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Professor WONG Chun Ka (黃浚嘉)

Dr Wong Chun-Ka

Clinical Assistant Professor
Specialist in Cardiology

  • MBBS(HK), MRCP(UK), FHKCP, FHKAM(Medicine)
email wongeck@hku.hk
email 2255-3597
email ORCID
Biography

 Prof. Chun-Ka Wong is Clinical Assistant Professor in Cardiology at the University of Hong Kong and an Honorary Specialist at Queen Mary Hospital, Hong Kong. Prof. Wong obtained his Bachelor of Medicine and Bachelor of Surgery degree from the University of Hong Kong in 2015. He is currently a Visiting Researcher at the Cambridge Stem Cell Institute in the United Kingdom.

Prof. Wong underwent training in structural heart intervention at Queen Mary Hospital, Hong Kong. He played a significant role in establishing the electrosurgery program at the center and was part of the team that invented the UNICORN technique for valve-in-valve TAVI with coronary obstruction risk. Since 2022, he has served as the co-director of the Hong Kong Valves conference. In 2023, Prof. Wong and the Hong Kong Valves team founded the Electrosurgery Classroom, the first dedicated symposium for transcatheter electrosurgical techniques in the Asia Pacific region.

Prof. Wong's research interests include atrial fibrillation and stem cells. He has published over 50 articles in peer-reviewed journals, including Nature Medicine, Circulation and the Journal of the American College of Cardiology (JACC).

Prof. Wong and his research team have been pioneers in cardiovascular diagnostics. They were the first to demonstrate the feasibility of low-cost atrial fibrillation screening using smartphone cameras and photoplethysmography (PPG). Additionally, they developed a smartphone application that automatically extracts electrocardiogram (ECG) voltage-time signals and determines cardiac rhythm diagnosis from photos of ECGs taken by clinicians, using computer vision and deep learning approaches.

Prof. Wong possesses extensive experience in utilizing human-induced pluripotent stem cells (iPSC) and their derived cells for disease modelling and translational therapies. In the early phase of the Coronavirus Disease 2019 (COVID-19) pandemic, Prof. Wong and his colleagues revealed the pathogenic mechanisms of COVID-19-associated myocardial injury using iPSC-derived cardiomyocytes and studied the effects of cardiometabolic medications on the disease phenotype. Currently, Prof. Wong focuses on mechanistic studies and therapeutic strategies for newly emerged disease entities, such as myocarditis from mRNA vaccines and emerging infectious diseases.

黃浚嘉教授是香港大學心臟科臨床助理教授及瑪麗醫院名譽專科醫生。黃教授於2015年在香港大學取得內外全科醫學士學位。他現為劍橋幹細胞研究所訪問研究員。

黃教授在瑪麗醫院接受了結構性心臟介入治療的培訓，並參與團隊引入導管電切割手術（Transcatheter Electroaurgery）的技術。黃教授是開發UNICORN技術用於有冠狀動脈阻塞風險的瓣中瓣經導管主動脈瓣置換術（TAVI）的團隊成員之一。自2022年起，他擔任香港瓣膜會議（Hong Kong Valves）的聯合主席。2023年，黃教授和香港瓣膜團隊創立了導管電切割手術教室（Electrosurgery Classroom），這是亞太地區第一個專門針對此專門技術的研討會。

黃教授的研究興趣包括心房顫動和幹細胞。他在學術期刊上發表了超過50篇文章，包括《Nature Medicine》、《Circulation》和《Journal of the American College of Cardiology》。

黃教授及其研究團隊在心血管診斷方面一直走在前沿。他們首次證明了使用智能手機攝像頭和光體積描記法（PPG）進行低成本心房顫動篩查的可行性。此外，他們開發了一款智能手機應用程序，該程序使用計算機視覺和深度學習方法，自動從臨床醫生拍攝的心電圖照片中提取心電圖電壓-時間信號並確定心律診斷。

黃教授在利用人類誘導多能幹細胞（iPSC）及其衍生細胞進行疾病建模和轉化治療方面擁有豐富的經驗。在2019年冠狀病毒病（COVID-19）大流行的早期階段，黃教授和他的同事們使用iPSC衍生的心肌細胞揭示了與COVID-19相關的心肌損傷的致病機制，並研究了心臟代謝藥物對疾病表型的影響。目前，黃教授專注於新出現疾病實體的機制研究和治療策略，例如mRNA疫苗和新興傳染病引起的心肌炎。


Selected publications
  1. Cheang I, Yao W, Zhou Y, Zhu X, Ni G, Lu X, Liao S, Gao R, Zhou F, Shen J, Leung AYL, Jiang M, Kong H, Bai L, Mahemuti A, Yuan H, Dong YG, Wong CK, Xu Q, Zhang G, Wu J, Lu Q, Zhang J, Cha C, Ren Q, Fu L, Wang B, Xu Y, Hu H, Dong J, Shang Z, Yu C, Li S, Yao C, Gao L, Zhang H, Rosenzweig A, Jia Z, Li X; QUEST Trial Committees and Investigators. The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial. Nat Med. 2024 Aug 2.
  2. Chan PH, Wong CK, Pun L, Wong YF, Wong MM, Chu DW, Siu CW. Head-to-Head Comparison of the AliveCor Heart Monitor and Microlife WatchBP Office AFIB for Atrial Fibrillation Screening in a Primary Care Setting. Circulation. 2017 Jan 3;135(1):110-112.
  3. Chan PH, Wong CK*, Poh YC, Pun L, Leung WW, Wong YF, Wong MM, Poh MZ, Chu DW, Siu CW. Diagnostic Performance of a Smartphone-Based Photoplethysmographic Application for Atrial Fibrillation Screening in a Primary Care Setting. J Am Heart Assoc. 2016 Jul 21;5(7):e003428. (*Co-first author)
  4. Poh MZ, Poh YC, Chan PH, Wong CK, Pun L, Leung WW, Wong YF, Wong MM, Chu DW, Siu CW. Diagnostic assessment of a deep learning system for detecting atrial fibrillation in pulse waveforms. Heart. 2018 Dec;104(23):1921-1928.
  5. Wong CK, Lau YM, Lui HW, Chan WF, San WC, Zhou M, Cheng Y, Huang D, Lai WH, Lau YM, Siu CW. Automatic Detection of Cardiac Conditions from Photos of Electrocardiogram (ECG) Captured by Smartphones. Heart. 2024. (in-press)
  6. Wong CK, Un KC, Zhou M, Cheng Y, Lau YM, Shea PC, Lui HW, Zuo ML, Yin LX, Chan EW, Wong ICK, Sin SWC, Yeung PPN, Chen H, Wibowo S, Wei TLN, Lee SM, Chow A, Tong RCF, Hai J, Tam FCC, Siu CW. Daily Ambulatory Remote Monitoring System for Drug Escalation in Chronic Heart Failure with Reduced Ejection Fraction: Pilot Phase of DAVID-HF Study. Eur Heart J Digit Health. 2022 May 7;3(2):284-295.
  7. Wong CK, Luk HK, Lai WH, Lau YM, Zhang RR, Wong AC, Lo GC, Chan KH, Hung IF, Tse HF, Woo PC, Lau SK, Siu CW. Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to Study SARS-CoV-2 Related Myocardial Injury. Circ J. 2020 Oct 23;84(11):2027-2031.
  8. Wong CK, Lau YM, Lai WH, Zhang RR, Luk HK, Wong AC, Woo PC, Lau SK, Chan KH, Hung IF, Siu CW. Angiotensin converting enzyme and sodium glucose cotransporter inhibitors alleviate inflammatory effects of SARS-CoV-2 in cardiomyocytes. Cardiol J. 2022 May 17.
  9. Chan KYE, Chan DTL, Lam CCS, Sze MSY, Un KC, Tam CCF, Lam YM, Wong CK*. First-in-Human Undermining Iatrogenic Coronary Obstruction With Radiofrequency Needle (UNICORN) Procedure During Valve-in-Valve Transcatheter Aortic Valve Replacement. Circ Cardiovasc Interv. 2022 Oct 21:e012399. (*Co-corresponding author)
  10. Ngan HT, Chan KY, Wong CK, Un KC, Sze SY, Shea P, Lam CC, Lam YM, Tam CC, Lau CP, Tse HF. Temporary Atrioventricular Sequential Conduction System Pacing in Patients With Acute Conduction Abnormalities and Cardiogenic Shock. JACC Clin Electrophysiol. 2023 Jun 29:S2405-500X(23)00392-4.

Grant record
  1. "Glucagon-like Peptide-1 Receptor Agonist for Reduction of Peri-operative Myocardial Injury in Non-cardiac Surgeries: A Randomized Controlled Trial" RGC General Research Fund 2023/24 (HKD 1,072,696; Principal Investigator).
  2. "Safety and effectiveness of cardiovascular drugs in the management of atrial fibrillation with mitral stenosis among Chinese patients: a real-world population-based cohort study" RGC General Research Fund 2023/24 (HKD 1,098,000; Co-investigator)
  3. "Impact of Left Bundle Area Pacing on Tricuspid Valve, Right Ventricular and Liver Function". Health and Medical Research Fund 2023/24. (HKD 941,112;Co-investigator)
  4. "Programmable RNA Pseudouridylation for Premature Termination Codon Suppression as Gene Therapy for Cardiac Laminopathy" Collaborative Research Fund (CRF) 2023/24. (HKD 2,661,362; Co-Principal Investigator)

Awards and Prizes
  • Li Shu Fan Medical Fellowship for Internal Medicine, Li Shu Fan Medical Foundation, Hong Kong
  • Rosie Young Medical Fellowship for Internal Medicine, Sun Chief Yeh Heart Foundation, Hong Kong