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Achievement Highlights

The Department of Medicine, School of Clinical Medicine is at the frontier of the discovery of cutting-edge medical research findings. Our academics are recognized globally for their research contribution, having published influential publications with high-impact factors.

International Recognition

Highly Cited Researchers (by Clarivate Analytics)


Two scholars from the Department of Medicine, School of Clinical Medicine have been named on the list of Highly Cited Researchers 2023:



This annual list by Clarivate Analytics recognizes researchers whose publications rank among the top 1% globally in terms of citations over the past decade. It serves as a testament to their significant impact within the academic community.


A full list of Highly Cited Researchers 2023 can be found here.


 

World’s Top 2% Scientists (by Stanford University)


Sixteen scholars from the Department of Medicine, School of Clinical Medicine are ranked as the World’s Top 2% scientists in 2023 by Stanford University. The ranking was based on the "Updated science-wide author databases of standardized citation indicators", encompassing various factors such as citations, individual's research output, co-authorship and a composite indicator for career-long citation impact.



This prestigious acknowledgement reaffirms our world-class research standards and highlights the international recognition received by our researchers.


Click here for a complete list of the World’s Top 2% scientists 2023.

 

*Honorary Professoriate




Recent Impact Publications
Award for Excellence (2022-2023)

Authors & Articles Impact Factor
β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130.
Leiluo Geng, Boya Liao, Leigang Jin, Jiasui Yu, Xiaoyu Zhao, Yuntao Zhao, Ling Zhong, Baile Wang, Jiufeng Li, Jie Liu, Jin Kui Yang, Wei Jia, Qizhou Lian*, Aimin Xu*. Nat Metab 4, 608–626 (2022). https://doi.org/10.1038/s42255-022-00572-2 *Corresponding author for this work
 19.950
A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis.
Lung-Yi Mak, Ed Gane, Christian Schwabe, Ki Tae Yoon, Jeong Heo, Russell Scott, Jeong-Hoon Lee, Jung Il Lee, Young Oh Kweon, Martin Weltman, Stephen A Harrison, Brent A Neuschwander-Tetri, Kenneth Cusi, Rohit Loomba, Bruce D Given, Dawn R Christianson, Eric Garcia-Medel, Min Yi, James Hamilton, Man-Fung Yuen. J Hepatol. 2023 Apr; 78(4):684-692. doi: 10.1016/j.jhep.2022.11.025. Epub 2022 Dec 10. 		30.083
Analysis of all-cause hospitalization and death among nonhospitalized patients with type 2 diabetes and SARS-CoV-2 infection treated with molnupiravir or nirmatrelvir-ritonavir during the Omicron wave in Hong Kong.
David T. W. Lui, Matthew S. H. Chung, Eric H. Y. Lau, Kristy T. K. Lau, Ivan C. H. Au, Chi Ho Lee, Yu Cho Woo, Carlos K. H. Wong, Benjamin J. Cowling. JAMA Netw Open. 2023;6(5): e2314393. doi: 10.1001/jamanetworkopen.2023.14393 		13.360
Cardiovascular risk in rheumatoid arthritis patients treated with targeted synthetic and biological disease-modifying antirheumatic drugs: A multi-centre cohort study.
Xinning Tong, Chin-Yao Shen, Ha-Lim Jeon, Yihua Li, Ju-Young Shin, Shirley CW Chan, Kai Hang Yiu, Nicole L. Pratt, Michael Ward, Chak Sing Lau, Ian CK Wong, Xue Li, Edward Chia-Cheng Lai. Journal of Internal Medicine, 06 June 2023, https://doi.org/10.1111/joim.13681 		13.068
Comparative effectiveness, safety and real-world outcomes of a nurse-led, protocol-driven penicillin allergy evaluation from the Hong Kong Drug Allergy Delabelling Initiative (HK-DADI).
Kan AKC, Hui HKS, Li TS, Chiang V, Wong JCY, Chan TS, Kwan IYK, Shum WZ, Yeung MSC, Au EYL, Ho CTK, Lau CS, Li PH. J Allergy Clin Immunol Pract. 2022 Sep 17 doi: 10.1016/j.jaip.2022.08.052. 		11.022
Cost-effectiveness of universal screening for chronic hepatitis B virus infection in China: an economic evaluation.
Shu Su, William CW Wong, Zhuoru Zou, Dan Dan Cheng, Jason J Ong, Polin Chan, Fanpu Ji, Man-Fung Yuen, Guihua Zhuang, Wai-Kay Seto, Lei Zhang. Lancet Glob Health. 2022 Feb; 10(2): e278-e287. doi: 10.1016/S2214-109X (21)00517-9. 		38.927
Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection.
Man-Fung Yuen, Seng-Gee Lim, Robert Plesniak, Keiji Tsuji, Harry L.A. Janssen, Cristina Pojoga, Adrian Gadano, Corneliu P. Popescu, Tatyana Stepanova, Tarik Asselah, Gheorghe Diaconescu, Hyung Joon Yim, Jeong Heo, Ewa Janczewska, Alexander Wong, Nevin Idriz, Michio Imamura, Giuliano Rizzardini, Koichi Takaguchi, Pietro Andreone, Manuela Arbune, Jinlin Hou, Sung Jae Park, Andrei Vata, Jennifer Cremer, Robert Elston, Tamara Lukić, Geoff Quinn, Lauren Maynard, Stuart Kendrick, Helene Plein, Fiona Campbell, Melanie Paff, and Dickens Theodore, for the B-Clear Study Group. N Engl J Med 2022; 387:1957-1968, doi: 10.1056/NEJMoa2210027 		176.082
Epidemiology, Management, and Treatment Access of Hereditary Angioedema in the Asia Pacific Region: Outcomes From an International Survey.
Philip H Li, Ruby Pawankar, Bernard Yu-Hor Thong, Jie Shen Fok, Hiroshi Chantaphakul, Michihiro Hide, Ankur Kumar Jindal, Hye-Ryun Kang, Amir Hamzah Abdul Latiff, Rommel Crisenio M Lobo, Sonomjamts Munkhbayarlakh, Dinh Van Nguyen, Shyh-Dar Shyur, Yuxiang Zhi, Marcus Maurer. J Allergy Clin Immunol Pract. 2023 Apr;11(4):1253-1260. doi: 10.1016/j.jaip.2022.12.021. Epub 2022 Dec 27. 		11.022
Evaluation of fracture risk among patients with type 2 diabetes and non-valvular atrial fibrillation receiving different oral anticoagulants.
Lui DTW*, Tang EHM*, Au ICH, Wu T, Lee CH, Wong CK, Cheung CYY, Fong CHY, Chow WS, Woo YC, Tan KCB, Lam KSL, Wong CKH. Diabetes Care. 2022 Nov 1;45(11):2620-2627. (2021 JIF: 17.152; 6/146 in Endocrinology & Metabolism; *co-first author) 		17.155
FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity.
Leigang Jin, Leiluo Geng, Lei Ying, Lingling Shu, Kevin Ye, Ranyao Yang, Yan Liu, Yao Wang, Yin Cai, Xue Jiang, Qin Wang, Xingqun Yan, Boya Liao, Jie Liu, Fuyu Duan, Gary Sweeney, Connie Wai Hong Woo, Yu Wang, Zhengyuan Xia, Qizhou Lian, Aimin Xu. Circulation. 2022 Nov 15; 146(20): 1537-1557. doi: 10.1161/CIRCULATIONAHA.122.059631. Epub 2022 Sep 22. 		39.918
Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice.
Lai Yee Cheong, Baile Wang, Qin Wang, Leigang Jin, Kelvin H. M. Kwok, Xiaoping Wu, Lingling Shu, Huige Lin, Sookja Kim Chung, Kenneth K. Y. Cheng, Ruby L. C. Hoo & Aimin Xu. Nat Commun 14, 1213 (2023). https://doi.org/10.1038/s41467-023-36737-0 		17.694
Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis.
Yunhao Li, Horace Choi, Kathy Leung, Fang Jiang, David Y Graham, Wai K Leung. The Lancet April 19, 2023. doi: https://doi.org/10.1016/S2468-1253(23)00070-5		 45.042
Glycemic burden and the risk of adverse hepatic outcomes in chronic hepatitis B patients with type 2 diabetes.
Mak LY, Hui RWH, Lee CH, Mao X, Cheung KS, Wong DKH, Lui DTW, Fung J, Yuen MF, Seto WK. Hepatology. 2022; 00:1–13. https://doi.org/10.1002/hep.32716 		17.298
Kidney outcomes associated with sodium-glucose cotransporter 2 inhibitors versus glucagon-like peptide 1 receptor agonists: a real-world population-based analysis.
David Tak Wai Lui, Ivan Chi Ho Au, Eric Ho Man Tang, Ching Lung Cheung, Chi Ho Lee, Yu Cho Woo, Tingting Wu, Kathryn Choon Beng Tan, Carlos King Ho Wong. eClinical Medicine June 25, 2022. doi: https://doi.org/10.1016/j.eclinm.2022.101510 		17.033

Prediabetes Is Associated With Increased Risk of Heart Failure Among Patients With Atrial Fibrillation.
Jia-Yi Huang, Yi-Kei Tse, Hang-Long Li, Cong Chen, Chun-Ting Zhao, Ming-Ya Liu, Mei-Zhen Wu, Qing-Wen Ren, Si-Yeung Yu, Denise Hung, Xin-Li Li, Hung-Fat Tse, Gregory Y H Lip, Kai-Hang Yiu. Diabetes Care. 2023 Jan 1;46(1):190-196.

17.155
Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared With Viral Myocarditis.
Francisco Tsz Tsun Lai, Edward Wai Wa Chan, Lei Huang, Ching Lung Cheung, Celine Sze Ling Chui, Xue Li, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Kai Hang Yiu, Ian Chi Kei Wong. J Am Coll Cardiol. 2022 Dec 13, doi: 10.1016/j.jacc.2022.09.049 		27.206

Prospective Study on the Efficacy and Impact of Cascade Screening and Evaluation of Hereditary Angioedema (CaSE-HAE).
Jane C.Y. Wong, Valerie Chiang, Ki Lam, Edmund Tung, Elaine Y.L. Au, Chak Sing Lau, Philip H. Li. J Allergy Clin Immunol Pract. 2022 Nov;10(11):2896-2903.e2. doi: 10.1016/j.jaip.2022.07.035. Epub 2022 Aug 12.

11.022
Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication.
Cheuk-Him Man, Xiaoyuan Zeng, Wing Lam, Timothy C C Ng, Tsz-Ho Kwok, Kenny C C Dang, Thomas W Y Leung, Nelson K L Ng, Stephen S Y Lam, Chae-Yin Cher, Anskar Y H Leung. Leukemia. 2022 Aug;36(8):1990-2001. doi: 10.1038/s41375-022-01606-0. Epub 2022 May 27. 		12.897

Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines.
Carlos King Ho Wong, Lung Yi Mak, Ivan Chi Ho Au, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Celine Sze Ling Chui, Esther Wai Yin Chan, Wing Yiu Cheng, Franco Wing Tak Cheng, Man Fung Yuen, Ian Chi Kei Wong. J Hepatology 2022; 77(5): 1339-1348

30.083
Risk of Postcolonoscopy Thromboembolic Events: A Real-World Cohort Study.
Yan Kiu Li, Chuan-Guo Guo, Ka Shing Cheung, Kevin S H Liu, Wai K Leung. Clin Gastroenterol Hepatol. 2022 Sep 24; S1542-3565(22)00919-3. doi: 10.1016/j.cgh.2022.09.021. 		13.576

Risk of thyroid dysfunction associated with mRNA and inactivated COVID-19 vaccines: a population-based study of 2.3 million vaccine recipients.
Wong CKH*, Lui DTW*, Xiong X*, Chui CSL, Lai FTT, Li X, Wan EYF, Cheung CL, Lee CH, Woo YC, Au ICH, Chung MSH, Cheng FWT, Tan KCB, Wong ICK. BMC Med. 2022 Oct 14;20(1):339. (2021 JIF: 11.150; 21/172 in Medicine, General & Internal; *co-first author)

11.806
SGLT2i reduces risk of developing HCC in patients with co-existing T2D and CHB infection - A territory-wide cohort study in Hong Kong.
Chi-Ho Lee, Lung-Yi Mak, Eric Ho-Man Tang, David Tak-Wai Lui, Jimmy Ho-Cheung Mak, Lanlan Li, Tingting Wu, Wing Lok Chan, Man-Fung Yuen, Karen Siu-Ling Lam, Carlos King Ho Wong. Hepatology. 2023 Apr 15. doi: 10.1097/HEP.0000000000000404. Online ahead of print. 		17.298

TLR7 agonist RO7020531 versus placebo in healthy volunteers and patients with chronic hepatitis B virus infection: a randomised, observer-blind, placebo-controlled, phase 1 trial.
Man-Fung Yuen, Rozalina Balabanska, Emmanuelle Cottreel, Ethan Chen, Dan Duan, Qiudi Jiang, Avinash Patil, Miriam Triyatni, Ruchi Upmanyu, Yonghong Zhu, Filippo Canducci, Edward J Gane. Lancet Infectious Diseases December 09, 2022, doi: https://doi.org/10.1016/S1473-3099(22)00727-7

71.421
Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong.
Xue Li, Xinning Tong, Winnie Wan Yin Yeung, Peng Kuan, Samson Hin Hei Yum, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Chak Sing Lau, Ian Chi Kei Wong. Annals of the Rheumatic Diseases, Volume 81, Issue 4 		28.003



Previous High Impact Publications

Authors & Articles Impact Factor
Cost-effectiveness of universal screening for chronic hepatitis B virus infection in China: an economic evaluation. 
Su, S., Wong, W.C., Zou, Z., Cheng, D.D., Ong, J.J., Chan, P., Ji, F., Yuen, M.F., Zhuang, G., Seto, W.K., Zhang, L. (2022). Lancet Global Health, 10(2): e278-287.
 26.763
Statin associated lower cancer risk and related mortality in patients with heart failure.
Ren, Q. W., Yu, S. Y., Teng, T. K., Li, X., Cheung, K. S., Wu, M. Z., Li, H. L., Wong, P. F., Tse, H. F., Lam, C., & Yiu, K. H. (2021). European heart journal, 42(32), 3049–3059. 		29.983
Role of serum HBV RNA and hepatitis B surface antigen levels in identifying Asian patients with chronic hepatitis B suitable for entecavir cessation.
Seto, W. K., Liu, K. S., Mak, L. Y., Cloherty, G., Wong, D. K., Gersch, J., Lam, Y. F., Cheung, K. S., Chow, N., Ko, K. L., To, W. P., Fung, J., & Yuen, M. F. (2021). Gut, 70(4), 775–783. 		23.059
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial.
Yuen, M. F., Heo, J., Jang, J. W., Yoon, J. H., Kweon, Y. O., Park, S. J., Tami, Y., You, S., Yates, P., Tao, Y., Cremer, J., Campbell, F., Elston, R., Theodore, D., Paff, M., Bennett, C. F., & Kwoh, T. J. (2021). Nature medicine, 27(10), 1725–1734. 		53.440
Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment.
Yuen, M. F., Wong, D. K., Schluep, T., Lai, C. L., Ferrari, C., Locarnini, S., Lo, R. C., Gish, R. G., Hamilton, J., Wooddell, C. I., Mak, L. Y., & Given, B. D. (2021).  Gut, gutjnl-2020-323445. Advance online publication. 		23.059
Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis.
Cheung, K. S., Hung, I., Chan, P., Lung, K. C., Tso, E., Liu, R., Ng, Y. Y., Chu, M. Y., Chung, T., Tam, A. R., Yip, C., Leung, K. H., Fung, A. Y., Zhang, R. R., Lin, Y., Cheng, H. M., Zhang, A., To, K., Chan, K. H., Yuen, K. Y., … Leung, W. K. (2020). Gastroenterology, 159(1), 81–95. 		22.682
Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori: a territory-wide cohort study.
Guo, C. G., Cheung, K. S., Zhang, F., Chan, E. W., Chen, L., Wong, I. C., & Leung, W. K. (2020). Gut, 69(3), 445–452. 		23.059
SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking a cruise ship: a case series.
Hung, I. F., Cheng, V. C., Li, X., Tam, A. R., Hung, D. L., Chiu, K. H., Yip, C. C., Cai, J. P., Ho, D. T., Wong, S. C., Leung, S. S., Chu, M. Y., Tang, M. O., Chen, J. H., Poon, R. W., Fung, A. Y., Zhang, R. R., Yan, E. Y., Chen, L. L., Choi, C. Y., … Yuen, K. Y. (2020). The Lancet. Infectious diseases, 20(9), 1051–1060. 		25.071
Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial.
Hung, I. F., Lung, K. C., Tso, E. Y., Liu, R., Chung, T. W., Chu, M. Y., Ng, Y. Y., Lo, J., Chan, J., Tam, A. R., Shum, H. P., Chan, V., Wu, A. K., Sin, K. M., Leung, W. S., Law, W. L., Lung, D. C., Sin, S., Yeung, P., Yip, C. C., … Yuen, K. Y. (2020). The Lancet (London, England), 395(10238), 1695–1704. 		79.321
Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention.
Liu, Y., Wang, Y., Ni, Y., Cheung, C., Lam, K., Wang, Y., Xia, Z., Ye, D., Guo, J., Tse, M. A., Panagiotou, G., & Xu, A. (2020). Cell metabolism, 31(1), 77–91.e5. 		27.287
Impacts of the Coronavirus 2019 Pandemic on Gastrointestinal Endoscopy Volume and Diagnosis of Gastric and Colorectal Cancers: A Population-Based Study.
Lui, T., Leung, K., Guo, C. G., Tsui, V., Wu, J. T., & Leung, W. K. (2020). Gastroenterology, 159(3), 1164–1166.e3. 		22.682
Diverse effects of hepatic steatosis on fibrosis progression and functional cure in virologically quiescent chronic hepatitis B.
Mak, L. Y., Hui, R. W., Fung, J., Liu, F., Wong, D. K., Cheung, K. S., Yuen, M. F., & Seto, W. K. (2020). Journal of hepatology, 73(4), 800–806.		 25.083
Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients.
Cheung, K. S., Chen, L., Chan, E. W., Seto, W. K., Wong, I., & Leung, W. K. (2019). Gut, 68(11), 1979–1985. 		23.059
Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.
Yuen, M. F., Gane, E. J., Kim, D. J., Weilert, F., Yuen Chan, H. L., Lalezari, J., Hwang, S. G., Nguyen, T., Flores, O., Hartman, G., Liaw, S., Lenz, O., Kakuda, T. N., Talloen, W., Schwabe, C., Klumpp, K., & Brown, N. (2019). Gastroenterology, 156(5), 1392–1403.e7. 		22.682

Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study.
Cheung, K. S., Chan, E. W., Wong, A., Chen, L., Wong, I., & Leung, W. K. (2018). Gut, 67(1), 28–35.

23.059
Effects of Helicobacter pylori Treatment on Incidence of Gastric Cancer in Older Individuals.
Leung, W. K., Wong, I., Cheung, K. S., Yeung, K. F., Chan, E. W., Wong, A., Chen, L., Wong, I., & Graham, D. Y. (2018). Gastroenterology, 155(1), 67–75. 		22.682

Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users.
Seto, W. K., Mak, S. K., Chiu, K., Vardhanabhuti, V., Wong, H. F., Leong, H. T., Lee, P., Ho, Y. C., Lee, C. K., Cheung, K. S., Yuen, M. F., & Leung, W. K. (2018). Journal of Hepatology, 69(1), 121–128.

25.083
Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial.
Hung, I. F., Zhang, A. J., To, K. K., Chan, J. F., Li, P., Wong, T. L., Zhang, R., Chan, T. C., Chan, B. C., Wai, H. H., Chan, L. W., Fong, H. P., Hui, R. K., Kong, K. L., Leung, A. C., Ngan, A. H., Tsang, L. W., Yeung, A. P., Yiu, G. C., Yung, W., … Yuen, K. Y. (2016). The Lancet. Infectious diseases, 16(2), 209–218. 		25.071

Selected Publications

2021 2020 2019
  • Gu P, Hui X, Zheng Q, Gao Y, Jin L, Jiang W, Zhou C, Liu T, Huang Y, Liu Q, Nie T, Wang Y, Wang Y, Zhao J, Xu A.; Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1β production; Sci Adv 2021 Dec 10;7(50):eabl4024. doi: 10.1126/sciadv.abl4024.
  • Ranyao Yang, Yue Hu, Chi Ho Lee, Yan Liu, Candela Diaz-Canestro, Carol Ho Yi Fong, Huige Lin, Kenneth K Y Cheng, Aparna Padmanabhan Pravelil, Erfei Song, Karen S L Lam, Aimin Xu; PM20D1 is a circulating biomarker closely associated with obesity, insulin resistance and metabolic syndrome; Eur J Endocrinol 2021 Dec 10;186(2):151-161.
     
  • Chan YH, Schooling CM, Zhao J, Au Yeung SL, Hai JJ, Thomas GN, Cheng KK, Jiang CQ, Wong YK, Au KW, Tang CS, Cheung CYY, Xu A, Sham PC, Lam TH, Lam KS, Tse HF.; Mendelian Randomization Focused Analysis of Vitamin D on the Secondary Prevention of Ischemic Stroke; Stroke 2021 Dec;52(12):3926-3937. doi: 10.1161/STROKEAHA.120.032634. 
     
  • Yap DYH, Li PH, Tang C, So BYF, Kwan LPY, Chan GCW, Lau CS, Chan; Long-term results of triple immunosuppression with tacrolimus added to mycophenolate and corticosteroids in the treatment of lupus nephritis; Kidney International Reports (2022), doi: https://doi.org/10.1016/j.ekir.2021.12.005.
     
  • Zhang Z, Guo L, Huang L, Zhang C, Luo R, Zeng L, Liang H, Li Q, Lu X, Wang X, Ma CY, Shao J, Luo W, Li L, Liu L, Li Z, Zhou X, Zhang X, Liu J, Yang J, Kwan KY, Liu W, Xu Y, Jiang H, Liu H, Du H, Wu Y, Yu G, Chen J, Wu J, Zhang J, Liao C, Chen HJ, Chen Z, Tse HF, Xia H, Lian Q.; Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells; Clin Infect Dis 2021 Dec 6;73(11):e4154-e4165. doi: 10.1093/cid/ciaa1911.
     
  • Wong CKH, Lui DTW, Lui AYC, Kwok ACY, Low MCH, Lau KTK, Au ICH, Xiong X, Chung MSH, Lau EHY, Cowling BJ.; Use of DPP4i reduced odds of clinical deterioration and hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: propensity score analysis of a territory-wide cohort in Hong Kong; Diabetes Metab 2021 Dec 1;101307. doi: 10.1016/j.diabet.2021.101307
     
  • Lee CO, Li HL, Tsoi MF, Cheung CL, Cheung BMY.; Association between the liver fat score (LFS) and cardiovascular diseases in the national health and nutrition examination survey 1999-2016; Ann Med 2021 Dec;53(1):1065-1073. doi: 10.1080/07853890.2021.1943514.
     
  • Li B, Leung JCK, Chan LYY, Li HY, Yiu WH, Lok SWY, Xue R, Zou YX, Chen W, Lai KN, Tang SCW.; Tubule-specific deletion of LincRNA-p21 ameliorates lipotoxic kidney injury; Mol Ther Nucleic Acids 2021 Nov 4;26:1280-1290. doi: 10.1016/j.omtn.2021.10.029.
     
  • Mak LY, Hoang J, Jun DW, Chen CH, Peng CY, Yeh ML, Kim SE, Huang DQ, Jeong JY, Yoon E, Oh H, Tsai PC, Huang CF, Ahn SB, Trinh H, Xie Q, Wong GLH, Enomoto M, Shim JJ, Lee DH, Liu L, Kozuka R, Cho YK, Jeong SW, Kim HS, Trinh L, Dao A, Huang R, Hui RW, Tsui V, Quek S, Khine HHTW, Ogawa E, Dai CY, Huang JF, Cheung R, Wu C, Chuang WL, Lim SG, Yu ML, Yuen MF, Nguyen MH; Longitudinal renal changes in chronic hepatitis B patients treated with entecavir versus TDF: a REAL-B study; Hepatol Int 2021 Nov 25. doi: 10.1007/s12072-021-10271-x.
     
  • Jiang F, Guo CG, Cheung KS, Leung WK.; Long-term risk of upper gastrointestinal bleeding after Helicobacter pylori eradication: a population-based cohort study; Aliment Pharmacol Ther 2021 Nov;54(9):1162-1169. doi: 10.1111/apt.16604. Epub 2021 Sep 16.
  • Guo CG, Jiang F, Cheung KS, Li B, Ooi PH, Leung WK.; Timing of prior exposure to antibiotics and failure of Helicobacter pylori eradication: a population-based study; J Antimicrob Chemother 2021 Nov 13;dkab415. doi: 10.1093/jac/dkab415. 
     
  • Liang Y, Du R, Chen R, Chu PH, Ip MSM, Zhang KYB, Mak JCW.; Therapeutic potential and mechanism of Dendrobium officinale polysaccharides on cigarette smoke-induced airway inflammation in rat; Biomed Pharmacother 2021 Nov;143:112101. doi: 10.1016/j.biopha.2021.112101. Epub 2021 Aug 30.
     
  • Lui MM, Tse HF, Lam DC, Lau KK, Chan CW, Ip MS.; Continuous positive airway pressure improves blood pressure and serum cardiovascular biomarkers in obstructive sleep apnoea and hypertension; Eur Respir J 2021 Nov 4;58(5):2003687. doi: 10.1183/13993003.03687-2020. Print 2021 Oct.
  • Huang J, Xu J, Lai JHC, Chen Z, Lee CY, Mak HKF, Chan KH, Chan KWY.; Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis; Neuroimage Clin 2021;32:102867. doi: 10.1016/j.nicl.2021.102867. Epub 2021 Oct 28.
     
  • Huang J, Xu J, Lai JHC, Chen Z, Lee CY, Mak HKF, Chan KH, Chan KWY.; Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis; Neuroimage Clin 2021 Oct 28;32:102867. doi: 10.1016/j.nicl.2021.102867
  • Rui Chen, Charalambos Michaeloudes, Yingmin Liang, Pankaj K Bhavsar, Kian Fan Chung, Mary S M Ip, Judith C W Mak; ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells; J Allergy Clin Immunol 2021 Oct 5;S0091-6749(21)01514-1. doi: 10.1016/j.jaci.2021.09.028.
  • Gane E, Yuen MF, Kim DJ, Chan HL, Surujbally B, Pavlovic V, Das S, Triyatni M, Kazma R, Grippo JF, Buatois S, Lemenuel-Diot A, Krippendorff BF, Mueller H, Zhang Y, Kim HJ, Leerapun A, Lim TH, Lim YS, Tanwandee T, Kim W, Cheng W, Hu TH, Wat C.; Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B; Hepatology. 2021 Oct;74(4):1795-1808. doi: 10.1002/hep.31920. Epub 2021 Aug 25.PMID: 34037271
  • Feng Q, Tsoi MF, Fei Y, Cheung CL, Cheung BMY.; Use of ticagrelor and the risks of pneumonia and pneumonia-specific death in patients with non-acute coronary syndrome conditions: a population-based cohort study; Sci Rep 2021 Oct 14;11(1):20468. doi: 10.1038/s41598-021-00105-z.
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  • Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, Xia Z, Ye D, Guo J, Tse MA, Panagiotou G, Xu A. Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention.  Cell Metab. 2020 Jan 7;31(1):77-91.
  • Mak LY. Switching from tenofovir disoproxil fumarate to tenofovir alafenamide: perhaps not as simple as we thought. Lancet Gastroenterol Hepatol 2020 [in press]
  • Chui ETF, Tsang HHL, Lee KH, Lau CS, Wong CH, Chung HY. MRI inflammation of facet and costovertebral joints is associated with restricted spinal mobility and worsened functional status. Rheumatology (Oxford). 2020 Jan 31. pii: kez649. doi: 10.1093/rheumatology/kez649.
  • Chong CK, Cheng CYS, Tsoi SYJ, Huang FY, Liu F, Fung J, Seto WK, Lai KK, Lai CL, Yuen MF, Wong DK. HBV X protein mutations affect HBV transcription and association of histone-modifying enzymes with covalently closed circular DNA. Sci Rep. 2020 Jan 21;10(1):802. doi: 10.1038/s41598-020-57637-z
  • Zhang C, Lam SSY, Leung GMK, Tsui SP, Yang N, Ng NKL, Ip HW, Au CH, Chan TL, Ma ESK, Yip SF, Lee HKK, Lau JSM, Luk TH, Li W, Kwong YL, Leung AYH. Sorafenib and omacetaxine mepesuccinate as a safe and effective treatment for acute myeloid leukemia carrying internal tandem duplication of Fms-like tyrosine kinase 3. Cancer. 2020 Jan 15;126(2):344-353.
  • Chan YH, Ngai MC, Chen Y, Wu MZ, Yu YJ, Zhen Z, Lai K, Cheung T, Ho LM, Chung HY, Lau CS, Tse HF, Yiu KH. Cumulative Rheumatic Inflammation Modulates the Bone-Vascular Axis and Risk of Coronary Calcification. J Am Heart Assoc. 2019 Jun 4;8(11):e011540.
  • Chau YP, Cheng YC, Sing CW, Tsoi MF, Cheng VK, Lee GK, Cheung CL, Cheung BMY. The lipid-lowering effect of once-daily soya drink fortified with phytosterols in normocholesterolaemic Chinese: a double-blind randomized controlled trial.  Eur J Nutr. 2019 Oct 23. doi: 10.1007/s00394-019-02119-w.
  • Cheung CYY, Lee CH, Tang CS, Xu A, Au KW, Fong CHY, Ng KKK, Kwok KHM, Chow WS, Woo YC, Yuen MMA, Hai J, Tan KCB, Lam TH, Tse HF, Sham PC, Lam KSL.Genetic Regulation of Pigment Epithelium-Derived Factor (PEDF): An Exome-Chip Association Analysis in Chinese Subjects With Type 2 Diabetes. Diabetes. 2019 Jan;68(1):198-206.
  • Cheung KS, Chan EW, Chen L, Seto WK, Wong ICK, Leung WK. Diabetes Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study With Propensity Score Analysis. Diabetes Care. 2019;42(9):1769-1775.
  • Cheung KS, Chan EW, Wong AYS, Chen L, Seto WK, Wong ICK, Leung WK. Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication. J Natl Cancer Inst. 2019 May 1;111(5):484-489
  • Cheung KS, Chan EW, Chen L, Seto WK, Wong ICK, Leung WK. Diabetes mellitus increases risk of gastric cancer after Helicobacter pylori eradication: a territory-wide study with propensity score analysis. Diabetes Care 2019 [epub ahead of print] (2018 impact factor 15.270)
  • Cheung KS, Chen L, Chan EW, Seto WK, Wong ICK, Leung WK. Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187897 patients. Gut 2019 [epub ahead of print] (2018 impact factor 17.943)
  • Chu JYS, Chau MKM, Chan CCY, Tai ACP, Cheung KF, Chan TM, Yung S*. miR-200c Prevents TGF-beta1-Induced Epithelial-to-Mesenchymal Transition and Fibrogenesis in Mesothelial Cells by Targeting ZEB2 and Notch1. Mol Ther Nucleic Acids 2019; 17: 78-91.
  • Cheung KS, Chen L, Seto WK, Leung WK. Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Asia: a population-based study. J Gastroenterol Hepatol 2019 [epub ahead of print] (2018 impact factor 3.632)
  • Geng L, Liao B, Jin L, Huang Z, Triggle CR, Ding H, Zhang J, Huang Y, Lin Z, Xu A. Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. Cell Rep. 2019 Mar 5;26(10):2738-2752.e4
  • Gill H, Ip HW, Yim R, Tang WF, Pang HH, Lee P, Leung GMK, Li J, Tang K, So JCC, Leung RYY, Li J, Panagioutou G, Lam CCK, Kwong YL. Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis. Ann. Hematol. 2019; 98(4): 869-879
  • Gill H, Kumana CR, Yim R, Hwang YY, Chan TS, Yip SF, Lee HK, Mak V, Lau JS, Chan CC, Kho B. Oral arsenic trioxide incorporation into frontline treatment with all?trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5?year prospective study. Cancer. 2019 May 15. [Epub]
  • Guo CG, Chen L, Chan EW, Cheung KS, Isshiki T, Wong ICK, Leung WK. Systematic review with meta-analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel. Aliment Pharmacol Ther. 2019 Jan;49(1):7-19
  • Fung J, Mak LY, Chan AC, et al. Model for end-stage liver disease with additional criteria to predict short-term mortality in severe flares in chronic hepatitis B. Hepatology 2019 [In press]
  • Fei Y, Tsoi MF, Cheung BMY. Cardiovascular outcomes in trials of new antidiabetic drug classes: a network meta-analysis.  Cardiovasc Diabetol. 2019 Aug 28;18(1):112. doi: 10.1186/s12933-019-0916-z.
  • Guo CG, Cheung KS, Zhang F, Chan EW, Chen L, Wong IC, Leung WK. Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori: a territory-wide cohort study. Gut. 2019 May 17. pii: gutjnl-2019-318352.
  • Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2019 Apr 14:1-24.
  • Guo CG, Cheung KS, Zhang F, Chan EW, Chen L, Wong ICK, Leung WK. Risks of hospitalization for upper gastrointestinal bleeding in users of selective serotonin reuptake inhibitors after Helicobacter pylori eradication therapy: a propensity score matching analysis. Aliment Pharmacol Ther. 2019 Nov;50(9):1001-1008. doi: 10.1111/apt.15507. Epub 2019 Oct 3.
  • Jian M, Kwan JS, Bunting M, Ng RC, Chan KH. Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway. J Neuroinflammation. 2019 May 25;16(1):110.
  • Ko KL, To WP, Mak LY, Seto WK, Ning Q, Fung J, Lai CL, Yuen MF. A large real-world cohort study examining the effects of long-term entecavir on hepatocellular carcinoma and HBsAg seroclearance. J Viral Hepat. 2020 Apr;27(4):397-406. doi: 10.1111/jvh.13237. Epub 2019 Dec 9.
  • Kwok HH, Ning Z, Chong PW, Wan TS, Ng MH, Ho GYF, Ip MS, Lam DC. Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma. Cancers (Basel). 2019 Jan 17;11(1)
  • Kwok WC, Liang BM, Lui MM, Tam TC, Sim JP, Tse EW, Leung AY, Kwong YL, Lie AK, Ip MS,Lam DC. Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome.Respirology2019 Jan 20.(In press)
  • Lam SK, Yan S, Xu S, U KP, Cheng PN, Ho JC*. Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma. Oncogenesis 2019 Feb 26;8(3):18. doi: 10.1038/s41389-019-0128-0.
  • Lee CH, Cheung CYY, Woo YC, Lui DTW, Yuen MMA, Fong CHY, Chow WS, Xu A, Lam KSL. Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes. Diabetologia. 2019 Jan;62(1):169-177
  • Li B, Leung JCK, Chan LYY, Yiu WH, Li Y, Lok SWY, Liu WH, Chan KW, Tse HF, Lai KN, Tang SCW. Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury. Stem Cells Transl Med. 2019 Sep;8(9):898-910
  • Leung GMK, Zhang C, Ng NKL, Yang N, Lam SSY, Au CH, Chan TL, Ma ESK, Tsui SP, Ip HW, So JCC, Ng MHL, Cheng KCK, Wong KF, Siu LLP, Yip SF, Lin SY, Lau JSM, Luk TH, Lee HKK, Lau CK, Kho B, Kwong YL, Leung AYH. Distinct mutation spectrum, clinical outcome and therapeutic responses of typical complex/monosomy karyotype acute myeloid leukemia carrying TP53 mutations. Am J Hematol. 2019 Jun;94(6):650-657. doi: 10.1002/ajh.25469. Epub 2019 Apr 16.
  • Li C, Yap DYH, Chan G, Wen YB, Li H, Tang C, Li XM, Li XW, Chan TM*. Clinical outcomes and clinico-pathological correlations in lupus nephritis with kidney biopsy showing thrombotic microangiopathy. J Rheumatology and Clinical Immunologytol,2019.
  • Li Z, Wong KY, Calin GA, Chng WJ, Chan GC, Chim CS. Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact. Clin Epigenetics. 2019 May 7;11(1):71.
  • Li PH et al. Beta-lactam allergy in Chinese and factors predicting genuine allergy. World Allergy Organ J. 2019; 12(8): 100048.
  • Liu F, Seto WK, Wong DK, Huang FY, Cheung KS, Mak LY, Sharma R, Zhang S, Fung J, Lai CL, Yuen MF. Plasma Fibronectin Levels Identified via Quantitative Proteomics Profiling Predicts Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B. J Infect Dis. 2019 Aug 9;220(6):940-950
  • Liu KSH, Seto WK, Lau EHY, Wong DK, Lam YF, Cheung KS, Mak LY, Ko KL, To WP, Law MWK, Wu JT, Lai CL, Yuen MF. A Territorywide Prevalence Study on Blood-Borne and Enteric Viral Hepatitis in Hong Kong. J Infect Dis. 2019 May 24;219(12):1924-1933.
  • Mak LY, Lee CH, Cheung KS, Wong DK, Liu F, Hui RW, Fung J, Xu A, Lam KS, Yuen MF, Seto WK. Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long-term nucleoside analogue. Liver Int. 2019 Jul;39(7):1217-1225.
  • Ma ZY, Law WL, Ng EKO, Chan CSY, Lau KS, Cheng YY, Shin VY, Kwong A, Leung WK. Methylated Septin 9 and Carcinoembryonic Antigen for Serological Diagnosis and Monitoring of Patients with Colorectal Cancer After Surgery.  Sci Rep. 2019 Jul 17;9(1):10326. doi: 10.1038/s41598-019-46876-4.
  • Mak LY, Wong DK, Seto WK, Ning Q, Cheung KS, Fung J, Lai CL, Yuen MF. Correlation of serum Mac-2-binding protein glycosylation isomer (M2BPGi) and liver stiffness in chronic hepatitis B infection. Hepatol Int. 2019 Mar;13(2):148-156
  • Mak LY, Seto WK, Hui RW, Fung J, Wong DK, Lai CL, Yuen MF. Fibrosis evolution in chronic hepatitis B e antigen-negative patients across a 10-year interval. J Viral Hepat. 2019 Jul;26(7):818-827.
  • Pan Y, Hui X, Hoo RLC, Ye D, Chan CYC, Feng T, Wang Y, Lam KSL, Xu A. Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation. J Clin Invest. 2019 Feb 1;129(2):834-849.
  • Pang SYY, Ho PWL, Liu HF, Leung CT, Li LF, Chang EES, Ramsden DB, Ho SL. The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease. Translational Neurodegeneration. 2019
  • Siew LQC*, Li PH* et al. Identifying Low-risk Beta-Lactam allergy Patients in a UK Tertiary Centre. J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2173-2181.e1.
  • To WP, Mak LY, Wong DK, Fung J, Liu F, Seto WK, Lai CL, Yuen MF.  Hepatitis B core-related antigen levels after HBeAg seroconversion is associated with the development of hepatocellular carcinoma. J Viral Hepat. 2019 Dec;26(12):1473-1480. doi: 10.1111/jvh.13191. Epub 2019 Sep 2.
  • Wang Y, Lee MYK, Mak JCW, Ip MSM. Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice. Diabetes Metab J. 2019 Apr 23.
  • Wong DK, Cheng SCY, Mak LL, To EW, Lo RC, Cheung TT, Seto WK, Fung J, Man K, Lai CL, Yuen MF. Among Patients with Undetectable Hepatitis B Surface Antigen and Hepatocellular Carcinoma, a High Proportion Has Integration of HBV DNA into Hepatocyte DNA and No Cirrhosis. Clin Gastroenterol Hepatol. 2020 Feb;18(2):449-456. doi: 10.1016/j.cgh.2019.06.029. Epub 2019 Jun 25.
  • Wu MZ, Chen Y, Zou Y, Zhen Z, Yu YJ, Liu YX, Yuen M, Ho LM, Siu-Ling Lam K, Tse HF, Yiu KH. Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus. Eur Heart J Cardiovasc Imaging. 2019 Jul 1;20(7):816-827
  • Yap DYH, Tam CH, Yung S, Wong S, Tang CSO, Mok TMY, Yuen CKY, Ma MKM, Lau CS, Chan TM*. Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis. Nephrol Dial Transplant,2019.
  • Xu S, Lam SK, Cheng PN, Ho JC*. Contactin 1 modulates pegylated arginase resistance in small cell lung cancer through induction of epithelial-mesenchymal transition. Sci Rep 2019 Aug 19;9(1):12030.
  • Yap DYH, Kwan LPY, Ma MKM, Mok MMY, Chan GCW, Chan TM*. Preemptive immunosuppressive treatment for asymptomatic serological reactivation may reduce Rehabilitation Medicine flares in patients with lupus nephritis: a cohort study. Nephrol Dial Transplant 2019; 34: 467-473.
  • Yuen MF, Gane EJ, Kim DJ, Weilert F, Chan HLY, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N. Antiviral activity, safety, and pharmacokinetics of capsid assembly modulator NVR 3-778 in patients with chronic HBV infection. Gastroenterology 2019;156(5):1392-1403.
  • Yim LY, Lau CS, Chan VS. Heightened TLR7/9-Induced IL-10 and CXCL13 Production with Dysregulated NF-ҝB Activation in CD11chiCD11b+ Dendritic Cells in NZB/W F1 Mice. Int J Mol Sci. 2019 Sep 19;20(18). pii: E4639. doi: 10.3390/ijms20184639.
  • Yuen MF, Gane EJ, Kim DJ, Weilert F, Yuen Chan HL, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N. Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection. Gastroenterology. 2019 Apr;156(5):1392-1403.e7.
  • Zhang C, Chan CCY, Cheung KF, Chau MKM, Yap DYH, Ma MKM, Chan KW, Yung S, Chan TM. Effect of mycophenolate and rapamycin on renal fibrosis in lupus nephritis. Clin Sci (Lond). 2019 Aug 5;133(15):1721-1744.
  • Yuen MF, Schiefke I, Yoon JH, Ahn SH, Heo J, Kim JH, Lik Yuen Chan H, Yoon KT, Klinker H, Manns M, Petersen J, Schluep T, Hamilton J, Given BD, Ferrari C, Lai CL, Locarnini SA, Gish RG. RNA Interference Therapy With ARC-520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection. Hepatology. 2019 Oct 26. doi: 10.1002/hep.31008.