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Professor CHEUNG Tak Fai, Raymond

Prof RTF Cheung

Lee Man Chiu Professor in Neuroscience

  • MBBS(HK), MRCP(UK), FRCP (Edin, Glasg, Lond), FHKCP, FHKAM(Medicine), FAHA, FAAN, FESO, FRSM
email rtcheung@hku.hk
email 2255-4049
email HKU Scholar Hub
Biography
Professor Raymond Cheung is Clinical Professor of Division of Neurology at Department of Medicine, School of Clinical Medicine, The University of Hong Kong. He is Director of Acute Stroke Services at Hong Kong West Cluster and Honorary Consultant Neurologist of Queen Mary Hospital, Tung Wah Hospital and Hong Kong Sanatorium & Hospital. He is also Honorary Professor of First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. He is Warden of Lee Hysan Hall, The University of Hong Kong.

Professor Cheung received his medical degree from The University of Hong Kong in 1987 and obtained his degree of Doctor of Philosophy from The University of Western Ontario, London, Canada in 1996. He was Medical & Health Officer at Department of Radiotherapy and Oncology of Queen Mary Hospital from 1988 to 1989 before joining Department of Medicine of Queen Mary Hospital in July 1989. He completed his basic physician training and obtained the qualification of Membership of Royal Colleges of Physicians of United Kingdom in 1991. He started his neurology training at the Queen Mary Hospital, Hong Kong, and completed the training at the University Hospital, London, Canada. He was accredited by Hong Kong College of Physicians in Advanced Internal Medicine as of January 1996 and in Neurology as of January 1995. He has been registered as a Specialist in Neurology at Medical Council of Hong Kong since March 1998.

Professor Cheung joined Department of Medicine of The University of Hong Kong in July 1996 as Assistant Professor. He was appointed Associate Professor in December 1988 and Clinical Professor in January 2006. Professor Cheung was endowed Lee Man-Chiu Professorship in Neuroscience in May 2008. In relation to his clinical and research expertise, he was admitted as Fellow of a number of professional bodies: Stroke Council of American Heart Association in 1996, Hong Kong College of Physicians in September 1996, Hong Kong Academy of Medicine in January 1997, Royal College of Physicians of Edinburgh in September 1999, Royal Society of Medicine in February 2000, Royal College of Physicians and Surgeons of Glasgow in October 2000, American Stroke Association in July 2001, Royal College of Physicians of London in May 2002, American Academy of Neurology in November 2004, European Stroke Council in September 2005, and European Stroke Organization in January 2008. He was awarded the prestigious Sir David Todd Lectureship in 2005. He was Assistant Dean in External Affairs & Fund Raising of Faculty of Medicine, The University of Hong Kong from 2006 to 2008.

Professor Cheung was a Member of Specialty Board in Neurology, Hong Kong College of Physicians, from 2003 to 2013 and the Regional Program Director of Hong Kong Island for the Specialty Board in Neurology from 2007 to 2011. He was President of the Hong Kong Stroke Society from 2007 to 2009, President of the Hong Kong Neurological Society from 2004 to 2006, Vice Chairman of the Hong Kong Brain Foundation from 2000 to 2011, Council Member of the Hong Kong Pain Society from 2006 to 2011, Membership Committee Member of the World Federation of Neurology from 2006 to 2011, Executive Committee Member of the Asian Headache Foundation from 2005 to 2008, and Member of the International Brain Research Organization Committee for Clinical/Basic Science Links Program from 2004 to 2007. He is/was also Honorary Advisor of a number of community organizations: Hong Kong Neuro-Muscular Disease Association, Hong Kong Society for Rehabilitation, Hong Kong Museum of Medical Societies, Hong Kong Parkinson Disease Association, and Charles K. Kao Foundation for Alzheimer's Disease. He is a member of North Point West Area Committee of Eastern District Office and Public Affairs Forum of Home Affairs Bureau, Steering Committee on Centre of Excellence in Neuroscience of Food and Health Bureau, Central Committee on Stroke Services and Task Force on Development of Neuroscience Centre of Hospital Authority.

Research Profile
Professor Cheung's main research interest is stroke and cerebrovascular disease. He has an established track record in experimental research. He is also interested in research on headache and central nervous system infections. He has published 156 journal articles, 5 books, 26 book chapters, 1 monograph and 20 extended abstracts. He is a regular reviewer of 59 international journals and a regular reviewer of 3 local/regional journals. He is/was also an editorial board member of 13 international journals and 2 regional journals, including Stroke, Chinese version of Stroke and Journal of Pineal Research.

Professor Cheung is very enthusiastic about participating in contemporary international multi-center clinical trials. He is/was principal investigator of the 26 multicentre international trials. He is/was also principal investigator of the several local clinical trials. He has been successful in competitive external grant applications. In addition, he has received generous donations from individuals, non-pharmaceutical organizations and pharmaceutical companies.

Selected Publications
  1. Sang YH, Liang YX, Liu LG, Ellis-Behnke RG, Wu WT, So KF, Cheung RTF. A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection. Experimental Animals 2013; 62(1): 63-69.
  2. Gao J, Cheung RTF, Chan YS, Chu LW, Lee TM. Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed. Neuropsychology, Development and Cognition. Section B: Aging, Neuropsychology and Cognition 2013; 20(1): 80-100.
  3. Sang YH, Su HX, Wu WT, So KF, Cheung RTF. Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury. Journal of Neurotrauma 2011; 28(12): 2523-2534.
  4. Tso AW, Lam TK, Xu A, Yiu KH, Tse HF, Li LS, Law LS, Cheung BM, Cheung RTF, Lam KS. Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death. Neurology 2011; 76(23): 1968-1975.
  5. Gao J, Cheung RTF, Lee TM, Chu LW, Chan YS, Mak HK, Zhang JX, Qiu D, Fung G, Cheung C. Possible retrogenesis observed with fiber tracking: An anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer's disease. Journal of Alzheimers Disease 2011; 26(1): 47-58.
  6. Cheung RTF, Lyden PD, Tsoi TH, Huang Y, Liu M, Hon SFK, Raman R, Liu L. Production and validation of Putonghua- and Cantonese-Chinese language National Institutes of Health Stroke Scale training and certification videos. International Journal of Stroke 2010; 5(2): 74-79.
  7. Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. An fMRI study showing effect of acupuncture in chronic stage stroke patients with aphasia. Journal of Acupuncture & Meridian Studies 2010; 3(1): 53-57.
  8. Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. Increased brain activation in motor cortex after acupuncture treatment for motor recovery in chronic stroke patients. The Open Rehabilitation Journal 2009; 2(1): 89-94.
  9. Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. Acupuncture of motor-implicated acupoints on subacute stroke: a fMRI study. Medical Acupuncture 2009; 21(4): 233-241.
  10. Yu J, Zeng J, Cheung RTF, Xiong L, He M, Liang Z, Hong H, Huang R. Intracerebroventricular injection of epidermal growth factor reduces neurological deficit and infarct volume and enhances nestin expression following focal cerebral infarction in adult hypertensive rats. Clinical and Experimental Pharmacology and Physiology 2009; 36(5-6): 539-546.
  11. Cheung RTF. Sexual dysfunctions after stroke: a need for more study. European Journal of Neurology 2008; 15(7): 641.
  12. Cheung RTF. Update on medical and surgical management of intracerebral hemorrhage. Reviews on Recent Clinical Trials 2007; 2(3): 174-181.
  13. Cheung RTF, Tipoe GL, Tam S, Ma ESK, Zou LY, Chan PS. Preclinical evaluation of pharmacokinetics and safety of melatonin in propylene glycol for intravenous administration. Journal of Pineal Research 2006; 41(4): 337-343.
  14. Zou LY, Cheung RTF, Liu SR, Li G, Huang L. Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice. Journal of Pineal Research 2006; 41(2): 150-156.
  15. Chen SH, Cheung RTF. Neuropeptide Y and its receptor analogs differentially modulate the immunoreactivity for neuronal or endothelial nitric oxide synthase in the rat brain following focal ischemia with reperfusion. Journal of Biomedical Science 2005; 12(2): 267-278.
  16. Chen SH, Cheung RTF. Neuropeptide Y-Y1 receptor agonist worsens while antagonist improves survival of cultured Y1-expressing neuronal cells following oxygen and glucose deprivation. Journal of Biomedical Science 2004; 11(6): 781-788.
  17. Pei Z, Cheung RTF. Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model. Journal of Pineal Research 2004; 37(2): 85-91.
  18. Li G, Huang L, Cheung RTF, Liu SR, Ma QY, Yang ES. Cortical activations upon stimulation of the sensorimotor-implicated acupoints. Magnetic Resonance Imaging 2004; 22(5): 639-644.
  19. Cheung RTF, Hachinski V. Cardiac effects of stroke. Current Treatment Options in Cardiovascular Medicine 2004; 6(3): 199-207.
  20. Chan KH, Cheung RTF, Fong CY, Tsang KL, Mak W, Ho SL. Clinical relevance of hydrocephalus as a presenting feature of tuberculous meningitis. Quarterly Journal of Medicine 2003; 96(9): 643-648.
  21. Cheung RTF, Eliasziw M, Meldrum HE, Fox AJ, Barnett HJM, the North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group. Risk, types, and severity of intracranial hemorrhage in patients with symptomatic carotid artery stenosis. Stroke 2003; 34(8): 1847-1851.
  22. Cheung RTF, Zou LY. Use of the original, modified or new Intracerebral Hemorrhage Score to predict mortality and morbidity after intracerebral hemorrhage. Stroke 2003; 34(7): 1717-1722.
  23. Li G, Cheung RTF, Ma QY, Yang ES. Visual cortical activations on fMRI upon stimulation of the vision-implicated acupoints. NeuroReport 2003; 14(5): 669-673.
  24. Pei Z, Pang SF, Cheung RTF. Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Stroke 2003; 34(3): 770-775.
  25. Pei Z, Cheung RTF. Melatonin protects SHSY5Y neuronal cells but not cultured astrocytes from ischemia due to oxygen and glucose deprivation. Journal of Pineal Research 2003; 34(3): 194-201.
  26. Cheung RTF. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. Journal of Pineal Research 2003; 34(3): 153-160.
  27. Cheung RTF, Hachinski V. Cardiac rhythm disorders and muscle changes with cerebral lesions. Advances in Neurology 2003; 92(1): 213-220.
  28. Li G, Liu HL, Cheung RTF, Hung YC, Wong KKK, Shen GGX, Ma QY, Yang ES. A functional MRI study comparing brain activation between word generation and electrical stimulation of language-implicated acupoints. Human Brain Mapping 2003; 18(3): 233-238.
  29. Pei Z, Fung PCW, Cheung RTF. Melatonin reduces nitric oxide level during ischemia but not blood-brain-barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. Journal of Pineal Research 2003; 34(2): 110-118.
  30. Chen SH, Cheung RTF. Intracerebroventricular injection of a neuropeptide Y-Y1 receptor agonist increases while BIBP3226, a Y1 antagonist, reduces the infarct volume following transient middle cerebral artery occlusion in rats. Neuroscience 2003; 116(1): 119-126.
  31. Cheung RTF, Pei Z, Feng ZH, Zou LY. Cyclooxygenase-1-gene knockout does not alter middle cerebral artery occlusion in a mouse stroke model. Neuroscience Letters 2002; 330(1): 57-60.
  32. Cheung RTF. Sexual functioning in Chinese stroke patients with mild or no disability. Cerebrovascular Diseases 2002; 14(2): 122-128.
  33. Chen SH, Fung PCW, Cheung RTF. Neuropeptide Y-Y1 receptor modulates nitric oxide level during stroke in the rat. Free Radical Biology and Medicine 2002; 32(8): 776-784.
  34. Pei Z, Pang SF, Cheung RTF. Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Journal of Pineal Research 2002; 32(3): 168-172.
  35. Chen SH, Cheung RTF. Peripheral and central administration of neuropeptide Y in a rat middle cerebral artery occlusion stroke model reduces cerebral blood flow and increases infarct volume. Brain Research 2002; 927(2): 138-143.
  36. Pei Z, Ho HTS, Cheung RTF. Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat. Neuroscience Letters 2002; 318(3): 141-144.
  37. Cheung RTF. Hong Kong patients' knowledge of stroke does not influence time-to-hospital presentation. Journal of Clinical Neuroscience 2001; 8(4): 311-314.
  38. Cheung RTF, Mak W, Chan KH. Circadian variation of stroke onset among Hong Kong Chinese: a hospital-based study. Cerebrovascular Diseases 2001; 12(1): 1-6.
  39. Cheung RTF, Li LSW, Tsang KL, Leung KP. Stroke prevention in atrial fibrillation among Hong Kong Chinese. Cerebrovascular Diseases 2001; 11(4): 353-354.
  40. Cheung RTF, Hachinski V. The insula and cerebrogenic sudden death. Archives of Neurology 2000; 57(12): 1685-1688.
  41. Cheung RTF, Cechetto DF. Neuropeptide Y-Y1 receptor antisense oligodeoxynucleotide increases the infarct volume after middle cerebral artery occlusion in rats. Neuroscience 2000; 98(4): 771-777.
  42. Cheung RTF. Prevalence of migraine, tension-type headache, and other headaches in Hong Kong. Headache 2000; 40(6): 473-479.
  43. Cheung RTF, Li LSW, Mak W, Tsang KL, Lauder IJ, Chan KH, Fong GCY. Knowledge of stroke in Hong Kong Chinese. Cerebrovascular Diseases 1999; 9(2): 119-123.

Key Offices
  1. Cluster Director of Acute Stroke Services, Hong Kong West Cluster Hospitals
  2. Honorary Professor, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou
  3. Past President, Hong Kong Stroke Society
  4. Past President, Hong Kong Neurological Society