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Dr HO Wing Lok, Philip

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Scientific Officer

email hwl2002@hku.hk
Biography
Dr. Philip Wing-Lok Ho obtained his PhD degree in the Department of Medicine, the University of Hong Kong in 2004 and went on to study the functional role of mitochondrial uncoupling protein homologues in the neuronal system. He is currently a Research Assistant Professor in the University of Hong Kong. His research focus includes exploring 1) the neuroprotective and functional properties of neuronal uncoupling proteins (UCPs); and 2) the pathophysiology of Parkinson's disease associated with mitochondrial dysfunction and oxidative stress using in vitro and in vivo experimental models. Furthermore, Dr. Ho is one of the inventors in designing novel protein tag and production of its corresponding antibodies in his current development of a novel kit in assessing environmental estrogenic compounds. This invention will be useful in developing novel assays of estrogenic endocrine disruptors, e.g. xenoestrogenic compounds and plasticizers. The application of the assay is filed in US, Europe, and China under patent protection.

Research Profile
  • Principal Researcher of The Research Centre Of Heart, Brain, Hormone & Healthy Aging, HKU
  • Principal Investigator of HKU SIRI

Grant Record
  1. Co-Investigator (Co-I): HK$0.92M from Health and Medical Research Fund (HMRF), Food and Health Bureau, Hong Kong. Pathophysiological Study of Parkinson's Disease Associated with Leucine-rich Repeat Kinase 2 (LRRK2) Gene Mutation. 2013 (Application no. 01120976)
  2. Co-Investigator (Co-I): HK$1.1M from Competitive Earmarked Research Grants (CERG), Research Grant Council (RGC), Hong Kong. Human Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform for Friedreich Ataxia. Sept. 2012. (Project code: HKU 776912M).
  3. Co-Investigator (Co-I): HK$0.9M from Competitive Earmarked Research Grants (CERG), Research Grant Council (RGC), Hong Kong. The Role of Neuronal Uncoupling Proteins (UCPs) in Mitochondrial Dysfunction in Parkinson's Disease (PD). 2007 (Project code: HKU 766107M).

Patents
Human Catechol-O-Methyltransferase (COMT) Assay – US Patent Application No: 2010/0081,147; PCT Patent Application No: PCT/CN2009/001011 filed on 8 Sept. 2009; International Publication No: WO2010/034183 (1 Apr. 2010)