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A photo of Dr NG Chun Laam, Roy
Dr NG Chun Laam, Roy
Research Assistant Professor
BS.c (HKPU), Ph.D (HKU)
an email logo royclng@hku.hk
a telephone logo 39179735
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Biography

Dr. Roy Chun-Laam NG obtained his PhD degree in the Department of Surgery, the University of Hong Kong in 2012. He is currently a Research Assistant Professor in the Department of Medicine, the University of Hong Kong. His research focuses on identifying risk factors of Alzheimer’s disease (AD) to invent novel early diagnostic method and therapeutic treatment.

Selected Publications

1.    JIAN M., NG R CL.*, CHAN KH*(2019) Adiponectin Suppresses Oligomeric Amyloid-β(AβO)-induced Inflammatory Response of Microglia via AdipoR1-AMPK- NF-κB signaling pathway. J Neuroinflammation 16(1):110. doi: 10.1186/s12974-019-1492-6 (*co-correspondence) [IF:5.7]
2.    Qian C., Wu Z., NG R CL., et al., (2018) Conditional deletion of platelet derived growth factor receptor alpha (Pdgfra) in urorectal mesenchyme causes mesenchyme apoptosis and urorectal developmental anomalies in mice. Cell Death Differ doi: 10.1038/s41418-018-0216-2.[IF:8.4]
3.    YICK LW, MA O KA, NG R CL, et al., (2018) Aquaporin-4 Autoantibodies From Neuromyelitis Optica Spectrum Disorder Patients Induce Complement-Independent Immunopathologies in Mice. Frontier of Immunology. 9:1438 [IF:5.5]
4.    NG R CL., CHAN KH (2017) Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease. International Journal of Molecular Sciences. 18(3):592 [IF:4.18]
5.    CHAN KH., NG R CL., YICK LW (2017) Immunopathological Effects of Aquaporin-4 IgG in Neuromyelitis Optica Spectrum Disorders. MOJ Immunology 5(5):00168
6.    NG R CL., Cheng OY, et al., (2016) Chronic adiponectin deficiency leads to cerebral insulin resistance and Alzheimer’s disease-like cognitive impairments in aged mice. Molecular Neurodegeneration 11 (1):71 [IF: 8.27]
7.    NG R CL., Matsumaru D, et al., (2014) Dysregulation of Wnt Inhibitory Factor 1 (Wif1) expression resulted in abnormal β-catenin signaling of the cloaca endoderm and anorectal malformations. Cell Death & Differentiation 21, 978-989 [IF:8.4]
8.    WONG EHM, NG CL, et al., (2013) Gene network analysis of candidate loci for human anorectal malformations. PloS One 8(8): e69142. doi:10.1371/journal.pone.0069142 [IF3.7]
9.    WONG EHM.# NG CL# , et al., (2012) Genome-wide copy number variation study in anorectal malformations. Human Molecular Genetics 22(3): 621-31 [#Co-first author] (# These authors contribute equally to the work)  [IF:7.7]

 

Awards

  1. Outstanding Alumni Award (2017, Carmel Alison Lam Foundation Secondary School)
  2. Outstanding Research Postgraduate (2015, The University of Hong Kong, Surgery)
  3. Resident Research Scholarship Award (2015, American Academy of Neurology)

Grant Record

  1. Human Medical Research Fund (2018/19); Food & Health Bureau, HK (PI; HKD 1,245,348)
  2. Seeding function of translational research (2018/19) The University of Hong Kong (PI; HKD 150,000)
  3. Dr. Vincent Liu Endowment of motor neuron disease (2018) Donation (PI; HKD 200,000)
  4. Seed funding of basic research new staff (2018); The University of Hong Kong (PI; HKD 150,000)
  5. Seed funding of basic research (2017/18); The University of Hong Kong (PI; HKD 45,000)
  6. Human Medical Research Fund (2015/16); Food & Health Bureau, HK (PI; HKD 956,608)
  7. Human Medical Research Fund (2015/16); Food & Health Bureau, HK (Co-PI; HKD 1,136,960)

Research Focus Area


1.    Adiponectin signaling and Neuroinflammation
Microglia is the resident innate immune cells of the brain that is involved in the development and progression of AD pathologies. The underlying mechanisms that modulate the transition of an initially neuroprotective to a chronic inflammatory state remain to be elucidated. Adiponectin is an anti-inflammatory adipokine that regulates inflammatory responses. We focus on the role of adiponectin in regulating microglia-mediated neuroinflammation and other microglia-related pathogenesis in Alzheimer’s disease.



2.    Cerebral insulin signaling and AD pathologies
Epidemiological association between diabetes, obesity and dementia represents an important public health challenge. Insulin resistance is one of the common pathophysiological conditions among three disorders. Insulin resistance is highly associated with Amyloid deposition and Tau hyperphosphorylation in neurons. Adiponectin is also an insulin sensitizing adipokine that modulates insulin signaling activities in neurons. Adiponectin deficiency induces aberrant cerebral insulin signaling and neurodegeneration. Our lab aims to develop therapeutic agent that can enhance insulin sensitivity to ameliorate AD pathologies.
 
Image result for adiponectin in alzheimer's disease
 
3.    Cerebrovascular risks factors for Alzheimer’s disease
Cerebrovascular lesions may manifest neuropathology of AD and precede neuronal damages in dementia. Breakdown of the blood-brain barrier (BBB) and cerebral amyloid angiopathy are the common cerebrovascular lesions in AD patients. Our lab aims to identify the risk factors that associate with these lesions and study the underlying mechanisms in AD pathogenesis