Achievement Highlights
The Department of Medicine, School of Clinical Medicine is at the frontier of the discovery of cutting-edge medical research findings. Our academics are recognized globally for their research contribution, having published influential publications with high-impact factors.International Recognition
Highly Cited Researchers (by Clarivate Analytics)
Two scholars from the Department of Medicine, School of Clinical Medicine have been named on the list of Highly Cited Researchers 2024:
This annual list by Clarivate Analytics recognizes researchers whose publications rank among the top 1% globally in terms of citations over the past decade. It serves as a testament to their significant impact within the academic community.
A full list of HKU Highly Cited Researchers 2024 can be found here.
World’s Top 2% Scientists (by Stanford University)
Twenty-seven scholars from the Department of Medicine, School of Clinical Medicine are ranked as the World’s Top 2% scientists in 2024 by Stanford University. The ranking was based on the "Updated science-wide author databases of standardized citation indicators", encompassing various factors such as citations, individual's research output, co-authorship and a composite indicator for career-long citation impact.
- Prof. Henry Chan Hin-lee*
- Prof. Daniel Chan Tak-mao
- Prof. Bernard Cheung Man-yung*
- Prof. Raymond Cheung Tak-fai
- Dr James Chim Chor-sang*
- Prof. Chu Leung-wing*
- Dr James Fung Yan-yue*
- Prof. Ivan Hung Fan-ngai
- Prof. Mary Ip Sau-man*
- Prof. Kwong Yok-lam
- Prof. Annie Kung Wai-chee*
- Prof. Lai Ching-lung*
- Prof. Lai Kar-neng*
- Prof. Karen Lam Siu-ling*
- Prof. Lau Chak-sing
- Dr Lau Chu-pak*
- Prof. Lee Sum-ping*
- Prof. Leung Wai-keung
- Prof. Raymond Liang Hin-suen*
- Prof. Walter Seto Wai-kay
- Prof. David Siu Chung-wah*
- Prof. Kathryn Tan Choon-beng
- Prof. Sydney Tang Chi-wai
- Prof. Tse Hung-fat
- Dr Benjamin Wong Chun-yu*
- Prof. Xu Aimin
- Prof. Yuen Man-fung
This prestigious acknowledgement reaffirms our world-class research standards and highlights the international recognition received by our researchers.
Click here for a complete list of the World’s Top 2% scientists 2024.
*Honorary Professoriate
Recent Impact Publications
2024| Year | Authors & Articles | Impact Factor |
|---|---|---|
| 2024 |
ALT to qHBsAg Ratio Predicts Long-term HBsAg Seroclearance after Entecavir Cessation in Chinese Patients with Chronic Hepatitis B Leung, R.H.M.*, Hui, R.W.H.*, Mak, L.Y., Mao, X.H., Liu, K.S.H., Wong, D.K.H., Fung, J., Seto, W.K.** & Yuen, M.F.** Journal of Hepatology, 81(2), 218-226. |
26.8 |
| 2024 |
Benefit and Harm of Aspirin on Mortality from Gastrointestinal Cancers vs Bleeding in Helicobacter pylori-Eradicated Patients Cheung, K.S.*, Li, B.F., Wong, I.Y.H., Law, S. & Leung, W.K.** Clinical Gastroenterology and Hepatology, 22(9), 1810-1820. |
11.6 |
| 2024 |
Cost-Effectiveness of Biosimilars vs Leflunomide in Patients with Rheumatoid Arthritis Peng, K., Chan, S.C.W., Wang, Y., Cheng, F.W.T., Yeung, W.W.Y., Jiao, Y.S., Chan, E.W.Y., Wong, I.C.K., Lau, C.S. & Li, X.** JAMA Network Open, 7(6), e2418800. |
10.5 |
| 2024 |
Early Renal Dysfunction in Middle-Aged Adults Predicts Fatal and Nonfatal Cardiovascular Events Chan, Y.H.*, Zhao, J.V., Yeung, S.L.A., Wong, Y.K., Au, K.W., Xu, A.M., Lam, T.H., Cheung, B.M.Y., Lam, K.S.L. & Tse, H.F.** Journal of the American College of Cardiology, 83(25), 2711-2713. |
21.7 |
| 2024 |
Effects of Empagliflozin on Liver Fat in Metabolic-Dysfunction Associated Steatotic Liver Disease Patients Without Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial Cheung, K.S.*, Ng, H.Y., Hui, W.H., Lam, L.K., Mak, L.Y., Ho, Y.C., Tan, J.T., Chan, W., Seto, W.K., Yuen, M.F. & Leung, W.K.** Hepatology, 80(4), 916-927. |
14.0 |
| 2024 |
Endocuff With or Without Artificial Intelligence-Assisted Colonoscopy in Detection of Colorectal Adenoma: A Randomized Colonoscopy Trial Lui, K.L.*, Lam, P.M., To, W.P., Ko, K.L., Tsui, W.M., Liu, S.H., Hui, K.Y., Cheung, K.S., Mak, L.Y., Hui, W.H., Wong, S.Y., Seto, W.K. & Leung, W.K.** The American Journal of Gastroenterology, 119(7), 1318-1325. |
10.2 |
| 2024 |
Impact of a Drug Allergy Education Course for Non-Specialists: Findings from ADAPT-A Randomized Crossover Trial Lucas, M., Mak, H.W.F., Lee, J.T.Y., Kulkarni, R., Chan, S.S.C. & Li, P.H.** Allergy. Online ahead of print. |
12.6 |
| 2024 |
Long Non-coding RNA NEAT1, NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury Xue, R., Yiu, W.H., Chan, K.W., Lok, S.W.Y., Zou, Y.X., Ma, J.Y., Li, H.Y., Chan, L.Y.Y., Huang, X.R., Lai, K.N., Lan, H.Y. & Tang, S.C.W.** Journal of the American Society of Nephrology, 35(8), 998-1015. |
10.3 |
| 2024 |
Optimal Glycaemic Control and the Reduced Risk of Colorectal Adenoma and Cancer in Patients with Diabetes: A Population-Based Cohort Study |
23.0 |
| 2024 |
Risk of Acute Kidney Injury in Critically-ill Patients with COVID-19 Compared with Seasonal Influenza: A Retrospective Cohort Study Ng, Y., Ip, A., Ng, K.Y., Sin, W.C., Chan, F.W., To, K.W. & Yap, Y.H.** eClinicalMedicine, 70, 102535. |
15.1 |
| 2024 |
Virological Response to Nucleos(t)ide Analogues Treatment in Chronic Hepatitis B Patients is Associated with Bacteroides-dominant Gut Microbiome Zhang, S.S.*, Chau, H.T., Tun, H.M., Huang, F.Y., Wong, D.K.H., Mak, L.Y., Yuen, M.F.** & Seto, W.K.** eBioMedicine, 103, 105101. |
11.1 |
** Staff member as corresponding author
2023
| Year | Authors & Articles | Impact Factor |
|---|---|---|
| 2023 |
A Phase I/II Study of ARO-HSD, an RNA Interference Therapeutic, for the Treatment of Non-Alcoholic Steatohepatitis Mak, L.Y.*, Gane, E., Schwabe, C., Yoon, K.T., Heo, J., Scott, R., Lee, J.H., Lee, J.I., Kweon, Y.O., Weltman, M., Harrison, S.A., Neuschwander-Tetri, B.A., Cusi, K., Loomba, R., Given, B.D., Christianson, D.R., Garcia-Medel, E., Yi, M., Hamilton, J. & Yuen, M.F.** Journal of Hepatology, 78(4), 684-692. |
30.1 |
| 2023 |
Analysis of All-Cause Hospitalization and Death Among Nonhospitalized Patients with Type 2 Diabetes and SARS-CoV-2 Infection Treated with Molnupiravir or Nirmatrelvir-Ritonavir During the Omicron Wave in Hong Kong Lui, D.T.W.*, Chung, M.S.H., Lau, E.H.Y., Lau, K.T.K., Au, I.C.H., Lee, C.H., Woo, Y.C., Wong, C.K.H. & Cowling, B.J. JAMA Network Open, 6(5), e2314393. |
13.4 |
| 2023 |
Cardiovascular Risk in Rheumatoid Arthritis Patients Treated with Targeted Synthetic and Biological Disease-Modifying Antirheumatic Drugs: A Multi-Centre Cohort Study Tong, X.N., Shen, C.Y., Jeon, H., Li, Y.H., Shin, J.Y., Chan, S.C., Yiu, K.H., Pratt, N.L., Ward, M., Lau, C.S., Wong, I.C., Li, X.** & Lai, E.C.C. Journal of Internal Medicine, 294(3), 314-325. |
13.1 |
| 2023 |
Comparative Effectiveness, Safety, and Real-World Outcomes of a Nurse-Led, Protocol-Driven Penicillin Allergy Evaluation from the Hong Kong Drug Allergy Delabelling Initiative (HK-DADI) Kan, A.K.C.*, Hui, H.K.S., Li, T.S., Chiang, V., Wong, J.C.Y., Chan, T.S., Kwan, I.Y.K., Shum, W.Z., Yeung, M.S.C., Au, E.Y.L., Ho, C.T.K., Lau, C.S. & Li, P.H.** Journal of Allergy and Clinical Immunology: In Practice, 11(2), 474-480. |
11.0 |
| 2023 |
Epidemiology, Management, and Treatment Access of Hereditary Angioedema in the Asia Pacific Region: Outcomes from an International Survey Li, P.H.*, Pawankar, R., Thong, B.Y.H., Fok, J.S., Chantaphakul, H., Hide, M., Jindal, A.K., Kang, H.R., Latiff, A.H.A., Lobo, R.C.M., Munkhbayarlakh, S., Nguyen, D.V., Shyur, S.D., Zhi, Y.X. & Maurer, M. Journal of Allergy and Clinical Immunology: In Practice, 11(4):1253-1260. |
11.0 |
| 2023 |
Fibroblastic Reticular Cells in Lymph Node Potentiate White Adipose Tissue Beiging Through Neuro-Immune Crosstalk in Male Mice Cheong, L.Y.*, Wang, B.L.*, Wang, Q., Jin, L.G., Kwok, K.H.M., Wu, X.P., Shu, L.L., Lin, H.G., Chung, S.K., Cheng, K.K.Y., Hoo, R.L.C. & Xu, A.M.** Nature Communications, 14(1), 1213. |
17.7 |
| 2023 |
Global Prevalence of Helicobacter Pylori Infection Between 1980 And 2022: A Systematic Review and Meta-Analysis Li, Y.H., Choi, H., Leung, K., Jiang, F., Graham, D.Y. & Leung, W.K.** Lancet Gastroenterology & Hepatology, 8(6), 553-564. |
45.0 |
| 2023 |
Glycemic Burden and The Risk of Adverse Hepatic Outcomes in Patients with Chronic Hepatitis B with Type 2 Diabetes Mak, L.Y.*, Hui, R.W.H., Lee, C.H., Mao, X.H., Cheung, K.S., Wong, D.K.H., Lui, D.T.W., Fung, J., Yuen, M.F.** & Seto, W.K.** Hepatology, 77(2):606-618. |
17.3 |
| 2023 |
Hepatitis B Virus Pre-genomic RNA and Hepatitis B Core-related Antigen Reductions at Week 4 Predict Favourable Hepatitis B Surface Antigen Response upon Long-term Nucleos(t)ide Analogue in Chronic Hepatitis B Mak, L.Y.*, Wong, D.*, Kuchta, A., Hilfiker, M., Hamilton, A., Chow, N., Mao, X.H., Seto, W.K. & Yuen, M.F.** Clinical and Molecular Hepatology, 29(1), 146-162. |
14.0 |
| 2023 |
Incidence of Diabetes Following COVID-19 Vaccination and SARS-CoV-2 Infection in Hong Kong: A Population-Based Cohort Study Xiong, X., Lui, T.W.*, Chung, S.H., Au, C.H., Lai, T.T., Wan, Y.F., Chui, S.L., Li, X., Cheng, W.T., Cheung, C.L., Chan, W.Y., Lee, C.H., Woo, Y.C., Tan, C.B., Wong, K.H. & Wong, C.K. PLoS Medicine, 20(7), e1004274. |
15.8 |
| 2023 |
Inhibition of PLK4 Remodels Histone Methylation and Activates the Immune Response via the cGAS-STING Pathway in TP53-mutated AML Man, C.H., Lam, W., Dang, C.C., Zeng, X.Y., Zheng, L.C., Chan, N.M., Ng, K.L., Chan, K.C., Kwok, T.H., Ng, C.C., Leung, W.Y., Huen, S.Y., Wong, C.L., So, C.W., Dou, Z., Goyama, S., Bray, M.R., Mak, T.W. & Leung, Y.H.** Blood, 142(23), 2002-2015. |
20.3 |
| 2023 |
Prediabetes is Associated with Increased Risk of Heart Failure Among Patients with Atrial Fibrillation Huang, J.Y., Tse, Y.K., Li, H.L., Chen, C., Zhao, C.T., Liu, M.Y., Wu, M.Z., Ren, Q.W., Yu, S.Y., Hung, D., Li, X.L., Tse, H.F., Lip, G.Y.H. & Yiu, K.H.** Diabetes Care, 46(1), 190-196. |
17.2 |
| 2023 |
Recapitulating Primary Immunodeficiencies with Expanded Potential Stem Cells: Proof of Concept with STAT1 Gain of Function Liu, X., Chan, S.F., Smith, G.C., Ming, C., Or, C.S., Tsui, T.W., Gao, B., Cook, C., Liu, P., Lau, C.S. & Li, H.** The Journal of Allergy and Clinical Immunology, 153(4), 1125-1139. |
14.2 |
| 2023 |
Risk of Autoimmune Diseases Following COVID-19 and the Potential Protective Effect from Vaccination: A Population-Based Cohort Study Peng, K., Li, X.**, Yang, D., Chan, C.W., Zhou, J., Wan, Y.F., Chui, S.L., Lai, T.T., Wong, K.H., Chan, W.Y., Leung, W.K., Lau, C.S. & Wong, C.K. eClinicalMedicine, 63, 102154. |
15.1 |
| 2023 |
Risk of Postcolonoscopy Thromboembolic Events: A Real-World Cohort Study Li, Y.K., Guo, C.G., Cheung, K.S., Liu, K.S.H. & Leung, W.K.** Clinical Gastroenterology and Hepatology, 21(12), 3051-3059. |
13.6 |
| 2023 |
SGLT2i Reduces Risk of Developing HCC in Patients with Co-Existing Type 2 Diabetes and Hepatitis B Infection: A Territory-Wide Cohort Study in Hong Kong |
17.3 |
| 2023 |
Single-cell Transcriptomic Analysis Uncovers Intratumoral Heterogeneity and Drug-Tolerant Persister in ALK-Rearranged Lung Adenocarcinoma Kwok, H.H., Li, H., Yang, J., Deng, J., Lee, C.M., Au, W.K., Sit, K.Y., Hsin, K.Y., Ma, K.Y., Cheung, W.T., Girard, L., Fujimoto, J., Wistuba, I.I., Gao, B., Minna, J.D. & Lam, C.L.** Cancer Communications, 43(8), 951-955. |
16.2 |
| 2023 |
TLR7 Agonist RO7020531 versus Placebo in Healthy Volunteers and Patients with Chronic Hepatitis B Virus Infection: A Randomised, Observer-Blind, Placebo-Controlled, Phase 1 Trial |
71.4 |
** Staff member as corresponding author
2022
| Year | Authors & Articles | Impact Factor |
|---|---|---|
| 2022 |
Autoimmune Conditions Following mRNA (BNT162b2) and Inactivated (CoronaVac) COVID-19 Vaccination: A Descriptive Cohort Study among 1.1 million Vaccinated People in Hong Kong Li, X.*, Gao, L., Tong, X., Chan, K.Y., Chui, S.L., Lai, T.T., Wong, K.H., Wan, Y.F., Chan, W.Y., Lau, K.K., Lau, C.S. & Wong, C.K. Journal of Autoimmunity, 130, 102830. |
12.8 |
| 2022 |
β-Klotho Promotes Glycolysis and Glucose-Stimulated Insulin Secretion via GP130 Geng, L.L.*, Liao, B.Y., Jin, L.G., Yu, J.S., Zhao, X.Y., Zhao, Y.T., Zhong, L., Wang, B.L., Li, J.F., Liu, J., Yang, J.K., Jia, W., Lian, Q.Z. & Xu, A.M.** Nature Metabolism, 4(5), 608-626. |
20.0 |
| 2022 |
Cost-effectiveness of Universal Screening for Chronic Hepatitis B Virus Infection in China: An Economic Evaluation Su, S., Wong, W.C., Zou, Z.R., Cheng, D.D., Ong, J.J., Chan, P.L., Ji, F.P., Yuen, M.F., Zhuang, G.H., Seto, W.K.** & Zhang, L. Lancet Global Health, 10(2), e278-e287. |
39.0 |
| 2022 |
Early Treatment of High-risk Hospitalized Coronavirus Disease 2019 (COVID-19) Patients with A Combination of Interferon Beta-1b and Remdesivir: A Phase 2 Open-label Randomized Controlled Trial Tam, A.R., Zhang, R., Lung, K.C., Liu, R., Leung, K.Y., Liu, D., Fan, Y., Lu, L., Lam, H.Y., Chung, W.H., Yip, C.Y., Lo, J., Wu, K.L., Lee, R., Sin, S., Ng, Y., Chan, W.M., Shum, H.P., Yan, W.W., Chan, F.W., Cheng, C.C., Lau, C.S., To, K.W., Chan, K.H., Yuen, K.Y. & Hung, F.N.** Clinical Infectious Diseases, 76(3), e216-e226. |
11.8 |
| 2022 |
Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection Yuen, M.F.*, Lim, S.G., Plesniak, R., Tsuji, K., Janssen, H.L.A., Pojoga, C., Gadano, A., Popescu, C.P., Stepanova, T., Asselah, T., Diaconescu, G., Yim, H.J., Heo, J., Janczewska, E., Wong, A., Idriz, N., Imamura, M., Rizzardini, G., Takaguchi, K., Andreone, P., Arbune, M., Hou, J.L., Park, S.J., Vata, A., Cremer, J., Elston, R., Lukic, T., Quinn, G., Maynard, L., Kendrick, S., Plein, H., Campbell, F., Paff, M., Theodore, D. & B-Clear Study Group. New England Journal of Medicine, 387(21), 1957-1968. |
176.1 |
| 2022 |
Evaluation of Fracture Risk Among Patients with Type 2 Diabetes and Nonvalvular Atrial Fibrillation Receiving Different Oral Anticoagulants Lui, D.T.W.*, Tang, E.H.M., Au, I.C.H., Wu, T.T., Lee, C.H., Wong, C.K., Cheung, C.Y.Y., Fong, C.H.Y., Chow, W.S., Woo, Y.C., Tan, K.C.B., Lam, K.S.L. & Wong, C.K.H. Diabetes Care, 45(11), 2620-2627. |
17.2 |
| 2022 |
FGF21-Srtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity Jin, L.G.*, Geng, L.L.*, Ying, L., Shu, L.L., Ye, K., Yang, R.Y., Liu, Y., Wang, Y., Cai, Y., Jiang, X., Wang, Q., Yan, X.Q., Liao, B.Y., Liu, J., Duan, F.Y., Sweeney, G., Woo, C.W.H., Wang, Y., Xia, Z.Y., Lian, Q.Z. & Xu, A.M.** Circulation, 146(20), 1537-1557. |
40.0 |
| 2022 |
Kidney Outcomes Associated with Sodium-Glucose Cotransporter 2 Inhibitors Versus Glucagon-Like Peptide 1 Receptor Agonists: A Real-World Population-Based Analysis Lui, D.T.W.*, Au, I.C.H., Tang, E.H.M., Cheung, C.L., Lee, C.H., Woo, Y.C., Wu, T.T., Tan, K.C.B. & Wong, C.K.H. eClinicalMedicine, 50, 101510 |
17.0 |
| 2022 |
Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared with Viral Myocarditis Lai, F.T.T., Chan, E.W.W., Huang, L., Cheung, C.L., Chui, C.S.L., Li, X., Wan, E.Y.F., Wong, C.K.H., Chan, E.W.Y., Yiu, K.H.** & Wong, I.C.K. Journal of the American College of Cardiology, 80(24), 2255-2265. |
27.2 |
| 2022 |
Prospective Study on the Efficacy and Impact of Cascade Screening and Evaluation of Hereditary Angioedema (CaSE-HAE) Wong, J.C.Y., Chiang, V., Lam, K., Tung, E., Au, E.Y.L., Lau, C.S. & Li, P.H.** Journal of Allergy and Clinical Immunology: In Practice, 10(11), 2896-2903. |
11.0 |
| 2022 |
Regulation of Proton Partitioning in Kinase-Activating Acute Myeloid Leukemia and Its Therapeutic Implication Man, C.H., Zeng, X.Y., Lam, W., Ng, T.C.C., Kwok, T.H., Dang, K.C.C., Leung, T.W.Y., Ng, N.K.L., Lam, S.S.Y., Cher, C.Y. & Leung, A.Y.H.** Leukemia, 36(8), 1990-2001. |
13.0 |
| 2022 |
Risk of Thyroid Dysfunction Associated with mRNA and Inactivated COVID-19 Vaccines: A Population-Based Study of 2.3 million Vaccine Recipients Wong, C.K.H., Lui, D.T.W.*, Xiong, X., Chui, C.S.L., Lai, F.T.T., Li, X., Wan, E.Y.F., Cheung, C.L., Lee, C.H., Woo, Y.C., Au, I.C.H., Chung, M.S.H., Cheng, F.W.T., Tan, K.C.B. & Wong, I.C.K. BMC Medicine, 20(1), 339. |
11.8 |
| 2022 |
Two-dose COVID-19 Vaccination and Possible Arthritis Flare Among Patients with Rheumatoid Arthritis in Hong Kong Li, X.*, Tong, X.N., Yeung, W.W.Y., Kuan, P., Yum, S.H.H., Chui, C.S.L., Lai, F.T.T., Wan, E.Y.F., Wong, C.K.H., Chan, E.W.Y., Lau, C.S. & Wong, I.C.K. Annals of the Rheumatic Diseases, 81(4), 564-568. |
28.0 |
** Staff member as corresponding author
