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A photo of Dr HO Wing Lok, Philip
Dr HO Wing Lok, Philip
Scientific Officer
an email logo hwl2002@hku.hk
a telephone logo 2819-9764
a fax logo 2816-2095

Biography

Dr. Philip Wing-Lok Ho obtained his PhD degree in the Department of Medicine, the University of Hong Kong in 2004 and went on to study the functional role of mitochondrial uncoupling protein homologues in the neuronal system. He is currently a research assistant professor in the University of Hong Kong. His research focus includes exploring 1) the neuroprotective and functional properties of neuronal uncoupling proteins (UCPs); and 2) the pathophysiology of Parkinson's disease associated with mitochondrial dysfunction and oxidative stress using in vitro and in vivo experimental models. Furthermore, Dr Ho is one of the inventers in designing novel protein tag and production of its corresponding antibodies in his current development of a novel kit in assessing environmental estrogenic compounds. This invention will be useful in developing novel assays of estrogenic endocrine disruptors, e.g. xenoestrogenic compounds and plasticizers. The application of the assay is filed in US, Europe, and China under patent protection.

Selected Publications

  1. Liu HF, Lu S, Ho PWL, Tse ZHM, Pang S, Kung MHW, Ho JWM, Ramsden DB, Zhou ZJ*, Ho SL*. LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity. Annals of Clinical and Translational Neurology. 2014; in press.
  2. Ho PWL, Tse ZHM, Liu HF, Lu S, Ho JWM, Kung MHW, Ramsden DB and Ho SL*. Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O-methyltransferase (COMT) expression in an ELISA-based system. PLoS ONE. 2013; 8(9):e74065. (doi: 10.1371/journal.pone.0074065).
  3. Ho PWL*, Ho JWM, Tse HM , So DHF , Yiu DCW, Liu HF, Chan KH, Kung MHW, Ramsden DB and Ho SL. Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells. PLoS ONE. 2012; 7(2): e32810. (doi:10.1371/journal.pone.0032810).
  4. Ho PWL, Ho JWM, Liu HF, So DHF, Tse ZHM, Chan KH, Ramsden DB and Ho SL*. Review: Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease. Translational Neurodegeneration. 2012, 1:3. (doi:10.1186/2047-9158-1-3).
  5. Ho JWM# , Ho PWL#, Liu HF, So DHF, Chan KH, Kung MHW, Ramsden DB, Ho SL*. UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress. Free Radical Biology and Medicine. 2012; 53(2): 383-94. (#Joint first author)
  6. Ramsden DB, Ho PWL, Ho JWM, Liu HF, So DHF, Tse HM, Chan KH, and Ho SL*. Review: Human Neuronal Uncoupling Proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation and physiological role in protection against oxidative stress and mitochondrial dysfunction. Brain and Behavior. 2012; 2(4): 468-478. (doi:10.1002/brb3.55).
  7. Ho PWL, Liu HF, Ho JWM, Zhang WY, Chu ACY, Kwok KHH, Ge X, Chan KH, Kung MHW, Ramsden DB, Ho SL*. Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells. Neurotoxicity Research. 2010; 17(4):332-43.
  8. Ho PWL, Chu ACY, Kwok KHH, Kung MHW, Ramsden DB, Ho SL*. Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells. Current Drug Metabolism. 2008; 9(4):276-9.
  9. Ho PWL, Garner CE, Ho JWM, Leung KC, Chu ACY, Kwok KHH, Kung MHW, Burka LT, Ramsden DB, Ho SL*. Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk. Current Drug Metabolism. 2008; 9(4):304-9.

Grant Record

  1. Co-Investigator (Co-I): HKD$0.92M from Health and Medical Research Fund (HMRF), food and Health Bureau, Hong Kong. 2013. Pathophysiological study of Parkinson's disease associated with Leucine-rich repeat kinase 2 (LRRK2) gene mutation. (application no. 01120976)
  2. Co-Investigator (Co-I): HKD$1.1M from Competitive Earmarked Research Grants (CERG), Research Grant Council (RGC), Hong Kong. Human Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform for Friedreich Ataxia. Sept. 2012. (Project code: HKU 776912M).
  3. Co-Investigator (Co-I): HKD$0.9M from Competitive Earmarked Research Grants (CERG), Research Grant Council (RGC), Hong Kong. The role of neuronal uncoupling proteins (UCPs) in mitochondrial dysfunction in Parkinson's disease (PD). 2007 (Project code: HKU 766107M).

Patents

Human Catechol-O-Methyltransferase (COMT) Assay – US Patent Application No: 2010/0081,147; PCT Patent Appln. No. PCT/CN2009/001011 filed on 8 Sept. 2009; International publication no. WO2010/034183 (1 Apr. 2010)

Membership

  • Principal Researcher of The Research Centre Of Heart, Brain, Hormone & Healthy Aging, HKU
  • Principal Investigator of HKU SIRI