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A photo of Dr SETO Wai Kay, Walter
Dr SETO Wai Kay, Walter
Clinical Associate Professor
MBBS(HK) MD(HK) MRCP (UK)
FRCP (Edin, Glasg, Lond) FHKCP FHKAM (Medicine)
an email logo wkseto@hku.hk
a telephone logo 2255-3994
a fax logo 2255-5411

Biography

Dr. Wai-Kay Seto graduated from the University of Hong Kong in 2003 and received his Fellowship in Gastroenterology and Hepatology in 2010 from the Hong Kong College of Physicians. He received his Doctor of Medicine from the University of Hong Kong in 2012. He is currently a Clinical Associate Professor in the Department of Medicine, the University of Hong Kong, Hong Kong. He is also Assistant Hospital Chief Executive (Research); Medical Director, Clinical Trials Center; and Consultant in Medicine of the University of Hong Kong-Shenzhen Hospital, Shenzhen, China. He has published more than 140 international journal articles and book chapters, including first-authored articles in the Lancet, Journal of Clinical Oncology, Gut, Journal of Hepatology and Hepatology, majority related to research on chronic liver diseases. He has been awarded the Distinguished Young Fellow (2013) from the Hong Kong Academy of Medicine; the Guangdong Province Outstanding Young Medical Talent Award (2017), the Outstanding Young Research Award (2016-2017) from The University of Hong Kong, and the Asia-Pacific Digestive Week Emerging Leader from the APDW Federation (2018).

Research Profile

  • Gastroenterology and Hepatology
  • Viral hepatitis and liver fibrosis

Selected Publications

  1. Seto WK, Lo YR, Pawlotsky JP, Yuen MF. Chronic hepatitis B virus infection. Lancet 2018; 392:2313-2324 (2017 impact factor 53.254).
  2. Seto WK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Lie AK, Lai CL, Kwong YL, Yuen MF. Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study. J Clin Oncol 2014; 32: 3736-43. (2017 impact factor 26.303)
  3. Seto WK, Hui AJ, Wong VW, Wong GL, Liu K, Lai CL, Yuen MF, Chan HL. Treatment cessation of entecavir in Asian patients with hepatitis B e antigen negative chronic hepatitis B: a multicenter prospective study. Gut 2015; 64: 667-72. (2017 impact factor 17.016)
  4. Seto WK, Yuen MF.  “Immune tolerance” in HBV infection: danger lurks. Nat Rev Gastroenterol Hepatol 2016 44: 1071-1079. (2017 impact factor 16.990)
  5. Seto WK, Mak SK, Chiu K, Vardhanabhuti V, Wong HF, Leong HT, Lee PS, Ho YC, Lee CK, Cheung KS, Yuen MF, Leung WK. Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users. J Hepatol 2018; 69:121-8 (2017 impact factor 15.040).
  6. Seto WK, Liu K, Wong DK, Fung J, Huang FY, Hung IF, Lai CL, Yuen MF. Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment. J Hepatol 2013; 4:709-16. (2017 impact factor 15.040).
  7. Seto WK, Lai CL, Fung J, Wong DK, Yuen JC, Hung IF, Yuen MF Significance of HBV DNA levels at 12 weeks of telbivudine treatment and the 3 years treatment outcome. J Hepatol 2011; 55(3): 522-8. (2017 impact factor 15.040)
  8. Seto WK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Lau HY, Cheung KS, Lie AK, Lai CL, Kwong YL, Yuen MF. Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: a prospective study. Hepatology 2017 65:1451-61 (2017 impact factor 14.079)
  9. Seto WK, Wong DK, Fung J, Huang FY, Lai CL, Yuen MF. Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy. Hepatology 2013; 58: 923-31. 61 (2017 impact factor 14.079)
  10. Seto WK, Wong DK, Fung J, Hung IF, Fong DY, Yuen JC, Tong T, Lai CL, Yuen MF. A large case-control study on the predictability of hepatitis B surface antigen three years before HBsAg seroclearance. Hepatology 2012 56: 812-9. 61 (2017 impact factor 14.079)
  11. Seto WK, Wong DK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Cheung KS, Lie AK, Lai CL, Kwong YL, Yuen MF.  Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy. Am J Gastroenterol 2016; 111:1788-1795. (2017 impact factor 10.231)

Key Offices

  1. Assistant Hospital Chief Executive (Research), The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
  2. Medical Director, Clinical Trials Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
  3. Council Member, Hong Kong Society of Gastroenterology, Hong Kong
  4. Council Member, Hong Kong Association for the Study of Liver Disease, Hong Kong
  5. Board of Examiners, Faculty of Dentistry, the University of Hong Kong
  6. Member, Faculty Research Committee, Li Ka Shing Faculty of Medicine, the University of Hong Kong
  7. Member, Faculty Human Resources Committee, Li Ka Shing Faculty of Medicine, the University of Hong Kong
  8. Member, Advanced Internal Medicine Assessment Board, Hong Kong College of Physicians, Hong Kong
  9. Member, Expert Committee on Health Science and Technology Education, Health and Family Planning Commission, Shenzhen Municipal Government, Shenzhen, China
  10. Member, Committee on Digestive Diseases, Shenzhen Medical Association, Shenzhen, China

Esteem Measures

  1. Asia Pacific Digestive Week Emerging Leader (2018), APDW Federation
  2. Outstanding Young Researcher Award (2016-2017), The University of Hong Kong
  3. Guangdong Province Outstanding Young Medial Talent Award (2017), Guangdong Health and Family Planning Commission, Guangdong Province, China
  4. Esteemed Staff Award (2017), Shenzhen Health and Family Planning Commission, Shenzhen, China
  5. Distinguished Research Paper Award for Young Investigator (2015), Hong Kong College of Physicians
  6. Distinguished Research Paper Award for Young Investigator (2014), Hong Kong College of Physicians
  7. Distinguished Research Paper Award for Young Investigator (2013), Hong Kong College of Physicians
  8. Distinguished Young Fellow (2013), Hong Kong Academy of Medicine
  9. Distinguished Research Paper Award for Young Investigator (2012), Hong Kong College of Physicians

Editorial Board Memberships

  • Hepatology (Hong Kong Edition)
  • World Journal of Gastroenterology

Competitive research grants as principal investigator

  • Gilead Sciences CHIME Grant, 2018 (ref no: ISR-CN-18-10455, HKD 2,183,290)
  • S. K. Yee Medical Foundation Grant, 2018 (ref no: 2171213, HKD 987,050)
  • Li Shu Pui Medical Foundation Research Grant, 2018 (HKD 1,494,584)
  • Health and Medical Research Fund, Food and Health Bureau, 2017 (ref no: 14150791, HKD 1,171,260)
  • General Research Fund, Research Grant Council, 2016 (ref no: 17125916, HKD 766,864)
  • Beat Drug Fund, Security Bureau, 2015 (ref no: 140031, HKD 984,920)
  • S. K. Yee Medical Foundation Grant, 2015 (ref no: 2151210, HKD 189,900)
  • S. K. Yee Medical Foundation Grant, 2014 (ref no: 2141213 HKD 717,780)
  • Health and Medical Research Fund, Food and Health Bureau, 2013 (ref no: 12111842, HKD 951,960)
  • Young Investigator Research Grant 2012, Hong Kong College of Physicians (HKD 50,000)