Prof SETO Wai Kay, Walter

Dr Seto

Clinical Professor

  • MBBS(HK) MD(HK) MRCP (UK) FRCP (Edin, Glasg, Lond) FHKCP FHKAM (Medicine)
Biography

Prof. Wai-Kay Seto graduated from the University of Hong Kong in 2003 and received his Fellowship in Gastroenterology and Hepatology in 2010 from the Hong Kong College of Physicians. He received his Doctor of Medicine from the University of Hong Kong in 2012. He is currently a Clinical Professor in the Department of Medicine and Principal Investigator of the State Key Laboratory of Liver Disease, the University of Hong Kong, Hong Kong. He is also Assistant Hospital Chief Executive (Research) and Medical Director, Clinical Trials Center of the University of Hong Kong-Shenzhen Hospital, Shenzhen, China.

Prof. Seto is currently ranked by Clarivate Analytics in the top 1% worldwide by research. He has published more than 190 international journal articles and book chapters, including leading-authored articles in the Lancet, Journal of Clinical Oncology, Nature Reviews Gastroenterology & Hepatology, Journal of Hepatology, Gut, Hepatology and American Journal of Gastroenterology, majority related to research on chronic liver diseases. He has secured a total of over 20 million HKD in external competitive grant funding, has over 80 local, regional and international invited lectureships. He is a principal investigator of 10 phase I-III international industry-sponsored clinical trials.

Prof. Seto has been awarded the Sir David Todd Lectureship, Hong Kong College of Physicians (2019); the Asia-Pacific Digestive Week Emerging Leader from the APDW Federation (2018); Faculty Knowledge Exchange Award (2018), The University of Hong Kong; Guangdong Province Outstanding Young Medical Talent Award (2017); Outstanding Young Research Award (2016-2017) from The University of Hong Kong; and the Distinguished Young Fellow (2013) from the Hong Kong Academy of Medicine. 


Research Profile
  • Chronic hepatitis B: Translational and clinical studies on treatment outcomes and functional cure
  • Non-alcoholic fatty liver disease: Animal models and molecular mechanisms
  • Liver fibrosis: Novel non-invasive diagnostic techniques and clinical outcomes
  • Gut microbiota and fecal microbiota transplantation: Animal models and associations with disease outcomes
  • Artificial intelligence: Deep machine learning and its application in liver diseases

Selected Publications
  1. Seto WK, Lo YR, Pawlotsky JP, Yuen MF. Chronic hepatitis B virus infection. Lancet 2018; 392:2313-2324 (2019 impact factor 60.392).
  2. Seto WK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Lie AK, Lai CL, Kwong YL, Yuen MF. Hepatitis B reactivation in patients with prior HBV exposure undergoing rituximab-containing chemotherapy for lymphoma: a prospective study. J Clin Oncol 2014; 32: 3736-43. (2019 impact factor 32.956).
  3. Seto WK, Yuen MF.“Immune tolerance” in HBV infection: danger lurks. Nat Rev Gastroenterol Hepatol 2016 44: 1071-1079. (2019 impact factor 23.570)
  4. Mak LY, Hui RW, Fung J, Liu F, Wong DK, Cheung KS, Yuen MF, Seto WK. Diverse effects of hepatic steatosis on fibrosis progression and functional cure in virologically quiescent chronic hepatitis B. J Hepatol 2020; 73: 800-806 (2019 impact factor 20.582).
  5. Seto WK, Mak SK, Chiu K, Vardhanabhuti V, Wong HF, Leong HT, Lee PS, Ho YC, Lee CK, Cheung KS, Yuen MF, Leung WK. Magnetic resonance cholangiogram patterns and clinical profiles of ketamine-related cholangiopathy in drug users. J Hepatol 2018; 69:121-8 (2019 impact factor 20.582).
  6. Seto WK, Liu K, Wong DK, Fung J, Huang FY, Hung IF, Lai CL, Yuen MF. Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment. J Hepatol 2013; 4:709-16. (2019 impact factor 20.582)
  7. Seto WK, Liu KS, Mak LY, Cloherty G, Wong DK, Gersch J, Lam YF, Cheung KS, Chow N, Ko KL, To WP, Fung J, Yuen MF. Role of serum HBV RNA and hepatitis B surface antigen levels in identifying Asian chronic hepatitis B patients suitable for entecavir cessation. Gut 2020 in press (2019 impact factor 19.819).
  8. Seto WK, Hui AJ, Wong VW, Wong GL, Liu K, Lai CL, Yuen MF, Chan HL. Treatment cessation of entecavir in Asian patients with hepatitis B e antigen negative chronic hepatitis B: a multicenter prospective study. Gut 2015; 64: 667-72. (2019 impact factor 19.819)
  9. Seto WK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Lau HY, Cheung KS, Lie AK, Lai CL, Kwong YL, Yuen MF. Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: a prospective study. Hepatology 2017 65:1451-61 (2019 impact factor 14.679)
  10. Seto WK, Wong DK, Fung J, Huang FY, Lai CL, Yuen MF. Reduction of hepatitis B surface antigen levels and HBsAg seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy. Hepatology 2013; 58: 923-31. 61 (2019 impact factor 14.679)
  11. Seto WK, Wong DK, Chan TS, Hwang YY, Wong DK, Fung J, Liu K, Gill H, Lam YF, Cheung KS, Lie AK, Lai CL, Kwong YL, Yuen MF.Association of hepatitis B core-related antigen with hepatitis B virus reactivation in occult viral carriers undergoing high-risk immunosuppressive therapy. Am J Gastroenterol 2016; 111:1788-1795. (2019 impact factor 10.171)

Key Offices
  1. Assistant Hospital Chief Executive (Research), The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
  2. Medical Director, Clinical Trials Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
  3. Committee Member, World Gastroenterology Organization (Young Members Committee)
  4. Principal Investigator, State Key Laboratory of Liver Disease, The University of Hong Kong
  5. Council Member, Hong Kong Society of Gastroenterology, Hong Kong
  6. Council Member, Hong Kong Association for the Study of Liver Disease, Hong Kong
  7. Council Member, Hong Kong Liver Foundation, Hong Kong
  8. Member, Advanced Internal Medicine Assessment Board, Hong Kong College of Physicians, Hong Kong
  9. Consultant and Chief of Division in Gastroenterology, Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
  10. Honorary Consultant, Medicine, Queen Mary Hospital, Hong Kong

Esteem Measures

1. Sir David Todd Lectureship (2019), Hong Kong College of Physicians

2. Asia Pacific Digestive Week Emerging Leader (2018), APDW Federation

3. Faculty Knowledge Exchange Award (2018), The University of Hong Kong

4. Outstanding Young Researcher Award (2016-2017), The University of Hong Kong

5. Guangdong Province Outstanding Young Medial Talent Award (2017), Guangdong Health Commission, Guangdong Province, China

6. Esteemed Staff Award (2017), Shenzhen Health and Family Planning Commission, Shenzhen, China

7. Distinguished Research Paper Award for Young Investigator (2015), Hong Kong College of Physicians

8. Distinguished Research Paper Award for Young Investigator (2014), Hong Kong College of Physicians

9. Distinguished Research Paper Award for Young Investigator (2013), Hong Kong College of Physicians

10. Distinguished Young Fellow (2013), Hong Kong Academy of Medicine

11. Distinguished Research Paper Award for Young Investigator (2012), Hong Kong College of Physicians

 


Editorial Board Memberships
  • World Journal of Gastroenterology
  • PLOS ONE
  • Hong Kong Medical Journal

Competitive Research Grants as Principal Investigator

- Health and Medical Research Fund (Commissioned Research Program), Food and Health Bureau, 2020 (ref no: COVID190220, HKD 2,082,272)

- Innovation and Technology Fund, 2019 (ref no: ITS/122/18FP, HKD 4,712,540)

- Guangdong Natural Science Fund (General Program), 2019 (ref no: 2019A1515012003, HKD 111,170)

- Gilead Sciences CHIME Grant, 2018 (ref no: ISR-CN-18-10455, HKD 2,183,290)

- S. K. Yee Medical Foundation Grant, 2018 (ref no: 2171213, HKD 987,050)

- Li Shu Pui Medical Foundation Research Grant, 2018 (HKD 1,494,584)

- Health and Medical Research Fund, Food and Health Bureau, 2017 (ref no: 14150791, HKD 1,171,260)

- General Research Fund, Research Grant Council, 2016 (ref no: 17125916, HKD 766,864)

- Beat Drug Fund, Security Bureau, 2015 (ref no: 140031, HKD 984,920)

- S. K. Yee Medical Foundation Grant, 2015 (ref no: 2151210, HKD 189,900)

- S. K. Yee Medical Foundation Grant, 2014 (ref no: 2141213 HKD 717,780)

- Health and Medical Research Fund, Food and Health Bureau, 2013 (ref no: 12111842, HKD 951,960)

- Young Investigator Research Grant 2012, Hong Kong College of Physicians (HKD 50,000)