Prof LEUNG Wai Keung

Prof WK Leung

Li Shu Fan Medical Foundation Professor in Gastroenterology
Associate Dean (Research), Li Ka Shing Faculty of Medicine, The University of Hong Kong

  • MBChB, MD, MRCP, FRCP(Edin), FRCP(Lond), FHKCP, FHKAM(Med)
Research Profile
  1. Screening and early detection of gastrointestinal cancers
  2. Inflammatory bowel diseases
  3. Gastrointestinal bleeding
  4. Helicobacter pylori
  5. Application of big data on gastrointestinal diseases
  6. Computer-assisted endoscopic diagnosis

Selected Publications
  1. Cheung KS, Chan EW, Chen L, Seto WK, Wong ICK, Leung WK. Diabetes Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study With Propensity Score Analysis. Diabetes Care. 2019;42(9):1769-1775.
  2. Guo CG, Cheung KS, Zhang F, Chan EW, Chen L, Wong IC, Leung WK. Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori: a territory-wide cohort study. Gut. 2019 May 17. pii: gutjnl-2019-318352.
  3. Cheung KS, Chen L, Chan EW, Seto WK, Wong ICK, Leung WK. Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients. Gut. 2019 Feb 26. pii: gutjnl-2018-317714.
  4. Cheung KS, Chan EW, Wong AYS, Chen L, Seto WK, Wong ICK, Leung WK. Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication. J Natl Cancer Inst. 2019;111(5):484-489.
  5. Leung WK, Wong IOL, Cheung KS, Yeung KF, Chan EW, Wong AYS, Chen L, Wong ICK, Graham DY. Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals. Gastroenterology 2018 Mar 14. pii: S0016-5085(18)30322-6. 
  6. Cheung KS, Chan EW, Wong AY, Chen L, Seto WK, Wong ICK, Leung WK. Aspirin and risk of gastric cancer after Helicobacter pylori eradication: A territory-wide study. J Natl Cancer Inst 2018;110(7);djx267
  7. Cheung KS, Chan EW, Wong AYS, Chen L, Wong ICK, Leung WK. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study. Gut 2018;67:28-35
  8. Liu KS, Hung IF, Seto WK, Tong T, Hsu AS, Lam FY, But DY, Wong SY, Leung WK. Ten day sequential versus 10 day modified bismuth quadruple therapy as firstline and secondline treatment for Helicobacter pylori in Chinese patients: an open label randomized crossover trial. Gut 2014;63:1410-5
  9. Leung WK, Wu MS, Kakugawa Y, Kim JJ, Yeoh KG, Goh KL, Wu KC, Wu DC, Sollano J, Kachitorm U, Gotoda T, Lin JT, You WC, Ng EK, Sung JJ, and the Asia Pacific Working Group on Gastric Cancer. Screening for gastric cancer in Asia: Current evidence and practice. Lancet Oncol 2008;9:279-287
  10. Lau JYW, Leung WK, Wu JCY, Chan FKL. Wong VWS, Chiu PWY, Lee VWY, Lee KKC, Cheung FKY, Siu P, Ng EKW, Sung JJY. Omeprazole before endoscopy in patients with gastrointestinal bleeding. N Engl J Med 2007;356:1631-40.

Grant Record
Grants as Principal Investigator:
  1. A prospective randomized trial to compare the safety and immunogenicity of intradermal and intramuscular influenza vaccines in patients with inflammatory bowel disease in Hong Kong. Health & Medical Research Fund 2013
  2. Molecular characterization of gastric microbiome in individuals at different stages of H. pylori associated gastric carcinogenesis cascade. RGC GRF 2013
  3. Detection of methylated septin 9 DNA in blood for diagnosis, prognosis and surveillance of patients with colorectal cancer. Health & Medical Research Fund 2014

Key Offices
  1. Associate Dean (Human Capital), Li Ka Shing Faculty of Medicine, University of Hong Kong (2018 – 2019)
  2. Assistant Dean (Platform Technologies), Li Ka Shing Faculty of Medicine, University of Hong Kong (2015-2018)
  3. Deputy Chairman, Institutional Review Board, Hong Kong West-University of Hong Kong
  4. Co-Director, Integrated Endoscopy Center, Queen Mary Hospital
  5. Member, Scientific Committee on Enteric Infections and Foodborne Diseases of the Centre for Health Protection, Department of Health, Hong Kong SAR Government
  6. Chairman, Credential Subcommittee, Licentiate Committee, Hong Kong Medical Council
  7. Past President, Hong Kong IBD Society (2013 – 2015)

Editorial Board Memberships
  1. Best Practice & Research – Clinical Gastroenterology
  2. Helicobacter
  3. Journal of Digestive Diseases