High-Impact Publications

2025
Authors & Articles Impact Factor
Asian Pacific Association of Gastroenterology Task Force Recommendations on Surveillance for Helicobacter pylori Associated Gastric Premalignant Conditions
Leung WK*, Ang TL, Shah S, Cheung KS, LI Y, Uedo N, Li WQ, Yeoh KG, Vilaichone RK, Lui TKL, Quach DT, Wang LM, Choi IJ, Suzuki H, Jung HY, Dao HV, Wu K, Boussioutas A, Dinis-Ribeiro M, Lee YC
Gut. 2026;75(4):685-704

26.2
Development and Clinical Validation of a Novel Protein Biomarkers-Based Algorithm for Risk Prediction and Diagnosis of Advanced Liver Fibrosis: A MultiCentre Study. Journal of Advanced Research
Cheung CYY*, Wan P*, Wan H, Xu C, Jia X, Fong CHY, Lui DTW, Song E, Chen X, Chow WS, Woo YC, Tan KCB, Seto WK, Wang C, Shen J, Lam KSL**, Lee CH**, Xu A**
J Adv Res. 2026;84:871-881

13.0
Glycaemic Control is a Modifiable Risk Factor for Pancreatic Cancer Development in Patients with Diabetes: A Population-Based Cohort Study
Tan JT*, Mao X, Lui DTW, Li C, Cheng HM, Leung WK, Seto WK**, Cheung KS**
Gut. 2025;75(1):94-104

26.2
Parathyroidectomy and Risk of Incident Diabetes in Patients with Primary Hyperparathyroidism
Liu X, Lui DTW*, Xiong X, Li L, Luk Y, Wong CH, Lee CH, Wong CKH, Fung MMH, Lang BHH
JAMA Surg. 2025;160(10), 1125-1132

14.9
Stroke-Heart Syndrome and Risk of Incident Dementia Among Patients with First-Ever Ischemic Stroke: A Territory-Wide Population-Based Cohort Study
Tsang CTW*, Choi SE, Bucci T, Lau ACW, Ren QW, Huang JY, Wu MZ, Gu WL, Guo R, Zhang JN, Ng YC, Buckley BJR, Scheitz JF, Chan YH, Lau KK, Tse HF, Abdul-Rahim AH, Lip GYH, Yiu KH**
Alzheimers Dement. 2025;21(9), e70716.

11.1
* Staff member as first author
** Staff member as corresponding author


Recent Impact Publications 2024
Authors & Articles Impact Factor
ALT to qHBsAg Ratio Predicts Long-term HBsAg Seroclearance after Entecavir Cessation in Chinese Patients with Chronic Hepatitis B
Leung RHM*, Hui RWH*, Mak LY, Mao XH, Liu KSH, Wong DKH, Fung J, Seto WK** & Yuen MF**
J Hepatol. 2024; 81(2), 218-226.

26.8
Benefit and Harm of Aspirin on Mortality from Gastrointestinal Cancers vs Bleeding in Helicobacter pylori-Eradicated Patients
Cheung KS*, Li BF, Wong IYH, Law S & Leung WK**
Clin Gastroenterol Hepatol. 2024;22(9), 1810-1820.

11.6
Cost-Effectiveness of Biosimilars vs Leflunomide in Patients with Rheumatoid Arthritis
Peng K, Chan SCW, Wang Y, Cheng FWT, Yeung WWY, Jiao YS, Chan EWY, Wong ICK, Lau CS & Li X**
JAMA Netw Open. 2024;7(6), e2418800.

13.0
Early Renal Dysfunction in Middle-Aged Adults Predicts Fatal and Nonfatal Cardiovascular Events
Chan YH*, Zhao JV, Yeung SLA, Wong YK, Au KW, Xu AM, Lam TH, Cheung BMY, Lam KSL & Tse HF**
J Am Coll Cardiol. 2024;83(25), 2711-2713.

14.9
Effects of Empagliflozin on Liver Fat in Metabolic-Dysfunction Associated Steatotic Liver Disease Patients Without Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial
Cheung KS*, Ng HY, Hui WH, Lam LK, Mak LY, Ho YC, Tan JT, Chan W, Seto WK, Yuen MF & Leung WK**
Hepatology.
 2024;80(4), 916-927.
26.2
Endocuff With or Without Artificial Intelligence-Assisted Colonoscopy in Detection of Colorectal Adenoma: A Randomized Colonoscopy Trial
Lui KL*, Lam PM, To WP, Ko KL, Tsui WM, Liu SH, Hui KY, Cheung KS, Mak LY, Hui WH, Wong SY, Seto WK & Leung WK**
Am J Gastroenterol. 2024;119(7), 1318-1325.

10.2
Impact of a Drug Allergy Education Course for Non-Specialists: Findings from ADAPT-A Randomized Crossover Trial
Lucas M, Mak HWF, Lee JTY, Kulkarni R, Chan SSC & Li PH**
Allergy, 2024;80(2):525-533.
12.6
Long Non-coding RNA NEAT1, NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury
Xue R, Yiu WH, Chan KW, Lok SWY, Zou YX, Ma JY, Li HY, Chan LYY, Huang XR, Lai KN, Lan HY & Tang SCW**
J Am Soc Nephrol. 2024;35(8), 998-1015.

10.3
Optimal Glycaemic Control and the Reduced Risk of Colorectal Adenoma and Cancer in Patients with Diabetes: A Population-Based Cohort Study
Mao XH, Cheung KS**, Tan JT, Mak LY, Lee CH, Chiang CL, Cheng HM, Hui RWH, Yuen MF, Leung WK & Seto WK**
Gut. 2024;73(8), 1313-1320.
23.0
Risk of Acute Kidney Injury in Critically-ill Patients with COVID-19 Compared with Seasonal Influenza: A Retrospective Cohort Study
Ng Y, Ip A, Ng KY, Sin WC, Chan FW. To KW & Yap YH**
EClinicalMedicine. 2024;14:70:102535.

15.1
Virological Response to Nucleos(t)ide Analogues Treatment in Chronic Hepatitis B Patients is Associated with Bacteroides-dominant Gut Microbiome
Zhang SS*, Chau HT, Tun HM, Huang FY, Wong DKH, Mak LY, Yuen MF** & Seto WK**
EBioMedicine. 2024;103: 105101.

11.1
* Staff member as first author
** Staff member as corresponding author


Recent Impact Publications 2023
Authors & Articles Impact Factor
A Phase I/II Study of ARO-HSD, an RNA Interference Therapeutic, for the Treatment of Non-Alcoholic Steatohepatitis
Mak LY*, Gane E, Schwabe C, Yoon KT, Heo J, Scott R, Lee JH, Lee JI, Kweon YO, Weltman M, Harrison SA, Neuschwander-Tetri BA, Cusi K, Loomba R, Given BD, Christianson DR, Garcia-Medel, E., Yi M, Hamilton J. & Yuen MF**
J Hepatol. 2023;78(4), 684-692.

30.1
Analysis of All-Cause Hospitalization and Death Among Nonhospitalized Patients with Type 2 Diabetes and SARS-CoV-2 Infection Treated with Molnupiravir or Nirmatrelvir-Ritonavir During the Omicron Wave in Hong Kong
Lui DTW*, Chung MSH, Lau EHY, Lau KTK, Au ICH, Lee CH, Woo YC, Wong CKH & Cowling BJ
JAMA Netw Open. 2023;6(5), e2314393.
13.4
Cardiovascular Risk in Rheumatoid Arthritis Patients Treated with Targeted Synthetic and Biological Disease-Modifying Antirheumatic Drugs: A Multi-Centre Cohort Study
Tong XN, Shen CY, Jeon H, Li YH, Shin JY, Chan SC, Yiu KH, Pratt NL, Ward M, Lau CS, Wong IC, Li X** & Lai ECC.
J Intern Med. 2023;294(3), 314-325.
13.1
Comparative Effectiveness, Safety, and Real-World Outcomes of a Nurse-Led, Protocol-Driven Penicillin Allergy Evaluation from the Hong Kong Drug Allergy Delabelling Initiative (HK-DADI)
Kan, AKC*, Hui HKS, Li TS, Chiang V, Wong JCY, Chan TS, Kwan IYK, Shum WZ, Yeung MSC, Au EYL, Ho CTK, Lau CS & Li PH**
J Allergy Clin Immunol Pract. 2023;11(2), 474-480.

11.0
Epidemiology, Management, and Treatment Access of Hereditary Angioedema in the Asia Pacific Region: Outcomes from an International Survey
Li PH*, Pawankar R, Thong BYH, Fok JS, Chantaphakul H, Hide M, Jindal AK, Kang HR, Latiff AHA, Lobo RCM, Munkhbayarlakh S, Nguyen DV, Shyur SD, Zhi YX & Maurer M
J Allergy Clin Immunol Pract. 2023;11(4):1253-1260.

11.0
Fibroblastic Reticular Cells in Lymph Node Potentiate White Adipose Tissue Beiging Through Neuro-Immune Crosstalk in Male Mice
Cheong LY*, Wang BL*,Cheong LY*, Wang BL*, Wang Q, Jin LG, Kwok KHM, Wu XP, Shu LL, Lin HG, Chung SK, Cheng KKY, Hoo RLC & Xu AM**
Nat Commun. 2023;14(1), 1213.

17.7
Global Prevalence of Helicobacter Pylori Infection Between 1980 And 2022: A Systematic Review and Meta-Analysis
Li YH, Choi H, Leung K, Jiang F, Graham DY & Leung WK**
Lancet Gastroenterol Hepatol. 8(6), 553-564.

45.0
Glycemic Burden and The Risk of Adverse Hepatic Outcomes in Patients with Chronic Hepatitis B with Type 2 Diabetes
Mak LY*, Hui RWH, Lee CH, Mao XH, Cheung KS, Wong DKH, Lui DTW, Fung J, Yuen MF** & Seto WK**
Hepatology. 77(2):606-618.
 
17.3
Hepatitis B Virus Pre-genomic RNA and Hepatitis B Core-related Antigen Reductions at Week 4 Predict Favourable Hepatitis B Surface Antigen Response upon Long-term Nucleos(t)ide Analogue in Chronic Hepatitis B
Mak LY*, Wong D*, Kuchta A, Hilfiker M, Hamilton A, Chow N, Mao XH, Seto WK & Yuen MF**
Clin Mol Hepatol. 29(1), 146-162.
14.0
Incidence of Diabetes Following COVID-19 Vaccination and SARS-CoV-2 Infection in Hong Kong: A Population-Based Cohort Study
Xiong X, Lui TW*, Chung SH, Au CH, Lai TT, Wan YF, Chui SL, Li X, Cheng WT, Cheung CL, Chan WY, Lee CH, Woo YC, Tan CB, Wong KH & Wong CK
PLoS Medicine, 20(7), e1004274.

15.8
Inhibition of PLK4 Remodels Histone Methylation and Activates the Immune Response via the cGAS-STING Pathway in TP53-mutated AML
Man CH, Lam W, Dang CC, Zeng XY, Zheng LC, Chan NM, Ng KL, Chan KC, Kwok TH, Ng CC, Leung WY, Huen SY, Wong CL, So CW, Dou Z, Goyama S, Bray MR, Mak TW & Leung YH**
Blood, 142(23), 2002-2015.
 
20.3
Prediabetes is Associated with Increased Risk of Heart Failure Among Patients with Atrial Fibrillation
Huang JY, Tse YK, Li HL, Chen C, Zhao CT, Liu MY, Wu MZ, Ren QW, Yu SY, Hung D, Li XL, Tse HF, Lip GYH & Yiu KH**
Diabetes Care, 46(1), 190-196.

17.2
Recapitulating Primary Immunodeficiencies with Expanded Potential Stem Cells: Proof of Concept with STAT1 Gain of Function
Liu X, Chan SF, Smith GC, Ming C, Or CS, Tsui TW, Gao B, Cook C, Liu P, Lau CS & Li H**
J Allergy Clin Immunol, 153(4), 1125-1139.
 
14.2
Risk of Autoimmune Diseases Following COVID-19 and the Potential Protective Effect from Vaccination: A Population-Based Cohort Study
Peng K, Li X**, Yang D, Chan CW, Zhou J, Wan YF, Chui SL, Lai TT, Wong KH, Chan WY, Leung WK, Lau CS & Wong CK
eClinicalMedicine, 63, 102154.
15.1
Risk of Postcolonoscopy Thromboembolic Events: A Real-World Cohort Study
Li YK, Guo CG, Cheung KS, Liu KSH & Leung WK**
Clin Gastroenterol Hepatol. 21(12), 3051-3059.

13.6

SGLT2i Reduces Risk of Developing HCC in Patients with Co-Existing Type 2 Diabetes and Hepatitis B Infection: A Territory-Wide Cohort Study in Hong Kong
Lee CH*, Mak LY*, Tang, EHM, Lui DTW, Mak JHC, Li LL, Wu TT, Chan WL, Yuen MF, Lam KSL & Wong CKH 
Hepatology. 78(5), 1569-1580.

17.3
Single-cell Transcriptomic Analysis Uncovers Intratumoral Heterogeneity and Drug-Tolerant Persister in ALK-Rearranged Lung Adenocarcinoma
Kwok HH, Li H, Yang J, Deng J, Lee CM, Au WK, Sit KY, Hsin KY, Ma KY, Cheung WT, Girard L, Fujimoto J, Wistuba II, Gao B, Minna JD & Lam CL**
Cancer Commun, 43(8), 951-955.

16.2

TLR7 Agonist RO7020531 versus Placebo in Healthy Volunteers and Patients with Chronic Hepatitis B Virus Infection: A Randomised, Observer-Blind, Placebo-Controlled, Phase 1 Trial
Yuen MF*, Balabanska R, Cottreel E, Chen ET. Duan D, Jiang QD, Patil A, Triyatni M, Upmanyu R, Zhu YH, Canducci F & Gane EJ
Lancet Infect Dis, 23(4), 496-507.

71.4
* Staff member as first author
** Staff member as corresponding author




Recent Impact Publications 2022
Authors & Articles Impact Factor
Autoimmune Conditions Following mRNA (BNT162b2) and Inactivated (CoronaVac) COVID-19 Vaccination: A Descriptive Cohort Study among 1.1 million Vaccinated People in Hong Kong
Li X*, Gao L, Tong X, Chan KY, Chui SL, Lai TT, Wong KH, Wan YF, Chan WY, Lau KK, Lau CS & Wong CK
J Autoimmun, 130, 102830.

12.8
β-Klotho Promotes Glycolysis and Glucose-Stimulated Insulin Secretion via GP130
Geng LL*, Liao BY, Jin LG, Yu JS, Zhao XY, Zhao YT, Zhong L, Wang BL, Li JF, Liu J, Yang JK, Jia W, Lian QZ & Xu AM**
Nat Metab, 4(5), 608-626.
20.0
Cost-effectiveness of Universal Screening for Chronic Hepatitis B Virus Infection in China: An Economic Evaluation
Su S, Wong WC, Zou ZR, Cheng DD, Ong JJ, Chan PL, Ji FP, Yuen MF, Zhuang GH, Seto WK** & Zhang, L
Lancet Glob Health, 10(2), e278-e287.

39.0
Early Treatment of High-risk Hospitalized Coronavirus Disease 2019 (COVID-19) Patients with A Combination of Interferon Beta-1b and Remdesivir: A Phase 2 Open-label Randomized Controlled Trial
Tam AR, Zhang R, Lung KC, Liu R, Leung KY, Liu D, Fan Y, Lu L, Lam HY, Chung WH, Yip CY, Lo J, Wu KL, Lee R, Sin S., Ng Y, Chan WM, Shum HP, Yan WW, Chan FW, Cheng CC, Lau CS, To KW, Chan KH, Yuen KY & Hung FN**
Clin Infect Dis, 76(3), e216-e226.

11.8
Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection
Yuen MF*, Lim SG, Plesniak R, Tsuji K, Janssen HLA, Pojoga C, Gadano A, Popescu CP, Stepanova T, Asselah T, Diaconescu G, Yim HJ, Heo J, Janczewska E, Wong A, Idriz N, Imamura M, Rizzardini G, Takaguchi K, Andreone P, Arbune M, Hou JL, Park SJ, Vata A, Cremer J, Elston R, Lukic T, Quinn G, Maynard L, Kendrick S, Plein H, Campbell F, Paff M, Theodore D & B-Clear Study Group.
N Engl J Med, 387(21), 1957-1968.

176.1
Evaluation of Fracture Risk Among Patients with Type 2 Diabetes and Nonvalvular Atrial Fibrillation Receiving Different Oral Anticoagulants
Lui DTW*, Tang EHM, Au ICH, Wu TT, Lee CH, Wong CK, Cheung CYY, Fong CHY, Chow WS, Woo YC, Tan KCB, Lam KSL & Wong CKH.
Diabetes Care, 45(11), 2620-2627.

17.2
FGF21-Srtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity
Jin LG*, Geng LL*, Ying L, Shu LL, Ye K, Yang RY, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan XQ, Liao BY, Liu J, Duan FY, Sweeney G, Woo CWH, Wang Y, Xia ZY, Lian QZ & Xu AM** 
Circulation, 146(20), 1537-1557.

40.0
Kidney Outcomes Associated with Sodium-Glucose Cotransporter 2 Inhibitors Versus Glucagon-Like Peptide 1 Receptor Agonists: A Real-World Population-Based Analysis
Lui DTW*, Au ICH, Tang EHM, Cheung CL, Lee CH, Woo YC, Wu TT, Tan KCB & Wong CKH
eClinicalMedicine, 50, 101510.
 
17.0
Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared with Viral Myocarditis
Lai FTT, Chan EWW, Huang L, Cheung CL, Chui CSL, Li X, Wan EYF, Wong CKH, Chan EWY, Yiu KH**  & Wong ICK
J Am Coll Cardiol. 80(24), 2255-2265.

27.2
Prospective Study on the Efficacy and Impact of Cascade Screening and Evaluation of Hereditary Angioedema (CaSE-HAE)
Wong JCY, Chiang V, Lam K, Tung E, Au EYL, Lau CS & Li PH** 
J Allergy and Clin Immunol Pract. 10(11), 2896-2903.

11.0
Regulation of Proton Partitioning in Kinase-Activating Acute Myeloid Leukemia and Its Therapeutic Implication
Man CH, Zeng XY, Lam W, Ng TCC, Kwok TH, Dang KCC, Leung TWY, Ng NKL, Lam SSY, Cher CY & Leung AYH**
Leukemia, 36(8), 1990-2001.Blood, 142(23), 2002-2015.

13.0
Risk of Thyroid Dysfunction Associated with mRNA and Inactivated COVID-19 Vaccines: A Population-Based Study of 2.3 million Vaccine Recipients
Wong CKH, Lui DTW*, Xiong X, Chui CSL, Lai FTT, Li X, Wan EYF, Cheung CL, Lee CH, Woo YC, Au ICH, Chung MSH, Cheng FWT, Tan KCB & Wong ICK
BMC Med, 20(1), 339.

11.8
Two-dose COVID-19 Vaccination and Possible Arthritis Flare Among Patients with Rheumatoid Arthritis in Hong Kong
Li X*, Tong XN, Yeung WWY, Kuan P, Yum SHH, Chui CSL, Lai FTT, Wan EYF, Wong CKH, Chan EWY, Lau CS & Wong ICK
Ann Rheum Dis, 81(4), 564-568.

28.0
* Staff member as first author
** Staff member as corresponding author