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Introduction Staff list Research Publications Education Clinical service
  • Chan PH, Wong CK, Pun L, Wong YF, Wong MM, Chu DW, Siu CW. Head-to-Head Comparison of the AliveCor Heart Monitor and Microlife WatchBP Office AFIB for Atrial Fibrillation Screening in a Primary Care Setting. Circulation 2017;135:110-112
  • Chan PH, Hai J, Yeung CY, Lip GY, Lam KS, Tse HF, Siu CW. Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis. Europace 2016;18:665-71
  • Chan PH, Huang D, Hai J, Li WH, Yin LX, Chan EW, Wong IC, Lau CP, Chiang CE, Zhu J, Tse HF, Siu CW. Stroke Prevention Using Dabigatran in the Very Elderly with Atrial Fibrillation. Heart Rhythm 2016;13:366-73
  • Chan PH, Huang D, Lau CP, Chan EW, Wong IC, Lip GY, Tse HF, Siu CW. Net Clinical Benefit of Dabigatran Over Warfarin in Patients With Atrial Fibrillation Stratified by CHA2DS2-VASc and Time in Therapeutic Range. Can J Cardiol 2016;32:1247.e15-1247.e21
  • Chan PH, Wong CK, Poh YC, Pun L, Leung WW, Wong YF, Wong MM, Poh MZ, Chu DW, Siu CW. Diagnostic Performance of a Smartphone-Based Photoplethysmographic Application for Atrial Fibrillation Screening in a Primary Care Setting. J Am Heart Assoc 2016;5(7). pii: e003428
  • Chan PH, Alegria-Barrero E, Foin N, et al. Extended use of the GuideLiner in complex coronary interventions. EuroIntervention 2015;11:325-35
  • Chan PH, Li WH, Hai JJ, Tse HF, Siu CW. Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease. PLoS One 2015;10:e0131479
  • Chan PH, Siu CW. Clinical Benefit of Warfarin in Dialysis Patients With Atrial Fibrillation. J Am Coll Cardiol 2015;66:1310-1
  • Alegria-Barrero E, Chan PH*, Foin N, et al. Concept of the central clip: when to use one or two MitraClips. EuroIntervention 2014;9:1217-24 (*co-first author)
  • Lau CP, Siu CW, Tse HF. The future of implantable devices for cardiac rhythm management. Circulation 2014;129:811-22.
  • Yiu KH, Wong A, Pu L, Chiang R, Sit KY, Chan D, Lee HY, Lam YM, Chen Y, Siu CW, Lau CP, Au WK, Tse HF. Prognostic value of preoperative right ventricular geometry and tricuspid valve tethering area in patients undergoing tricuspid annuloplasty. Circulation 2014;129:87-92.
  • Lau CP, Tachapong N, Wang CC, Wang JF, Abe H, Kong CW, Liew R, Shin DG, Padeletti L, Kim YH, Omar R, Jirarojanakorn K, Kim YM, Chen MC, Sriratanasathavorn C, Munawar M, Kam R, Chen JY, Cho YK, Li YG, Wu SL, Bailleul C, Tse HF, for SAFE Study Prospective Randomized Study to Assess the Efficacy of Site and Rate of Atrial Pacing on Long-term Progression of Atrial Fibrillation in Sick Sinus Syndrome- Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) study. Circulation 2013;128:687-93.
  • Tse HF, Ho JC, Buter AW, Lee YK, Choi SW, Ng KM, Siu CW, Simpson MA, Lai WH, Chan YC, Zhang J, Lay KW, Esteban MA, Colman A, Sham PC. Patient-specific induced pluripotent stem cells derived cardiomyocytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel desmin gene mutation identified by whole exome sequencing. Hum Mol Genet 2013;22:1395-1403.
  • Viceconte N, Chan PH, Alegria-Barrero E, et al. Frequency domain optical coherence tomography for guidance of coronary stenting. Int J Cardiol 2013;166:722-8
  • Yiu KH, Yeung CK, Zhao CT, Chan JC, Siu CW, Tam S, Wong CS, Yan GH, Yue WS, Khong PL, Chan HH, Tse HF. Prevalence and extent of subclinical atherosclerosis in patients with psoriasis. J Intern Med. 2013 ;273:273-82.
  • Alegría-Barrero E, Chan PH, Di Mario C, et al. Tools and techniques: edge-to-edge percutaneous MitraClip implantation. EuroIntervention 2012;7:1476-8
  • Alegria-Barrero E, Chan PH, Paulo M, et al. Edge-to-Edge Percutaneous Repair of Severe Mitral Regurgitation - state-of-the-art for Mitraclip implantation. Circ J 2012;76:801-8
  • Alegría-Barrero E, Foin N, Chan PH, et al. Optical coherence tomography for guidance of distal cell recrossing in bifurcation stenting: choosing the right cell matters. EuroIntervention 2012;8:205-13
  • Chan PH, Alegria-Barrero E, Di Mario C. Tools and Techniques: Intravascular Ultrasound and Optical Coherence Tomography. EuroIntervention 2012;7:1343-1349
  • Chan PH, Di Mario C, Franzen O. Dissociation between anatomical and functional results after MitraClip implantation. Int J Cardiol 2012;155:175-6
  • Chan PH, She HL, Alegria-Barrero E, et al. Real-World Experience of MitraClip for Treatment of Severe Mitral Regurgitation. Circ J 2012;76:2488-9
  • Lip GY, Tse HF, Lane DA. Management of atrial fibrillation. Lancet 2012 18;379:648-61.
  • Siu CW, Lee YK, Ho JC, Lai WH, Chan YC, Ng KM, Wong LY, Au KW, Lau YM, Zhang J, Lay KW,Colman A, Tse HF. Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells. Aging (Albany NY). 2012 Nov;4(11):803-822.
  • Siu CW, Wong MP, Ho CM, Lam CL, Tse HF. Fatal lung toxic effects related to dronedarone. Arch Intern Med. 2012;172:516-7.
  • Yeung CY, Lam KS, Li SW, Lam KF, Tse HF, Siu CW. Sudden cardiac death after myocardial infarction in type 2 diabetic patients with no residual myocardial ischemia. Diabetes Care. 2012 Dec;35(12):2564-9
  • Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, Marsan NA, Veltman CE, de Roos A, Pazhenkottil A, Kroft LJ, Boersma E, Herzog B, Leung M, Maffei E, Leung DY, Kaufmann PA, Cademartiri F, Bax JJ, Jukema JW. Age- and gender-specific differences in the prognostic value of CT coronary angiography. Heart. 2012;98:232-7.
  • Chan PH, Di Mario C, Davies SW, et al. Transcatheter Aortic Valve Implantation in Degenerate Aortic Homograft Root Replacements. J Am Coll Cardiol 2011;58:1729-30
  • Lee YK, Ng KM, Lai WH, Chan YC, Lau YM, Lian Q, Tse HF, Siu CW. Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Rev. 2011 Nov;7(4):976-86.
  • Lee YK, Ng KM, Lai WH, Man C, Lieu DK, Lau CP, Tse HF, Siu CW. Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway. Acta Pharmacol Sin. 2011 Jan;32(1):52-61.
  • Ng AC, Yiu KH*, Ewe SH, van der Kley F, Bertini M, de Weger A, de Roos A, Leung DY, Schuijf JD, Schalij MJ, Bax JJ, Delgado V. Influence of left ventricular geometry and function on aortic annular dimensions as assessed with multi-detector row computed tomography: implications for transcatheter aortic valve implantation. Eur Heart J. 2011;32:2806-13. * Co-first author
  • Ng KM, Lee YK, Lai WH, Chan YC, Fung ML, Tse HF, Siu CW. Exogenous expression of human apoA-I enhances cardiac differentiation of pluripotent stem cells. PLoS One. 2011 May 11;6(5):e19787.
  • Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ. Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Arthritis Rheum. 2011;63:3969-78.
  • Yiu KH, Tse HF, Mok MY, Lau CS. Ethnic differences in cardiovascular risk in rheumatic disease: focus on Asians. Nat Rev Rheumatol. 2011;7:609-18.
  • Yiu KH, Wang S, Mok MY, Ooi GC, Khong PL, Lau CS, Tse HF. Relationship between cardiac valvular and arterial calcification in patients with rheumatoid arthritis and systemic lupus erythematosus. J Rheumatol. 2011;38:621-7.
  • Yiu KH, Yeung CK, Chan HT, Wong RM, Tam S, Lam KF, Yan GH, Yue WS, Chan HH, Tse HF. Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation. Br J Dermatol. 2011;164:514-20.
  • Lai WH, Ho JC, Lee YK, Ng KM, Au KW, Chan YC, Lau CP, Tse HF, Siu CW. ROCK inhibition facilitates the generation of human-induced pluripotent stem cells in a defined, feeder-, and serum-free system. Cell Reprogram. 2010 Dec;12(6):641-53.
  • Lee YK, Ng KM, Chan YC, Lai WH, Au KW, Ho CY, Wong LY, Lau CP, Tse HF, Siu CW. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol Endocrinol. 2010 Sep;24(9):1728-36.
  • Lian Q, Zhang Y, Zhang J, Zhang HK, Wu X, Zhang Y, Lam FY, Kang S, Xia JC, Lai WH, Au KW, Chow YY, Siu CW, Lee CN, Tse HF. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation 2010;121:1113-23.
  • Siu CW, Pong V, Ho HH, Liu S, Lau CP, Li SW, Tse HF. Are MADIT II criteria for implantable cardioverter defibrillator implantation appropriate for Chinese patients? J Cardiovasc Electrophysiol. 2010 Mar;21(3):231-5.
  • Yiu KH, Wang S, Mok MY, Ooi GC, Khong PL, Lau CP, Lai WH, Wong LY, Lam KF, Lau CS, Tse HF. Role of circulating endothelial progenitor cells in patients with rheumatoid arthritis with coronary calcification. J Rheumatol. 2010;37:529-35.
  • Zhang J, Lian Q, Zhu G, Zhou F, Sui L, Tan C, Abdul Mutalif R, Navasankari R, Zhang Y, Tse HF, Stewart CL, Colman A. A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell. 2010;8:31-45.
  • Siu CW, Jim MH, Zhang X, Chan YH, Pong V, Kwok J, Kung AW, Lau CP, Tse HF. Comparison of atrial fibrillation recurrence rates after successful electrical cardioversion in patients with hyperthyroidism-induced versus non-hyperthyroidism-induced persistent atrial fibrillation. Am J Cardiol. 2009 Feb 15;103(4):540-3. .
  • Siu CW, Lau CP, Lee WL, Lam KF, Tse HF. Intravenous diltiazem is superior to intravenous amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation. Crit Care Med. 2009 Jul;37(7):2174-9
  • Siu CW, Pong V, Zhang X, Chan YH, Jim MH, Liu S, Yiu KH, Kung AW, Lau CP, Tse HF. Risk of ischemic stroke after new-onset atrial fibrillation in patients with hyperthyroidism. Heart Rhythm. 2009 Feb;6(2):169-73.
  • Wang S, Yiu KH*, Mok MY, Ooi GC, Khong PL, Mak KF, Lau CP, Lam KF, Lau CS, Tse HF. Prevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritis. J Intern Med. 2009 ;266:445-52. * Co-first author
  • Yiu KH, Jim MH, Siu CW, Lee CH, Yuen M, Mok M, Shea YF, Fan K, Tse HF, Chow WH. Amiodarone-induced thyrotoxicosis is a predictor of adverse cardiovascular outcome. J Clin Endocrinol Metab. 2009 Jan;94:109-14.
  • Chan YH, Lau KK, Yiu KH, Li SW, Chan HT, Fong YT, Tam S, Lau CP, Tse HF. Reduction of C-Reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke. Eur Heart J 2008;29:2800-2807.
  • Lip GY, Tse HF. Management of atrial fibrillation. Lancet 2007;370:604-18.
  • Siu CW, Jim MH, Ho HH, Miu R, Lee SW, Lau CP, Tse HF. Transient atrial fibrillation complicating acute inferior myocardial infarction: implications for future risk of ischemic stroke. Chest. 2007 Jul;132(1):44-9.
  • Siu CW, Yeung CY, Lau CP, Kung AW, Tse HF. Incidence, clinical characteristics and outcome of congestive heart failure as the initial presentation in patients with primary hyperthyroidism. Heart. 2007 Apr;93(4):483-7.
  • Siu CW, Zhang XH, Yung C, Kung AW, Lau CP, Tse HF. Hemodynamic changes in hyperthyroidism-related pulmonary hypertension: a prospective echocardiographic study. J Clin Endocrinol Metab. 2007 May;92(5):1736-42.
  • Tse HF, Thambar S, Kwong YL, Rowlings P, Bellamy G, McCrohon J, Thomas P. Bastian B, Chan JKF, Lo G, Ho CL, Chan WS, Kwong RY, Parker A, Hauser T, Chan J, Fong YT, Lau CP. Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial).Eur Heart J. 2007; 28: 2998-3005.
  • Yiu KH, Siu CW, Lee KL, Fong YT, Chan HW, Lee SW, Lau CP, Tse HF. Emerging trends of community acquired infective endocarditis. Int J Cardiol. 2007;121:119-22
  • Siu CW, Au WY, Yung C, Kumana CR, Lau CP, Kwong YL, Tse HF. Effects of oral arsenic trioxide therapy on QT intervals: implications on long-term cardiac safety. Blood. 2006; 108: 103-6.
  • Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA. Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model. Circulation. 2006; 114: 1000-11.
  • Tse HF, Kwong YL, Lo G, Ho CL, Chan JKF, Yeung DW, Lau CP. Angiogenesis in ischemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet. 2003; 361: 47-9.
  • Tse HF, Siu CW, Lee KLF, Fan K, Chan HW, Tang MO, Tsang V, Lee SWL, Lau CP. The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy. J Am Coll Cardiol. 2005; 46: 2292-97.