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Publications

Introduction Staff list Research Publications Education Clinical service
  • YK Wong, CYY Cheung, CS Tang, KW Au, JSH Hai, PCH Lee, KK Lau, BMY Cheung, PC Sham, A Xu, KSL Lam (Co-corresponding author), HF Tse.  Age-Biomarkers-Clinical (ABC) risk factor for prediction of cardiovascular events in patients with coronary artery disease.  Arterioscler Thromb Vasc Biol 2018 (Accepted) [IF:6.086]
  • PCH Lee, CYY Cheung, YC Woo, DTW Lui, MMA Yuen, CHY Fong, WS Chow, A Xu, KSL Lam.  Circulating adipocyte fatty acid-binding protein concentrations predict multiple mortality outcomes among men and women with diabetes.  Clin Chem 2018 Jul 18 Epub ahead of print [IF:8.636] #citations on 19/11/18: 1
  • CYY Cheung, PCH Lee, C Tang, A Xu, KW Au, CHY Fong, K Ng, K Kwok, WS Chow, CY Woo, MMY Yuen, JJ Hai, KCB Tan, TH Lam, HF Tse, PC Sham, KSL Lam.  Genetic regulation of pigment epithelium-derived factor (PEDF): an Exome-chip association analysis in Chinese subjects with type 2 diabetes.  Diabetes [IF:7.273] 2018 Oct 10 Epub ahead of print
  • PCH Lee, CYY Cheung, YC Woo, DTW Lui, MMA Yuen, CHY Fong, WS Chow, A Xu, KSL Lam.  Prospective association of circulating adipocyte fatty acid-binding protein levels with risk of renal outcomes and mortality in type 2 diabetes.  Diabetologia 2018 Sep 28 Epub ahead of print [IF:6.023]
  • Lee CH, Lam KS.  Biomarkers of progression in diabetic nephropathy – the past, present and future.  J Diabetes Investig 2015 (Epub ahead of print)
  • Woo YC, Cheung BMY, Yeung CY, Lee CH, Hui EYL, Fong CHY, Tso AWK, Tam S, Lam KSL.  Cardiometabolic risk profile of subjects with prediabetes diagnosed by HbA1c criteria in an urban Hong Kong Chinese population over 40 years of age.  Diabet Med 2015 (Epub ahead of print)
  • CH Lee, EYL Hui, YC Woo, CY Yeung, WS Chow, MAM Yuen, CHY Fong, A Xu, KSL Lam.  Circulating fibroblast growth factor 21 levels predict progressive kidney disease in subjects with type 2 diabetes and normoalbuminuria.  J Clin Endocrinol Metab 2015;100:1368-75  [IF:5.789] #citations on 19/11/18: 32
  • CS Tang, H Zhang, CYY Cheung, M Xu, JCY Ho, Wi Zhou, SS Cherny, Y Zhang, O Holmen, KW Au, H Yu, L Xu, J Jia,  RM Porsch, L Sun, W Xu, H Zheng, LY Wong, Y Mu, J Dou, CHY Fong, Su Wang, X Hung, L Dong, Y Liao, J Wang, LSM Lam, ML Yang, J Chen, CW Siu, G Xie, YC Woo, Y Wu, KCB Tan, K Hveem, BMY Cheung, S Zöllner,  A Xu, YE Chen, CQ Jiang, Y Zhang, TH Lam, S Ganesh, Y Huo, *PC Sham, *KSL Lam, *CJ Willer, *HF Tse, *W Gao. (co-supervising authors)  Exome-wide Association Analysis Reveals Novel Coding Sequence Variants Associated with Lipid Traits in Chinese.  Nat Commun2015;6:10206 [IF:12.353] #citations on 19/11/18: 21
  • Lee CH, Cheung CYY, Chow WS, Woo YC, Yeung CY, Lang BHH, Fong CHY, Kwok KHM, Chen SPL, Mak CM, Tan KCB, Lam KSL.  Genetics of apparently sporadic phaeochromocytoma in a Chinese population.  Horm Metab Res 2015 (Provisionally accepted)
  • Lee CH, Woo YC, Fong CHY, Lam JKY, Cheung BMY, Lam KSL, Tan KCB.  Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese.  J Clin Lipidol 2015 (In Press)
  • Hui E, Xu A, Chow WS, Lee CH, Fong HY, Cheung CW, Tse HF, Chau MT, Cheung BMY, Lam KSL.  Hypoadiponectinaemia as an independent predictor for the progression of carotid atherosclerosis: a 5-year prospective study.  Metab Syndr Relat Disord 2014, 12: 517-522
  • Shiu SWM, Xiao SM, Wong Y, Chow WS, Lam KS, Tan KC.  Carbamylation of LDL and its relationship with myeloperoxidase in type 2 diabetes mellitus.  Clin Sci 2014;126:175-181
  • Hui E, Yeung CY, Lee CH, Woo YC, Fong CH, Chow WS, Xu A, Lam KS.  Elevated circulating pigment epithelium-derived factor predicts the progression of diabetic nephropathy in patients with type 2 diabetes.  J Clin Endocrinol Metab 2014, 99:E2169-E2177
  • Lee CH, Woo YC, Wang Y, Yeung CY, Xu A, Lam KS.  Obesity, adipokines and cancer: an update.  Clin Endocrinol (Oxf). 2014 (Epub ahead of print)
  • Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, Itoh N, Wang Y, Bornstein SR, Xu A*, Li X.  Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice.  Cell Metabolism. 2013, 17:779-89 (cited ~30 times within 8 months after publication)
  • RL Hoo, PC Lee, Mi Zhou, YL Wong, X Hui, A Xu, KSL Lam.  Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice.  J Hepatol 2013;58:358-64  [IF:15.04] #citations on 19/11/18: 27
  • WS Chow, A Xu, YC Woo, AWK Tso, SC Cheung, CHY Fong, HF Tse, MT Chau, BMY Cheung, KSL Lam.  Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors.  Arterioscler Thromb Vasc Biol 2013;33:2454-9  [IF:6.086] #citations on 19/11/18: 78
  • Lee CH, Yuen MM, Chow WS, Tso AW, Yeung CK, Chan JC, Chau CH, Lam KS.  A man with blistering eruption and tuberculosis.  BMJ 2012; 344:d8351
  • Cheng KK, Lam KS, Wu D, Wang Y.. and Xu A*.  APPL1 potentiates insulin secretion in pancreatic beta-cells by increasing Akt-dependent expression of SNARE proteins in mice. Proc. Natl. Acad. Sci. USA. 2012, 109:8919-24, selected for commentary.
  • Shea YF, Lee CH, Gill H, Chow WS, Lam YM, Luk HM, Lam ST, Chu LW.  Delayed diagnosis of 22q11.2 deletion syndrome in an adult Chinese lady.  Chin Med J 2012, 125:2945-2947
  • Y Xiao, A Xu, LSC Law, C Chen, H Li, X Li, L Yang, S Liu, Z Zhou, KSL Lam.  Distinct changes in serum fibroblast growth factor 21 level in different subtypes of diabetes.  J Clin Endocrinol Metab2012;97(1):E54-8  [IF:5.789] #citations on 19/11/18: 60
  • Li FY, Lam KS, Tse HF, Chen C, Wang Y, Vanhoutte PM, Xu A*. Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice.  Circulation. 2012, 126:1267-77.
  • Ye D, Li Y, Lam KS, Li H, Jia W, Wang Y, Man K, Li X and Xu A*.  TLR4 mediates obesity-induced nonalcoholic steatohepatitis through activation of X-box binding protein in mice.  Gut. 2012, 61: 1058-67
  • Wang Y, Cheng KK, Lam KS, Wu D, Wang Y, Huang Y, Vanhoutte PM, Sweeney G, Li Y, Xu A*.  APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice.  Diabetes, 2011, 60: 3044-54.
  • Tam HL, Shiu SWM, Leng L, Bucala R, Betteridge DJ, Tan KC.  Enhanced expression of receptor for advanced glycation end products is associated with low circulating soluble isoforms of the receptor in type 2 diabetes.  Clin Sci 2011;120:81-89.
  • C Chen, BMY Cheung, AWK Tso, Y Wang, LS Law, KL Ong, NMS Wat, A Xu, KSL Lam.  High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects.   Diabetes Care 2011;34:2113-5  [IF:13.397] #citations on 19/11/18: 86
  • X Zhang, A Xu, SK Chung, JH Cresser, G Sweeney, RLC Wong, A Lin, KSL Lam.  Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice.  Diabetes 2011;60:486-95  [IF:7.273] #citations on 19/11/18: 69
  • AWK Tso, TKY Lam, A Xu, KH Yiu, HF Tse, LSW Li, LSC Law, BMY Cheung, RTF Cheung, KSL Lam.  Serum adipocyte fatty acid-binding protein is associated with ischemic stroke and early death.  Neurology 2011;76:1968-75  [IF:8.055] #citations on 19/11/18: 31
  • Wong WT, Tian XY, Xu A*, Yu J, Lau CW, Hoo R, Wang Y, Lee VW, Lam KS, Vanhoutte PM, and Huang Y.  The obligatory role of adiponectin in restoring endothelial function in PPARγ agonist-treated diabetic mice.  Cell Metabolism, 2011, 16:101-15.
  • Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao W, DeMicco DA, Preston GM, Tan K, Fuller JH.   Total soluble and endogenous secretory receptor for advanced glyation endproducts as predictive biomarkers of Coronary Heart Disease risk in patients with type 2 diabetes; an analysis from the CARDS trial. Diabetes, 2011;60:2379-85.
  • Chang J , Li Y , Huang Y , Lam KS, Hoo LC, Wong WT, Cheng KK, Wang Y, Vanhoutte PM , and Xu A*.  Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP kinase/p16INK4A Signaling Pathway.  Diabetes, 2010, 59: 2949-59
  • Tam HL, Shiu SWM, Wong Y, Chow WS, Betteridge DJ, Tan KC.  Effects of atorvastatin on serum soluble receptors for advanced glycation end-products in type 2 diabetes.  Atherosclerosis 2010;209:173-177.
  • CYY Cheung, AWK Tso, BMY Cheung, A Xu, KL Ong, CHY Fong, NMS Wat, ED Janus, PC Sham, KSL Lam.  Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a Chinese population.  J Clin Endocrinol Metab 2010; 95:1395-403  [IF:5.789] #citations on 19/11/18: 58
  • Yiu KH, Jim MH, Siu CW, Lee CH, Yuen M, Mok M, Shea YF, Fan K, Tse HF, Chow WH.  Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome.  J Clin Endocrinol Metab 2009, 94: 109-114
  • Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney, Zhu W, Vanhoutte PM, Kraegen EW and Xu A*.  APPL1 Potentiates Insulin-mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice.  Cell Metabolism, 2009, 9:417-27.
  • DCY Yeung, A Xu, AWK Tso, WS Chow, NMS Wat, CHY Fong, S Tam, PC Sham, KSL Lam.  Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients.  Diabetes Care 2009;32:132-4  [IF: 13.397]  #citations on 19/11/18: 40
  • Shiu SWM, Tan KC, Wong Y, Leng L, Bucala R. G lycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus.  Atherosclerosis, 2009;203:522-52.
  • Tan KC.  Reverse cholesterol transport in type 2 diabetes mellitus.  Diabetes, Obes Metab 2009;11:534-43.
  • XM Zhang, DCY Yeung, M Karpisek, D Stejskal, F Liu, RLC Wong, *KSL Lam, *A Xu. (*co-corresponding authors).  Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans.  Diabetes 2008;57:1246-53  [IF:7.273] #citations on 19/11/18: 443
  • Tan KC, Shiu SWM, Wong Y, Leng L, Bucala R.  Soluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitus.  J Lipid Res 2008;49:1438-1444.
  • Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A*.  Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.  Diabetes. 2007, 56:1387-94 (cited over 170 times).
  • A Xu, AWK Tso, BMY Cheung, Y Wang, NMS Wat, CHY Fong, ED Janus, KSL Lam.  Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study.  Circulation 2007;115:1537-43  [IF:18.881] #citations on 19/11/18: 239
  • AWK Tso, A Xu, PC Sham, NMS Wat, Y Wang, CHY Fong, BMY Cheung, ED Janus, KSL Lam.  Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes - a 10-year prospective study in Chinese.  Diabetes Care 2007:30:2667-72  [IF:13.397] #citations on 19/11/18: 172
  • DCY Yeung, A Xu, SCW Cheung, NMS Wat, MH Yau, CHY Fong, MT Chau, KSL Lam.  Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis.  Arterioscler Thromb Vasc Biol 2007;27:1796-802  [IF:6.086] #citations on 19/11/18: 129
  • Tan KC, Chow WS, Tso AWK, Xu A, Tse HF, Hoo RLC, Betteridge DJ, Lam KS.  Thiazolidinedione increases serum soluble receptor for advanced glycation end products in type 2 diabetes.  Diabetologia 2007;50:1819-1825.
  • Tan KC, Chow WS, Lam JCM, Lam B, Bucala R, Betteridge DJ, Ip MSM.  Advanced glycation end products in non-diabetic patients with obstructive sleep apnea.  Sleep 2006;29:329-33
  • Tan KC, Shiu SWM, Chow WS, Leng L, Bucala R, Betteridge DJ.  Association between serum level of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes.  Diabetologia 2006;49:2756-2762.
  • Xu A*, Lam MCL, Chan KW, Wang Y, Hoo RCL, Zhang JL, Tso A and Lam KSL,  ANGPTL4 decreases blood glucose, improve glucose tolerance, but induces hyperlipidemia and hepatic steatosis in mice,  Proc. Natl. Acad. Sci. USA, 2005, 102, 6089-6091
  • Xu A*, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ.  The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice.  J. Clin. Invest. 2003, 112:91-100. (selected for the cover story of this issue, CITED OVER 980 times).