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A photo of Dr HO Chung Man, James
Dr HO Chung Man, James
Clinical Associate Professor
M.B.,B.S. (HK), M.D. (HK), MRCP (UK), FRCP (Edin, Lond, Glasg), FHKCP, FHKAM (Medicine), FCCP, FAPSR
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Dr. James Ho is a Clinical Associate Professor at the Department of Medicine, The University of Hong Kong. He received his medical degree (M.B.,B.S.) from The University of Hong Kong in 1993, with training in internal medicine and respiratory medicine in the Department of Medicine, Queen Mary Hospital. He obtained Doctor of Medicine from The University of Hong Kong with his thesis entitled "Non-small cell lung cancer: from bench to bedside". He is a Specialist in Respiratory Medicine in Hong Kong, Fellow of the American College of Chest Physicians, Fellow of the Royal College of Physicians and Surgeons of Glasgow, Fellow of the Royal College of Physicians of Edinburgh and London. He underwent basic research in lung cancer biology at the Cleveland Clinic Foundation, USA from 2000-01. Among his various appointments in professional societies, he was the President of the Hong Kong Thoracic Society in 2011-13. Currently, he is a member of the Education Committee of the International Association for the Study of Lung Cancer and a board member of the Respiratory Subspecialty Board of the Hong Kong College of Physicians.

Dr. Ho has an established track record in lung cancer research, and the areas of focus over the years include the role of antioxidants, epidemiology, diagnostics, and management. The emphasis of recent projects is on translational research into novel lung cancer therapeutic options, and clinical trials. Based on the earlier findings on altered antioxidant expression in lung cancer tissues (Ho JC et al. Cancer Research 2001;61:8578-8585), a subsequent clinical study was conducted demonstrating the independent alterations of systemic superoxide dismutase and glutathione peroxidase levels among lung cancer subjects (Ho JC et al. Eur Respir J 2007;29:273-278). This may further enhance the understanding of the role of antioxidants in lung carcinogenesis. Lymphoepithelioma-like carcinoma (LELC) of lung has been an uncommon type of Epstein-Barr virus-related lung cancer with special interest among the Asians. Apart from being one of the pioneers in first-line systemic chemotherapy treatment for advanced LELC of lung (Ho JC et al. Respir Med 2000;94(10):943-947), Dr. Ho and his team have reported a novel clinical application of oral capecitabine as a salvage chemotherapy treatment of this uncommon type of lung cancer (Ho JC et al. J Thorac Oncol 2009;4(9):1174-1177). His clinical experience in LELC of lung has been summarized in one of the few reviews on the area (Ho JC et al. Respirology 2006;11:539-545). In recent years, targeted therapy (e.g. against epidermal growth factor receptor (EGFR)) has emerged as a promising approach in treatment of non-small cell lung cancer, though acquired resistance is almost inevitable. A recent pre-clinical study on the combination of autophagy inhibitor with erlotinib (targeted therapy against EGFR) may further improve the outcome of this treatment approach (Li YY, Lam SK, Mak JC, Zheng CY, Ho JC. Lung Cancer 2013;81(3):354-61). In addition, another recent pre-clinical model has demonstrated a synergistic combination of arsenic trioxide (available in HKU as an oral treatment for acute promyelocytic leukaemia) and cisplatin in small cell lung cancer (Zheng CY, Lam SK, Li YY, Fong BM, Mak JC, Ho JC. Lung Cancer 2013;82(2):222-30), which holds promise to improve the existing treatment.

Selected Publications

  1. Zheng CY, Lam SK, Li YY, Fong BM, Mak JC, Ho JC*. Combination of arsenic trioxide and chemotherapy in small cell lung cancer. Lung Cancer 2013 ;82(2):222-30.
  2. Ho JC *, Au WY, Han L, Kwong YL, Ip MS. Effect of therapeutic arsenic exposure on pulmonary function. Respiratory Medicine 2013; 107(9):1423-30.
  3. Wu YL, Lee JS, Thongprasert S, Yu CJ, Zhang L, Ladrera G, Srimuninnimit V, Sriuranpong V, Sandoval-Tan J, Zhu Y, Liao M, Zhou C, Pan H, Lee V, Chen YM, Sun Y, Margono B, Fuerte F, Chang GC, Seetalarom K, Wang J, Cheng A, Syahruddin E, Qian X, Ho JC, Kurnianda J, Liu HE, Jin K, Truman M, Bara I, Mok TS. Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small cell lung cancer. Lancet Oncology 2013;14(8):777-86.
  4. Li YY, Lam SK, Mak JC, Zheng CY, Ho JC *. Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer. Lung Cancer 2013; 81(3):354-61.
  5. Thompson P, Salvi S, Lin J, Cho YJ, Eng P, Manap RA, Boonsawat W, Hsu JY, Faruqi RA, Moreno-Cantu JJ, Fish JE, Ho JC. Insights, attitudes, and perceptions about asthma and its treatment: Findings from a multinational survey of patients from 8 Asia-Pacific countries and Hong Kong. Respirology 2013; 18(6):957-67.
  6. Wong MK, Tam TC, Lam DC, Ip MS, Ho JC *. EBUS-TBNA in patients presented with superior vena cava syndrome. Lung Cancer 2012;77(2):277-280.
  7. Ho JC *, Lam DC, Wong MK, Lam B, Ip MS, Lam WK. Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung. J Thorac Oncol 2009;4(9):1174-1177.
  8. Ho JC *, Chan-Yeung M, Ho SP, Mak JC, Ip MS, Ooi GC, Wong MP, Tsang KW, Lam WK. Disturbance of systemic antioxidant profile in non-small cell lung carcinoma. Eur Respir J 2007;29:273-278.
  9. Ho JC, Mak JC, Ho SP, Ip MS, Tsang KW, Lam WK, Chan-Yeung M. Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. J Thorac Oncol 2006;1:648-653.
  10. Ho JC, Zheng S, Comhair SA, Farver C, Erzurum SC. Differential expression of manganese superoxide dismutase and catalase in lung cancer. Cancer Research 2001;61:8578-8585.

Key Offices

  1. Hong Kong Thoracic Society: President (2011-13)
  2. Hong Kong Lung Foundation: executive board member (since 2009)
  3. Subspecialty Board in Respiratory Medicine, Hong Kong College of Physicians: board member (since 2013)
  4. Institutional Review Board of the University of Hong Kong/HKWC: deputy chairman (since 2013)
  5. International Association for the Study of Lung Cancer (IASLC): member of Education Committee (since 2013)