Professor LEUNG Wai Keung

Prof WK Leung

Li Shu Fan Medical Foundation Professor in Gastroenterology

  • MBChB, MD, MRCP, FRCP(Edin), FRCP(Lond), FHKCP, FHKAM(Med)
Research Profile
  1. Screening and early detection of gastrointestinal cancers
  2. Inflammatory bowel diseases
  3. Gastrointestinal bleeding
  4. Helicobacter pylori
  5. Application of big data on gastrointestinal diseases
  6. Computer-assisted endoscopic diagnosis

Selected Publications
  1. Li Y, Choi H, Leung K, Jiang F, Graham DY, Leung WK. Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2023 Apr 19:S2468-1253(23)00070-5.
  2. Wang L, Yao H, Morgan DC, Lau KS, Leung SY, Ho JWK, Leung WK. Altered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori. Nat Commun. 2023 Apr 17;14(1):2196.
  3. Li YK, Guo CG, Cheung KS, Liu KSH, Leung WK. Risk of Postcolonoscopy Thromboembolic Events: A Real-World Cohort Study. Clin Gastroenterol Hepatol. 2022 Sep 24:S1542-3565(22)00919-3.
  4. Guo CG, Cheung KS, Zhang F, Chan EW, Chen L, Wong ICK, Leung WK. Delay in Retreatment of Helicobacter pylori Infection Increases Risk of Upper Gastrointestinal Bleeding. Clin Gastroenterol Hepatol. 2021 Feb;19(2):314-322.e2.
  5. Cheung KS, Lam LK, Seto WK, Leung WK. Use of Antibiotics during Immune Checkpoint Inhibitor Treatment Is Associated with Lower Survival in Hepatocellular Carcinoma. Liver Cancer. 2021 Aug 18;10(6):606-614.
  6. Lui TKL, Leung K, Guo CG, Tsui VWM, Wu JT, Leung WK. Impacts of the Coronavirus 2019 Pandemic on Gastrointestinal Endoscopy Volume and Diagnosis of Gastric and Colorectal Cancers: A Population-Based Study. Gastroenterology. 2020 Sep;159(3):1164-1166.e3.
  7. Cheung KS, Hung IFN, Chan PPY, Lung KC, Tso E, Liu R, Ng YY, Chu MY, Chung TWH, Tam AR, Yip CCY, Leung KH, Fung AY, Zhang RR, Lin Y, Cheng HM, Zhang AJX, To KKW, Chan KH, Yuen KY, Leung WK. Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis. Gastroenterology. 2020 Jul;159(1):81-95.
  8. Guo CG, Cheung KS, Zhang F, Chan EW, Chen L, Wong IC, Leung WK. Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori: a territory-wide cohort study. Gut 2020 Mar;69(3):445-452.
  9. Cheung KS, Chan EW, Chen L, Seto WK, Wong ICK, Leung WK. Diabetes Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study With Propensity Score Analysis. Diabetes Care. 2019;42(9):1769-1775.
  10. Cheung KS, Chan EW, Wong AYS, Chen L, Seto WK, Wong ICK, Leung WK. Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication. J Natl Cancer Inst. 2019 May 1;111(5):484-489.
  11. Cheung KS, Chen L, Chan EW, Seto WK, Wong ICK, Leung WK. Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients. Gut. 2019 Nov;68(11):1979-1985
  12. Leung WK, Wong IOL, Cheung KS, Yeung KF, Chan EW, Wong AYS, Chen L, Wong ICK, Graham DY. Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals. Gastroenterology 2018 Mar 14. pii: S0016-5085(18)30322-6. 
  13. Cheung KS, Chan EW, Wong AYS, Chen L, Seto WK, Wong ICK, Leung WK. Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study. J Natl Cancer Inst. 2018 Jul 1;110(7):743-749.
  14. Cheung KS, Chan EW, Wong AYS, Chen L, Wong ICK, Leung WK. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study. Gut 2018;67:28-35
  15. Seto WK, Mak SK, Chiu K, Vardhanabhuti V, Wong HF, Leong HT, Lee PSF, Ho YC, Lee CK, Cheung KS, Yuen MF, Leung WK. Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users. J Hepatol. 2018 Jul;69(1):121-128.
  16. Liu KS, Hung IF, Seto WK, Tong T, Hsu AS, Lam FY, But DY, Wong SY, Leung WK. Ten day sequential versus 10 day modified bismuth quadruple therapy as firstline and secondline treatment for Helicobacter pylori in Chinese patients: an open label randomized crossover trial. Gut 2014;63:1410-5
  17. Leung WK, Wu MS, Kakugawa Y, Kim JJ, Yeoh KG, Goh KL, Wu KC, Wu DC, Sollano J, Kachitorm U, Gotoda T, Lin JT, You WC, Ng EK, Sung JJ, and the Asia Pacific Working Group on Gastric Cancer. Screening for gastric cancer in Asia: Current evidence and practice. Lancet Oncol 2008;9:279-287

Grant Record
Grants as Principal Investigator:
  1. A prospective randomized trial to compare the safety and immunogenicity of intradermal and intramuscular influenza vaccines in patients with inflammatory bowel disease in Hong Kong. Health & Medical Research Fund 2013
  2. Molecular characterization of gastric microbiome in individuals at different stages of H. pylori associated gastric carcinogenesis cascade. RGC GRF 2013
  3. Detection of methylated septin 9 DNA in blood for diagnosis, prognosis and surveillance of patients with colorectal cancer. Health & Medical Research Fund 2014

Key Offices
  1. Chief Director, Clinical Trial Center, University of Hong Kong (2020-2025)
  2. Associate Dean (Research), LKS Faculty of Medicine, University of Hong Kong (2020-2024)
  3. Associate Dean (Human Capital), LKS Faculty of Medicine, University of Hong Kong (2018-2019)
  4. Co-Director, Integrated Endoscopy Centre, Queen Mary Hospital (2011-2021)
  5. President, Hong Kong IBD Society (2013-2015)
  6. President, Hong Kong Society of Gastroenterology (2022-2024)
  7. Treasurer, Asia Pacific Association of Gastroenterology (2023-2025)

Editorial Board Memberships
  1. Endoscopy
  2. Helicobacter
  3. Journal of Digestive Diseases