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Publications

Introduction Staff list Research Publications Education Clinical service
  • Kwok HH, Ning Z, Chong PW, Wan TS, Ng MH, Ho GY, Ip MS,Lam DC. Transfer of extracellular vesicle-associated-RNAs induces drug resistance in ALK-translocated lung adenocarcinoma.Cancers2019; Jan 17;11(1). pii: E104.
  • Kwok WC, Liang BM, Lui MM, Tam TC, Sim JP, Tse EW, Leung AY, Kwong YL, Lie AK, Ip MS,Lam DC. Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome.Respirology2019 Jan 20.(In press)
  • Lam SK, Yan S, Xu S, U KP, Cheng PN, Ho JC*. Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma. Oncogenesis 2019 Feb 26;8(3):18. doi: 10.1038/s41389-019-0128-0.
  • Chan HS, Ko FK, Chan JW, So LK,Lam DC, Chan VL, Tam CY, Yu WC. Co-morbidities, mortality and management of chronic obstructive pulmonary disease patients who required admissions to public hospitals in Hong Kong – computerized data collection and analysis.International Journal of COPD 2018; Jun 13; 13: 1913-1925.
  • Lam DCL, Kwok HH, Yu WC, Ko FW, Tam CY, Lau AC, Fong DY, Ip MS. Serum CC16 levels correlates with smoking-related lung function decline. Submitted toBMC Pulmonary Medicine2018 Mar 16;18(1):47.
  • Man KM, Tian Z,Lam DC, Wan JM, Tan-Un KC. Satisfaction, preference and error occurrence of three dry powder inhalers as assessed by a cohort naïve to inhaler operation.International Journal of COPD2018; Jun 15; 13: 1949-1963.
  • Muruganandani S, Azzopardi M, Fitzgerald DB, Shrestha R, Kwan BCH,Lam DCL, de Chaneet CC, Rashid Ali MRS, Yap E, Tobin CL, Garske LA, Nguyen PT, Stanley C, Popowicz ND, Kosky C, Thomas R, Read CA, Budgeon CA, Feller-Kopman D, Maskell NA, Murray K, Lee YCG. Aggressive versus Symptom-guided Drainage of Malignant Pleural Effusion via Indwelling Pleural Catheters: The Australasian Malignant Pleural Effusion (AMPLE) Trial-2 randomized clinical trial.Lancet Respiratory Medicine2018 Sep;6(9):671-680.
  • Wu YL, Lu S, Lu Y, Zhou JY, Shi YK, Sriuranpong V, Ho JCM, Ong CK, Tsai CM, Chung CH, Wilner KD, Tang Y, Masters ET, Selaru, P, Mok TS. First-line crizotinib versus chemotherapy in East Asian patients with ALK-positive advanced non-small cell lung cancer: phase III study results. J Thorac Oncol 2018;pii: S1556-0864(18)30721-4. doi: 10.1016/j.jtho.2018.06.012.
  • Xu S, Lam SK, Cheng PN, Ho JC*. Recombinant human arginase induces apoptosis via oxidative stress and cell cycle arrest in small cell lung cancer. Cancer Sci 2018 Aug 28. doi: 10.1111/cas.13782.
  • Han L, Lee CK, Pang H, Chan HT, Lo IL, Lam SK, Cheong TH, Ho JC*. Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status. Lung Cancer 2017;114:79-89.
  • Ho JC*, Lam SK. Combining arginine depletion and chemotherapy in thoracic malignancies. J Clin Oncol 2017;35(16):1758-1759.   
  • Lam SK, Li YY, Xu S, Leung LL, U KP, Zheng YF, Cheng PN, Ho JC*. Growth suppressive effect of pegylated arginase in malignant pleural mesothelioma xenografts. Respir Res 2017;18(1):80. Doi: 10.1186/s12931-017-0564-3.
  • Lam SK, U KP, Li YY, Xu S, Cheng PN, Ho JC*. Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models. Oncology Reports 2018;40(4):1994-2004.
  • Thomas R, Fysh ETH, Smith NA, Lee P, Kwan BCH, Yap E, Horwood FC, Piccolo F, Lam DCL, Garske LA, Shrestha R, Kosky C, Read CA, Murray K, Lee YCG. Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients with Malignant Pleural Effusion: The AMPLE Randomized Clinical Trial.JAMA2017 Nov 21;318(19):1903-1912.
  • Bai CX, Choi CM, Chu CM, Anantham D, Ho JC, Khan AZ, Lee JM, Li SY, Saenghirunvattana S, Yim A. Evaluation of pulmonary nodules: clinical practice consensus guidelines for Asia. Chest 2016; 150(4):877-893.
  • Lam SK, Leung LL, Li YY, Zheng CY, Ho JC*. Combination effects of arsenic trioxide and fibroblast growth factor receptor inhibitor in squamous cell lung carcinoma. Lung Cancer 2016;100:111-119.
  • Lam DC, Luo SY, Deng W, Cheung AL, Cheng GH, Lin CH, Sham PC, Wan TS, Tsao SW. Oncogenic mutation profiling in new lung cancer and mesothelioma cell lines.Journal of OncoTargets and Therapy2015; 8: 195 – 209.
  • Lam DC, Tam TC, Lau KM, Wong WM, Hui CK, Lam JC, Wang JK, Lui MM, Ho JC, Ip MS. EGFR Array for diagnostic detection of plasmaEGFRmutation and association with survival outcomes in advanced stage lung cancer patients.Clinical Lung Cancer2015 Nov;16(6):507-13.
  • Lam DC,Chan SC, Mak JC, Freeman C, Ip MSM, Shum DK. S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation.Scientific Reports2015 Aug; 10; 5: 12945.
  • Lam DC,Fu KH, Luo SY, Lui MS, Chan KH, Wistuba II, Gao B, Tsao SW, Ip MS, Minna JD. Expression of nicotinic acetylcholine receptor subunit genes in bronchial epithelium correlates with lung function.American Journal of Physiology – Lung Cell and Molecular Physiology2015; Nov 25:ajplung.00101.2015.
  • Luo SY, Sit AK, Sihoe AD, Suen WS, Au WK, Tang X, Ma ES, Chan WK, Wistuba II, Minna JD, Tsao SW,Lam DC. Aberrant Large Tumor Suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas.Lung Cancer2014; 85(2): 282 - 292
  • Cooper W,Lam DC, O’Toole S, Minna JD. Oncogenes and Tumor suppressor hallmarks in lung cancer.J Thoracic Disease2013; 5(Suppl 5): S479-490.
  • Guan S, Tee W, Ng D, Chan T, Peh H, Ho W, Cheng C, Mak J, Wong W. Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br. J. Pharmacol. 2013;168:1707-1718. (2012 Impact F. 5.067; 5-year Impact F. 4.898)
  • Han KQ, Yeung SC, Ip MSM, Mak JCW. Intermittent hypoxia-induced NFkB and HO-1 regulation in human endothelial EA.hy926 cells. Cell Biochemistry & Biophysics. 2013; 66(3): 431-441.
  • Ho JC *, Au WY, Han L, Kwong YL, Ip MS. Effect of therapeutic arsenic exposure on pulmonary function. Respiratory Medicine 2013; 107(9):1423-30.
  • Lai AYK, Fong DYT, Lam JCM, Weaver T, Ip MSM. Linguistic and psychometric validation of the Chinese version of the Self-Efficacy Measures for Sleep Apnea. Sleep Medicine 2013; 14(11): 1192-1198.
  • Li YY, Lam SK, Mak JC, Zheng CY, Ho JC*. Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer. Lung Cancer 2013; 81(3):354-61.
  • Tam TC, Ho JC, Wong MK, Wong WM, Wang JK, Lam JC, Lui MM, Lam WK, Ip MS,Lam DC. Treatment Outcomes in Elderly with Advanced-stage Non-small Cell Lung Cancer.LUNG2013; 191(6):645-654.
  • Thompson P, Salvi S, Lin J, Cho YJ, Eng P, Manap RA, Boonsawat W, Hsu JY, Faruqi RA, Moreno-Cantu JJ, Fish JE, Ho JC. Insights, attitudes, and perceptions about asthma and its treatment: Findings from a multinational survey of patients from 8 Asia-Pacific countries and Hong Kong. Respirology 2013; 18(6):957-67.
  • Wu YL, Lee JS, Thongprasert S, Yu CJ, Zhang L, Ladrera G, Srimuninnimit V, Sriuranpong V, Sandoval-Tan J, Zhu Y, Liao M, Zhou C, Pan H, Lee V, Chen YM, Sun Y, Margono B, Fuerte F, Chang GC, Seetalarom K, Wang J, Cheng A, Syahruddin E, Qian X, Ho JC, Kurnianda J, Liu HE, Jin K, Truman M, Bara I, Mok TS. Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small cell lung cancer. Lancet Oncology 2013;14(8):777-86.
  • Zheng CY, Lam SK, Li YY, Fong BM, Mak JC, Ho JC*. Combination of arsenic trioxide and chemotherapy in small cell lung cancer. Lung Cancer 2013 ;82(2):222-30.
  • Chan KH, Chan SCH, Yeung SC, Man RYK, Ip MSM, Mak JCW*. Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity. Free Radic. Res. 2012; 46:1123-1129. (2012 Impact F. 3.279; 5-year Impact F. 2.836)
  • Ho Y-S, Yang X, Yeung S-C, Chiu K, Lau CF, Tsang AW-T, Mak JC-W, Chang RC-C. Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats. PLoS One. 7:e36752, 2012. (2012 Impact F. 3.730; 5-year Impact F. 4.244)
  • Lam DC, Fong DYT, Yu WC, Ko FW, Lau AC, Chan JW, Choo KL, Mok TY, Tam CY, Ip MSM, Chan-yeung M. FEV3, FEV6 and their derivatives for detecting airflow obstruction in adult Chinese.Int J Tuberc Lung Dis. 2012 May;16(5):681-6.
  • Lau WKW, Chan SC, Law AC, Ip MS, Mak JCW*. The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells. Toxicol. Sci. 2012; 125:569-577. (2012 Impact F. 4.328; 5-year Impact F. 4.836)
  • Lau WKW, Chan-Yeung MMW, Yip BHK, Cheung AHK, Ip MSM, Mak JCW*. The Role of Circulating Serotonin in Development of Chronic Obstructive Pulmonary Disease. PLoS One 2012; 7:e31617. (2012 Impact F. 3.730; 5-year Impact F. 4.244)
  • Lau WKW, Li X, Yeung DSC, Chan KH, Ip MSM, Mak JCW*. The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo. Free Radic. Res. 2012;46:1413-1419. (2012 Impact F. 3.279; 5-year Impact F. 2.836)
  • Yam I,Lam DC, Chan K, Chung-Man Ho J, Ip M, Lam WK, Chan TK, Chan V. EGFR array: uses in the detection of plasma EGFR mutations in non-small cell lung cancer patients.J Thorac Oncol. 2012 Jul; 7(7):1131-40.
  • Lam DC, Lam B, Wong MKY, Lu C, Au WY, Tse EWC, Leung AYH, Kwong YL, Liang RHS, Lam WK, Ip MSM, Lie AKW. Effects of Azithromycin in bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation – a randomized double-blinded placebo-controlled study.Bone Marrow Transplantation2011; 46 (12): 1551 – 56.
  • Chan KH, Yeung SC, Yao TJ, Ip MSM, Cheung AHK, Chan-Yeung MMW, Mak JCW*. Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease. Int. J. Tuberc. Lung Dis. 14:1193-200, 2010. (2012 Impact F. 2.610; 5-year Impact F. 2.502)
  • Lam DC, Lui MM, Lam JC, Ong LH, Lam KS, Ip MSM. Prevalence and recognition of obstructive sleep apnea in Chinese patients with type 2 diabetes mellitus. Chest 2010; 138: 1101-1107.
  • Lam JCM, Lam B, Yao TJ, Lai AYK, Ooi CG, Tam S, Lam KSL, Ip MSM. A randomized controlled trial of nCPAP on insulin sensitivity in obstructive sleep apnea. European Respiratory Journal 2010; 35(1): 138-145.
  • Chan KH, Ho SP, Yeung SC, So WHL, Cho CH, Koo MWL, Lam WK, Ip MSM, Man RYK, Mak JCW*. Chinese green tea ameliorates lung injury in cigarette smoke-exposed rats. Respir. Med. 103:1746-1754, 2009. (2012 Impact F. 2.585; 5-year Impact F. 2.659)
  • Ho JC*, Lam DC, Wong MK, Lam B, Ip MS, Lam WK. Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung. J Thorac Oncol 2009;4(9):1174-1177.
  • Lam DCL, Girard L, Ramirez R, Chau WS, Suen WS, Sheridan S, Tin VPC, Chung LP, Wong MP, Shay JW, Gazdar AF, Lam WK, Minna JD. Expression of Nicotinic Acetylcholine Receptor Subunit Genes showed difference in expression pattern in smokers and non-smokers.Cancer Research2007; 67(10): 4638 – 47.
  • Lam DCL, Xu A, Lam KSL, Lam B, Lam JCM, Lui MMS, Ip MSM. Serum adipocyte-fatty acid binding protein (A-FABP) level is elevated in severe obstructive sleep apnea (OSA) and correlates with insulin resistance. European Respiratory Journal 2009; 33(2): 346-351.
  • Lui MMS, Lam JCM, Mak H, Xu A, Ooi C, Lam DCL, Mak J, Khong PL, Ip MSM. C-reactive protein is associated with obstructive sleep apnea independent of visceral obesity. Chest 2009; 135: 950-956.
  • Lam JCM, Xu A, Tam S, Khong PL, Yao TJ, Lam DCL, Lai AYK, Lam B, Lam KSL, Ip MSM. Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea. Sleep 2008; 31: 1721-1727.
  • Ho JC*, Chan-Yeung M, Ho SP, Mak JC, Ip MS, Ooi GC, Wong MP, Tsang KW, Lam WK. Disturbance of systemic antioxidant profile in non-small cell lung carcinoma. Eur Respir J 2007;29:273-278.
  • Lam B, Sam K, Mok WYW, Cheung MT, Fong DY, Lam J, Lam DC, Yam L, Ip MSM. Randomised study of three non-surgical treatments in mild to moderate obstructive sleep apnoea. Thorax 2007; 62; 354-359.
  • Ho JC*, Mak JC, Ho SP, Ip MS, Tsang KW, Lam WK, Chan-Yeung M. Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. J Thorac Oncol 2006;1:648-653.
  • Ip MSM, Ko KW, Lau CW, Yu WC, Choo K, Tang KS, Chan-Yeung M. Update reference values of spirometry for adult Chinese in Hong Kong and implications on clinical utilization. Chest 2006; 129: 384-392.
  • Lam DC, Girard L, Suen WS, Chung LP, Tin VP, Lam WK, Minna JD, Wong MP. Establishment and Expression Profiling of New Primary Lung Cancer Cell Lines from Chinese Smokers and Life-time Never-Smokers.Journal of Thoracic Oncology2006; 1(9): 932 – 942.
  • Ip MSM, Tse HF, Lam B, Tsang KWT, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. American Journal of Respiratory and critical Care Medicine 2004; 169: 348-353.
  • Mak JCW*, Leung HCM, Ho SP, Law BK, Lam WK, Tsang KW, Ip MS, Chan-Yeung M.  Systemic antioxidant and oxidant status in Chinese asthmatic patients.  J. Allergy Clin. Immunol.  114:260-264, 2004. (2012 Impact F. 12.047; 5-year Impact F. 10.108)
  • Ip MSM, Lam B, Ng MMT, Lam WK, Tsang KWT, Lam KSL. Obstructive sleep apnoea is independently associated with insulin resistance. American Journal of Respiratory and Critical Care Medicine 2002; 165: 670-676.
  • Ho JC, Zheng S, Comhair SA, Farver C, Erzurum SC. Differential expression of manganese superoxide dismutase and catalase in lung cancer. Cancer Research 2001;61:8578-8585.
  • Ip MSM, Lam B, Lauder I, Tsang K, Chung KF, Mok W, Lam WK. A community study of sleep disordered breathing in middle-aged Chinese men in Hong Kong. Chest 2001; 119: 62-69.