Yap DY, Kwan LPY, Ma MKM, Mok MMY, Chan GCW, Chan TM. Pre-emptive immunosuppressive treatment for asymptomatic serological reactivation may reduce renal flares in patients with lupus nephritis. Nephrol Dial Transplant, in press.
Li C, Yap DY, Chan G, Wen YB, Li H, Tang C, Li XM, Li WW, Chan TM. Clinical outcomes and clinic-pathological correlations in lupus nephritis with kidney biopsy showing thrombotic microangiopathy. J Rheumatol, in press.
Yap DY, Tam CH, Yung S, Wong S, Tang CS, Mok TMY, Yuen CKY, Ma MKM, Lau CS, Chan TM. Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis. Nephrol Dial Transplant, in press.
Yap DY, Tang C, Chan GCW, Kwan LPY, Ma MKM, Mok MMY, Chan TM. Long-term data on sirolimus treatment in patients with lupus nephritis. J Rheumatol 2018; 45: 1663-1670.
Yap DY, Tang C, Ma MKM, Mok MMY, Chan GCW, Kwan LPY, Chan TM. Long-term Data on Disease Flares in Patients with Proliferative Lupus Nephritis in Recent Years. J Rheumatol 2017; 44: 1375-1383.
Yap DY, Chan TM. Lupus Nephritis in Asia: Clinical Features and Management. Kidney Dis (Basel) 2015; 1: 100-109.
Chan TM. Treatment of severe lupus nephritis: the new horizon. Nat Rev Nephrol 2015; 11: 46-61.
Yap DYH, Ma MKM, Mok MMY, Kwan LPY, Chan GCW, Chan TM. Long-term data on tacrolimus treatment in lupus nephritis. Rheumatology (Oxford) 2014; 53: 2232-2237.
Yap DYH, Yung S, Ma MKM, Mok MMY, Kwan LPY, Chan GCW, Chan TM. Serum immunoglobulin G level in patients with lupus nephritis and the effect of treatment with corticosteroids and mycophenolate mofetil. Lupus 2014; 23: 678-683.
Mok CC, Yap DY, Navarra SV, Liu ZH, Zhao MH, Lu L, Takeuchi T, Avihingsanon Y, Yu XQ, Lapid EA, Lugue-Lizardo LR, Sumethkul V, Shen N, Chen SL, Chan TM. Asian Lupus Nephritis Network (ALNN). Overview of Lupus Nephritis Management Guidelines and Perspective from Asia. Co-published in Int J Rheum Dis 2013; 16; 625-636 & Nephrology (Carlton) 2014; 19: 11-20.
Yap DYH, Ma MKM, Mok MMY, Tang CSO, Chan TM. Long-term data on corticosteroids and mycophenolate mofetil treatment in lupus nephritis. Rheumatology (Oxford) 2013; 52: 480-486.
Yap DYH, Ma MKM, Tang CSO, Chan TM. Proliferation signal inhibitors in the treatment of lupus nephritis: preliminary experience. Nephrology (Carlton) 2012; 17: 676-680.
Chan TM. Recent progress in the treatment of lupus nephritis. Am J Med 2012; 125: 642-648.
Yap DYH, Tang CSO, Ma MKM, Lam MF, Chan TM. Survival analysis and causes of mortality in patients with lupus nephritis. Nephrol Dial Transplant 2012; 27: 3248-3254.
Yap DYH, Yu X, Chen XM, Lu F, Chen N, Li XW, Tang CS, Chan TM. Pilot 24 month study to compare mycophenolate mofetil and tacrolimus in the treatment of membranous lupus nephritis with nephrotic syndrome. Nephrology (Carlton) 2012; 17: 352-357.
Chan TM, Tse KC, Tang CS, Mok MMY, Li FK. Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis. J Am Soc Nephrol 2005; 16: 1076-1084.
Chan TM, Tse KC, Tang CSO, Lai KN, Li FK. Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine. Lupus 2005; 14: 265-272.
Chan TM, Li FK, Tang CSO, Wong RW, Fang GX, Ji YL, Lau CS, Wong AKM, Tong MKL, Chan KW, Lai KN, for the Hong Kong Guangzhou Nephrology Study Group. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. N Engl J Med 2000; 343: 1156-1162.
B. Basic / Translational Research
Zhang C, Chan CC, Cheung KF, Chau MKM, Ma MK, Chan KW, Yung S, Chan TM. Effect of mycophenolate and rapamycin on renal fibrosis in lupus nephritis. Clin Sci 2019; 133: 1721-1744.
Yung S, Ng CY, Au KY, Cheung KF, Zhang Q, Zhang C, Yap DY, Chau MK, Chan TM. Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation. Clin Sci 2017; 131: 49-67.
Cheung KF, Yung S, Chau MK, Yap DY, Chan KW, Lee CK, Tang CS, Chan TM. Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations. Clin Sci 2017; 131: 653-671.
Yung S, Chan TM. Molecular and immunological basis of tubulo-interstitial injury in lupus nephritis: a comprehensive review. Clin Rev Allergy Immunol 2017; 52: 149-163.
Yap DYH, Yung S, Zhang Q, Tang SC, Chan TM. Serum level of proximal renal tubular epithelial cell-binding immunoglobulin G in patients with lupus nephritis. Lupus 2016; 25: 46-53.
Yung S, Ng CY, Ho SK, Cheung KF, Chan KW, Zhang Q, Chau MK, Chan TM. Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-beta1 and collagen synthesis. J Autoimmun 2015; 58: 111-122.
Yung S, Zhang Q, Chau MKM, Chan TM. Distinct effects of mycophenolate mofetil and cyclophosphamide on renal fibrosis in NZBWF1/J mice. Autoimmunity 2015; 48:471-487.
Yung S, Cheung KF, Zhang Q, Chan TM. Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. J Am Soc Nephrol 2010; 21: 1912-1927.
Yung S, Zhang Q, Zhang CZ, Chan KW, Lui SL, Chan TM. Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid. Arthritis Rheum 2009; 60: 2071-2082.
Lui SL, Yung S, Tsang R, Zhang F, Chan KW, Tam S, Chan TM. Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice. Lupus 2008; 4: 305-313.
Lui SL, Tsang R, Chan KW, Zhang F, Tam S, Yung S, Chan TM. Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice. Nephrol Dial Transplant 2008; 23: 2768-2776.
Yung S, Tsang RC, Leung JK, Chan TM. Increased mesangial cell hyaluronan expression in lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta. Kidney Int 2006; 69: 272-280.
Yung S, Tsang RC, Sun Y, Leung JK, Chan TM. Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis. J Am Soc Nephrol 2005; 16: 3281-3294.
Chan TM, Leung JK, Ho SK, Yung S. Mesangial cell-binding anti-DNA antibodies in patients with systemic lupus erythematosus. J Am Soc Nephrol 2002; 13: 1219-1229.
A. Clinical Research
Tang SC, Sharma K. Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease (Ch. 30, Section V). In Comprehensive Clinical Nephrology (6th Ed), Edited by John Feehally, Jurgen Floege, Richard Johnson and Marcello Tonelli, Elsevier, Philadelphia, USA, pp 357-375, 2019.
Cheung CY, Ma MK, Chak WL, Tang SC. Cancer risk in patients with diabetic nephropathy: a retrospective cohort study. Medicine (Baltimore) 2017; 96: e8077.
Jiao F, Wong CKH, Tang SC, Fung CSC, Tan KC, McGhee S, Gangwani R, Lam CLK. Annual direct medical costs associated with diabetes-related complications in the event year and in subsequent years in Hong Kong. Diabet Med 2017; 34: 1276-1283.
Jiao F, Wong CK, Gangwani R, Tan KC, Tang SC, Lam CL. Health-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications. Health Qual Life Outcomes 2017; 15: 125.
Chan KW, Ip TP, Kwong AS, Lui SL, Chan GC, Cowling BJ, Yiu WH, Wong DW, Liu Y, Feng Y, Tan KC, Chan LY, Leung JC, Lai KN, Tang SC. Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial. BMJ Open 2016; 6:e010741
Tang SC, Leung VT, Chan LY, Wong SH, Chu DW, Leung JC, Lai KN, Ma L, Elbein SC, Bowden DW, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI. The acetyl-coenzyme A carboxylase beta gene (ACACB) is associated with nephropathy in Chinese patients with type 2 diabetes. Nephrol Dial Transplant 2010; 25: 3931-3934.
B. Basic / Translational Research
Yiu WH, Li RX, Wong DWL, Wu HJ, Chan KW, Chan LYY, Leung JCK, Lai KN, Sacks SH, Zhou W, Tang SCW. Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy. Nephrol Dial Transplant 2018; 33:1323-1332.
Yiu WH, Wong DW, Wu HJ, Li RX, Yam I, Chan LY, Leung JC, Lan HY, Lai KN, Tang SC. Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress. Kidney Int 2016; 89: 386-398.
Li RX, Yiu WH, Wu HJ, Wong DW, Chan LY, Lin M, Leung JC, Lai KN, Tang SC. BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy. Clin Sci 2015; 128: 269-280.
Yung S, Chau MKM, Zhang Q, Zhang CZ, Chan TM. Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy. PLoS One 2013; 8: e54501.
Lin M, Yiu WH, Li RX, Wu HJ, Wong DL, Chan LY, Leung JC, Lai KN, Tang SC. The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy. Kidney Int 2013; 83: 887-900.
Lin M, Au WS, Chan AW, Yiu WH, Chan LY, Leung JC, Chan KW, Lai KN, Tang SC. Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. J Am Soc Nephrol 2012; 23: 86-102.
Leung JC, Chan LY, Lam MF, Tang SC, Chow CW, Lim AI, Lai KN. The role of leptin and its short-form receptor in inflammation in db/db mice infused with peritoneal dialysis fluid. Nephrol Dial Transplant 2012; 27: 3119-3129,
Tang SC, Chan LY, Leung JC, Cheng AS, Lan HY, Lai KN. Additive renoprotective effects of B2-kinin receptor blocker and PPAR-γ agonist in uninephrectomized db/db mice. Lab Invest 2011; 91: 1351-1362.
Tang SC, Leung JC, Chan LY, Lan HY, Lai KN. Renoprotection by rosiglitazone in accelerated type 2 diabetic nephropathy: role of STAT1 inhibition and nephrin restoration. Am J Nephrol 2010; 32: 145-155.
Tang SC, Chan LY, Leung JC, Cheng AS, Lan HY, Lai KN. Bradykinin and high glucose promote diabetic renal tubular inflammation. Nephrol Dial Transplant 2010; 25: 698-710.
Tang SC, Leung JC, Chan LY, Tsang AW, Lai KN. Activation of tubular epithelial cells in diabetic nephropathy and the role of the PPAR-ϒ agonist. J Am Soc Nephrol 2006; 17: 1633-1643.
Yung S, Lee CY, Zhang Q, Lau SK, Tsang RC, Chan TM. Elevated glucose induction of thrombospondin-1 upregulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-beta1 dependent and TGF-beta1 independent pathways. Nephrol Dial Transplant 2006; 21: 1504-1513.
A. Clinical Research
Mok MMY, Liu CK, Lam MF, Kwan LP, Chan GC, Ma MKM, Yap DY, Chiu F, Choy CB, Tang SC, Chan TM. A longitudinal study on the prevalence and risk factors for depression and anxiety, quality of life, and clinical outcomes in incident peritoneal dialysis patients. Perit Dial Int 2019; 39: 74-82.
Chan GC, Mok MM, Hung DL, Chan JF, Kwan LP, Ma MK, Yap DY, Tang SC. Mycobacterium chlorophenolicum: an uncommon cause of peritonitis in a peritoneal dialysis patient. Nephrology (Carlton) 2017; 22: 498-499.
Lui SL, Zhu D, Cheng SW, Ng F, Hui PC, Yip T, Lo WK. Effect of Astragalus membranaceus based Chinese medicine formulae on residual renal function in patients on peritoneal dialysis. Perit Dial Int 2015; 35: 595-597.
Wang AY, Brimble KS, Brunier G, et al. ISPD cardiovascular and metabolic guidelines in adult peritoneal dialysis patients part II - Management of various cardiovascular complications. Perit Dial Int 2015; 35: 388-396.
Wang AY, Brimble KS, Brunier G, et al. ISPD cardiovascular and metabolic guidelines in adult peritoneal dialysis patients part I - Assessment and management of various cardiovascular risk factors. Perit Dial Int 2015; 35: 379-387.
Verukonda RK, Zhu TY, Yip T, Lui SL, Lo WK. Body Mass Index and Mortality Risk in Asian Peritoneal Dialysis Patients In Hong Kong - Impact of Diabetes and Cardiovascular Disease Status. Perit Dial Int 2014; 34: 390-398.
Choy BY, Lam MF, Yip T, Tang HL, Wong PN, Chow CC, Yap DY, Chan TM. Dosing regimen and tolerability of methoxy polyethylene glycol-epoetin beta in Chinese dialysis patients. Nephrology (Carlton) 2013; 18: 533-538.
Zuo ML, Yue WS, Yip T, Ng F, Lam KF, Yiu KH, Lui SL, Tse HF, Siu CW, Lo WK. Prevalence of and associations with reduced exercise capacity in peritoneal dialysis patients. Am J Kidney Dis 2013; 62: 939-946
Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY, Yang CW. Chronic Kidney Disease: Global Dimension and Perspectives. The Lancet 2013; 382: 260-272.
Yip T, Lui SL, Lo WK. The choice of peritoneal dialysis catheter implantation technique by nephrologists. Int J Nephrol 2013, 2013: 940106.
Ikizler AT, Cano NJ, Franch HA, Fouque D, Himmelfarb J, Kalantar-Zadeh K, Kuhlmann M, Stenvinkel P, TerWee P, Teta D, Wang AY, Wanner C. Prevention and Treatment of Protein Energy Wasting in Chronic Kidney Disease Patients: A joint statement from the International Society of Renal Nutrition and Metabolism. Kidney Int 2013; 84: 1096-1107.
Lui SL, Yung S, Yim A, Wong KM, Tong KL, Wong KS, Li CS, Au TC, Lo WK Ho YW, Ng F, Tang C, Chan TM. A Combination of Biocompatible Peritoneal Dialysis Solutions and Residual Renal Function, Peritoneal Transport and Inflammation Markers: A Randomized Clinical Trial. Am J Kidney Dis 2012; 60: 966-975.
Yip T, Tse KC, Ng F, Hung I, Lam MF, Tang S, Lui SL, Lai KN, Chan TM, Lo WK. Clinical course and outcomes of single-organism Enterococcus peritonitis in peritoneal dialysis patients. Perit Dial Int 2011; 31: 522-528.
Yip T, Lui SL, Tse KC, Xu H, Ng FS, Cheng SW, Chan TM, Lai KN, Lo WK. A prospective randomized study comparing tenckhoff catheters inserted using the triple incision method with standard swan neck catheters. Perit Dial Int 2010; 30: 56-62.
Tang SC, Lam B, Leung WS, Chu CM, Ho YW, Ip MS, Lai KN. Sleep apnea as a novel risk predictor for cardiovascular morbidity and death in peritoneal dialysis patients. Kidney Int 2010; 77: 1031-1038.
Tang SC, Lam B, Lai AS, Pang CB, Tso WK, Khong PL, Ip MS, Lai KN. Improvement in sleep apnea during nocturnal peritoneal dialysis is associated with reduced airway congestion and better uremic clearance. Clin J Am Soc Nephrol 2009; 4: 410-418.
Yip T, Tse KC, Lam MF, Cheng SW, Lui SL, Tang S, Ng M, Chan TM, Lai KN, Lo WK. Risks and outcomes of peritonitis after flexible colonoscopy in CAPD patients. Perit Dial Int 2007; 27: 560-564.
Yip T, Tse KC, Lam MF, Tang S, Li FK, Choy BY, Lui SL, Chan TM, Lai KN, Lo WK. Risk factors and outcomes of extended-spectrum beta-lactamase-producing E. coli peritonitis in CAPD patients. Perit Dial Int 2006; 26: 191-197.
Lo WK, Bargman J, Burkart J, Krediet RT, Pollock C, Kawanishi H, Blake P. The International Society for Peritoneal Dialysis (ISPD) guideline on targets for solute and fluid removal in adult patients on chronic peritoneal dialysis. Perit Dial Int 2006; 26:520-522.
Lo WK, SL Lui, TM Chan, K Li, MF Lam, KC Tse, SCW Tang, CBY Choy, KN Lai. Minimal and Optimal Peritoneal Kt/V targets - Results of an anuric peritoneal dialysis patients survival analysis. Kidney Int 2005; 67: 2032 - 2038.
Wang AY, Ho SS, Wang M, Liu EK, Ho S, Li PK, Lui SF, Sanderson JE. Is cardiac valvular calcification a marker of atherosclerosis and arterial calcification in end-stage renal disease patients? Arch Intern Med 2005; 165: 327-332.
Lo WK, Lui SL, Li FK, Choy BY, Lam MF, Tse KC, Yip TPS, Ng FSK, SC Lam, WL Chu, SW Cheng. A Prospective Randomized Study on Three Different Peritoneal Dialysis Catheters. Perit Dial Int 2003; 23:S127-S131.
Li FK, Chan LY, Woo JC, Ho SK, Lo WK, Lai KN, Chan TM. A 3-year, prospective, randomized, controlled study on amino acid dialysate in patients on CAPD. Am J Kidney Dis 2003; 42: 173-183.
B. Basic / Translational Research
Chu JYS, Chau MKM, Chan CCY, Tai ACP, Cheung KF, Chan TM, Yung S. miR-200c Prevents TGF-beta1-Induced Epithelial-to-Mesenchymal Transition and Fibrogenesis in Mesothelial Cells by Targeting ZEB2 and Notch1. Mol Ther Nucleic Acids 2019; 17: 78-91.
Yung S, Lui SL, Ng CKF, Yim A, Ma MKM, Lo KY, Chow CC, Chu KH, Chak WL, Lam MF, Yung CY, Yip TP, Wong S, Tang CSO, Ng FS, Chan TM. Impact of a low-glucose peritoneal dialysis regimen on fibrosis and inflammation markers. Perit Dial Int 2015; 35: 147-158.
Leung JC, Chan LY, Lam MF, Tang SC, Chow CW, Lim AI, and Lai KN. The role of leptin and its short-form receptor in inflammation in db/db mice infused with peritoneal dialysis fluid. Nephrol Dial Transplant 2012; 27: 3119-3129.
Lai KN, Leung JC. Peritoneal adipocytes and their role in inflammation during peritoneal dialysis. Mediators Inflamm 2010; 495416.
Leung JC, Lam FM, Tang SC, Chan YY, Tam KY, Yip TP, Lai KN. Roles of neutrophil gelatinase-associated lipocalin in continuous ambulatory peritoneal dialysis-related peritonitis. J Clin Immunol 2009; 29: 365-378.
Guo H, Leung JC, Lam MF, Chan LY, Tsang AW, Lan HY, Lai KN. Smad7 transgene attenuates peritoneal fibrosis in uremic rats on peritoneal dialysis. J Am Soc Nephrol 2007; 10: 2689-2703.
Leung JC, Chan LY, Tang SC, Chu KM, and Lai KN. Leptin induces TGF-beta synthesis through functional leptin receptor expressed by human peritoneal mesothelial cell. Kidney Int 2006; 69: 2078-2086.
Yung S, Chen XR, Tsang RC, Zhang Q, Chan TM. Reduction of perlecan synthesis and induction of TGF-beta1 in human peritoneal mesothelial cells due to high dialysate glucose concentration: implication in peritoneal dialysis. J Am Soc Nephrol 2004; 15: 1178-1188.
Chan TM, Leung JK, Tsang RC, Liu ZH, Li LS, Yung S. Emodin ameliorates glucose-induced matrix synthesis in human peritoneal mesothelial cells. Kidney Int 2003; 64: 519-533.
A. Clinical Research
Floege J, Barbour SJ, Cattran DC, Hogan JJ, Nachman PH, Tang SCW, Wetzels JFM, Cheung M, Wheeler DC, Winkelmayer WC, Rovin BH; Conference Participants. Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 2019; 95:268-280.
Barratt J, Tang SCW. Treatment of IgA Nephropathy: Evolution Over Half a Century. Semin Nephrol 2018; 38: 531-540.
Leung JCK, Lai KN, Tang SCW. Role of mesangial-podocytic-tubular cross-talk in IgA nephropathy. Semin Nephrol 2018; 38: 485-495.
Tang SCW. An Overview of IgA Nephropathy: 50 Years On. Semin Nephrol 2018; 38: 433-434
Lai KN, Tang SC, Schena FP, Novak J, Tomino Y, Fogo AB, Glassock RJ. IgA nephropathy. Nat Rev Dis Primers 2016; 2: 16001.
Tang SC, Lin M, Tam, S, Au WS, Ma KM, Yap DY, Ho YW, Lai KN. Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study. Nephrol Dial Transplant 2012; 27: 613-618.
Tang SC, Tang AW, Wong SH, Ho YW, and Lai KN. Long-term study of mycophenolate mofetil in IgA nephropathy. Kidney Int 2010; 77: 543-549.
B. Basic / Translational Research
Leung JC, Chan LY, Saleem MA, Mathieson PW, Tang SC, Lai KN. Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells. Apoptosis 2015; 20:907-920.
Lai KN. Pathogenesis of IgA nephropathy. Nat Rev Nephrol 2012; 8: 275-283.
Leung JC, Chan LY, Tang SC, Lam MF, Chow CW, Lim AI, Lai KN. Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone. J Transl Med 2011; 9: 169.
Tam KY, Leung JC, Chan LY, Lam MF, Tang SC, Lai KN. In vitro enhanced chemotaxis of CD25+ mononuclear cells in patients with familial IgAN through glomerulotubular interaction. Am J Physiol Renal Physiol 2010; 299: F359-F368,
Tam KY, Leung JC, Chan LY, Lam MF, Tang SC, Lai KN. Macromolecular IgA1 taken from patients with familial IgA Nephropathy or their asymptomatic relatives have higher reactivity to mesangial cells in vitro. Kidney Int 2009; 75:1330-1339.
Chan WL, Leung JC, Chan LY, Tam KY, Tang SC, Lai KN. BMP-7 protects mesangial cells from injury by polymeric IgA. Kidney Int 2008; 74:1026-1039.
Lai KN, Leung JC, Chan LY, Saleem MA, Mathieson PW, Lai FM, Tang SC. Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy. Am J Physiol Renal Physiol 2008; 294: F945-955.
Chan LY, Leung JC, Tang SC, Choy CB, Lai KN. Tubular Expression of Angiotensin II Receptors and Their Regulation in IgA Nephropathy. J Am Soc Nephrol 2005; 16: 2306-2317.
TUBULO-INTERSTITIAL INFLAMMATION & FIBROSIS
Wong DWL, Yiu WH, Chan KW, Li Y, Li B, Lok SWY, Taketo MM, Igarashi P, Chan LYY, Leung JCK, Lai KN, Tang SCW. Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria. Kidney Int 2018; 93: 1367-1383.
Wong DW, Yiu WH, Wu HJ, Li RX, Liu Y, Chan KW, Leung JC, Chan LY, Lai KN, Tang SC. Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy. Cell Death Dis 2016; 7: e2155.
Yiu WH, Lin M, Tang SC. Toll-Like receptor activation: from renal inflammation to fibrosis. Kidney Int Suppl 2014; 4: 20-25.
Lim AI, Chan LY, Tang SC, Yiu WH, Li R, Lai KN, Leung JC. BMP-7 represses albumin-induced chemokine synthesis in kidney tubular epithelial cells through destabilization of NF-κB-inducing kinase. Immunol Cell Biol 2014; 92: 427-35.
Lim AI, Tang SC, Lai KN, Leung JC. Kidney injury molecule-1: more than just an injury marker of tubular epithelial cells? J Cell Physiol 2013; 228: 917-24.
Lim AI, Chan LY, Lai KN, Tang SC, Chow CW, Lam MF, and Leung JC. Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells. Int J Biochem Cell Biol 2012; 44: 1040-1050.
Lai KN, Leung JC, Chan LY, Tang S. Interaction between proximal tubular epithelial cells and infiltrating monocytes/T cells in the proteinuric state. Kidney Int 2007; 71: 526-538.
Tang S, Leung JC, Abe K, Chan KW, Chan LY, Chan TM, Lai KN: Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest 2003; 111: 515-527.
Yap DY, Tang C, Fung JYY, Seto WK, Ma MKM, Choy BY, Chan TM. Long-term data on entecavir treatment for treatment-naïve or lamivudine-resistant chronic hepatitis B infection in kidney transplant recipients. Transplant Infect Dis, in press.
Lin M, Chan GCW, Chan KW, Lai KN, Tang SCW. Vascular age is associated with the risk of dialysis or death in chronic kidney disease. Nephrology (Carlton), in press.
Cheung CY, Tang SCW. An update on cancer after kidney transplantation. Nephrol Dial Transplant 2019; 34: 914-920.
Ma MK, Law HK, Tse KS, Chan KW, Chan GC, Yap DY, Mok MM, Kwan LP, Tang SC, Choy BY, Chan TM. Non-invasive assessment of kidney allograft fibrosis with shear wave elastography: A radiological-pathological correlation analysis. Int J Urol 2018; 25: 450-455.
Cheung CY, Ma MK, Chak WL, Chau KF, Tang SC. Posttransplant lymphoproliferative disorders in kidney transplant recipients: a retrospective cohort analysis over two decades in Hong Kong. Oncotarget 2017; 8: 96903-96912.
Cheung CY, Ma MK, Chak WL, Chau KF, Tang SC. Conversion to mammalian target of rapamycin inhibitors in kidney transplant recipients with de novo cancers. Oncotarget 2017; 8: 44833-44841.
Ma MK, Leung AY, Lo KY, Lio WI, Chan HW, Wong I, Hau AK, Tam CH, Wong AK, Kuok UI, Chau KF, Fung SK, Kwan TH, Wong SS, Tang SC. Screening algorithm for BK virus-associated nephropathy using sequential testing of urinary cytology: a probabilistic model analysis. Am J Nephrol 2016; 42: 410-417.
Yap DY, Chan TM. Use of telbivudine in kidney transplant recipients with chronic hepatitis B virus infection: A preliminary experience. Nephrology 2016; 21: 438-441.
Yap DYH, Yung S, Tang CS, Seto WK, Ma MK, Mok MM, Kwan LP, Chan GC, Choy BY, Yuen MF, Chan TM. Entecavir treatment in kidney transplant recipients infected with hepatitis B. Clin Transplant 2014; 28: 1010-1015.
Ma MKM, Lim WH, Turner RM, Chapman JR, Craig JC, Wong G. The risk of cancer in recipients of living-donor, standard and expanded criteria deceased donor kidney transplants: a registry analysis. Transplantation 2014; 98: 1286-1293.
Ma MKM, Zuo ML, Yap DYH, Mok MM, Kwan LPY, Chan GCW, Siu DCW, Chan TM. Chronotropic incompetence, echocardiographic abnormalities and exercise intolerance in renal transplant recipients. J Nephrol 2014; 27: 451-456.
Yap DYH, Tang CSO, Yung S, Choy BY, Yuen MF, Chan TM. Long-term outcome of renal transplant recipients with chronic hepatitis B infection-impact of antiviral treatments. Transplantation 2010; 90: 325-330.
Choy BY, Chan TM, Lai KN. Recurrent glomerulonephritis after kidney transplantation. Am J Transplant 2006; 6: 2535-2542.
Chan TM, Tse KC, Tang CSO, Lai KN, Ho SKN. A prospective study on lamivudine-resistant hepatitis B in renal allograft recipients. Am J Transplantation 2004; 4: 1103-1109.
Choy BY , Chan TM, Lo SK, Lo WK, Lai KN. Renal transplantation in patients with primary immunoglobulin A nephropathy. Nephrol Dial Transplant 2003; 18: 2399-2404.
Choy BY, Peiris JSM, Chan TM, Lo SKF, Lui SL, Lai KN. Immunogenicity of intradermal hepatitis B vaccination in renal transplant recipients not responding to conventional intramuscular vaccination. Am J Transplant 2002; 2: 965-969.
Chan TM, Fang GX, Tang CSO, Cheng IKP, Lai KN, Ho SKN. Pre-emptive lamivudine therapy based on HBV DNA level in HBsAg-positive kidney allograft recipients. Hepatology 2002; 36: 1246-1252.
Chan TM, Wu PC, Lau JYN, Lai CL, Lok ASF, Cheng IKP. Clinico-pathologic features of hepatitis C virus (HCV) infection in renal allograft recipients. Transplantation 1994; 58: 996-1000.
Chan TM, Lok ASF, Cheng IKP, Chan RT. Hepatitis C virus (HCV) infection in hemodialysis patients: a longitudinal study comparing HCV RNA and anti-HCV assays. Hepatology 1993, 17: 5-8.
Chan TM, Lok ASF, Cheng IKP, Chan RT. A prospective study of hepatitis C virus infection among renal transplant recipients. Gastroenterology 1993; 104: 862-8.
Chan TM, Lok ASF, Cheng IKP. Hepatitis C in renal transplant recipients. Transplantation 1991; 52: 810-813.
Chan TM. Chapters on ‘Hepatitis B in Patients on Dialysis’, ‘Hepatitis B after Kidney Transplantation’, and ‘Hepatitis B Associated Renal Diseases’ in UpToDate.
Li B, Leung JCK, Chan LYY, Yiu WH, Li Y, Lok SWY, Liu WH, Chan KW, Tse HF, Lai KN, Tang SCW. Amelioration of endoplasmic reticulum stress by mesenchymal stem cells via hepatocyte growth factor/c-Met signaling in obesity-associated kidney injury. Stem Cells Transl Med 2019, doi: 10.1002/sctm.18-0265.
Wu HJ, Yiu WH, Wong DWL, Li RX, Chan LYY, Leung JCK, Zhang Y, Lian Q, Lai KN, Tse HF, Tang SCW. Human induced pluripotent stem cell-derived mesenchymal stem cells prevent adriamycin nephropathy in mice. Oncotarget 2017; 8: 103640-103656.
Chan GC, Lam B, Yap DY, Ip MS, Lai KN, Tang SC. Proteinuria is associated with sleep apnea in chronic kidney disease. Nephrol Dial Transplant 2016; 31: 772-779.
Pai P. Cardiorenal syndrome. Hong Kong J Neph 2015; 17: 36-45.
Li XY, Jiang Y, Li JH, Zhu SL, Li J, Pai P. Growth Differentiation Factor 15 does not influence iron metabolism in stable chronic hemodialysis patients. Annals of Clin Biochem 2015; 52: 399-403.
Wang AY, Wong CK, Yau YY, Wong S, Chan IH, Lam CW. Skin Autofluorescence associates with vascular calcification in chronic kidney disease. Arterioscler Thromb Vasc Biol 2014; 34: 1784-1790.
Cai QZ, Lu XZ, Lu Y, Wang AY. Longitudinal changes of cardiac structure and function in CKD (CASCADE Study). J Am Soc Nephrol 2014; 25: 1599-1608.
Wang AY, Fang F, Chan J, Wen YY, Qing S, Chan IH, Lo G, Lai KN, Lo WK, Lam CWK, Yu CM. Oral paricalcitol treatment on left ventricular mass and function in stages 3-5 chronic kidney disease patients with cardiac hypertrophy (OPERA Study): a randomized controlled trial. J Am Soc Nephrol 2014; 25: 175-186.
Saxena R, Pai P, Bell GM. Nephrotoxic effects of workplace exposures. In: Baxter, Adams, Aw, Cockcroft and Harrington (eds). Hunter’s Diseases of Occupations 10th ed. New York: Oxford University Press, 2010.
McIntyre C, Pai P, Warwick G, Wilkie M, Toft A, Hutchison A. Iron-magnesium hydroxycarbonate (Fermagate): a novel non-calcium-containing phosphate binder for the treatment of hyperphosphataemia in chronic haemodialysis patients. Clin J Am Soc Nephrol 2009; 4: 401-409.
Choy BY, Ho YW, Chau KF, Leung CB, Tsang WK, Lui SF. Renal replacement therapy for patients with diabetes mellitus in Hong Kong. Hong Kong J Nephrol 2001; 3: 89-96.
Pai P, Thomas S, Hoenich N, Roberts R, House I, Brown AL. Treatment of a case of severe mercuric salt overdose with DMPS and haemofiltration. Nephrol Dial Transplant 2000; 15: 1889-1890.
Pai P, Stevenson A, Mason H, Bell GM. Occupational hydrocarbon exposure and nephrotoxicity - a cohort study and review of literature. Postgrad Med J 1998; 74: 225-228.
Pai P, Hindell P, Stevenson A, Mason H, Bell GM. Genetic variants of microsomal metabolism and susceptibility to hydrocarbon-associated glomerulonephritis. QJM 1997; 90: 693-698.
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