2025

ALT to qHBsAg Ratio Predicts Long-term HBsAg Seroclearance after Entecavir Cessation in Chinese Patients with Chronic Hepatitis B
Leung RH, Hui RW, Mak LY, Mao X, Liu KS, Wong DK, Fung J, Seto WK, Yuen MF
J Hepatol. 2024 Aug;81(2):218-226. doi: 10.1016/j.jhep.2024.03.022.

Cabozantinib Plus Atezolizumab Versus Sorafenib for Advanced Hepatocellular Carcinoma (COSMIC-312): Final Results of a Randomised Phase 3 Study
Yau T, Kaseb A, Cheng AL, Qin S, Zhu AX, Chan SL, Melkadze T, Sukeepaisarnjaroen W, Breder V, Verset G, Gane E, Borbath I, Rangel JDG, Ryoo BY, Makharadze T, Merle P, Benzaghou F, Milwee S, Wang Z, Curran D, Kelley RK, Rimassa L
Lancet Gastroenterol Hepatol. 2024 Apr;9(4):310-322. doi: 10.1016/S2468-1253(23)00454-5.

VIR-2218 (elebsiran) Plus Pegylated Interferon-alfa-2a in Participants with Chronic Hepatitis B Virus Infection: a Phase 2 Study
Yuen MF, Lim YS, Yoon KT, Lim TH, Heo J, Tangkijvanich P, Tak WY, Thanawala V, Cloutier D, Mao S, Arizpe A, Cathcart AL, Gupta SV, Hwang C, Gane E
Lancet Gastroenterol Hepatol. 2024 Dec;9(12):1121-1132. doi: 10.1016/S2468-1253(24)00237

Comparative Effectiveness of Combination Therapy with Nirmatrelvir-ritonavir and Remdesivir Versus Monotherapy with Remdesivir or Nirmatrelvir-ritonavir in Patients Hospitalised with COVID-19: a Target Trial Emulation Study
Choi MH, Wan EYF, Wong ICK, Chan EWY, Chu WM, Tam AR, Yuen KY, Hung IFN
Lancet Infect Dis. 2024 Nov;24(11):1213-1224. doi: 10.1016/S1473-3099(24)00353-0.

2024

Effectiveness of Aerobic Exercise and Tai Chi Interventions on Sleep Quality in Patients with Advanced Lung Cancer: A Randomized Clinical Trial
Takemura N, Cheung DST, Fong DYT, Lee AWM, Lam TC, Ho JC, Kam TY, Chik JYK, Lin CC
JAMA Oncol. 2024 Feb 1;10(2):176-184. doi: 10.1001/jamaoncol.2023.5248.

Global Prevalence of Helicobacter Pylori Infection Between 1980 and 2022: a Systematic Review and Meta-analysis 
Li Y, Choi H, Leung K, Jiang F, Graham DY, Leung WK
Lancet Gastroenterol Hepatol. 2023 Jun;8(6):553-564. doi: 10.1016/S2468-1253(23)00070-5.

Viral Burden Rebound in Hospitalised Patients with COVID-19 Receiving Oral Antivirals in Hong Kong: a Population-wide Retrospective Cohort Study
Wong CKH, Lau KTK, Au ICH, Lau EHY, Poon LLM, Hung IFN, Cowling BJ, Leung GM
Lancet Infect Dis. 2023 Jun;23(6):683-695. doi: 10.1016/S1473-3099(22)00873-8.

Vaccine Effectiveness of BNT162b2 and CoronaVac Against SARS-CoV-2 Omicron Infection and Related Hospital Admission Among People with Substance use Disorder in Hong Kong: a Matched Case-control Study
Huang C, Wei Y, Yan VKC, Ye X, Kang W, Yiu HHE, Shami JJP, Cowling BJ, Tse ML, Castle DJ, Chui CSL, Lai FTT, Li X, Wan EYF, Wong CKH, Hayes JF, Chang WC, Chung AKK, Lau CS, Wong ICK, Chan EW
Lancet Psychiatry. 2023 Jun;10(6):403-413. doi: 10.1016/S2215-0366(23)00111-6.

Oral Emergency Contraception with Levonorgestrel Plus Piroxicam: a Randomised Double-blind Placebo-controlled Trial
Li RHW, Lo SST, Gemzell-Danielsson K, Fong CHY, Ho PC, Ng EHY
Lancet. 2023 Sep 9;402(10405):851-858. doi: 10.1016/S0140-6736(23)01240-0

2023

Carditis After COVID-19 Vaccination With a Messenger RNA Vaccine and an Inactivated Virus Vaccine : A Case-Control Study.
Lai FTT, Li X, Peng K, Huang L, Ip P, Tong X, Chui CSL, Wan EYF, Wong CKH, Chan EWY, Siu DCW, Wong ICK
Ann Intern Med. 2022 Mar;175(3):362-370. doi: 10.7326/M21-3700.

Cost-effectiveness of Universal Screening for Chronic Hepatitis B Virus Infection in China: an Economic Evaluation.
Su S, Wong WC, Zou Z, Cheng DD, Ong JJ, Chan P, Ji F, Yuen MF, Zhuang G, Seto WK, Zhang L
Lancet Glob Health. 2022 Feb;10(2):e278-e287. doi: 10.1016/S2214-109X(21)00517-9.

FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity.
Jin L, Geng L, Ying L, Shu L, Ye K, Yang R, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan X, Liao B, Liu J, Duan F, Sweeney G, Woo CWH, Wang Y, Xia Z, Lian Q, Xu A
Circulation. 2022 Nov 15;146(20):1537-1557.
doi:10.1161/CIRCULATIONAHA.122.059631.
 
Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection.
Yuen MF, Lim SG, Plesniak R, Tsuji K, Janssen HLA, Pojoga C, Gadano A, Popescu CP, Stepanova T, Asselah T, Diaconescu G, Yim HJ, Heo J, Janczewska E, Wong A, Idriz N, Imamura M, Rizzardini G, Takaguchi K, Andreone P, Arbune M, Hou J, Park SJ, Vata A, Cremer J, Elston R, Lukić T, Quinn G, Maynard L, Kendrick S, Plein H, Campbell F, Paff M, Theodore D; B-Clear Study Group
N Engl J Med. 2022 Nov 24;387(21):1957-1968. doi: 10.1056/NEJMoa2210027.

2022

Bell’s Palsy Following Vaccination with mRNA (BNT162b2) and Inactivated (CoronaVac) SARS-CoV-2 Vaccines: a Case Series andNested Case-Control Study.
Wan EYF, Chui CSL, Lai FTT, Chan EWY, Li X, Yan VKC, Gao L, Yu Q, Lam ICH, Chun RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Leung GM, Wong ICK
Lancet Infect Dis. 2022 Jan;22(1):64-72. doi: 10.1016/S1473-3099(21)00451-5.

Circulating Thrombospondin-2 as a Novel Fibrosis Biomarker of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes.
Lee CH, Seto WK, Lui DT, Fong CH, Wan HY, Cheung CY, Chow WS, Woo YC, Yuen MF, Xu A, Lam KS
Diabetes Care. 2021 Sep;44(9):2089-2097. doi: 10.2337/dc21-0131.

Patient pIgR-enriched Extracellular Vesicles Drive Cancer Stemness, Tumorigenesis and Metastasis in Hepatocellular Carcinoma.
Tey SK, Wong SWK, Chan JYT, Mao X, Ng TH, Yeung CLS, Leung Z, Fung HL, Tang AHN, Wong DKH, Mak LY, Yuen MF, Sin CF, Ng IO, Ma SKY, Lee TKW, Cao P, Zhong K, Gao Y, Yun JP, Yam JWP
J Hepatol. 2022 Apr;76(4):883-895. doi: 10.1016/j.jhep.2021.12.005.

Safety, Tolerability and Antiviral Activity of the Antisense Oligonucleotide Bepirovirsen in Patients with Chronic Hepatitis B: a Phase 2 Randomized Controlled Trial.
Yuen MF, Heo J, Jang JW, Yoon JH, Kweon YO, Park SJ, Tami Y, You S, Yates P, Tao Y, Cremer J, Campbell F, Elston R, Theodore D, Paff M, Bennett CF, Kwoh TJ Nat Med. 2021 Oct;27(10):1725-1734. doi: 10.1038/s41591-021-01513-4.
Nat Med. 2021 Oct;27(10):1725-1734. doi: 10.1038/s41591-021-01513-4.

Statin Associated with Lower Cancer Risk and Related Mortality in Patients with Heart Failure.
Ren QW, Yu SY, Teng TK, Li X, Cheung KS, Wu MZ, Li HL, Wong PF, Tse HF, Lam CSP, Yiu KH
Eur Heart J. 2021 Aug 21;42(32):3049-3059. doi: 10.1093/eurheartj/ehab325.

Two-dose COVID-19 Vaccination and Possible Arthritis Flare Among Patients with Rheumatoid Arthritis in Hong Kong.
Li X, Tong X, Yeung WWY, Kuan P, Yum SHH, Chui CSL, Lai FTT, Wan EYF, Wong CKH, Chan EWY, Lau CS, Wong ICK
Ann Rheum Dis. 2022 Apr;81(4):564-568. doi: 10.1136/annrheumdis-2021-221571.

2021

Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib - The CheckMate 040 Randomized Clinical Trial
Yau T, Kang YK, Kim TY, El-Khoueiry AB, Santoro A, Sangro B, Melero I, Kudo M, Hou MM, Matilla A, Tovoli F, Knox JJ, Ruth He A, El-Rayes BF, Acosta-Rivera M, Lim HY, Neely J, Shen Y, Wisniewski T, Anderson J, Hsu C
JAMA Oncol. 2020 Nov 1;6(11):e204564. doi: 10.1001/jamaoncol.2020.4564.

Diverse Effects of Hepatic Steatosis on Fibrosis Progression and Functional Cure in Virologically Quiescent Chronic Hepatitis B
Mak LY, Hui RW, Fung J, Liu F, Wong DK, Cheung KS, Yuen MF, Seto WK
J Hepatol. 2020 Oct;73(4):800-806. doi: 10.1016/j.jhep.2020.05.040.

Triple Combination of Interferon beta-1b, Lopinavir–ritonavir, and Ribavirin in the Treatment of Patients Admitted to Hospital with COVID-19: an Open-label, Randomised, Phase 2 trial
Hung IF, Lung KC, Tso EY, Liu R, Chung TW, Chu MY, Ng YY, Lo J, Chan J, Tam AR, Shum HP, Chan V, Wu AK, Sin KM, Leung WS, Law WL, Lung DC, Sin S, Yeung P, Yip CC, Zhang RR, Fung AY, Yan EY, Leung KH, Ip JD, Chu AW, Chan WM, Ng AC, Lee R, Fung K, Yeung A, Wu TC, Chan JW, Yan WW, Chan WM, Chan JF, Lie AK, Tsang OT, Cheng VC, Que TL, Lau CS, Chan KH, To KK, Yuen KY
Lancet. 2020 May 30;395(10238):1695-1704. doi: 10.1016/S0140-6736(20)31042-4.