CHY, Law CY, To KKW, Lam CW, Chow WS, Woo YC, Lam KSL, Tan KCB. The impact of interferon beta-1b therapy on thyroid function and autoimmunity among COVID-19 survivors. Front Endocrinol (Lausanne). 2021 Sep 30;12:746602.
    • Lui DTW*, Fung MMH*, Chiu KWH, Lee CH, Chow WS, Lee ACH, Tam AR, Pang P, Ho TY, Wong WW, Lee CYY, Fong CHY, Loong CHN, Law CY, To KKW, Lam CW, Tan KCB, Woo YC, Hung IFN, Lam KSL, Lang BHH. Higher SARS-CoV-2 viral loads correlated with smaller thyroid volumes on ultrasound among male COVID-19 survivors. Endocrine. 2021 Nov;74(2):205-214. (*co-first author)
    • Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Pang P, Ho TY, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL. Long COVID in patients with mild to moderate disease: do thyroid function and autoimmunity play a role? Endocr Pract. 2021 Sep;27(9):894-902.
    • Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Fong CHY, Law CY, Leung EKH, To KKW, Tan KCB, Woo YC, Lam CW, Hung IFN, Lam KSL. Insights from prospective follow-up of thyroid function and autoimmunity among COVID-19 survivors. Endocrinol Metab (Seoul). 2021 Jun;36(3):582-589.
    • Xiong X, Wong CKH, Au ICH, Lai FTT, Li X, Wan EYF, Chui CSL, Chan EWY, Cheng FWT, Lau KTK, Lee CH, Woo YC, Lui DTW*, Wong ICK*. Safety of inactivated and mRNA COVID-19 vaccination among patients treated for hypothyroidism: a population-based cohort study. Thyroid. 2022 May;32(5):505-514. (*co-corresponding author)
    • Lui DTW*, Lee CH, Cheung CYY, Mak JHC, Fong CHY, Lui BWC, Cheung VSY, Chow WS, Lee ACH, Tam AR, Pang P, Ho TY, Tan KCB, Woo YC, Hung IFN, Lam KSL. Effect of COVID-19 vaccines on thyroid function and autoimmunity and effect of thyroid autoimmunity on antibody response. J Clin Endocrinol Metab. 2022 Jun 9;dgac355. (*first and corresponding author)

     

    COVID-19 and Diabetes

    • Lui DTW, Li YK, Lee CH, Chow WS, Lee ACH, Tam AR, Pang P, Ho TY, Cheung CYY, Fong CHY, To KKW, Tan KCB, Woo YC, Hung IFN, Lam KSL. A prospective study of the impact of glycaemic status on clinical outcomes and anti-SARS-CoV-2 antibody responses among patients with predominantly non-severe COVID-19. Diabetes Res Clin Pract. 2022 Mar;185:109232.
    • Wong CKH*, Lui DTW*, Lui AYC*, Kwok ACY, Low MCH, Lau KTK, Au ICH, Xiong X, Chung MSH, Lau EHY, Cowling BJ. Metformin use in relation to clinical outcomes and hyperinflammatory syndrome among COVID-19 patients with type 2 diabetes: a propensity score analysis of a territory-wide cohort. Front Endocrinol (Lausanne). 2022 Mar 7;13:810914. (*co-first author)
    • Wong CKH*, Lui DTW*, Lui AYC*, Kwok ACY, Low MCH, Lau KTK, Au ICH, Xiong X, Chung MSH, Lau EHY, Cowling BJ. Use of DPP4i reduced odds of clinical deterioration and hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: propensity score analysis of a territory-wide cohort in Hong Kong. Diabetes Metab. 2022 Jan;48(1):101307. (*co-first author)
    • Lui DTW, Lee CH, Chow WS, Fong CHY, Woo YC, Lam KSL, Tan KCB. A territory‐wide study on the impact of COVID‐19 on diabetes‐related acute care. J Diabetes Investig. 2020 Sep;11(5):1303-1306.

     

    Pharmacoepidemiology in Type 2 Diabetes

    • Lui DTW*, Au ICH*, Tang EHM, Cheung CL, Lee CH, Woo YC, Wu T, Tan KCB, Wong CKH. Kidney outcomes associated with sodium-glucose cotransporter 2 inhibitors versus glucagon-like peptide 1 receptor agonists: a real-world population-based analysis. EClinicalMedicine. 2022 Jun 25;50:101510. (*co-first author)
    • Wong CKH, Lau KTK, Tang EHM, Lee CH, Lee CYY, Woo YC, Tan KCB, Lui DTW*. Cardiovascular benefits of SGLT2 inhibitors in type 2 diabetes, interaction with metformin and role of erythrocytosis: a self-controlled case series study. Cardiovasc Diabetol. 2022 Jun 3;21(1):92. (*corresponding author)

     

    Osteoporosis and Fragility Fractures

    • Lui DTW, Lee CH, Chan YH, Chow WS, Fong CHY, Siu DCW, Tse HF, Woo YC, Lam KSL. HbA1c variability, in addition to mean HbA1c, predicts incident hip fractures in Chinese people with type 2 diabetes. Osteoporos Int. 2020 Oct;31(10):1955-1964.
    • Lui DTW, Lee CH, Chau VWK, Fong CHY, Yeung KMY, Lam JKY, Lee ACH, Chow WS, Tan KCB, Woo YC, Lam KSL. Potential role of fibroblast growth factor 21 in the deterioration of bone quality in impaired glucose tolerance. J Endocrinol Invest. 2021 Mar;44(3):523-530.
    • Lui DTW*, Fung MMH*, Lee CH, Fong CHY, Woo YC, Lang BHH. A territory-wide assessment of the incidence of persistent hypoparathyroidism following elective thyroid surgery and its impact on new fracture risk over time. Surgery. 2021 Nov;170(5):1369-1375. (*co-first author)
    • Lui DTW*, Fung MMH*, Lee CH, Fong CHY, Loong CHN, Lam AHK, Tan KCB, Woo YC, Lang BHH. The potential role of preoperative trabecular bone score in predicting changes in bone mineral density after parathyroidectomy. World J Surg. 2021 Feb;45(2):522-530. (*co-first author)

     

    Lipidology

    • Lui DTW, Cheung CL, Lee ACH, Wong Y, Shiu SWM, Tan KCB. Carbamylated HDL and mortality outcomes in type 2 diabetes. Diabetes Care. 2021 Mar;44(3):804-809.
    • Lui DTW, Lee ACH, Tan KCB. Management of familial hypercholesterolemia: current status and future perspectives. Journal of the Endocrine Society. 2020 Aug 21;5(1):bvaa122. (Endocrine Society Thematic Issue on Lipids and Adipocytes 2021)

     

    Immunotherapy-related endocrinopathies

    • Lui DTW, Lee CH, Tang V, Fong CHY, Lee ACH, Chiu JWY, Leung RCY, Kwok GGW, Li BCW, Cheung TT, Woo YC, Lam KSL, Yau T. Thyroid immune-related adverse events in cancer patients treated with anti-PD1/anti-CTLA4 immune-checkpoint inhibitor combination: clinical course and outcomes. Endocr Pract. 2021 Sep;27(9):886-893.

Awards
  • Endocrine Society Outstanding Abstract Award, ENDO 2022 (2022)
  • Best Abstract in Clinical Medicine (Poster), 27th Medical Research Conference (2022)
  • Best Poster Exhibition Award in 9th Seoul International Congress of Endocrinology and Metabolism (2021)
  • Rising Star Award, International Congress of Diabetes and Metabolism (2021)
  • Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians (2021)
  • Best Abstract in Clinical Medicine (Oral), 26th Medical Research Conference (2021)
  • International Non-Fellow Physician AACE Travel Grant Award, AACE 29th Annual Scientific & Clinical Congress (2020)
  • Poster Award, Asia Islet Biology & Incretin Symposium (2019)
  • Best Abstract in Clinical Medicine (Poster), 24th Medical Research Conference (2019)

Grant Record
  • Health and Medical Research Fund, Food and Health Bureau, The Government of the HKSAR, 2020 (Ref: 19200931; HKD $1,478,393)