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Publications

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  • Ho PWL, Leung MCT, Liu HF, Pang SYY, Lam CSC, Xian JW, Li LF, Kung MHW, Ramsden DB, Ho SL. (2019) Age-dependent accumulation of oligomeric α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson's disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).. Autophagy. 2019 Apr 14:1-24. doi: 10.1080/15548627.2019.1603545.
  • Pang SYY, Ho PWL, Liu HF, Leung CT, Li LF, Chang EES, Ramsden DB, Ho SL. The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease. Translational Neurodegeneration. 2019
  • Lau KK, Li L, Simoni M, Mehta Z, Kuker W, Rothwell PM. Long-term premorbid blood pressure and cerebral small vessel disease burden on imaging in TIA and ischaemic stroke: population-based study. Stroke 2018; 49(9): 2053-2060 (Impact factor 6.046)
  • Lau KK, Lovelock CE, Li L, Simoni M, Gutnikov S, Kuker W, Mak HKF, Rothwell PM. Antiplatelet treatment after TIA and ischaemic stroke in patients with cerebral microbleeds in two large cohorts and an updated systematic review. Stroke 2018; 40(6):1434-1442. (Impact factor 6.046)
  • Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR. (2018) Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase. Biochem J. 2018 Jan 2;475(1):1-22. doi: 10.1042/BCJ20170802.
  • Lau KK, Li L, Lovelock CE, Zamboni G, Chan TT, Chiang MF, Lo KT, Kuker W, Mak HKF, Rothwell PM. Clinical correlates, ethnic differences and prognostic implications of perivascular spaces in TIA and ischaemic stroke. Stroke 2017; 48:1470-1477 (Impact factor 6.046)
  • Lau KK, Li L, Schulz U, Simoni M, Chan KH, Ho SL, Cheung RTF, Kuker W, Mak HKF, Rothwell PM. Total Small Vessel Disease Score and risk of recurrent stroke – validation in two large cohorts. Neurology 2017; 88: 2260-2267 (Impact factor 8.689)
  • Lau KK, Wong YK, Teo KC, Chang RSK, Tse MY, Hoi CP, Chan CY, Chan OL, Cheung RHK, Wong EKM, Kwan JSK, Hui ES, Mak HKF. Long-term prognostic implications of cerebral microbleeds in Chinese with ischaemic stroke. Journal of American Heart Association 2017; 7;6(12). pii: e007360 (Impact factor 4.45)
  • Liu HF, Ho PW, Leung GC, Lam CS, Pang SY, Li L, Kung MH, Ramsden DB, Ho SL. (2017) Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease. Scientific Reports. 7:40887. doi: 10.1038/srep40887. 2017
  • Pang SY, Hsu JS, Teo KC, Li Y, Kung MHW, Cheah KSE, Chan D, Cheung KMC, Li MX, Sham PC, Ho SL. (2017) Burden of rare variants in ALS genes influences survival in familial and sporadic ALS. Neurobiol Aging. 2017 Oct;58:238.e9-238.e15. doi: 10.1016/j.neurobiolaging. 2017.06.007.
  • Pang SY, Teo KC, Hsu JS, Chang RSK, Li MX, Sham PC, Ho SL. (2017) The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review. Translational Neurodegeneration.2017  6:27. doi: 10.1186/s40035-017-0098-0.
  • Ito G, Katsemonova K, Tonelli F, Lis P, Baptista M, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi D. (2016) Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochemical Journal. 473(17):2671-85. 2016
  • Lau KK, Wong YK, Chan YH, Li Oi, Chan KH, Lee P, Yuen P, Wong YK, Tong S, Wong D, Cheung RTF, Siu CW, Ho SL, Tse HF. Mediterranean-style diet is associated with reduced blood pressure variability and subsequent stroke risk in patients with coronary artery disease. American Journal of Hypertension 2015; 28(4): 501-507 (Impact factor 2.530)
  • Lau KK, Wong YK, Chan YH, Teo KC, Chan KH, Li LSW, Cheung RTF, Siu CW, Ho SL and Tse HF. Visit-to-visit blood pressure variability as a prognostic marker in patients with cardiovascular and cerebrovascular diseases – relationships and comparisons with vascular markers of atherosclerosis. Atherosclerosis 2014; 235(1): 230-5 (Impact factor: 4.255)
  • Lau KK, Wong YK, Chang RSK, Teo KC, Hon SFK, Chan KH, Wat KL, Cheung RTF, Li LSW, Siu CW, Ho SL and Tse HF. Visit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct. European Journal of Neurology 2014; 21(2): 319-25 (Impact factor 4.387)
  • Lau KK, Wong YK, Teo KC, Chang RSK, Chan KH, Hon SFK, Wat KL, Cheung RTF, Li LSW, Siu CW and Tse HF. Long-term prognostic implications of visit-to-visit blood pressure variability in patients with ischemic stroke. American Journal of Hypertension 2014; 27(12): 1486-94 (Impact factor 2.530)
  • Liu HF, Lu S, Ho PWL, Tse HM, Pang SYY, Kung MHW, Ho JWM, Ramsden DB, Zhou ZJ, Ho SL. (2014) LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity. Annals of Clinical and Translational Neurology. 1(3):199-208..2014
  • Chan KH, R Lee, JCY Lee, ACT Tse, SYY Pang, GKK Lau, KC Teo, PWL Ho. Central nervous system inflammatory demyelinating disorders among Hong Kong Chinese. Journal of Neuroimmunology 2013;262:100-105 (JIF 3.10)
  • Gao J, Cheung RTF, Chan YS, Chu LW, Lee TM. Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed. Neuropsychology, Development and Cognition. Section B: Aging, Neuropsychology and Cognition 2013; 20(1): 80-100.
  • Guo Y, Chan KH, Lai WH, Siu CW, Kwan SC, Tse HF, Ho WL, Ho WM. Human mesenchymal stem cells upregulate CD1dhighCD5+ regulatory B cells in experimental autoimmune encephalomyelitis. Neuroimmunomodulation 2013;20:294-303 (JIF 2.38)
  • Ho PWL, Tse HM, So DHF, Ho JWM, Liu HF, Kung MHW, Ramsden DB, Ho SL. (2013) Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O-methyltransferase (COMT) expression in an ELISA-based system. PloS One. 8(9):e74065. doi: 10.1371/journal.pone.0074065. eCollection 2013.
  • Sang YH, Liang YX, Liu LG, Ellis-Behnke RG, Wu WT, So KF, Cheung RTF. A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection. Experimental Animals 2013; 62(1): 63-69.
  • Teo KC, Ho SL. (2013) Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson’s disease. Translational Neurodegeneration. 2(1):19. doi: 10.1186/2047-9158-2-19. 2013
  • Chan KH, Lam KSL, Cheng OY, Kwan JSC, Ho PWL, Cheng KKY, Chung SK, Ho JWM, Guo VY, Xu A. Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity. PLOS ONE 2012;7(12):e52354 (JIF 4.35)
  • Chan KH, Zhang R, Kwan JSC, Guo VY, Ho PWL, Ho JWM, Chu ACY. Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse. Journal of Neuroimmunology 2012;245:32-38 (JIF 3.10)
  • Lau KK, Wong YK, Chan YH, Yiu KH, Teo KC, Li LS, Ho SL, Chan KH, Siu CW and Tse HF. Prognostic implications of surrogate markers of atherosclerosis in low to intermediate risk patients with type 2 diabetes. Cardiovascular Diabetology 2012; 11: 101 (Impact factor 5.948)
  • Chan KH, Tse CT, Chung CP, Lee R, Kwan JSC, Ho PWL, Ho. JWM Brain involvement of neuromyelitis optica spectrum disorders. Archives of Neurology 2011;68(11):1432-1439 (JIF 7.58)
  • Gao J, Cheung RTF, Lee TM, Chu LW, Chan YS, Mak HK, Zhang JX, Qiu D, Fung G, Cheung C. Possible retrogenesis observed with fiber tracking: An anteroposterior pattern of white matter disintegrity in normal aging and Alzheimer's disease. Journal of Alzheimers Disease 2011; 26(1): 47-58.
  • Sang YH, Su HX, Wu WT, So KF, Cheung RTF. Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury. Journal of Neurotrauma 2011; 28(12): 2523-2534.
  • Tso AW, Lam TK, Xu A, Yiu KH, Tse HF, Li LS, Law LS, Cheung BM, Cheung RTF, Lam KS. Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death. Neurology 2011; 76(23): 1968-1975.
  • Chan KH, Kwan JSC, Ho PWL, Ho SL, Chui WH, Chu ACY, Ho JWM, Zhang WY, Kung MHW. Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis. Journal of Neuroimmunology 2010, 227, 178-184. (JIF 3.10)
  • Chan KH, Kwan SC, Ho WL, Ho WM, Chu ACY, Ramsden DB. Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays. Journal of Neuroinflammation, 2010, 7(1), 50 (JIF =4.53)
  • Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. An fMRI study showing effect of acupuncture in chronic stage stroke patients with aphasia. Journal of Acupuncture & Meridian Studies 2010; 3(1): 53-57.
  • Cheung RTF, Lyden PD, Tsoi TH, Huang Y, Liu M, Hon SFK, Raman R, Liu L. Production and validation of Putonghua- and Cantonese-Chinese language National Institutes of Health Stroke Scale training and certification videos. International Journal of Stroke 2010; 5(2): 74-79.
  • Chan KH, Ramsden DB, Yu YL, Kwok KHH, Chu ACY, Ho PWL, Kwan JSC, Lee R, Lim E, Kung MHW, Ho SL. NMO-IgG in idiopathic inflammatory demyelinating disorders among Hong Kong Chinese. European Journal of Neurology 2009;16:310-316 (JIF 4.17)
  • Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. Acupuncture of motor-implicated acupoints on subacute stroke: a fMRI study. Medical Acupuncture 2009; 21(4): 233-241.
  • Chau ACM, Cheung RTF, Jiang X, Au Yeung PKM, Li LSW. Increased brain activation in motor cortex after acupuncture treatment for motor recovery in chronic stroke patients. The Open Rehabilitation Journal 2009; 2(1): 89-94.
  • Yu J, Zeng J, Cheung RTF, Xiong L, He M, Liang Z, Hong H, Huang R. Intracerebroventricular injection of epidermal growth factor reduces neurological deficit and infarct volume and enhances nestin expression following focal cerebral infarction in adult hypertensive rats. Clinical and Experimental Pharmacology and Physiology 2009; 36(5-6): 539-546.
  • Cheung RTF. Sexual dysfunctions after stroke: a need for more study. European Journal of Neurology 2008; 15(7): 641.
  • Chan KH, Tsang KL, Fong CY, Ho SL, Cheung RTF, Mak W. Idiopathic inflammatory demyelinating disorders after acute transverse myelitis. European Journal of Neurology 2006;13:862-868 (JIF 4.17)
  • Cheung RTF, Tipoe GL, Tam S, Ma ESK, Zou LY, Chan PS. Preclinical evaluation of pharmacokinetics and safety of melatonin in propylene glycol for intravenous administration. Journal of Pineal Research 2006; 41(4): 337-343.
  • Cheung RTF. Update on medical and surgical management of intracerebral hemorrhage. Reviews on Recent Clinical Trials 2007; 2(3): 174-181.
  • Zou LY, Cheung RTF, Liu SR, Li G, Huang L. Melatonin reduces infarction volume in a photothrombotic stroke model in the wild-type but not cyclooxygenase-1-gene knockout mice. Journal of Pineal Research 2006; 41(2): 150-156.
  • Chen SH, Cheung RTF. Neuropeptide Y and its receptor analogs differentially modulate the immunoreactivity for neuronal or endothelial nitric oxide synthase in the rat brain following focal ischemia with reperfusion. Journal of Biomedical Science 2005; 12(2): 267-278.
  • Chen SH, Cheung RTF. Neuropeptide Y-Y1 receptor agonist worsens while antagonist improves survival of cultured Y1-expressing neuronal cells following oxygen and glucose deprivation. Journal of Biomedical Science 2004; 11(6): 781-788.
  • Cheung RTF, Hachinski V. Cardiac effects of stroke. Current Treatment Options in Cardiovascular Medicine 2004; 6(3): 199-207.
  • Li G, Huang L, Cheung RTF, Liu SR, Ma QY, Yang ES. Cortical activations upon stimulation of the sensorimotor-implicated acupoints. Magnetic Resonance Imaging 2004; 22(5): 639-644.
  • Pei Z, Cheung RTF. Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model. Journal of Pineal Research 2004; 37(2): 85-91.
  • Chan KH, Cheung RTF, Fong CY, Tsang KL, Mak W, Ho SL. Clinical relevance of hydrocephalus as a presenting feature of tuberculous meningitis. Quarterly Journal of Medicine 2003; 96(9): 643-648.
  • Chen SH, Cheung RTF. Intracerebroventricular injection of a neuropeptide Y-Y1 receptor agonist increases while BIBP3226, a Y1 antagonist, reduces the infarct volume following transient middle cerebral artery occlusion in rats. Neuroscience 2003; 116(1): 119-126.
  • Cheung RTF, Eliasziw M, Meldrum HE, Fox AJ, Barnett HJM, the North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group. Risk, types, and severity of intracranial hemorrhage in patients with symptomatic carotid artery stenosis. Stroke 2003; 34(8): 1847-1851.
  • Cheung RTF, Hachinski V. Cardiac rhythm disorders and muscle changes with cerebral lesions. Advances in Neurology 2003; 92(1): 213-220.
  • Cheung RTF, Zou LY. Use of the original, modified or new Intracerebral Hemorrhage Score to predict mortality and morbidity after intracerebral hemorrhage. Stroke 2003; 34(7): 1717-1722.
  • Cheung RTF. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. Journal of Pineal Research 2003; 34(3): 153-160.
  • Li G, Cheung RTF, Ma QY, Yang ES. Visual cortical activations on fMRI upon stimulation of the vision-implicated acupoints. NeuroReport 2003; 14(5): 669-673.
  • Li G, Liu HL, Cheung RTF, Hung YC, Wong KKK, Shen GGX, Ma QY, Yang ES. A functional MRI study comparing brain activation between word generation and electrical stimulation of language-implicated acupoints. Human Brain Mapping 2003; 18(3): 233-238.
  • Pei Z, Cheung RTF. Melatonin protects SHSY5Y neuronal cells but not cultured astrocytes from ischemia due to oxygen and glucose deprivation. Journal of Pineal Research 2003; 34(3): 194-201.
  • Pei Z, Fung PCW, Cheung RTF. Melatonin reduces nitric oxide level during ischemia but not blood-brain-barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. Journal of Pineal Research 2003; 34(2): 110-118.
  • Pei Z, Pang SF, Cheung RTF. Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Stroke 2003; 34(3): 770-775.
  • Chen SH, Cheung RTF. Peripheral and central administration of neuropeptide Y in a rat middle cerebral artery occlusion stroke model reduces cerebral blood flow and increases infarct volume. Brain Research 2002; 927(2): 138-143.
  • Chen SH, Fung PCW, Cheung RTF. Neuropeptide Y-Y1 receptor modulates nitric oxide level during stroke in the rat. Free Radical Biology and Medicine 2002; 32(8): 776-784.
  • Cheung RTF, Pei Z, Feng ZH, Zou LY. Cyclooxygenase-1-gene knockout does not alter middle cerebral artery occlusion in a mouse stroke model. Neuroscience Letters 2002; 330(1): 57-60.
  • Cheung RTF. Sexual functioning in Chinese stroke patients with mild or no disability. Cerebrovascular Diseases 2002; 14(2): 122-128.
  • Pei Z, Ho HTS, Cheung RTF. Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat. Neuroscience Letters 2002; 318(3): 141-144.
  • Pei Z, Pang SF, Cheung RTF. Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Journal of Pineal Research 2002; 32(3): 168-172.
  • Chan KH, Vernino S, Lennon VA. ANNA-3 Anti-Neuronal Nuclear Antibody: Marker of Lung Cancer Related Autoimmunity. Annals of Neurology 2001;50:301-311 (JIF 11.09)
  • Cheung RTF, Li LSW, Tsang KL, Leung KP. Stroke prevention in atrial fibrillation among Hong Kong Chinese. Cerebrovascular Diseases 2001; 11(4): 353-354.
  • Cheung RTF, Mak W, Chan KH. Circadian variation of stroke onset among Hong Kong Chinese: a hospital-based study. Cerebrovascular Diseases 2001; 12(1): 1-6.
  • Cheung RTF. Hong Kong patients' knowledge of stroke does not influence time-to-hospital presentation. Journal of Clinical Neuroscience 2001; 8(4): 311-314.
  • Cheung RTF, Cechetto DF. Neuropeptide Y-Y1 receptor antisense oligodeoxynucleotide increases the infarct volume after middle cerebral artery occlusion in rats. Neuroscience 2000; 98(4): 771-777.
  • Cheung RTF, Hachinski V. The insula and cerebrogenic sudden death. Archives of Neurology 2000; 57(12): 1685-1688.
  • Cheung RTF. Prevalence of migraine, tension-type headache, and other headaches in Hong Kong. Headache 2000; 40(6): 473-479.
  • Cheung RTF, Li LSW, Mak W, Tsang KL, Lauder IJ, Chan KH, Fong GCY. Knowledge of stroke in Hong Kong Chinese. Cerebrovascular Diseases 1999; 9(2): 119-123.